{"id":16796,"date":"2023-10-30T11:06:01","date_gmt":"2023-10-30T03:06:01","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=16796"},"modified":"2023-10-30T11:06:02","modified_gmt":"2023-10-30T03:06:02","slug":"%e7%97%85%e7%90%86%e5%9b%be%e5%83%8f%e5%85%ac%e5%85%b1%e6%95%b0%e6%8d%ae%e5%88%86%e6%9e%90%e8%bf%98%e8%83%bd%e5%8f%917%e5%88%86%e7%ba%af%e7%94%9f%e4%bf%a1%ef%bc%9f%e5%8f%b0%e6%b9%be%e6%88%90%e5%8a%9f","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=16796","title":{"rendered":"\u75c5\u7406\u56fe\u50cf\u516c\u5171\u6570\u636e\u5206\u6790\u8fd8\u80fd\u53d17\u5206+\u7eaf\u751f\u4fe1\uff1f\u53f0\u6e7e\u6210\u529f\u5927\u5b66\u8c22\u5b59\u6e90\u56e2\u961f\u7528\u6df1\u5ea6\u5b66\u4e60\u8d85\u5f3abuff\u65a9\u83b7\u9ad8\u5206\uff01"},"content":{"rendered":"<p>\u751f\u4fe1\u5185\u5377\u600e\u4e48\u7834\uff1f<\/p>\n<p>\u5c0f\u4e91\u5efa\u8bae\uff1a\u4e24\u6761\u817f\u751a\u81f3\u4e09\u6761\u817f\u8d70\u8def\uff01\u5e38\u89c4\u751f\u4fe1\u9886\u57df\u7528\u521b\u65b0\u601d\u8def\u3001\u5206\u6790\u624b\u6bb5\u548c\u9a8c\u8bc1\u5b9e\u9a8c\u7834\u5708\uff0c\u4e34\u5e8a\u533b\u751f\u5efa\u8bae\u7528\u4e34\u5e8a\u6570\u636e\u5e93\u5206\u6790\u548c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5f00\u8f9f\u65b0\u9886\u5730\uff0c\u90a3\u9488\u5bf9\u751f\u4fe1\u7b97\u6cd5\u76f8\u5173\u56e2\u961f\u5c31\u66f4\u63a8\u8350\u5229\u7528\u201c\u6df1\u5ea6\u5b66\u4e60\u201d\u901a\u9053\u5728\u201c\u75c5\u7406\u56fe\u50cf\u5206\u6790\u201d\u548c\u201c\u5f71\u50cf\u7ec4\u5b66\u5206\u6790\u201d\u65b9\u5411\u53d1\u5149\u53d1\u70ed~ ~<strong>\uff08ps\uff1a\u5c0f\u4e91\u4e4b\u524d\u5c31\u63a8\u8350\u8fc7\u751f\u4fe1+\u75c5\u7406\u5206\u6790\u3001\u6df1\u5ea6\u5b66\u4e60\u75c5\u7406\u56fe\u50cf\u5206\u6790\u3001\u5f71\u50cf\u7ec4\u5b66\u7b49\u65b0\u601d\u8def\uff0c\u8fd8\u6ca1\u6709\u770b\u5230\u7684\u670b\u53cb\uff0c\u6293\u7d27\u6076\u8865\u4e00\u4e0b\u54e6\uff09<\/strong>\uff0c\u8fd9\u4e9b\u53ef\u90fd\u662f\u51b2\u523a\u9ad8\u5206\u751f\u4fe1\u7684\u597d\u673a\u4f1a\uff0c\u54b1\u4eec\u53ef\u4e0d\u80fd\u76f4\u63a5\u653e\u8fc7\u00b7\u00b7\u00b7<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"240\" height=\"240\" class=\"wp-image-16797\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-1.jpeg?resize=240%2C240\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-1.jpeg?w=240 240w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-1.jpeg?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-1.jpeg?resize=100%2C100 100w\" sizes=\"(max-width: 240px) 100vw, 240px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4eca\u5929\u5c0f\u4e91\u5c31\u7528\u4e00\u4e2a7\u5206+\u7684\u7eaf\u751f\u4fe1\u6587\u7ae0\u6765\u7ed9\u670b\u53cb\u4eec\u770b\u770b\u522b\u7684\u56e2\u961f\u662f\u600e\u4e48\u7528\u201c\u6df1\u5ea6\u5b66\u4e60\u201d\u8fd9\u4e2a\u751f\u4fe1MVP\u9009\u624b\u9ad8\u9891\u53d1\u6587\u7684\uff01\u8be5\u6587\u7ae0\u7531<strong>\u53f0\u6e7e\u6210\u529f\u5927\u5b66\u8c22\u5b59\u6e90\u6559\u6388\u56e2\u961f<\/strong>\u57282023\u5e7410\u6708\u6700\u65b0\u53d1\u8868\u4e8eJ Transl Med.\u6742\u5fd7\uff1a\u5229\u75282\u5927\u516c\u5171\u6570\u636e\u5e93\uff08NCT\u548cTCGA\uff09\u4e2d\u7684\u7ec4\u7ec7\u75c5\u7406\u56fe\u50cf\u6570\u636e\u6784\u5efa\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u7528\u6765\u9884\u6d4b\u80bf\u7624\u9884\u540e\u3002\u5206\u6790\u4e3b\u4f53\u5728\u4e8e\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u7684\u6784\u5efa\u548c\u5206\u6790\uff0c\u5206\u6790\u624b\u6bb5\u4e0a\u9996\u5148\u521b\u65b0\u6027\u5c31\u5f88\u9ad8\uff1b\u5176\u6b21\uff0c\u5206\u6790\u76ee\u6807\u662f\u516c\u5171\u75c5\u7406\u56fe\u50cf\uff0c\u76f8\u8f83\u4e8e\u5e38\u89c4\u8f6c\u5f55\u7ec4\u6570\u636e\u4e5f\u662f\u9ad8\u521b\u65b0\u6027\u7684\u6570\u636e\u7c7b\u578b\uff0c\u6240\u4ee5\u53cc\u5c42\u53e0\u52a0\u7684\u521b\u65b0\u6027\u97604\u5f20\u56fe\u62ff\u4e0b7\u5206+\u6587\u7ae0\u4e5f\u5c31\u4e0d\u5728\u8bdd\u4e0b\u5566\uff01\u6df1\u5ea6\u5b66\u4e60\u8054\u5408\u75c5\u7406\u56fe\u50cf\u5206\u6790\u65b9\u5411\u53d1\u6587\u7a7a\u95f4\u76f8\u5f53\u5927\uff0c\u5bf9\u8fd9\u4e2a\u601d\u8def\u611f\u5174\u8da3\u7684\u670b\u53cb\u5343\u4e07\u4e0d\u8981\u9519\u8fc7\u54df\uff01<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"271\" class=\"wp-image-16798\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-2.png?resize=640%2C271\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-2.png?w=695 695w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-2.png?resize=300%2C127 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-2.png?resize=600%2C254 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u4e00\u79cd\u65b0\u7684\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u7b97\u6cd5\u7ed3\u5408\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u548c\u7ec4\u7ec7\u9762\u79ef\u4ece\u5168\u5207\u7247\u56fe\u50cf\u9884\u6d4b\u7ed3\u76f4\u80a0\u764c\u751f\u5b58\u7387<\/li>\n<li>\u6742\u5fd7\uff1a<em>J Transl Med.<\/em><\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.4<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7410\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u75c5\u7406\u56fe\u50cf\u7684\u8bc4\u4f30\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u8bca\u65ad\u548c\u9884\u540e\u7684\u91d1\u6807\u51c6\uff0c\u8bb8\u591a\u75c5\u7406\u7279\u5f81\u6709\u52a9\u4e8e\u9884\u6d4b\u7ed3\u76f4\u80a0\u764c\u7684\u9884\u540e\u3002\u8bb8\u591a\u7528\u4e8e\u9009\u62e9\u7ec4\u7ec7\u75c5\u7406\u5b66\u56fe\u50cf\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u6765\u81ea\u611f\u5174\u8da3\u533a\u57df(ROI)\u7684\u6837\u672c\u56fe\u50cf\u8865\u7247\u6216\u7247\u6bb5\u7ec4\u7ec7\u5b66\u6216\u5168\u5207\u7247\u56fe\u50cf(WSIs)\uff0c\u5df2\u88ab\u7528\u4e8e\u5f00\u53d1\u751f\u5b58\u6a21\u578b\u3002\u7531\u4e8egigapixel WSIs\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u7ec4\u7ec7\u5b66\u8868\u73b0\uff0c\u83b7\u5f97\u4e34\u5e8a\u9884\u540e\u548c\u53ef\u89e3\u91ca\u7684\u7279\u5f81\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u7b97\u6cd5\uff0c\u7ed3\u5408\u7ec4\u7ec7\u9762\u79ef\u548c\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u6765\u9884\u6d4b\u764c\u75c7\u751f\u5b58\u671f\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u96c6\/\u961f\u5217<\/td>\n<td>\u6570\u636e\u5e93<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u6837\u672c\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>TCGA-COAD<\/td>\n<td>Xena<\/td>\n<td>\u75c5\u7406\u56fe\u50cf+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>\u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u7684\u77f3\u8721\u5305\u57cb(FFPE) H&amp;E\u67d3\u8272\u7684\u5b8c\u6574\u5207\u7247\u56fe\u50cf(WSIs)<\/td>\n<\/tr>\n<tr>\n<td>NCT-CRC-HE-100K<\/td>\n<td>NCT<\/td>\n<td>\u75c5\u7406\u56fe\u50cf\u6570\u636e<\/td>\n<td>FFPE\u00b7\u7684H&amp;E\u67d3\u8272\u7684\u75c5\u7406\u56fe\u50cf\u7247\u6bb5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p><a id=\"post-16796-_Hlk133142201\"><\/a> \u9996\u5148\u4eceWSIs\u4e2d\u8fdb\u884cpatches\u91c7\u6837\uff0c\u4f7f\u7528NCT-CRC-HE-100K\u6570\u636e\u96c6\u6765\u8bad\u7ec3\u57fa\u4e8epatches\u7684ResNet50\u7ec4\u7ec7\u5206\u7c7b\u5668\uff0c\u5e76\u4f7f\u7528\u8be5\u6a21\u578b\u5c06\u91c7\u6837\u7684patches\u5206\u7c7b\u4e3a\u4e0d\u540c\u7684\u7ec4\u7ec7\u7c7b\u578b(ADI\u3001BACK\u3001DEB\u3001LYM\u3001MUC\u3001MUS\u3001NORM\u3001STR\u548cTUM)\uff08\u56fe1A\uff09\u3002\u7136\u540e\u4f7f\u7528DeepConvSurv\u6a21\u578b\u63d0\u53d6\u80bf\u7624\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u95f4\u8d28\u548c\u7c98\u6db2\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\uff08\u56fe1B\uff09\u3002\u901a\u8fc7\u8bc4\u4f30\u80bf\u7624\u3001\u6dcb\u5df4\u7ec6\u80de\u548c\u95f4\u8d28\u7684\u9762\u79ef\u548c\u6bd4\u7387\uff0c\u4ece\u7ec4\u7ec7\u56fe\u50cf\u4e2d\u68c0\u7d22\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\uff08\u56fe1C\uff09\u3002\u6700\u540e\u4f7f\u7528\u63d0\u53d6\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u548c\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\uff0c\u8bad\u7ec3\u516d\u4e2a\u751f\u5b58\u6a21\u578b\u6765\u9884\u6d4b\u60a3\u8005\u9884\u540e\u98ce\u9669\uff0c\u5c06C\u6307\u6570\u4f5c\u4e3a\u6a21\u578b\u8bc4\u4f30\u6307\u6807\uff08\u56fe1D\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"362\" class=\"wp-image-16799\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-3.png?resize=640%2C362\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-3.png?w=784 784w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-3.png?resize=300%2C170 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-3.png?resize=768%2C435 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-3.png?resize=600%2C340 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 \u7814\u7a76\u8bbe\u8ba1\u56fe<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. \u57fa\u4e8eDeepConvSurv\u6a21\u578b\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u8bc6\u522b<\/strong><\/p>\n<p>\u4f5c\u8005\u4f7f\u7528\u60a3\u8005\u7684\u603b\u4f53\u5b58\u6d3b\u7387(OS)\u6570\u636e\u4e3a\u6bcf\u4e2apatch\u5206\u914d\u6807\u7b7e\uff0c\u5e76\u4f7f\u7528\u9884\u8bad\u7ec3\u7684DeepConvSurv\u6a21\u578b\u4ece\u7ec4\u7ec7\u4e2d\u63d0\u53d6\u7279\u5f81\uff08\u56fe2\uff09\u3002\u4e3a\u4e86\u786e\u5b9a\u54ea\u79cd\u7ec4\u7ec7\u7ec4\u5408\u4e0e\u5b58\u6d3b\u7387\u6700\u76f8\u5173\uff0c\u4f5c\u8005\u4e3a\u6240\u6709\u7ec4\u7ec7\u7ec4\u5408\u8bad\u7ec3\u4e866\u4e2a\u751f\u5b58\u6a21\u578b\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u80bf\u7624\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u57fa\u8d28\u548c\u7c98\u6db2\u7684\u7ec4\u5408\u8fbe\u5230\u4e86\u6700\u4f73\u6548\u679c\uff0c\u5e76\u4e14\u8fd9\u4e9b\u7ec4\u7ec7\u7c7b\u578b\u4e5f\u5177\u6709\u4e34\u5e8a\u610f\u4e49\uff08\u88681\uff09\u3002\u4f5c\u8005\u5c06\u8fd9\u56db\u79cd\u7ec4\u7ec7\u7c7b\u578b(\u5177\u670932\u4e2a\u7279\u5f81)\u7ed3\u5408\u8d77\u6765\uff0c\u4ece\u800c\u83b7\u5f974 \u00d7 32 = 128\u4e2a\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"271\" class=\"wp-image-16800\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-4.png?resize=640%2C271\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-4.png?w=784 784w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-4.png?resize=300%2C127 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-4.png?resize=768%2C325 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-4.png?resize=600%2C254 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 DeepConvSurv\u6a21\u578b\u7684\u67b6\u6784<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"176\" class=\"wp-image-16801\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-5.png?resize=640%2C176\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-5.png?w=817 817w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-5.png?resize=300%2C83 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-5.png?resize=768%2C212 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-5.png?resize=600%2C165 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u88681 \u901a\u8fc7\u4e94\u91cd\u4ea4\u53c9\u9a8c\u8bc1\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u7684\u8868\u73b0<\/p>\n<p><strong>2. \u4ece\u7ec4\u7ec7\u56fe\u50cf\u4e2d\u63d0\u53d6\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81<\/strong><\/p>\n<p>\u4f5c\u8005\u5c06WSI\u88c1\u526a\u6210patches\uff0c\u4f7f\u7528\u9884\u8bad\u7ec3\u7684ResNet50\u5206\u7c7b\u5668\u5c06patches\u5206\u4e3a\u56db\u7c7b(\u80bf\u7624\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u95f4\u8d28\u548c\u5176\u4ed6)\uff0c\u5229\u7528\u5206\u7c7b\u7ed3\u679c\u5c06\u4e0d\u540c\u7684\u989c\u8272\u6620\u5c04\u5230\u4e0d\u540c\u7ec4\u7ec7\u7684patches\u4e0a\uff0c\u5f97\u5230\u7ec4\u7ec7\u56fe\u50cf\u3002\u6700\u540e\u4f7f\u7528\u95ed\u5408\u64cd\u4f5c\u548c\u8fde\u901a\u5206\u91cf\u5206\u6790\u56fe\u50cf\u5904\u7406\u6280\u672f\u6765\u63d0\u53d6\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\uff08\u56fe3\uff09\u3002\u6700\u7ec8\u63d0\u53d6\u4e86\u4e94\u4e2a\u4e34\u5e8a\u9884\u540e\u76f8\u5173\u4e14\u53ef\u89e3\u91ca\u7684\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\uff0c\u5305\u62ec\u6700\u5927\u80bf\u7624\u9762\u79ef\u3001\u80bf\u7624\u5185\u6dcb\u5df4\u7ec6\u80de\u3001\u80bf\u7624\u5468\u56f4\u6dcb\u5df4\u7ec6\u80de\u3001\u80bf\u7624\u5468\u56f4\u5185\u6dcb\u5df4\u7ec6\u80de\u6bd4\u7387\u548c\u603b\u57fa\u8d28\u9762\u79ef\uff08\u88682\uff09\u3002\u7136\u540e\u901a\u8fc7\u6700\u5927\u9009\u62e9\u7b49\u7ea7\u7edf\u8ba1\u65b9\u6cd5\u786e\u5b9a5\u4e2a\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u7684\u4e34\u754c\u70b9\uff0c\u5e76\u5c06\u60a3\u8005\u5c06\u60a3\u8005\u5206\u6210\u4e24\u7ec4\uff0c\u4f7f\u7528Kaplan Meier\u65b9\u6cd5\u8ba1\u7b97\u5b58\u6d3b\u66f2\u7ebf\u3002\u7ed3\u679c\u663e\u793a\uff0c\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u5bf9\u5b58\u6d3b\u7387\u6709\u663e\u8457\u5f71\u54cd\uff08\u56fe4\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"487\" class=\"wp-image-16802\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-6.png?resize=640%2C487\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-6.png?w=784 784w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-6.png?resize=300%2C228 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-6.png?resize=768%2C585 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-6.png?resize=600%2C457 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 \u63d0\u53d6\u7ec4\u7ec7\u533a\u57df\u7279\u5f81\u7684\u56fe\u50cf\u5904\u7406\u6280\u672f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"480\" class=\"wp-image-16803\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-7.jpeg?resize=640%2C480\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-7.jpeg?w=894 894w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-7.jpeg?resize=300%2C225 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-7.jpeg?resize=768%2C576 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-7.jpeg?resize=600%2C450 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"169\" class=\"wp-image-16804\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-8.png?resize=640%2C169\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-8.png?w=806 806w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-8.png?resize=300%2C79 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-8.png?resize=768%2C203 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-8.png?resize=600%2C159 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"174\" class=\"wp-image-16805\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?resize=640%2C174\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?w=1269 1269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?resize=300%2C82 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?resize=1024%2C279 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?resize=768%2C209 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-9.jpeg?resize=600%2C164 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> \u88682 \u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u4fe1\u606f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"741\" class=\"wp-image-16806\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-10.png?resize=640%2C741\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-10.png?w=784 784w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-10.png?resize=259%2C300 259w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-10.png?resize=768%2C889 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-10.png?resize=600%2C695 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 \u57fa\u4e8e\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u7684KM\u751f\u5b58\u5206\u6790<\/p>\n<p><strong>3. \u57fa\u4e8e\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u548c\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u7684\u764c\u75c7\u5b58\u6d3b\u9884\u6d4b<\/strong><\/p>\n<p>\u901a\u8fc7\u5408\u5e76128\u4e2a\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u548c5\u4e2a\u7ec4\u7ec7\u533a\u57df\u7279\u5f81\uff0c\u83b7\u5f97\u4e86\u6700\u7ec8\u7684133\u4e2a\u7279\u5f81\u3002\u4e3a\u4e86\u8bc4\u4f30\u7279\u5f81\u7684\u9884\u540e\u80fd\u529b\uff0c\u4f5c\u8005\u4f7f\u7528\u4e86\u516d\u4e2a\u751f\u5b58\u6a21\u578b\uff1aLASSO-Cox\u3001 RIDGE-Cox\u3001EN-Cox\u3001SSVM\u3001RSF\u548cGBRT\uff0c\u5e76\u5229\u7528C\u6307\u6570\u8bc4\u4f30\u9884\u6d4b\u6027\u80fd\u3002\u4f7f\u7528k-means\u901a\u8fc7\u4e94\u91cd\u4ea4\u53c9\u9a8c\u8bc1\u8fdb\u884c\u6027\u80fd\u6bd4\u8f83\uff0c\u7ed3\u679c\u663e\u793a\u672c\u7814\u7a76\u5efa\u7acb\u7684\u5404\u79cd\u751f\u5b58\u6a21\u578b\u90fd\u53d6\u5f97\u4e86\u6bd4WSISA\uff08\u4e00\u79cd\u6700\u5148\u8fdb\u7684\u57fa\u4e8eWSI\u7684\u751f\u5b58\u9884\u6d4b\u65b9\u6cd5\uff09\u66f4\u597d\u7684\u6027\u80fd\uff0c\u5176\u4e2d\u4f7f\u7528\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u7684\u6700\u4f73\u6027\u80fd\u662f\u4f7f\u7528LASSO-Cox\u6a21\u578b\uff0c\u4f7f\u7528\u7ed3\u5408\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u548c\u7ec4\u7ec7\u9762\u79ef\u7279\u5f81\u7684\u6700\u4f73\u6027\u80fd\u662f\u4f7f\u7528RIDGE-Cox\u6a21\u578b\uff0c\u5e76\u4e14\u4f7f\u7528\u7ec4\u7ec7\u533a\u57df\u7279\u5f81\u6539\u5584\u4e86\u4ec5\u4f7f\u7528\u7ec4\u7ec7\u75c5\u7406\u5b66\u7279\u5f81\u7684C\u6307\u6570\uff08\u88683\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"483\" height=\"344\" class=\"wp-image-16807\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-11.png?resize=483%2C344\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-11.png?w=483 483w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/10\/word-image-16796-11.png?resize=300%2C214 300w\" sizes=\"(max-width: 483px) 100vw, 483px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u88683 \u4f7f\u7528K-means\u901a\u8fc7\u4e94\u91cd\u4ea4\u53c9\u9a8c\u8bc1\u8fdb\u884c\u6027\u80fd\u6bd4\u8f83<\/p>\n<p><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n<p>\u8fd9\u4e2a\u6587\u7ae0\u5229\u7528\u516c\u5171\u75c5\u7406\u56fe\u50cf\u6570\u636e\u6784\u5efa\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u7528\u6765\u9884\u6d4b\u80bf\u7624\u9884\u540e\u3002\u4e0d\u8bba\u662f\u6df1\u5ea6\u5b66\u4e60\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u8fd8\u662f\u75c5\u7406\u56fe\u50cf\u6570\u636e\u7684\u9009\u7528\uff0c\u90fd\u662f\u5728\u6253\u7834\u5e38\u89c4\u6c42\u521b\u65b0\uff0c\u6240\u4ee5\u624d\u80fd4\u5f20\u56fe\u5c31\u53d1\u52307\u5206+\u7eaf\u751f\u4fe1\uff01\u60f3\u53d1\u9ad8\u5206\u751f\u4fe1\u7684\u5c0f\u4f19\u4f34\uff0c\u8fd9\u4e2a\u601d\u8def\u76f8\u5f53\u4e0d\u9519\uff0c\u53ef\u4ee5\u7801\u4f4f\u5b66\u8d77\u6765\u5566\uff01<\/p>\n<p><strong>\u5c0f\u4e91\u6709\u8bdd\u8bf4<\/strong><\/p>\n<p><strong>\u5c0f\u4e91\u516c\u4f17\u53f7\u6301\u7eed\u4e3a\u5927\u5bb6\u5e26\u6765\u6700\u65b0\u751f\u4fe1\u601d\u8def\uff0c\u60f3\u590d\u73b0\u8fd9\u79cd\u601d\u8def\u6216\u8005\u5b9a\u5236\u66f4\u591a\u521b\u65b0\u6027\u601d\u8def\u6b22\u8fce\u76f4\u63a5call\u5c0f\u4e91\uff0c\u4e91\u751f\u4fe1\u56e2\u961f\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01 <\/strong><\/p>\n<p>1. 11\u5206+\u201c\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u201d\u8303\u6587\u2014\u2014\u516c\u5171\u75c5\u7406\u56fe\u50cf\u5206\u6790\u8054\u5408\u7a81\u53d8\u6253\u9020\u9ad8\u5206\u7eaf\u751f\u4fe1\uff01\u7a81\u7834\u5185\u5377\u7684\u5229\u5668\uff0c\u5feb\u6765\u5206\u676f\u7fb9\uff01<\/p>\n<p>2. 1\u4e2a\u6708\u5373\u63a5\u6536\uff0c\u4e0d\u8d70\u5bfb\u5e38\u8def\u7684\u751f\u4fe1+\u516c\u5171\u75c5\u7406\u56fe\u50cf\u5206\u6790\uff01\u805a\u7126\u201c\u514d\u75ab\u51b7\u70ed\u80bf\u7624\u201d\uff0c\u8d85\u7b80\u5355\u7684\u5206\u6790\u62ff\u4e0b6\u5206+\uff0c\u771f\u9999\u4e86\uff01<\/p>\n<p>3. 13\u5206+\u7eaf\u751f\u4fe1\u53ea\u97005\u5f20\u56fe\uff01DNA\u7532\u57fa\u5316\u642d\u4e0a\u6d41\u884c\u75c5\u5b66\uff0c\u539f\u6765TCGA+GEO\u6570\u636e\u5e93\u8fd8\u80fd\u8fd9\u4e48\u73a9\uff01<\/p>\n<p>4. \u6c55\u5934\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u80bf\u7624\u533b\u9662\u9a6c\u957f\u6625\u56e2\u961f\uff1a4\u5f20\u56fe\u62ff\u4e0b7\u5206+\uff0cCAR\u7ec6\u80de\u6cbb\u7597\u6253\u8d62\u80bf\u7624\u514d\u75ab\u7a81\u56f4\u6218\uff01<\/p>\n<p>5. 1\u533a9\u5206+\u7684NHANES \u6570\u636e\u5e93\u7eaf\u751f\u4fe1\u5206\u6790\uff0c\u5357\u660c\u5927\u5b66\u4e8c\u9644\u9662\u6c88\u4e91\u5cf0\u56e2\u961f\u539f\u6765\u662f\u8fd9\u4e48\u505a\u4e34\u5e8a\u9884\u6d4b\u7684\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u4fe1\u5185\u5377\u600e\u4e48\u7834\uff1f \u5c0f\u4e91\u5efa\u8bae\uff1a\u4e24\u6761\u817f\u751a\u81f3\u4e09\u6761\u817f\u8d70\u8def\uff01\u5e38\u89c4\u751f\u4fe1\u9886\u57df\u7528\u521b\u65b0\u601d\u8def\u3001\u5206\u6790\u624b\u6bb5\u548c\u9a8c\u8bc1\u5b9e\u9a8c\u7834\u5708\uff0c\u4e34\u5e8a\u533b\u751f\u5efa\u8bae [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/16796"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16796"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/16796\/revisions"}],"predecessor-version":[{"id":16808,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/16796\/revisions\/16808"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16796"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}