{"id":1427,"date":"2023-01-17T21:34:22","date_gmt":"2023-01-17T13:34:22","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=1427"},"modified":"2023-01-17T21:34:22","modified_gmt":"2023-01-17T13:34:22","slug":"thymosin-beta-15-a-novel-regulator-of-tumor-cell-motility-upregulated-in-metastatic-prostate-cancer-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=1427","title":{"rendered":"Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer."},"content":{"rendered":"<p>Research |Published:1996\/12\/1\u00a0 | ISSN:1078-8956\u00a0 |doi:10.1038\/nm1296-1322 |pmid:8946830<\/p>\n<hr \/>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<hr \/>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.<\/p>\n<hr \/>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">\u6d4b\u8bd5<\/h2>\n<hr \/>\n<p>\u53ca\u7b2c\u4e09\u65b9\u4f9b\u5e94\u5546\u5c06\u901a\u8fc7\u6d4f\u89c8\u5668\u5b58\u50a8\u3001\u8bbf\u95ee\u60a8\u7684\u8d26\u53f7\u4fe1\u606f\uff0c\u4ee5\u4fbf\u6301\u7eed\u4e3a\u60a8\u63d0\u4f9b\u826f\u597d\u670d\u52a1\u3001\u7ef4\u62a4\u5bf9\u5e94\u5e7f\u544a\u4fe1\u606f\u3002\u5982\u679c\u60a8\u540c\u610f\uff0c\u6211\u4eec\u5c06\u4e2a\u6027\u5316\u60a8\u770b\u5230\u7684\u5185\u5bb9\u53ca\u5e7f\u544a\u3002\u60a8\u53ef\u4ee5\u901a\u8fc7\u70b9\u51fb\u9009\u62e9\u201c\u6211\u63a5\u53d7\u201d\u4ee5\u793a\u540c\u610f\uff0c\u60a8\u53ef\u4ee5\u901a\u8fc7\u70b9\u51fb\u201c\u7ba1\u7406\u8bbe\u7f6e\u201d\u67e5\u770b\u60a8\u7684\u9009\u62e9\uff0c\u5e76\u901a\u8fc7\u201c\u7ba1\u7406\u8bbe\u7f6e\u201d\u4fee\u6b63\u60a8\u7684\u9009<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research |Published:1996\/12\/1\u00a0 | ISSN:1078-8956\u00a0 |doi:1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1427"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1427"}],"version-history":[{"count":0,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1427\/revisions"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1427"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}