{"id":1482,"date":"2023-01-19T14:43:59","date_gmt":"2023-01-19T06:43:59","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=1482"},"modified":"2023-01-19T14:43:59","modified_gmt":"2023-01-19T06:43:59","slug":"thymosin-beta-15-a-novel-regulator-of-tumor-cell-motility-upregulated-in-metastatic-prostate-cancer","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=1482","title":{"rendered":"Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer."},"content":{"rendered":"<p>Research |Published:1996-12-1\u00a0 | ISSN:1078-8956\u00a0 |doi:10.1038\/nm1296-1322 |pmid:8946830<\/p>\n<hr \/>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<hr \/>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.<\/p>\n<hr \/>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">\u80f8\u817a\u7d20\u03b215:\u4e00\u79cd\u5728\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u4e2d\u4e0a\u8c03\u7684\u80bf\u7624\u7ec6\u80de\u8fd0\u52a8\u6027\u7684\u65b0\u578b\u8c03\u8282\u5242\u3002<\/h2>\n<hr \/>\n<p>Dunning\u5927\u9f20\u524d\u5217\u817a\u764c\u662f\u4e00\u4e2a\u6a21\u578b\u7cfb\u7edf\uff0c\u5176\u4e2d\u7ec6\u80de\u8fd0\u52a8\u6027\u4e0e\u8f6c\u79fb\u8868\u578b\u5bc6\u5207\u76f8\u5173\u3002\u6211\u4eec\u5df2\u7ecf\u9274\u5b9a\u4e86\u4e00\u79cd\u65b0\u57fa\u56e0\uff0c\u5b83\u5728\u9ad8\u6d3b\u52a8\u6027\u548c\u8f6c\u79fb\u6027Dunning\u764c\u7ec6\u80de\u7cfb\u4e2d\u4e0a\u8c03\uff0c\u4ee3\u8868\u80f8\u817a\u7d20\u03b2\u5bb6\u65cf\u7684\u4e00\u4e2a\u65b0\u6210\u5458\uff0c\u80f8\u817a\u7d20\u03b215\u3002\u5c06\u53cd\u4e49\u80f8\u817a\u7d20\u03b215\u6784\u5efa\u4f53\u8f6c\u67d3\u5230\u5927\u9f20\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2d\u8868\u660e\uff0c\u8be5\u5206\u5b50\u6b63\u8c03\u8282\u7ec6\u80de\u8fd0\u52a8\u6027\uff0c\u7ec6\u80de\u8fd0\u52a8\u6027\u662f\u8f6c\u79fb\u9014\u5f84\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\u3002\u80f8\u817a\u7d20\u03b215\u6c34\u5e73\u5728\u4eba\u524d\u5217\u817a\u764c\u4e2d\u5347\u9ad8\uff0c\u5e76\u4e14\u4e0eGleason\u80bf\u7624\u5206\u7ea7\u6b63\u76f8\u5173\u3002\u80f8\u817a\u7d20\u03b215\u53ef\u80fd\u4ee3\u8868\u4eba\u7c7b\u524d\u5217\u817a\u764c\u8fdb\u5c55\u7684\u6f5c\u5728\u7684\u65b0\u751f\u5316\u6807\u8bb0\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research |Published:1996-12-1\u00a0 | ISSN:1078-8956\u00a0 |doi:1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1482"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1482"}],"version-history":[{"count":0,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1482\/revisions"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1482"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}