{"id":21458,"date":"2023-12-21T17:12:24","date_gmt":"2023-12-21T09:12:24","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21458"},"modified":"2023-12-21T17:12:26","modified_gmt":"2023-12-21T09:12:26","slug":"%e3%80%90oncoenrichr%e3%80%91%e7%99%8c%e7%97%87%e5%88%86%e6%9e%90%e5%88%a9%e5%99%a8","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21458","title":{"rendered":"\u3010oncoEnrichR\u3011\u764c\u75c7\u5206\u6790\u5229\u5668"},"content":{"rendered":"<p>\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e2a\u7b80\u5355\u597d\u7528\u7684\u751f\u4fe1\u5206\u6790\u5de5\u5177\u7bb1\u2014 \u2014<strong>oncoEnrichR<\/strong>\uff082023\u5e748\u6708 \u53d1\u8868 \u4e8e<em>International Journal of Cancer <\/em>(<em>IJC<\/em>)\uff09\u529f\u80fd\u975e\u5e38\u5f3a\u5927\uff01<\/p>\n<p>oncoEnrichR \u662f\u4e00\u4e2a R \u8f6f\u4ef6\u5305\uff0c\u7528\u4e8e\u5728\u764c\u75c7\u80cc\u666f\u4e0b\u5bf9\u4eba\u7c7b\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u529f\u80fd\u68c0\u6d4b\u3002\u8be5\u8f6f\u4ef6 \u5305\u5229\u7528\u5927\u91cf\u7684\u5148\u9a8c\u5206\u5b50\u77e5\u8bc6\uff0c\u4ece\u7cfb\u7edf\u5c42\u9762\u548c\u5355\u4e2a\u57fa\u56e0\u5c42\u9762\u8fdb\u884c\u591a\u7ef4\u5ea6\u7684\u751f\u7269\u5b66\u89e3\u91ca\u3002\u4e3b\u8981\u7528 \u4e8e\u5bf9\u6765\u81ea\u9ad8\u901a\u91cf\u764c\u75c7\u751f\u7269\u5b66\u5b9e\u9a8c\uff08\u5982 CRISPR \u7b5b\u9009\u3001\u86cb\u767d\u8d28\u8fd1\u4f3c\u6807\u8bb0\u6216\u57fa\u56e0\u8868\u8fbe\u8c31\u5206\u6790\uff09\u7684 \u57fa\u56e0\u5217\u8868\uff08\u6b64\u5904\u79f0\u4e3a\u67e5\u8be2\u96c6\uff09\u8fdb\u884c\u63a2\u7d22\u6027\u5206\u6790\u548c\u4f18\u5148\u6392\u5e8f\u3002\u8be5\u5de5\u5177\u53ef\u67e5\u8be2\u5927\u91cf\u9ad8\u8d28\u91cf\u7684\u6570\u636e \u8d44\u6e90\uff0c\u4ee5\u4fbf\u5728\u4ea4\u4e92\u5f0f\u62a5\u544a\u4e2d\u6c47\u603b\u764c\u75c7\u76f8\u5173\u6ce8\u91ca\u548c\u5206\u6790\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"220\" class=\"wp-image-21460\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-2.jpeg?resize=640%2C220\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-2.jpeg?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-2.jpeg?resize=300%2C103 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-2.jpeg?resize=600%2C206 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u503c\u5f97\u6ce8\u610foncoEnrichR \u8fd8\u6709\u5728\u7ebf\u5de5\u5177\uff1a <a href=\"https:\/\/oncotools.elixir.no\/tool_runner?tool_id=toolshed.g2.bx.psu.edu%2Frepos%2Fsigven%2Foncoenrichr%2Foncoenrichr_wrapper%2F1.4.2\"><strong>https:\/\/oncotools.elixir.no<\/strong><\/a><\/p>\n<p>\u4e00 \u3001\u5b89\u88c5<\/p>\n<p>\u4e0b\u9762\u5c0f\u679c\u6765\u6559\u4f60\u600e\u4e48\u8fdb\u884c\u5b89\u88c5<\/p>\n<p>\u8981\u6c42\uff1a <em>oncoEnrichR <\/em>requires R (&gt;= version 4.1)<\/p>\n<p>\u5b89\u88c5\u547d\u4ee4<\/p>\n<p>install.packages(&#8216;remotes&#8217;)<\/p>\n<p>remotes::install_github(&#8216;sigven\/oncoEnrichR&#8217;, ref = &#8220;v1.4.2&#8221;) library(oncoEnrichR)]()<\/p>\n<p>\u4e8c \u3001\u8fd0\u884c<\/p>\n<p>oncoEnrichR \u901a\u8fc7\u4ee5\u4e0b\u4e09\u4e2a\u51fd\u6570\u6267\u884c\u5176\u64cd\u4f5c\uff1a<\/p>\n<p>1\u3001oncoEnrichR::load_db()<\/p>\n<p>\u52a0\u8f7d oncoEnrichR \u7684\u5e95\u5c42\u6ce8\u91ca\u6570\u636e\u5b58\u50a8\u5e93\uff0c\u5e76\u5c06\u5176\u4fdd\u5b58\u5230\u672c\u5730\u7f13\u5b58\u76ee\u5f55\u3002\u4f7f\u7528 googledrive R \u8f6f\u4ef6\u5305<\/p>\n<p>2\u3001oncoEnrichR::oncoo_enrich()\uff1a<\/p>\n<p>\u5305\u62ec\u4e24\u4e2a\u4e3b\u8981\u5904\u7406\u6b65\u9aa4<\/p>\n<p>\uff081\uff09\u5c06\u4eba\u7c7b\u57fa\u56e0\/\u86cb\u767d\u8d28\u6807\u8bc6\u7b26\uff08\u5982 UniProt \u7f16\u53f7\u3001 RefSeq\/Ensembl \u8f6c\u5f55\u672c\u6807\u8bc6\u7b26\u7b49\uff09\u7684 \u8f93\u5165\/\u67e5\u8be2\u5217\u8868\u4f5c\u4e3a\u8f93\u5165\uff0c\u5e76\u8fdb\u884c\u7edf\u4e00\u7684\u6807\u8bc6\u7b26\u8f6c\u6362\uff1b<\/p>\n<p>\uff082\uff09\u6839\u636e\u4eba\u7c7b\u57fa\u56e0\u7684\u764c\u75c7\u76f8\u5173\u5c5e\u6027\u53ca\u5176\u76f8\u4e92\u5173\u7cfb\u7684\u57fa\u7840\u6570\u636e\u6e90\uff0c\u5bf9\u67e5\u8be2\u96c6\u8fdb\u884c\u5e7f\u6cdb\u7684\u6ce8 \u91ca\u3001\u5bcc\u96c6\u548c\u6210\u5458\u5206\u6790\u3002<\/p>\n<p>\u4ece\u6280\u672f\u4e0a\u8bb2\uff0c\u8be5\u65b9\u6cd5\u8fd4\u56de\u4e00\u4e2a\u5305\u542b\u6240\u6709\u5206\u6790\u5185\u5bb9\u7684\u5217\u8868\u5bf9\u8c61\u3002\u5177\u4f53\u53c2\u6570\/\u9009\u9879\u548c\u9ed8\u8ba4\u503c\u6982\u8ff0 \u5982\u4e0b\uff1a<\/p>\n<p>onco_enrich(<\/p>\n<p>query = NULL,<\/p>\n<p>oeDB = NULL,<\/p>\n<p>query_id_type = &#8220;symbol&#8221;,<\/p>\n<p>ignore_id_err = TRUE,<\/p>\n<p>html_floating_toc = T,<\/p>\n<p>html_report_theme = &#8220;default&#8221;,<\/p>\n<p>project_title = &#8220;_Project title_&#8221;,<\/p>\n<p>project_owner = &#8220;_Project owner_&#8221;,<\/p>\n<p>project_description = &#8220;_Project description_&#8221;,<\/p>\n<p>bgset = NULL,<\/p>\n<p>bgset_id_type = &#8220;symbol&#8221;,<\/p>\n<p>bgset_description = &#8220;All protein-coding genes&#8221;,<\/p>\n<p>enrichment p value_cutoff = 0.05,<\/p>\n<p>enrichment p value_adj = &#8220;BH&#8221;,<\/p>\n<p>enrichment q value_cutoff = 0.2,<\/p>\n<p>enrichment_min_geneset_size = 10,<\/p>\n<p>enrichment_max_geneset_size = 500,<\/p>\n<p>enrichment_plot_num_terms = 20,<\/p>\n<p>enrichment_simplify_go = TRUE,<\/p>\n<p>subcellcomp_min_confidence = 3,<\/p>\n<p>subcellcomp_min_channels = 1,<\/p>\n<p>subcellcomp_show_cytosol = FALSE,<\/p>\n<p>regulatory_min_confidence = &#8220;D&#8221;,<\/p>\n<p>fitness_max_score = -2,<\/p>\n<p>ppi_add_nodes = 30,<\/p>\n<p>ppi_string_min_score = 0.9,<\/p>\n<p>ppi_string_network_type = &#8220;functional&#8221;,<\/p>\n<p>ppi_biogrid_min_evidence = 3,<\/p>\n<p>ppi_node_shadow = TRUE,<\/p>\n<p>ppi_show_drugs = TRUE,<\/p>\n<p>ppi_show_isolated_nodes = FALSE,<\/p>\n<p>show_ppi = TRUE,<\/p>\n<p>show_disease = TRUE,<\/p>\n<p>show_top_diseases_only = TRUE,<\/p>\n<p>show_cancer_hallmarks = TRUE,<\/p>\n<p>show_drug = TRUE,<\/p>\n<p>show_enrichment = TRUE,<\/p>\n<p>show_aberration = TRUE,<\/p>\n<p>show_coexpression = TRUE,<\/p>\n<p>show_cell_tissue = FALSE,<\/p>\n<p>show_ligand_receptor = TRUE,<\/p>\n<p>show_regulatory = TRUE,<\/p>\n<p>show_unknown_function = TRUE,<\/p>\n<p>show_prognostic = TRUE,<\/p>\n<p>show_subcell_comp = TRUE,<\/p>\n<p>show_synleth = TRUE,<\/p>\n<p>show_fitness = TRUE,<\/p>\n<p>show_complex = TRUE,<\/p>\n<p>show_domain = TRUE)<\/p>\n<p>3\u3001oncoEnrichR::write()<\/p>\n<p>\u5305\u62ec\u4e24\u4e2a\u4e3b\u8981\u5904\u7406\u6b65\u9aa4\uff1a<\/p>\n<p>\uff081\uff09\u5c06 oncoEnrichR::oncoo_enrich() \u8fd4\u56de\u7684\u539f\u59cb\u5206\u6790\u7ed3\u679c\u8f6c\u6362\u4e3a\u5404\u79cd\u53ef\u89c6\u5316\u548c\u4ea4\u4e92\u5f0f\u8868 \u683c<\/p>\n<p>\uff082\uff09\u901a\u8fc7\u4ee5\u4e0b\u65b9\u5f0f\u7ec4\u88c5\u548c\u751f\u6210\u6700\u7ec8\u5206\u6790\u62a5\u544a<\/p>\n<p>A) \u7ed3\u6784\u5316\u4ea4\u4e92\u5f0f oncoEnrichR HTML \u62a5\u544a<\/p>\n<p>B) \u591a\u8868 Excel \u5de5\u4f5c\u7c3f<\/p>\n<p>\u4e09 \u3001\u8f93\u51fa\u8bf4\u660e<\/p>\n<p>\u4f7f\u7528 oncoEnrichR \u8fdb\u884c\u5206\u6790\u7684\u8f93\u51fa\u7ed3\u679c\u4ee5\u4e24\u79cd\u4e0d\u540c\u7684\u683c\u5f0f\u63d0\u4f9b\uff1a<\/p>\n<p>\uff081\uff09\u4ea4\u4e92\u5f0f HTML \u62a5\u544a<\/p>\n<p>\uff082\uff09\u591a\u8868 Excel \u5de5\u4f5c\u7c3f<\/p>\n<p>1\u3001HTML \u62a5\u544a<\/p>\n<p>\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u6765\u81ea OncoEnricHR \u4ea4\u4e92\u5f0f HTML \u62a5\u544a\u7684\u7ed3\u679c\uff0c\u4e0b\u9762\u662f\u53ef\u4ee5\u4f7f\u7528\u8be5\u5de5\u5177 \u56de\u7b54\u7684\u5404\u79cd\u7c7b\u578b\u7684\u95ee\u9898\u3002<\/p>\n<p>\u67e5\u8be2\u9a8c\u8bc1<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"7\" height=\"7\" class=\"wp-image-21461\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-3.png?resize=7%2C7\" data-recalc-dims=\"1\"> \u6240\u6709\u7684\u57fa\u56e0\/\u67e5\u8be2\u6807\u8bc6\u7b26\u90fd\u88ab\u6b63\u786e\u8bc6\u522b\u4e86\u5417\uff1f\u67d0\u4e9b\u67e5\u8be2\u6807\u8bc6\u7b26\u662f\u5426\u5df2\u8fc7\u65f6\uff0c \u5e76\u4e14\u4e0d \u518d\u88ab\u89c6\u4e3a\u4e3b\u6807\u8bc6\u7b26\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/query_verification.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"433\" class=\"wp-image-21462\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-4.jpeg?resize=640%2C433\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-4.jpeg?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-4.jpeg?resize=300%2C203 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-4.jpeg?resize=600%2C406 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p>\u7279\u5f81\u672a\u77e5\u57fa\u56e0<\/p>\n<p>\u00b7 \u67e5\u8be2\u96c6\u7684\u54ea\u4e9b\u6210\u5458\u5177\u6709\u7279\u5f81\u4e0d\u660e\u663e\/\u672a\u77e5\u7684\u529f\u80fd\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/unknown_function.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"349\" class=\"wp-image-21463\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-5.jpeg?resize=640%2C349\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-5.jpeg?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-5.jpeg?resize=300%2C164 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-5.jpeg?resize=600%2C328 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p>\u764c\u75c7\u8054\u7cfb<\/p>\n<p>\u00b7 \u54ea\u4e9b\u80bf\u7624\u7c7b\u578b\u4e0e QuerySet \u4e2d\u7684\u57fa\u56e0\u76f8\u5173\uff1f\u5230\u4ec0\u4e48\u7a0b\u5ea6\uff1f\u54ea\u4e9b\u57fa\u56e0\u88ab\u5f52\u7c7b\u4e3a\u80bf\u7624\u6291 \u5236\u57fa\u56e0\u3001\u539f\u764c\u57fa\u56e0\u6216\u6f5c\u5728\u7684\u764c\u75c7\u9a71\u52a8\u57fa\u56e0\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/cancer_association_I.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"716\" class=\"wp-image-21464\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-6.jpeg?resize=640%2C716\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-6.jpeg?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-6.jpeg?resize=268%2C300 268w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-6.jpeg?resize=600%2C671 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"728\" class=\"wp-image-21465\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-7.png?resize=640%2C728\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-7.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-7.png?resize=264%2C300 264w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-7.png?resize=600%2C682 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u764c\u75c7\u6807\u5fd7\u6027\u8bc1\u636e<\/p>\n<p>\u00b7 \u54ea\u4e9b\u57fa\u56e0\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u7684\u7279\u5f81\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"708\" class=\"wp-image-21466\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-8.png?resize=640%2C708\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-8.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-8.png?resize=271%2C300 271w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-8.png?resize=600%2C664 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u836f\u7269\u8054\u7cfb<\/p>\n<p>\u00b7 \u662f\u5426\u6709\u9002\u7528\u4e8e\u67e5\u8be2\u96c6\u6210\u5458\u7684\u9776\u5411\u764c\u75c7\u836f\u7269\uff1f\u5bf9\u4e8e\u54ea\u4e9b\u764c\u75c7\u9002\u5e94\u75c7\uff0c\u6709\u9488\u5bf9\u67e5\u8be2\u96c6\u6210 \u5458\u7684\u5df2\u6279\u51c6\u836f\u7269\uff1f\u6240\u6709\u67e5\u8be2\u96c6\u6210\u5458\u7684\u76ee\u6807\u53ef\u8ddf\u8e2a\u6027\u662f\u4ec0\u4e48\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"475\" class=\"wp-image-21467\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-9.png?resize=640%2C475\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-9.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-9.png?resize=300%2C223 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-9.png?resize=600%2C446 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"559\" class=\"wp-image-21468\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-10.png?resize=640%2C559\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-10.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-10.png?resize=300%2C262 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-10.png?resize=600%2C524 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u5408\u6210\u81f4\u6b7b\u7387<\/p>\n<p>\u00b7 \u9884\u6d4b\u54ea\u4e9b\u57fa\u56e0\u53c2\u4e0e\u5408\u6210\u81f4\u6b7b\u6027\u76f8\u4e92\u4f5c\u7528\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"707\" class=\"wp-image-21469\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-11.png?resize=640%2C707\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-11.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-11.png?resize=272%2C300 272w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-11.png?resize=600%2C663 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u57fa\u56e0\u9002\u5408\u5ea6\u5f97\u5206<\/p>\n<p>\u00b7 \u8003\u8651\u5230\u764c\u7ec6\u80de\u7cfb\u7684\u5927\u89c4\u6a21\u5168\u57fa\u56e0\u7ec4 CRISPR\u2013Cas9 \u8131\u843d\u7b5b\u9009\u6570\u636e\uff0c\u67e5\u8be2\u96c6\u4e2d\u7684\u54ea\u4e9b \u6210\u5458\u5bf9\u7ec6\u80de\u9002\u5408\u5ea6\u6709\u663e\u8457\u5f71\u54cd\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"715\" class=\"wp-image-21470\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-12.png?resize=640%2C715\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-12.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-12.png?resize=269%2C300 269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-12.png?resize=600%2C670 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"586\" class=\"wp-image-21471\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-13.png?resize=640%2C586\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-13.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-13.png?resize=300%2C275 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-13.png?resize=600%2C549 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u86cb\u767d\u8d28\u590d\u5408\u7269<\/p>\n<p>\u00b7 \u67e5\u8be2\u96c6\u7684\u6210\u5458\u662f\u5426\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269\u6709\u5173\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"731\" class=\"wp-image-21472\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-14.png?resize=640%2C731\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-14.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-14.png?resize=263%2C300 263w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-14.png?resize=600%2C685 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u86cb\u767d\u8d28\u7ed3\u6784\u57df<\/p>\n<p>\u00b7 \u54ea\u4e9b\u86cb\u767d\u8d28\u7ed3\u6784\u57df\u5728\u67e5\u8be2\u96c6\u7684\u6210\u5458\u4e2d\u6700\u5e38\u89c1\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"508\" class=\"wp-image-21473\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-15.png?resize=640%2C508\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-15.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-15.png?resize=300%2C238 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-15.png?resize=600%2C476 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc<\/p>\n<p>\u00b7 \u5982\u4f55\u5728\u67e5\u8be2\u96c6\u4e2d\u8868\u793a\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff1f\u54ea\u4e9b\u86cb\u767d\u8d28\u662f\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u4e2d\u7684\u67a2 \u7ebd\uff1f\u67e5\u8be2\u96c6\u7684\u54ea\u4e9b\u6210\u5458\u5f62\u6210\u7f51\u7edc\u4e2d\u7684\u793e\u533a\u7ed3\u6784\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"543\" class=\"wp-image-21474\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-16.png?resize=640%2C543\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-16.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-16.png?resize=300%2C255 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-16.png?resize=600%2C509 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"495\" class=\"wp-image-21475\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-17.png?resize=640%2C495\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-17.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-17.png?resize=300%2C232 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-17.png?resize=600%2C464 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u8c03\u8282\u76f8\u4e92\u4f5c\u7528<\/p>\n<p>\u00b7 \u67e5\u8be2\u96c6\u4e2d\u662f\u5426\u5b58\u5728\u8f6c\u5f55\u8c03\u63a7\u76f8\u4e92\u4f5c\u7528\uff1f\u662f\u5426\u540c\u65f6\u5b58\u5728 TF\/\u8c03\u63a7\u56e0\u5b50\u548c\u9776\u6807\uff1f \u5b58\u5728\u54ea \u4e9b\u5176\u4ed6 TF \u7684\u8c03\u63a7\u9776\u6807\uff1f\u5176\u4ed6\u76ee\u6807\u7684\u8c03\u63a7\u56e0\u5b50\u662f\u4ec0\u4e48\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"735\" class=\"wp-image-21476\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-18.png?resize=640%2C735\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-18.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-18.png?resize=261%2C300 261w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-18.png?resize=600%2C689 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"547\" class=\"wp-image-21477\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-19.png?resize=640%2C547\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-19.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-19.png?resize=300%2C256 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-19.png?resize=600%2C513 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4e9a\u7ec6\u80de\u533a\u5ba4<\/p>\n<p>\u00b7 \u5982\u4f55\u5728\u67e5\u8be2\u96c6\u4e2d\u8868\u793a\u4e9a\u7ec6\u80de\u9694\u5ba4\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"670\" class=\"wp-image-21478\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-20.png?resize=640%2C670\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-20.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-20.png?resize=287%2C300 287w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-20.png?resize=600%2C628 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"580\" class=\"wp-image-21479\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-21.png?resize=640%2C580\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-21.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-21.png?resize=300%2C272 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-21.png?resize=600%2C544 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u529f\u80fd\u548c\u9014\u5f84\u5bcc\u96c6<\/p>\n<p>\u00b7 \u67e5\u8be2\u96c6\u4e2d\u5bcc\u96c6\u4e86\u54ea\u4e9b\u751f\u7269\u9014\u5f84\/\u8fc7\u7a0b\u3001\u5206\u5b50\u529f\u80fd\u6216\u764c\u75c7\u57fa\u56e0\u6807\u8bb0\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/enrichment_I.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"634\" class=\"wp-image-21480\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?resize=640%2C634\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?resize=300%2C297 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?resize=600%2C594 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-22.png?resize=100%2C100 100w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"468\" class=\"wp-image-21481\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-23.png?resize=640%2C468\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-23.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-23.png?resize=300%2C220 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-23.png?resize=600%2C439 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u7ec4\u7ec7\u548c\u7ec6\u80de\u7c7b\u578b\u5bcc\u96c6<\/p>\n<p>\u00b7 \u6b63\u5e38\/\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u67e5\u8be2\u57fa\u56e0\u7684\u7ec4\u7ec7\u548c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u8868\u8fbe\u6a21\u5f0f\u662f\u4ec0\u4e48\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"587\" class=\"wp-image-21482\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-24.png?resize=640%2C587\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-24.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-24.png?resize=300%2C275 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-24.png?resize=600%2C550 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"551\" class=\"wp-image-21483\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-25.png?resize=640%2C551\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-25.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-25.png?resize=300%2C258 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-25.png?resize=600%2C517 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u80bf\u7624\u7578\u53d8\u9891\u7387<\/p>\n<p>\u00b7 \u901a\u8fc7\u62f7\u8d1d\u6570\u6539\u53d8\u6216\u70b9\u7a81\u53d8\/INDEL\uff0c\u67e5\u8be2\u96c6\u4e2d\u7684\u57fa\u56e0\u5728\u80bf\u7624\u6837\u672c\u4e2d\u7684\u7a81\u53d8\u7a0b\u5ea6\u5982 \u4f55\uff1f<\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/aberration_I.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"658\" class=\"wp-image-21484\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-26.png?resize=640%2C658\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-26.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-26.png?resize=292%2C300 292w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-26.png?resize=600%2C617 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/aberration_II.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"598\" class=\"wp-image-21485\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-27.png?resize=640%2C598\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-27.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-27.png?resize=300%2C280 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-27.png?resize=600%2C561 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/aberration_III.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"698\" class=\"wp-image-21486\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-28.png?resize=640%2C698\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-28.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-28.png?resize=275%2C300 275w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-28.png?resize=600%2C654 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"716\" class=\"wp-image-21487\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-29.png?resize=640%2C716\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-29.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-29.png?resize=268%2C300 268w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-29.png?resize=600%2C671 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u80bf\u7624\u5171\u8868\u8fbe<\/p>\n<p>\u00b7 \u5728\u80bf\u7624\u6837\u672c\u4e2d\uff0c\u67e5\u8be2\u96c6\u7684\u6210\u5458\u662f\u5426\u4e0e\u5176\u4ed6\u764c\u75c7\u57fa\u56e0\u5171\u8868\u8fbe\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"602\" class=\"wp-image-21488\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-30.png?resize=640%2C602\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-30.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-30.png?resize=300%2C282 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-30.png?resize=600%2C564 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u9884\u540e\u5173\u8054<\/p>\n<p>\u00b7 \u8003\u8651\u5230\u80bf\u7624\u6837\u672c\u4e2d\u67e5\u8be2\u57fa\u56e0\u7684\u8868\u8fbe\u6216\u7532\u57fa\u5316\u6c34\u5e73\u6216\u7a81\u53d8\u72b6\u6001\uff0c\u54ea\u4e9b\u57fa\u56e0\u4e0e\u764c\u75c7\u60a3\u8005 \u7684\u751f\u5b58\u6709\u5173\uff1f<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"581\" class=\"wp-image-21489\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-31.png?resize=640%2C581\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-31.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-31.png?resize=300%2C272 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-31.png?resize=600%2C545 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><a href=\"https:\/\/i0.wp.com\/sigven.github.io\/oncoEnrichR\/articles\/module_screenshots\/prognostic_II.jpg?ssl=1\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"778\" class=\"wp-image-21490\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-32.png?resize=640%2C778\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-32.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-32.png?resize=247%2C300 247w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-32.png?resize=600%2C729 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/a><\/p>\n<p>Excel \u5de5\u4f5c\u7c3f<\/p>\n<p>\u00b7 Excel \u5de5\u4f5c\u7c3f\u5305\u542b\u6240\u8fdb\u884c\u7684\u5404\u79cd\u5206\u6790\u7684\u6240\u6709\u7ed3\u679c\uff0c\u8fd9\u4e9b\u7ed3\u679c\u88ab\u7ec4\u7ec7\u5230\u591a\u4e2a\u5de5\u4f5c\u8868\u4e2d \uff08\u5982\u4e0b\u9762\u5c4f\u5e55\u622a\u56fe\u4e2d\u7684\u7ea2\u8272\u5706\u5708\u6240\u793a\uff09<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"320\" class=\"wp-image-21491\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-33.png?resize=640%2C320\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-33.png?w=641 641w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-33.png?resize=300%2C150 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21458-33.png?resize=600%2C300 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56db \u3001\u793a\u4f8b\u4ee3\u7801<\/p>\n<p>library(oncoEnrichR)<\/p>\n<p>myc_interact_targets &lt;-<\/p>\n<p>read.csv(system.file(&#8220;extdata&#8221;,&#8221;myc_data.csv&#8221;, package = &#8220;oncoEnrichR&#8221;), stringsAsFactors = F)<\/p>\n<p>oeDB &lt;- oncoEnrichR::load_db(cache_dir = &#8220;LOCAL_FOLDER&#8221;) myc_report &lt;- oncoEnrichR::onco_enrich(query =<\/p>\n<p>myc_interact_targets$symbol, oeDB = oeDB, show_cell_tissue = T, project_title = &#8220;cMYC_BioID_screen&#8221;, project_owner = &#8220;Raught et al.&#8221;)<\/p>\n<p>oncoEnrichR::write(report = myc_report, oeDB = oeDB, file =<\/p>\n<p>&#8220;LOCAL_FOLDER\/myc_report_oncoenrichr.html&#8221;, format = &#8220;html&#8221;) oncoEnrichR::write(report = myc_report, oeDB = oeDB, file =<\/p>\n<p>&#8220;LOCAL_FOLDER\/myc_report_oncoenrichr.xlsx&#8221;, format = &#8220;excel&#8221;)<\/p>\n<p>\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u5e26\u6765\u4e86oncoEnrichR\uff0c\u4e0d\u77e5\u9053\u5c0f\u4f19\u4f34\u4eec\u6709\u6ca1\u6709\u6536\u83b7\u5462\uff1f\u5feb\u8fd0\u884c\u4ee3\u7801\u4eb2\u81ea\u4f53\u4f1a \u5427~<\/p>\n<p>\u4e94 \u3001\u53c2\u8003\u6587\u732e<\/p>\n<p>Sigve Nakken, Sveinung Gundersen, Fabian L. M. Bernal, Dimitris Polychronopoulos, Eivind Hovig, and J\u00f8rgen Wesche. <strong>Comprehensive interrogation of gene lists from genome-scale cancer screens with oncoEnrichR <\/strong>(2023). Int J Cancer.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1002\/ijc.34666\">doi:10.1002\/ijc.34666<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e2a\u7b80\u5355\u597d\u7528\u7684\u751f\u4fe1\u5206\u6790\u5de5\u5177\u7bb1\u2014 \u2014oncoEnrichR\uff082023\u5e748\u6708 \u53d1\u8868 \u4e8eInter [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21458"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21458"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21458\/revisions"}],"predecessor-version":[{"id":21501,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21458\/revisions\/21501"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21458"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}