{"id":21185,"date":"2023-12-20T14:25:18","date_gmt":"2023-12-20T06:25:18","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21185"},"modified":"2023-12-20T14:25:20","modified_gmt":"2023-12-20T06:25:20","slug":"q1%e5%8c%ba9%e5%88%86%e5%9b%bd%e8%87%aa%e7%84%b6%e5%8f%8c%e7%83%ad%e7%82%b9%e8%84%82%e4%bb%a3%e8%b0%a2%e3%80%81%e4%bb%a3%e8%b0%a2%e9%87%8d%e7%bc%96%e7%a8%8b%e7%bb%93%e5%90%88","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21185","title":{"rendered":"Q1\u533a9\u5206+\u56fd\u81ea\u7136\u53cc\u70ed\u70b9\u201c\u8102\u4ee3\u8c22\u3001\u4ee3\u8c22\u91cd\u7f16\u7a0b\u201d\u7ed3\u5408\u591a\u7ec4\u5b66\u5206\u6790\u5957\u8def\uff1a\u5355\u7ec6\u80de+\u8f6c\u5f55\u7ec4+\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u4f60\u503c\u5f97\u62e5\u6709\uff01"},"content":{"rendered":"<p>\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u662f\u4e00\u79cd\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u5206\u6790\u590d\u6742\u7ec4\u7ec7\u8f6c\u5f55\u7ec4\u7684\u6280\u672f\uff0c\u968f\u7740scRNA-seq\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5229\u7528\u8be5\u6280\u672f\u6784\u5efa\u4e0d\u540c\u80bf\u7624\u7ec6\u80de\u4e9a\u7fa4\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\u5e93\uff0c\u63d0\u9ad8\u6211\u4eec\u5bf9\u80bf\u7624\u751f\u7269\u5b66\u7684\u57fa\u672c\u8ba4\u8bc6\uff0c\u9610\u660e\u80bf\u7624\u53d1\u751f\u548c\u53d1\u5c55\u7684\u673a\u5236\uff0c\u63ed\u793a\u4e0d\u540c\u80bf\u7624\u60a3\u8005\u5fae\u73af\u5883\u4e2d\u7ec6\u80de\u4e9a\u7fa4\u7684\u5f02\u8d28\u6027\uff0c\u5206\u6790\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7a0b\u5ea6\u548c\u80bf\u7624\u6297\u539f\u8868\u8fbe\u7a0b\u5ea6\u3002\u8be5\u6280\u672f\u5728\u533b\u5b66\u79d1\u7814\u9886\u57df\u4e5f\u8868\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u548c\u5f71\u54cd\u529b\uff0c\u4e3a\u65e0\u5b9e\u9a8c\u6570\u636e\u4eba\u5458\u53d1\u8868\u66f4\u591a\u9ad8\u8d28\u91cf\u6587\u7ae0\uff0c\u63d0\u4f9b\u4e86\u65e0\u9650\u53ef\u80fd\uff01<\/p>\n<p>\u4eca\u5929\u5c0f\u4e91\u8ddf\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u591a\u7ec4\u5b66\u7c7b\u6587\u7ae0\u3002\u8fd9\u7bc7\u6587\u7ae0\u91c7\u7528\u4e86\u5355\u7ec6\u80de\u7ed3\u5408\u8f6c\u5f55\u7ec4\u7684\u5206\u6790\u5f62\u5f0f\uff0c\u540c\u65f6\u57fa\u4e8e\u4ee3\u8c22\u901a\u8def\u5bf9\u80bf\u7624\u8fdb\u884c\u5206\u578b\uff0c\u53ef\u8c13\u662f\u601d\u8def\u65b0\u9896\uff0c\u5de5\u4f5c\u91cf\u9971\u548c\uff0c\u6700\u91cd\u8981\u7684\u4e00\u70b9\u662f\u4f5c\u8005\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u7531\u7ec6\u80de\u5b9e\u9a8c\u548c\u52a8\u7269\u9020\u6a21\u53cc\u91cd\u52a0\u6301\uff0c\u53ef\u8c13\u9526\u4e0a\u6dfb\u82b1\uff01\u60f3\u53d1\u9ad8\u5206SCI\u5374\u6ca1\u6709\u601d\u8def\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u6293\u7d27\u7801\u4f4f\uff01\u62ff\u9ad8\u5206\u4e0d\u6210\u95ee\u9898\uff01<strong>(ps\uff1a\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff01\u8fd9\u91cc\u6709\u6700\u65b0\u7684\u751f\u4fe1\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u4e00\u832c\u63a5\u4e00\u832c\u7684\u53ef\u590d\u73b0\u521b\u65b0\u601d\u8def\uff0c\u611f\u5174\u8da3\u7684\u76f4\u63a5\u626b\u7801\u8054\u7cfb\u6211\u5662\uff01)\u3002<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-21005 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?resize=187%2C188\" alt=\"\" width=\"187\" height=\"188\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?resize=100%2C100 100w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png?w=568 568w\" sizes=\"(max-width: 187px) 100vw, 187px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"361\" class=\"wp-image-21186\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-1.png?resize=640%2C361\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-1.png?w=715 715w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-1.png?resize=300%2C169 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-1.png?resize=600%2C338 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1aBulk\u548c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u4e86\u901a\u8fc7YAP\/TEAD4\/ACADL\u8f74\u5728\u809d\u7ec6\u80de\u764c\u4e2d\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u673a\u68b0\u8c03\u8282<\/li>\n<li>\u6742\u5fd7\uff1aInternational Journal of Biological Sciences<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=9.2<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e744\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u809d\u764c\uff08HCC\uff09\u662f\u5168\u7403\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u5e38\u89c1\u539f\u56e0\uff0c\u4e3b\u8981\u662f\u56e0\u4e3a\u60a3\u8005\u5728\u665a\u671f\u88ab\u8bca\u65ad\u4ee5\u53ca\u809d\u764c\u5177\u6709\u9ad8\u8f6c\u79fb\u7387\u3002\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u5ea6\u5f02\u8d28\u6027\u7684\u80bf\u7624\uff0c\u8feb\u5207\u9700\u8981\u66f4\u5168\u9762\u5730\u4e86\u89e3HCC\u7ec6\u80de\u589e\u6b96\u5931\u8c03\u7684\u5206\u5b50\u673a\u5236\u3002\u57fa\u8d28\u786c\u5ea6\u589e\u52a0\u662fHCC\u53d1\u75c5\u7387\u7684\u6709\u529b\u9884\u6d4b\u56e0\u7d20\uff0c\u4f46\u5728\u57fa\u8d28\u786c\u5ea6\u8bf1\u5bfc\u7684\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u4ee3\u8c22\u8fc7\u7a0b\u5c1a\u4e0d\u6e05\u695a\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u7814\u7a76\u4e86\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u5bf9\u57fa\u8d28\u786c\u5ea6\u5f15\u53d1\u7684HCC\u8fdb\u5c55\u7684\u4f5c\u7528\u57fa\u8d28\uff0c\u4ee5\u671f\u4e3aHCC\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u6570\u636e\u96c6\/\u961f\u5217<\/strong><\/td>\n<td><strong>\u6570\u636e\u5e93<\/strong><\/td>\n<td><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n<td><strong>\u8be6\u7ec6\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n<tr>\n<td>TCGA-LIHC<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u809d\u764c\u8f6c\u5f55\u7ec4\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>GSE14520<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u809d\u764c\u8f6c\u5f55\u7ec4\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>GSE151530<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>46\u4e2a\u809d\u764c\u7684\u5355\u7ec6\u80de\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>\u4ee3\u8c22\u76f8\u5173\u57fa\u56e0<\/td>\n<td>KEGG<\/td>\n<td>\u57fa\u56e0\u96c6<\/td>\n<td>86\u6761\u4ee3\u8c22\u9014\u5f84\u76f8\u5173\u76842886\u4e2a\u57fa\u56e0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u4f7f\u7528TCGA-LIHC\u6570\u636e\u96c6\u548cGSE14520\u6570\u636e\u96c6\u7814\u7a76HCC\u7684\u4ee3\u8c22\u5931\u8c03\uff0cHCC\u6837\u672c\u88ab\u5206\u4e3a\u4e09\u79cd\u5177\u6709\u4e0d\u540c\u4ee3\u8c22\u8c31\u7684\u5f02\u8d28\u6027\u4ee3\u8c22\u9014\u5f84\u4e9a\u578b\uff1acluster1\u30012\u30013\u3002\u901a\u8fc7\u5355\u56e0\u7d20COX\u5206\u6790\u786e\u5b9a\u4e86\u57fa\u8d28\u786c\u5ea6\u548c\u8c03\u8282\u8102\u8d28\u4ee3\u8c22\u7684\u5173\u952e\u9176\uff08ACADL\uff09\u3002\u901a\u8fc7\u7ec6\u80de\u5b9e\u9a8c\u548c\u52a8\u7269\u9020\u6a21\u9a8c\u8bc1\u4e86ACADL\u5728HCC\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u3002<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. Bulk\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\u63ed\u793aHCC\u4e2d\u7684\u4ee3\u8c22\u5931\u8c03<\/strong><\/p>\n<p>\u4e3a\u4e86\u7814\u7a76HCC\u4ee3\u8c22\u91cd\u7f16\u7a0b\u80cc\u540e\u7684\u673a\u5236\uff0c\u4eceKEGG\u6570\u636e\u5e93\u4e2d\u9009\u62e9\u4e86\u4e0e86\u6761\u4ee3\u8c22\u9014\u5f84\u76f8\u5173\u76842886\u4e2a\u57fa\u56e0\u8fdb\u884c\u5206\u6790\uff0c\u57fa\u4e8e\u57fa\u56e0\u96c6\u53d8\u5f02\u5206\u6790\uff08GSVA\uff09\u8bc4\u4f30TCGA\u961f\u5217\u6bcf\u4e2a\u6837\u672c\u4e2d74\u6761\u4ee3\u8c22\u901a\u8def\u7684\u5bcc\u96c6\u5206\u6570\uff0c\u5176\u4e2d12\u6761\u901a\u8def\u7531\u4e8e\u6837\u672c\u91cf\u76f8\u5bf9\u8f83\u5c0f\u800c\u88ab\u8fc7\u6ee4\u6389\u3002\u57fa\u4e8e\u5206\u5c42\u805a\u7c7b\u7ed3\u679c\uff0c\u5c06HCC\u6837\u672c\u5206\u4e3a3\u4e2a\u4e9a\u578b\uff0c\u5373cluster 1\u30012\u30013\uff08\u56fe1A-E\uff09\u3002\u76f8\u6bd4\u4e8ecluster 3\uff0ccluster 1\u7ec4\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u660e\u663e\u8f83\u5dee\uff08\u56fe1F-G\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"830\" class=\"wp-image-21187\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?resize=640%2C830\" alt=\"ijbsv19p2114g001\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?w=825 825w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?resize=231%2C300 231w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?resize=790%2C1024 790w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?resize=768%2C996 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g001.jpeg?resize=600%2C778 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe1 Bulk\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\u63ed\u793aHCC\u4e2d\u7684\u4ee3\u8c22\u5931\u8c03<\/p>\n<p><strong>2. \u57fa\u4e8e\u4ee3\u8c22\u9014\u5f84\u7684\u7c07\u663e\u793a\u51fa\u72ec\u7279\u7684\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u5b66\u7279\u5f81<\/strong><\/p>\n<p>\u7ed8\u5236\u706b\u5c71\u56fe\u5c55\u793acluster 1\u548ccluster 3\u4e2d\u7684\u5dee\u5f02\u8868\u8fbe\u60c5\u51b5\uff08\u56fe2A\uff09\u3002\u63a5\u7740\u5bf9\u6bcf\u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u8fdb\u884cKEGG\u548cREACTOME\u5206\u6790\uff0c\u6709\u4e1d\u5206\u88c2\u7ec6\u80de\u5468\u671f\u68c0\u67e5\u7ad9\u3001\u7ec6\u80de\u5468\u671f\u9636\u6bb5\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7ec4\u7ec7\u901a\u8def\u5728cluster 1\u4e2d\u76f8\u5bf9\u5bcc\u96c6\uff0c\u800c\u4e0e\u6c28\u57fa\u9178\u53ca\u5176\u884d\u751f\u7269\u4ee3\u8c22\u3001\u8102\u80aa\u9178\u4ee3\u8c22\u548c\u7ec6\u80de\u8272\u7d20P450\u7b49\u7269\u8d28\u4ee3\u8c22\u8fc7\u7a0b\u76f8\u5173\u7684\u57fa\u56e0\u96c6\u5728cluster 3\u4e2d\u5bcc\u96c6\uff08\u56fe2B\uff09\u3002KEGG\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u201c\u7ec6\u80de\u5468\u671f\u201d\u548c\u201cECM\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u201d\u5728cluster 1\u4e2d\u5bcc\u96c6\uff0c\u8102\u8d28\u76f8\u5173\u4ee3\u8c22\u9014\u5f84\u5728cluster 3\u4e2d\u5bcc\u96c6\uff08\u56fe2C-D\uff09\u3002GSEA\u5206\u6790\u8fdb\u4e00\u6b65\u8bc1\u660e\uff0ccluster 1\u4e2d\u7ec6\u80de\u7c98\u9644\u5206\u5b50\u3001ECM -\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u548cHippo\u4fe1\u53f7\u901a\u8def\u4e0a\u8c03\uff0ccluster 3\u4e2d\u8102\u80aa\u9178\u548c\u80c6\u6c41\u9178\u76f8\u5173\u7684\u4ee3\u8c22\u9014\u5f84\u663e\u8457\u4e0a\u8c03\uff08\u56fe2E-F\uff09\u3002<strong>\uff08ps\uff1a\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u3001\u514d\u75ab\u6d78\u6da6\u5206\u6790\u4e5f\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"1002\" class=\"wp-image-21188\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g002.jpeg?resize=640%2C1002\" alt=\"ijbsv19p2114g002\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g002.jpeg?w=672 672w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g002.jpeg?resize=192%2C300 192w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g002.jpeg?resize=654%2C1024 654w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g002.jpeg?resize=600%2C939 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe2 \u57fa\u4e8e\u4ee3\u8c22\u9014\u5f84\u7684\u7c07\u663e\u793a\u51fa\u72ec\u7279\u7684\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u5b66\u7279\u5f81<\/p>\n<p><strong>3. \u57fa\u4e8e\u5355\u7ec6\u80de\u6570\u636e\u9274\u5b9a\u7ec6\u80de\u4e9a\u578b\u548c\u4ee3\u8c22\u901a\u8def<\/strong><\/p>\n<p>\u6839\u636e\u5355\u7ec6\u80de\u6570\u636e\u96c6\u4e2d\u7684\u6807\u8bb0\uff0c\u5c06\u7ec6\u80de\u6ce8\u91ca\u805a\u7c7b\u4e3a7\u79cd\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\uff08\u56fe3A\uff09\u3002\u4f7f\u7528scMetabolism R\u5305\u4ee5UMAP\u5f62\u5f0f\u53ef\u89c6\u5316\u5355\u4e2a\u7ec6\u80de\u7684\u4ee3\u8c22\u591a\u6837\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8102\u80aa\u9178\u964d\u89e3\u9014\u5f84\u4e3b\u8981\u5bcc\u96c6\u4e8e\u6076\u6027\u7ec6\u80de\u4e2d\uff0c\u800cECM\u86cb\u767d\u591a\u7cd6\u9014\u5f84\u5bcc\u96c6\u4e8eCAFs\u4e2d\uff08\u56fe3B-C\uff09\u3002\u901a\u8fc7GSVA\u8bc4\u4f30\u6bcf\u4f4d\u60a3\u8005\u7684\u901a\u8def\u5bcc\u96c6\u8bc4\u5206\u3002\u4f7f\u7528\u76f8\u540c\u7684\u805a\u7c7b\u65b9\u6cd5\u8fdb\u884c\u805a\u7c7b\uff0c\u7ed3\u679c\u663e\u793a\u6240\u6709\u60a3\u8005\u88ab\u5212\u5206\u4e3a\u4e09\u4e2a\u4ee3\u8c22\u4e9a\u578b\uff08\u56fe3D-E\uff09\uff0c\u4e14\u8102\u8d28\u4ee3\u8c22\u9014\u5f84\u5728\u6076\u6027\u7ec6\u80de\u548ccluster 3\u4e2d\u663e\u8457\u5bcc\u96c6\uff08\u56fe3F-G\uff09\uff0c\u4e0ebulk\u8f6c\u5f55\u7ec4\u7ed3\u679c\u4e00\u81f4\uff0c\u5373\u8102\u80aa\u9178\u964d\u89e3\u53ef\u80fd\u4e0eCAFs\u7684\u529f\u80fd\u76f8\u5173\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"939\" class=\"wp-image-21189\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004.jpeg?resize=640%2C939\" alt=\"ijbsv19p2114g004\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004.jpeg?w=756 756w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004.jpeg?resize=205%2C300 205w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004.jpeg?resize=698%2C1024 698w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004.jpeg?resize=600%2C880 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"939\" class=\"wp-image-21190\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004-1.jpeg?resize=640%2C939\" alt=\"ijbsv19p2114g004\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004-1.jpeg?w=756 756w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004-1.jpeg?resize=205%2C300 205w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004-1.jpeg?resize=698%2C1024 698w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g004-1.jpeg?resize=600%2C880 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe3 \u57fa\u4e8e\u5355\u7ec6\u80de\u6570\u636e\u9274\u5b9a\u7ec6\u80de\u4e9a\u578b\u548c\u4ee3\u8c22\u901a\u8def<\/p>\n<p><strong>4. ACADL\u4f5c\u4e3a\u8102\u80aa\u4ee3\u8c22\u7684\u5173\u952e\u9176\u5728HCC\u4e2d\u4e0b\u8c03<\/strong><\/p>\n<p>\u5355\u56e0\u7d20Cox\u56de\u5f52\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cFAO\u76f8\u5173\u57fa\u56e0\uff08ACADL\uff09\u663e\u8457\u8868\u8fbe\uff08\u56fe4A\uff09\u3002\u4e0e\u6b63\u5e38\u809d\u810f\u76f8\u6bd4\uff0c\u5728HCC\u7ec4\u7ec7\u4e2d\u53d1\u73b0ACADL\u542b\u91cf\u964d\u4f4e\uff08\u56fe4B\uff09\u3002\u76f8\u5173\u6027\u70ed\u56fe\u663e\u793a\uff0cACADL\u4e0e\u591a\u79cdCAF\u548c\u80f6\u539f\u86cb\u767d\u76f8\u5173\u57fa\u56e0\u5448\u8d1f\u76f8\u5173\uff08\u56fe4C\uff09\u3002\u6b64\u5916\uff0c\u53d1\u73b0ACADL\u5728\u5404\u79cd\u764c\u75c7\u4e2d\u8868\u8fbe\u5747\u663e\u8457\u964d\u4f4e\uff08\u56fe4D\uff09\uff1b\u4e0eACADL\u9ad8\u8868\u8fbe\u7684HCC\u60a3\u8005\u76f8\u6bd4\uff0cACADL\u4f4e\u8868\u8fbe\u7684HCC\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u548c\u65e0\u75c5\u751f\u5b58\u671f\u8f83\u5dee\uff08\u56fe4E-F\uff09\u3002\u6839\u636e\u6709\u65e0\u809d\u786c\u5316\u5c06HCC\u60a3\u8005\u5206\u4e3a\u4e24\u7ec4\uff0c\u809d\u786c\u5316\u7684\u60a3\u8005ACADL\u8868\u8fbe\u8f83\u4f4e\uff08\u56fe4G\uff09\u3002\u5728\u5916\u90e8\u9a8c\u8bc1\u96c6\u4e2d\u4e5f\u53d1\u73b0\u4e86\u540c\u6837\u7684\u7ed3\u679c\uff08\u56fe4H-J\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"921\" class=\"wp-image-21191\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g005.jpeg?resize=640%2C921\" alt=\"ijbsv19p2114g005\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g005.jpeg?w=749 749w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g005.jpeg?resize=208%2C300 208w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g005.jpeg?resize=711%2C1024 711w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g005.jpeg?resize=600%2C864 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe4 ACADL\u4f5c\u4e3a\u8102\u80aa\u4ee3\u8c22\u7684\u5173\u952e\u9176\u5728HCC\u4e2d\u4e0b\u8c03<\/p>\n<p><strong>5. \u5b9e\u9a8c\u8bc1\u5b9e\u57fa\u8d28\u786c\u5ea6\u901a\u8fc7YAP-TEAD4-ACADL\u8c03\u8282\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b<\/strong><\/p>\n<p>\u57fa\u8d28\u786c\u5ea6\u53ef\u80fd\u4f1a\u5f71\u54cd\u8102\u8d28\u4ee3\u8c22\uff0c\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u7ec6\u80de\u5b9e\u9a8c\u3002\u5c06HCC\u7ec6\u80de\u7cfb\u5206\u522b\u63a5\u79cd\u5728\u4e0d\u540c\u786c\u5ea6\u57fa\u8d28\u4e0a\uff0c\u53d1\u73b0\u9ad8\u57fa\u8d28\u786c\u5ea6\u7684\u809d\u764c\u7ec6\u80de\u4e2d\u6e38\u79bb\u8102\u80aa\u9178\u6c34\u5e73\u5347\u9ad8(\u56fe5B)\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cACADL\u7684mRNA\u548c\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u4e0b\u8c03(\u56fe5C-D)\u3002\u5728\u4eba\u7c7bACADL\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u533a\u57df\u8bc6\u522b\u4e86\u4e09\u4e2a\u4fdd\u5b88\u7684TEAD4\u7ed3\u5408\u4f4d\u70b9\uff08AGCATTCTTT\uff09\uff08\u56fe5L\uff09\uff0c\u67d3\u8272\u8d28\u514d\u75ab\u6c89\u6dc0\uff08ChIP\uff09-PCR\u7ed3\u679c\u663e\u793aTEAD4\u53ef\u80fd\u7ed3\u5408\u5230ACADL\u542f\u52a8\u5b50\u7684\u8fdc\u7aef\u4fdd\u5b88\u4f4d\u70b9\uff08R3\uff09\uff08\u56fe5M\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"960\" class=\"wp-image-21192\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006.jpeg?resize=640%2C960\" alt=\"ijbsv19p2114g006\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006.jpeg?w=697 697w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006.jpeg?resize=200%2C300 200w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006.jpeg?resize=682%2C1024 682w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006.jpeg?resize=600%2C900 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"960\" class=\"wp-image-21193\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-1.jpeg?resize=640%2C960\" alt=\"ijbsv19p2114g006\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-1.jpeg?w=697 697w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-1.jpeg?resize=200%2C300 200w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-1.jpeg?resize=682%2C1024 682w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-1.jpeg?resize=600%2C900 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"960\" class=\"wp-image-21194\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-2.jpeg?resize=640%2C960\" alt=\"ijbsv19p2114g006\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-2.jpeg?w=697 697w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-2.jpeg?resize=200%2C300 200w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-2.jpeg?resize=682%2C1024 682w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g006-2.jpeg?resize=600%2C900 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe5 \u5b9e\u9a8c\u8bc1\u5b9e\u57fa\u8d28\u786c\u5ea6\u901a\u8fc7YAP-TEAD4-ACADL\u8c03\u8282\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b<\/p>\n<p><strong>6. \u8f6f\u57fa\u8d28\u589e\u52a0\u4f53\u5185ACADL\u7684mRNA\u548c\u86cb\u767d\u8868\u8fbe\u6c34\u5e73<\/strong><\/p>\n<p>\u52a8\u7269\u5b9e\u9a8c\u6d41\u7a0b\u5982\u56fe6A\uff0c\u7ed3\u679c\u663e\u793a\uff0cBAPN\u7ec4\u80bf\u7624\u4f53\u79ef\u660e\u663e\u5c0f\u4e8e\u5bf9\u7167\u7ec4\uff08\u56fe6B-C\uff09\u3002\u53e6\u5916\uff0c\u5bf9\u7167\u7ec4\u80bf\u7624\u91cd\u91cf\u660e\u663e\u5927\u4e8eBAPN\u7ec4\uff08\u56fe6D\uff09\u3002\u7f9f\u57fa\u812f\u6c28\u9178\u5206\u6790\u663e\u793a\uff0c\u4e0ePBS\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cBAPN\u7ec4\u80f6\u539f\u542b\u91cf\u663e\u8457\u964d\u4f4e\uff08\u56fe6E\uff09\u3002BAPN\u7ec4\u80bf\u7624\u7ec4\u7ec7\u4e2dACADL\u7684mRNA\u548c\u86cb\u767d\u6c34\u5e73\u9ad8\u4e8ePBS\u5bf9\u7167\u7ec4\uff08\u56fe6F-G\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"575\" class=\"wp-image-21195\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g007.jpeg?resize=640%2C575\" alt=\"ijbsv19p2114g007\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g007.jpeg?w=754 754w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g007.jpeg?resize=300%2C270 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/ijbsv19p2114g007.jpeg?resize=600%2C540 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"317\" height=\"209\" class=\"wp-image-21196\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-11.png?resize=317%2C209\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-11.png?w=317 317w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21185-11.png?resize=300%2C198 300w\" sizes=\"(max-width: 317px) 100vw, 317px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>F<\/strong><\/p>\n<p><strong>G<\/strong><\/p>\n<p style=\"text-align: center;\">\u56fe6 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