{"id":21550,"date":"2023-12-22T15:40:15","date_gmt":"2023-12-22T07:40:15","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21550"},"modified":"2023-12-22T15:40:17","modified_gmt":"2023-12-22T07:40:17","slug":"%e7%bb%86%e8%83%9e%e6%ad%bb%e4%ba%a1%e8%82%bf%e7%98%a4%e9%a2%84%e5%90%8eout%e4%ba%86%ef%bc%9f%e5%93%88%e5%8c%bb%e5%a4%a7%e8%82%bf%e7%98%a4%e5%8c%bb%e9%99%a2%e5%88%98%e8%8a%b3%e5%9b%a2%e9%98%9f","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21550","title":{"rendered":"\u7ec6\u80de\u6b7b\u4ea1+\u80bf\u7624\u9884\u540eout\u4e86\uff1f\u54c8\u533b\u5927\u80bf\u7624\u533b\u9662\u5218\u82b3\u56e2\u961f\uff1a\u96c6\u7ed315\u79cd\u7ec6\u80de\u6b7b\u4ea1+\u5355\u7ec6\u80de\u641e\u5b9a7.9\u5206!"},"content":{"rendered":"<p>\u7ec6\u80de\u6b7b\u4ea1\u751f\u4fe1OUT\u4e86\uff1f\u5e38\u89c4\u80bf\u7624\u9884\u540e\u601d\u8defOUT\u4e86\uff1f<\/p>\n<p>\u7ec6\u80de\u6b7b\u4ea1+\u80bf\u7624\u9884\u540e\u601d\u8def\u73a9\u817b\u4e86\uff1f<\/p>\n<p>\u90a3\u662f\u5355\u4e00\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f\u7684\u7b80\u5355\u9884\u540e\u601d\u8def\u70c2\u5927\u8857\u4e86\uff0c\u53ef\u4e0d\u80fd\u628a\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u8fd9\u4e2a\u5927\u70ed\u70b9\u4e00\u68d2\u5b50\u6253\u6b7b\uff0c\u5b83\u7684\u751f\u4fe1\u53d1\u6587\u80fd\u529b\u8fd8\u662f\u6709\u76ee\u5171\u7779\u7684\uff01\u76ee\u524d\u5f62\u52bf\u4e0b\u600e\u4e48\u53d1\u9ad8\u5206\u624d\u662f\u6211\u4eec\u8981\u91cd\u70b9\u5173\u6ce8\u7684\u70b9\uff0c\u5c0f\u4e91\u5e26\u5c0f\u4f19\u4f34\u4eec\u4ece\u6700\u65b0\u6587\u732e\u4e2d\u5bfb\u627e\u7a81\u7834\u53e3~<\/p>\n<p>\u6765\u770b\u8fd9\u7bc7\u7531<strong>\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u80bf\u7624\u533b\u9662\u5218\u82b3\u6559\u6388\u56e2\u961f<\/strong>\u6700\u65b0\u53d1\u8868\u76847.9\u5206\u6587\u7ae0\uff0c\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5411\uff0c\u8fd8\u662f\u80ba\u817a\u764c\u9884\u540e\uff0c\u8fd9\u79cd\u7ecf\u5178\u5927\u764c\u79cd\u9884\u540e\u5206\u6790\u8fd8\u80fd\u53d1\u5230\u63a5\u8fd18\u5206\u7684\u6c34\u5e73\uff0c\u54b1\u4eec\u5f97\u597d\u597d\u770b\u770b\u8fd9\u7bc7\u6587\u7ae0\u662f\u600e\u4e48\u5e94\u7528\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u7684\uff1a<\/p>\n<p><strong>1\uff09\u9009\u9898\u521b\u65b0\uff1a<\/strong>\u96c6\u5408\u4e8615\u79cd\u5e38\u89c1\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f\uff0c\u4ece\u9009\u9898\u4e0a\u5c31\u8d62\u4e86\u5355\u4e00\u7ec6\u80de\u6b7b\u4ea1\u5206\u6790\u4e00\u5927\u622a<strong>\uff08ps\uff1a\u8fd9\u4e2a\u9009\u9898\u4e0e\u5c0f\u4e91\u524d\u9762\u5206\u4eab\u8fc7\u768418\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7eaf\u751f\u4fe1\u5206\u6790\u6709\u5f02\u66f2\u540c\u5de5\u4e4b\u5904\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u70b9\u51fb\u6587\u672b\u94fe\u63a5\u89c2\u770b\u54e6\uff09<\/strong>\uff1b<\/p>\n<p><strong>2\uff09\u6570\u636e\u91cf\u5927\u3001\u5206\u6790\u65b9\u6cd5\u591a\u6837\u5316\uff1a<\/strong>\u5e94\u75286\u4e2abulk-RNA seq\u6570\u636e\u96c6\u548c1\u4e2ascRNA-seq\u6570\u636e\u96c6\uff0c\u5e76\u4e14\u8fdb\u884c\u4e86\u5355\u7ec6\u80de\u5206\u6790\uff1b<\/p>\n<p><strong>3\uff09\u5e72\u6e7f\u7ed3\u5408\uff1a<\/strong>\u5229\u7528\u7ec6\u80de\u548c\u4e34\u5e8a\u7ec4\u7ec7\u6837\u672c\u8fdb\u884c\u5173\u952e\u57fa\u56e0\u7684\u8868\u8fbe\u548c\u529f\u80fd\u9a8c\u8bc1\u3002<\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u6700\u5927\u7684\u4eae\u70b9\u5c31\u662f\u201c\u96c6\u540815\u79cd\u7ec6\u80de\u6b7b\u4ea1\u201d\u7684\u9009\u9898\uff0c\u6240\u4ee5\u53ea\u8981\u7ec6\u80de\u6b7b\u4ea1\u7528\u7684\u597d\uff0c\u5373\u4f7f\u662f\u505a\u80ba\u764c\u7b49\u5927\u764c\u79cd\u9884\u540e\u5206\u6790\u4e5f\u53d1\u52301\u533a\u63a5\u8fd18\u5206\u7684\u6587\u7ae0\uff01<strong>\u60f3\u8981\u7ee7\u7eed\u518d\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u65b9\u5411\u6dfb\u4e00\u628a\u706b\u7684\u670b\u53cb\uff0c\u53ef\u4ee5\u590d\u73b0\u8fd9\u4e2a\u521b\u65b0\u6027\u548c\u5185\u5bb9\u4e30\u5bcc\u5ea6\u4ff1\u4f73\u4f46\u5206\u6790\u96be\u5ea6\u53c8\u4e0d\u5927\u7684\u601d\u8def\uff0c\u5e76\u4e14\u5e72\u6e7f\u7ed3\u5408\u662f\u5ba1\u7a3f\u4eba\u6bd4\u8f83\u559c\u6b22\u7684\u7c7b\u578b\uff0c\u66f4\u5bb9\u6613\u53d1\u9ad8\u5206\u54df\uff01\u60f3\u590d\u73b0\/\u8bbe\u8ba1\u601d\u8def\u6216\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u7684\u670b\u53cb\uff0c\u6b22\u8fce\u626b\u7801\u8054\u7cfb\u5c0f\u4e91~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-21551\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-1.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-1.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-1.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-1.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"225\" class=\"wp-image-21552\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-2.png?resize=640%2C225\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-2.png?w=705 705w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-2.png?resize=300%2C106 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-2.png?resize=600%2C211 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u4e0d\u540c\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u5bf9\u80ba\u817a\u764c\u9884\u540e\u548c\u514d\u75ab\u7684\u5f71\u54cd<\/li>\n<li>\u6742\u5fd7\uff1aN<em>PJ Precis Oncol.<\/em><\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.9<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u8fd1\u5e74\u6765\uff0c\u80ba\u817a\u764c(LUAD)\u7531\u4e8e\u5176\u5bf9\u6cbb\u7597\u7684\u4f4e\u53cd\u5e94\u6027\u3001\u4e0d\u826f\u9884\u540e\u4ee5\u53ca\u7f3a\u4e4f\u9884\u6d4bLUAD\u8fdb\u5c55\u6216\u6cbb\u7597\u6548\u679c\u7684\u53ef\u9760\u6307\u6807\u800c\u6210\u4e3a\u5173\u6ce8\u7684\u7126\u70b9\u3002\u4e0d\u540c\u7684\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u5728\u80bf\u7624\u53d1\u5c55\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5e76\u6709\u671b\u9884\u6d4bLUAD\u7684\u9884\u540e\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u96c6<\/td>\n<td>\u6765\u6e90<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u6837\u672c\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>TCGA-LUAD<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>439\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>GSE37745<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>196\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>GSE68465<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>442\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>GSE135222<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>27\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>GSE78220<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>27\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>IMvigor210<\/td>\n<td><\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>348\u540dLUAD\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>GSE171145<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>9\u4e2aLUAD\u60a3\u8005\u7684\u5355\u7ec6\u80de\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>\u7ec6\u80de\u6b7b\u4ea1\u57fa\u56e0\u96c6<\/td>\n<td colspan=\"2\">MsigDB\u3001KEGG\u3001Genecards\u3001\u6587\u732e<\/td>\n<td>15\u79cd\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f\u51713925\u4e2a\u8c03\u63a7\u57fa\u56e0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p><a id=\"post-21550-_Hlk149223017\"><\/a> \u4f5c\u8005\u9996\u5148\u57fa\u4e8eTCGA-LUAD\u961f\u5217\u4f7f\u7528\u5355\u53d8\u91cfCox\u56de\u5f52\u7b5b\u900915\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7c7b\u578b\u7684\u9884\u540e\u76f8\u5173\u57fa\u56e0\uff0c\u7136\u540e\u4f7f\u7528LASSO\u5206\u6790\u8fdb\u4e00\u6b65\u7b5b\u9009\u4e0eLUAD\u9884\u540e\u7d27\u5bc6\u76f8\u5173\u7684\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\uff0c\u5e76\u5c06\u5176\u7eb3\u5165\u591a\u53d8\u91cfCox\u56de\u5f52\u6a21\u578b\uff0c\u4ee5\u5206\u522b\u5efa\u7acb15\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7684\u98ce\u9669\u8bc4\u5206\u6a21\u578b\u3002\u6839\u636e\u98ce\u9669\u8bc4\u5206\u4e34\u754c\u503c\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u4f4e\u98ce\u9669\u7ec4\uff0c\u7b5b\u9009\u4e24\u7ec4\u95f4\u7684\u5dee\u5f02\u57fa\u56e0\u3002\u5229\u7528ROC\u66f2\u7ebf\u7684AUC\u503c\u8bc4\u4f3015\u79cd\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u7279\u5f81\u7684\u9884\u6d4b\u53ef\u9760\u6027\uff0c\u5e76\u9009\u62e9\u4e86AUCs &gt;0.7\u7684\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u98ce\u9669\u8bc4\u5206\u6a21\u578b\uff0c\u5c06\u5b83\u4eec\u914d\u5bf9\uff0c\u6700\u7ec8\u5f97\u523028\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7ec4\u5408\u7c7b\u578b\uff0c\u518d\u57fa\u4e8eAUC\u503c\u9009\u62e9\u574f\u6b7b\u6027\u51cb\u4ea1+\u514d\u75ab\u7ec6\u80de\u6b7b\u4ea1\u7ec4\u5408\u4f5c\u4e3a\u6700\u4f73\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570(CDI)\u7279\u5f81\uff0c\u7528\u4e8e\u9884\u6d4bLUAD\u60a3\u8005\u7684\u9884\u540e\u3002\u5bf9\u6bd4CDI\u6a21\u578b\u4e0e\u5176\u4ed615\u79cd\u6a21\u578b\u7684AUC\u503c\uff0c\u5229\u7528KM\u66f2\u7ebf\u5206\u6790OS\u4e0eCDI\u6a21\u578b\u3001\u574f\u6b7b\u6027\u51cb\u4ea1\u548c\u514d\u75ab\u7ec6\u80de\u6b7b\u4ea1\u7684\u76f8\u5173\u6027\u3002Cox\u56de\u5f52\u5206\u6790CDI\u7279\u5f81\u4e0e\u4e34\u5e8a\u53d8\u91cf\u7684\u76f8\u5173\u6027\u5e76\u5efa\u7acb\u5217\u7ebf\u56fe\u3002\u5c06CDI\u7279\u5f81\u4e0e\u5176\u4ed6\u5df2\u53d1\u8868\u7684\u9884\u540e\u6a21\u578b\u8fdb\u884c\u6bd4\u8f83\uff0c\u5206\u6790\u5176\u4e0e\u514d\u75ab\u6d78\u6da6\u7684\u76f8\u5173\u6027\u5e76\u8bc4\u4f30\u9ad8\u4f4eCDI\u7ec4\u95f4\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u3002\u5229\u7528\u5355\u7ec6\u80de\u6570\u636e\u5206\u6790\u4e86LUAD\u4e2d\u7684\u514d\u75ab\u7279\u5f81\u5e76\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u5206\u6790CDI\u7279\u5f81\u57fa\u56e0\u7684\u7ec6\u80de\u4e9a\u578b\u5206\u5e03\u548c\u8868\u8fbe\u3002\u6700\u540e\uff0c\u5728\u4e34\u5e8a\u7ec4\u7ec7\u6837\u672c\u4e2d\u9a8c\u8bc1\u5173\u952e\u57fa\u56e0\u8868\u8fbe\uff0c\u5e76\u5229\u7528CCK-8\u3001EDU\u5206\u6790\u3001\u4f24\u53e3\u6108\u5408\u5b9e\u9a8c\u7b49\u7ec6\u80de\u5b9e\u9a8c\u68c0\u6d4b\u5176\u529f\u80fd\u3002<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. LUAD\u9884\u540e\u76f8\u5173\u7ec6\u80de\u6b7b\u4ea1\u57fa\u56e0\u6b7b\u4ea1\u7b5b\u9009<\/strong><\/p>\n<p>\u9996\u5148\u57fa\u4e8eTCGA-LUAD\u961f\u5217\u4f7f\u7528\u5355\u53d8\u91cfCox\u56de\u5f52\u7b5b\u900915\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7c7b\u578b\u7684\u9884\u540e\u76f8\u5173\u57fa\u56e0\uff0c\u7136\u540e\u4f7f\u7528LASSO\u5206\u6790\u8fdb\u4e00\u6b65\u7b5b\u9009\u4e0eLUAD\u9884\u540e\u7d27\u5bc6\u76f8\u5173\u7684\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u3002\u5c06\u5404\u7ec6\u80de\u6b7b\u4ea1\u7c7b\u578b\u7684\u9884\u540e\u76f8\u5173\u57fa\u56e0\u7eb3\u5165\u591a\u53d8\u91cfCox\u56de\u5f52\u6a21\u578b\uff0c\u5206\u522b\u5efa\u7acb15\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7684\u98ce\u9669\u8bc4\u5206\u6a21\u578b\u3002\u6839\u636e\u5404\u98ce\u9669\u8bc4\u5206\u7684\u4e34\u754c\u503c\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u4f4e\u98ce\u9669\u7ec4\uff0c\u7b5b\u9009\u4e24\u7ec4\u95f4\u7684\u5dee\u5f02\u8868\u8fbe\u7684\u7ec6\u80de\u6b7b\u4ea1\u57fa\u56e0\uff0c\u5e76\u4f7f\u7528\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u8fd9\u4e9b\u57fa\u56e0\u4e0eLUAD\u9884\u540e\u7684\u5173\u7cfb\uff08\u56fe1\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6bd4\u5982\u5305\u62ecTPM2\u3001PPP1R3G\u3001IGF2BP1\u3001ID1\u3001HNRNPF\u548cCCT6A\u5728\u5185\u7684\u574f\u6b7b\u6027\u51cb\u4ea1\u76f8\u5173\u57fa\u56e0\u5728\u9ad8\u5371\u4eba\u7fa4\u4e2d\u663e\u8457\u8868\u8fbe\uff0c\u8868\u660e\u8fd9\u4e9b\u57fa\u56e0\u5728\u764c\u75c7\u53d1\u5c55\u548c\u8fdb\u5c55\u4e2d\u8d77\u7740\u6f5c\u5728\u7684\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"699\" class=\"wp-image-21553\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?resize=640%2C699\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?w=990 990w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?resize=274%2C300 274w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?resize=937%2C1024 937w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?resize=768%2C839 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-4.png?resize=600%2C656 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 LUAD\u9884\u540e\u76f8\u5173\u7ec6\u80de\u6b7b\u4ea1\u57fa\u56e0\u6b7b\u4ea1\u7b5b\u9009<\/p>\n<p><strong>2. CDI\u7279\u5f81\u7684\u5efa\u7acb\u548c\u9a8c\u8bc1<\/strong><\/p>\n<p>\u9996\u5148\u8ba1\u7b97\u5e76\u6bd4\u8f83\u4e8615\u79cd\u7ec6\u80de\u6b7b\u4ea1\u7279\u5f81\u76841\u5e74\u30012\u5e74\u30013\u5e74\u30014\u5e74\u548c5\u5e74AUC\u503c\uff08\u56fe2a\uff0cb\uff09\uff0c\u4e3a\u4e86\u63a2\u7d22\u5177\u6709\u6700\u9ad8AUC\u503c\u7684\u7ec4\u5408\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u7279\u5f81\uff0c\u4f5c\u8005\u53c8\u8bc4\u4f30\u4e86\u4e00\u7cfb\u5217\u7531\u4e0d\u540c\u7ec6\u80de\u6b7b\u4ea1\u7c7b\u578b\u7ec4\u5408\u7ec4\u6210\u7684\u5019\u9009\u6a21\u578b\uff0c\u7ed3\u679c\u53d1\u73b0\u574f\u6b7b\u6027\u51cb\u4ea1+\u514d\u75ab\u7ec6\u80de\u6b7b\u4ea1\u7279\u5f81\u7ec4\u5408\u5177\u6709\u6700\u9ad8AUC\u503c\uff0c\u5c06\u5176\u79f0\u4e4b\u4e3a\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570(CDI)\u7279\u5f81\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u9884\u6d4b\u6027\u80fd\uff0cROC\u66f2\u7ebf\u4e5f\u652f\u6301\u8fd9\u4e00\u7ed3\u679c\uff08\u56fe2a-d\uff09\u3002\u5206\u522b\u57fa\u4e8eCDI\u3001\u574f\u6b7b\u6027\u51cb\u4ea1\u548c\u514d\u75ab\u7ec6\u80de\u6b7b\u4ea1\u8bc4\u5206\uff0c\u5c06LUAD\u60a3\u8005\u5206\u4e3a\u9ad8\u3001\u4f4e\u98ce\u9669\u7ec4\uff0c\u8fdb\u884cKM\u751f\u5b58\u5206\u6790\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u548c\u574f\u6b7b\u6027\u51cb\u4ea1\u7279\u5f81\u76f8\u6bd4\uff0c\u901a\u8fc7CDI\u7279\u5f81\u5206\u5c42\u7684\u9ad8\u98ce\u9669\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\u4e4b\u95f4\u5b58\u5728\u66f4\u663e\u8457\u7684\u9884\u540e\u5dee\u5f02\uff08\u56fe2e-g\uff09\u3002\u5e76\u4e14\u57fa\u4e8eUMAP\u7684\u57fa\u56e0\u5206\u7c7b\u7ed3\u679c\u4e5f\u663e\u793a\uff0c\u901a\u8fc7CDI\u7279\u5f81\u5206\u5c42\u7684\u9ad8\u98ce\u9669\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\u53ef\u4ee5\u660e\u663e\u5206\u6790\uff08\u56fe2h-j\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"459\" height=\"426\" class=\"wp-image-21554\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-5.png?resize=459%2C426\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-5.png?w=459 459w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-5.png?resize=300%2C278 300w\" sizes=\"(max-width: 459px) 100vw, 459px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"420\" height=\"488\" class=\"wp-image-21555\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-6.png?resize=420%2C488\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-6.png?w=420 420w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-6.png?resize=258%2C300 258w\" sizes=\"(max-width: 420px) 100vw, 420px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"545\" height=\"647\" class=\"wp-image-21556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-7.png?resize=545%2C647\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-7.png?w=545 545w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-7.png?resize=253%2C300 253w\" sizes=\"(max-width: 545px) 100vw, 545px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 CDI\u7279\u5f81\u7684\u5efa\u7acb\u548c\u9a8c\u8bc1<\/p>\n<p><strong>3. \u5217\u7ebf\u56fe\u6784\u5efa\u4ee5\u53caCDI\u7279\u5f81\u4e0e\u5176\u4ed6\u5df2\u53d1\u8868\u7684\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u7684\u6bd4\u8f83<\/strong><\/p>\n<p>\u4e3a\u4e86\u7814\u7a76CDI\u7279\u5f81\u4e0e\u4e34\u5e8a\u53d8\u91cf\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cfCox\u56de\u5f52\uff0c\u53d1\u73b0CDI\u548cN\u5206\u671f\u662fOS\u7684\u72ec\u7acb\u9884\u540e\u56e0\u7d20\uff08\u56fe3a\uff0cb\uff09\uff0c\u968f\u540e\u7ed3\u5408\u4e34\u5e8a\u56e0\u7d20\uff0c\u5305\u62ecCDI\u548cN\u5206\u671f\uff0c\u5efa\u7acb\u4e86\u4e00\u4e2a\u5217\u7ebf\u56fe\u5e76\u901a\u8fc7ROC\u66f2\u7ebf\u8bc4\u4f30\u5176\u9884\u6d4b\u6027\u80fd\uff08\u56fe3c\uff0cd\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u4ece\u524d\u671f\u7814\u7a76\u4e2d\u9009\u62e9\u4e86\u56db\u4e2a\u6a21\u578b\uff08\u574f\u6b7b\u6027\u51cb\u4ea1\u7279\u5f81\u3001ICD\u7279\u5f81\u3001\u7126\u4ea1\u7279\u5f81\u548c\u94c1\u6b7b\u4ea1\u7279\u5f81\uff09\u4e0eCDI\u7279\u5f81\u8fdb\u884c\u6bd4\u8f83\uff0c\u663e\u793aCDI\u7279\u5f81\u76841-5\u5e74AUC\u503c\u663e\u8457\u9ad8\u4e8e\u56db\u4e2a\u5df2\u53d1\u8868\u7279\u5f81\u7684AUC\u503c\uff08\u56fe4c\uff09\uff0c\u5e76\u4e14CDI\u7279\u5f81\u7684C\u6307\u6570\u6700\u9ad8\uff08\u56fe4d\uff09\u200b\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"376\" class=\"wp-image-21557\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-8.png?resize=640%2C376\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-8.png?w=918 918w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-8.png?resize=300%2C176 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-8.png?resize=768%2C452 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-8.png?resize=600%2C353 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 \u72ec\u7acb\u9884\u540e\u5206\u6790\u7684\u5217\u7ebf\u56fe\u6784\u5efa<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"256\" class=\"wp-image-21558\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-9.png?resize=640%2C256\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-9.png?w=764 764w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-9.png?resize=300%2C120 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-9.png?resize=600%2C240 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 CDI\u7279\u5f81\u4e0e\u5176\u4ed6\u6a21\u578b\u6bd4\u8f83<\/p>\n<p><strong>4.\u514d\u75ab\u6d78\u6da6\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u5229\u7528MCP counter\u6bd4\u8f83\u9ad8\u548c\u4f4eCDI\u7ec4\u4e2d8\u79cd\u514d\u75ab\u7ec6\u80de\u548c2\u79cd\u57fa\u8d28\u7ec6\u80de\u7684\u6d78\u6da6\u6c34\u5e73\uff0c\u663e\u793aT\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u9ad3\u6837\u6811\u7a81\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u7684\u7edd\u5bf9\u4e30\u5ea6\u5206\u6570\u5728\u4f4eCDI\u7ec4\u4e2d\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u800c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u7edd\u5bf9\u4e30\u5ea6\u5206\u6570\u5728\u9ad8CDI\u7ec4\u4e2d\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08\u56fe5a\uff0cb\uff09\u3002\u7136\u540e\u4f7f\u7528CIBERSORT\u7b97\u6cd5\u6765\u68c0\u67e5\u9ad8CDI\u7ec4\u548c\u4f4eCDI\u7ec4\u5728\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u65b9\u9762\u7684\u5dee\u5f02\uff0c\u7ed3\u679c\u663e\u793a\u80a5\u5927\u9759\u606f\u7ec6\u80de\u3001\u5e7c\u7a1aB\u7ec6\u80de\u548cCD4+\u8bb0\u5fc6\u9759\u606fT\u7ec6\u80de\u4e3b\u8981\u5bcc\u96c6\u5728\u4f4eCDI\u7ec4\uff08\u56fe5c\uff09\u3002CIBERSORT\u7b97\u6cd5\u7814\u7a76CDI\u4e0e22\u79cd\u514d\u75ab\u7ec6\u80de\u7684\u5173\u7cfb\uff0c\u53d1\u73b0CD4 +\u8bb0\u5fc6\u6fc0\u6d3bT\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80deM0\u548cM1\u3001\u80a5\u5927\u7ec6\u80de\u6fc0\u6d3b\u7ec6\u80de\u548cNK\u9759\u606f\u7ec6\u80de\u7684\u6d78\u6da6\u6c34\u5e73\u4e0eCDI\u6b63\u76f8\u5173\uff08\u56fe5d\uff09\u3002<strong>\uff08ps\uff1a\u591a\u79cd\u514d\u75ab\u6d78\u6da6\u5206\u6790\u7b49\u90fd\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\u54e6\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"689\" class=\"wp-image-21559\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?resize=640%2C689\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?w=1134 1134w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?resize=279%2C300 279w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?resize=951%2C1024 951w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?resize=768%2C827 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-10.png?resize=600%2C646 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 \u514d\u75ab\u6d78\u6da6\u5206\u6790<\/p>\n<p><strong>5. \u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u6bd4\u8f83\u9ad8\u4f4eCDI\u7ec4\u95f4\u7684TIDE\u8bc4\u5206\uff0c\u663e\u793a\u4f4eCDI\u7ec4\u7684TIDE\u8bc4\u5206\u660e\u663e\u4f4e\u4e8e\u9ad8CDI\u7ec4\uff0c\u4e14CDI\u4e0eTIDE\u8bc4\u5206\u5448\u6b63\u76f8\u5173\uff08\u56fe6a\uff0cb\uff09\u3002\u5728\u63a5\u53d7\u514d\u75ab\u6cbb\u7597LUAD\u60a3\u8005\u7684GSE135222\u6570\u636e\u96c6\u4e2d\u68c0\u6d4b\u9884\u540e\u548cCDI\u7279\u5f81\u4e4b\u95f4\u7684\u5173\u7cfb\uff0cKM\u66f2\u7ebf\u663e\u793a\u4f4eCDI\u7ec4\u7684\u603b\u751f\u5b58\u7387\u9ad8\u4e8e\u9ad8CDI\u7ec4(\u56fe6e)\u3002\u968f\u540e\uff0c\u6bd4\u8f83\u4e86\u9ad8CDI\u7ec4\u548c\u4f4eCDI\u7ec4\u4e2d\u5e94\u7b54\u8005\u548c\u65e0\u5e94\u7b54\u8005\u7684\u6bd4\u4f8b\uff0c\u4ee5\u53ca\u514d\u75ab\u6cbb\u7597\u5e94\u7b54\u8005\u548c\u65e0\u5e94\u7b54\u8005\u4e4b\u95f4\u7684CDI\u5dee\u5f02\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u4f4eCDI\u7ec4\u7684\u5e94\u7b54\u7387\u663e\u8457\u8f83\u9ad8\u4f46\u53cd\u5e94\u60a3\u8005\u548c\u65e0\u53cd\u5e94\u60a3\u8005\u4e4b\u95f4\u7684CDI\u503c\u6ca1\u6709\u663e\u8457\u6027\uff08\u56fe6f\uff0cg\uff09\u3002\u6bd4\u8f83\u9ad8CDI\u7ec4\u548c\u4f4eCDI\u7ec4\u95f4\u514d\u75ab\u8868\u578b\u8bc4\u5206(IPS)\u4ee5\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(\u5305\u62ec\u6297PD1\/PDL1\/PDL2\u3001\u6297CTLA4\u4ee5\u53ca\u4e24\u79cd\u6cbb\u7597)\u7684\u5dee\u5f02\uff0c\u7ed3\u679c\u5747\u663e\u793a\u5176\u5728\u4f4eCDI\u7ec4\u76f8\u5bf9\u8f83\u9ad8(\u56fe6n)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"592\" height=\"244\" class=\"wp-image-21560\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-11.png?resize=592%2C244\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-11.png?w=592 592w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-11.png?resize=300%2C124 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"144\" class=\"wp-image-21561\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?resize=640%2C144\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?w=1137 1137w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?resize=300%2C68 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?resize=1024%2C231 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?resize=768%2C173 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-12.png?resize=600%2C135 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"165\" class=\"wp-image-21562\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-13.png?resize=640%2C165\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-13.png?w=887 887w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-13.png?resize=300%2C77 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-13.png?resize=768%2C197 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-13.png?resize=600%2C154 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe7 \u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u8bc4\u4f30<\/p>\n<p><strong>6. \u5355\u7ec6\u80de\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u57fa\u4e8e\u5355\u7ec6\u80de\u6570\u636e\u96c6GSE171145\u4f7f\u7528t-SNE\u65b9\u6cd5\u6839\u636e\u6807\u51c6\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5c06\u6240\u6709\u514d\u75ab\u7ec6\u80de\u5206\u4e3a10\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ecT\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u4e0a\u76ae\u7ec6\u80de\u3001\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u3001NK\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u548cDC\u7ec6\u80de\uff08\u56feS4a\uff09\u3002\u6b64\u5916\uff0c\u8ba1\u7b97\u4e86\u574f\u6b7b\u6027\u51cb\u4ea1\u548cICD\u7684\u98ce\u9669\u8bc4\u5206\uff0c\u663e\u793a\u4e86\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u663e\u8457\u5dee\u5f02\uff08\u56feS4c\uff09\u3002\u5927\u591a\u6570\u574f\u6b7b\u6027\u51cb\u4ea1\u548cICD\u76f8\u5173\u7684\u6a21\u578b\u57fa\u56e0\u901a\u5e38\u5728\u6bcf\u4e2a\u7ec6\u80de\u4e9a\u578b\u4e2d\u8868\u8fbe\uff0c\u5e76\u4e14\u6a21\u578b\u57fa\u56e0\u5728\u4e0d\u540c\u7ec6\u80de\u4e9a\u578b\u4e2d\u7684\u8868\u8fbe\u503c\u5dee\u5f02\u8fdb\u4e00\u6b65\u8bf4\u660e\u4e86LUAD\u5fae\u73af\u5883\u4e2d\u7684\u5f02\u8d28\u6027\uff08\u56feS4d\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"270\" class=\"wp-image-21563\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-14.png?resize=640%2C270\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-14.png?w=795 795w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-14.png?resize=300%2C127 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-14.png?resize=768%2C325 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-14.png?resize=600%2C254 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"627\" height=\"315\" class=\"wp-image-21564\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-15.png?resize=627%2C315\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-15.png?w=627 627w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-15.png?resize=300%2C151 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-15.png?resize=600%2C301 600w\" sizes=\"(max-width: 627px) 100vw, 627px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"636\" height=\"284\" class=\"wp-image-21565\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-16.png?resize=636%2C284\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-16.png?w=636 636w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-16.png?resize=300%2C134 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-16.png?resize=600%2C268 600w\" sizes=\"(max-width: 636px) 100vw, 636px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56feS4 \u5355\u7ec6\u80de\u5206\u6790<\/p>\n<p><strong>7. \u5173\u952e\u57fa\u56e0\u7684\u9a8c\u8bc1<\/strong><\/p>\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u9a8c\u8bc1CDI\u4fe1\u53f7\u7684\u6027\u80fd\uff0c\u4f5c\u8005\u5206\u522b\u9009\u62e9\u4e86\u5bf9\u574f\u6b7b\u6027\u51cb\u4ea1\u548c\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u98ce\u9669\u6a21\u578b\u8d21\u732e\u6700\u5927\u7684HNRNPF\u548cFGF2\u8fdb\u884c\u9a8c\u8bc1\u3002\u9996\u5148\u6536\u96c6\u4e94\u5bf9\u4e34\u5e8aLUAD\u6807\u672c\uff0cWB\u9a8c\u8bc1HNRNPF\u548cFGF2\u7684\u8868\u8fbe\uff0c\u663e\u793aHNRNPF\u548cFGF2\u5728\u5927\u591a\u6570\u80bf\u7624\u7ec4\u7ec7(T)\u4e2d\u7684\u8868\u8fbe\u5347\u9ad8\uff08\u56fe8a\uff09\u3002\u968f\u540e\u5728HBE\u548c\u4e0d\u540c\u80ba\u764c\u7ec6\u80de\u7cfb\u4e2dWB\u9a8c\u8bc1HNRNPF\u548cFGF2\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u5728HNRNPF\u9ad8\u8868\u8fbe\u7684H1299\u7ec6\u80de\u548cFGF2\u9ad8\u8868\u8fbe\u7684A549\u7ec6\u80de\u8fdb\u884c\u4e86\u6572\u9664\u5206\u6790\uff08\u56fe8b\uff0cc\uff09\u3002CCK-8\u5206\u6790\u548cEDU\u5206\u6790\u7684\u7ed3\u679c\u8bc1\u660eHNRNPF\u548cFGF2\u7684\u6572\u4f4e\u660e\u663e\u6291\u5236\u80ba\u764c\u7ec6\u80de\u589e\u6b96(\u56fe8d\uff0ce)\uff0c\u4f24\u53e3\u6108\u5408\u8bd5\u9a8c\u8868\u660e\uff0c\u5728\u6572\u9664HNRNPF\u548cFGF2\u540e\uff0c\u7ec6\u80de\u7684\u8fc1\u79fb\u53d7\u5230\u6291\u5236(\u56fe8f)\u3002\u7531\u4e8e\u5316\u7597\u7ecf\u5e38\u5bfc\u81f4\u5404\u79cd\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4f5c\u8005\u53c8\u68c0\u6d4b\u4e86\u987a\u94c2\u5bf9\u574f\u6b7b\u6027\u51cb\u4ea1\u7684\u5f71\u54cd\u4ee5\u53ca\u5965\u6c99\u5229\u94c2\u5bf9ICD\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u8868\u660e\u987a\u94c2\u523a\u6fc0H1299\u7ec6\u80de\u4e2d\u7684\u574f\u6b7b\u6027\u51cb\u4ea1\uff0c\u6572\u4f4eHNRNPF\u8fdb\u4e00\u6b65\u589e\u52a0\u987a\u94c2\u8bf1\u5bfc\u7684\u574f\u6b7b\u6027\u51cb\u4ea1\u200b(\u56fe8g)\uff0c\u5965\u6c99\u5229\u94c2\u4fc3\u8fdbA549\u7ec6\u80de\u4e2dICD\u76f8\u5173\u86cb\u767d(P-eIF2\u03b1)\u7684\u8868\u8fbe\uff0cFGF2\u7684\u6572\u9664\u8fdb\u4e00\u6b65\u589e\u5f3a\u5965\u6c99\u5229\u94c2\u8bf1\u5bfc\u7684ICD\u200b(\u56fe8h)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"864\" class=\"wp-image-21566\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?resize=640%2C864\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?w=1045 1045w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?resize=222%2C300 222w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?resize=758%2C1024 758w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?resize=768%2C1037 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-17.png?resize=600%2C810 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe8 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decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-21567\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-18.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-18.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-18.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21550-18.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u60f3\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u601d\u8def\u8bf7\u6301\u7eed\u5173\u6ce8\u5c0f\u4e91\u516c\u4f17\u53f7\u54e6\uff0c\u9700\u8981\u590d\u73b0\u6216\u5b9a\u5236\u5206\u6790\u601d\u8def\u7684\u670b\u53cb\u6b22\u8fcecall\u5c0f\u4e91\uff0c\u98ce\u91cc\u96e8\u91cc\u5c0f\u4e91\u516c\u4f17\u53f7\u7b49\u4f60\uff01<\/strong><\/p>\n<p>1. \u8fd9\u7bc77\u5206+\u7eaf\u751f\u4fe1\u73a9\u51fa\u4e86\u82b1\uff01\u96c6\u9f50\u7ebf\u7c92\u4f53\u300118\u79cd\u7ec6\u80de\u6b7b\u4ea1\u548c10\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff0c\u5ba1\u7a3f\u4eba\u90fd\u79f0\u7edd\uff01<\/p>\n<p>2. \u53cc\u786b\u6b7b\u4ea1\u4e0e\u94c1\u6b7b\u4ea1\u78b0\u649e\uff0c\u673a\u5668\u5b66\u4e60\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u8054\u8882\uff0c\u738b\u70b8\u7ec4\u5408\u62ff\u4e0b7\u5206+\uff01<\/p>\n<p>3. \u56fd\u5bb6\u6276\u6301\uff0c\u53d1\u6587\u4e0d\u6101\uff01\u6e56\u5357\u4e2d\u533b\u836f\u5927\u5b66\u6210\u7ecd\u6b66\u56e2\u961f\uff0c\u8d76\u4e0a\u4e2d\u836f\u751f\u4fe1\u8fd9\u73ed\u8f66\uff0c7\u5206+\u6587\u7ae0\u5373\u523b\u5230\u624b!<\/p>\n<p>4. 1\u4e2a\u591a\u6708\u63a5\u6536\uff0c24\u5206+\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff01\u53cc\u75be\u75c5\u5206\u6790\u8fd9\u4e48\u505a\uff0c0\u5b9e\u9a8c\u53d1\u9ad8\u5206\u5c31\u662f\u5982\u6b64\u7b80\u5355\uff01<\/p>\n<p>5. 10\u5927\u673a\u5668\u5b66\u4e60\u7b97\u6cd5+10\u4e2a\u6570\u636e\u96c6+\u5355\u7ec6\u80de\u5206\u6790\uff0c3\u62db\u8fde\u53d1\uff0c\u52a9\u529b\u201c\u4e0a\u76ae\u7ec6\u80de\u201d\u62ff\u4e0b7\u5206+\u751f\u4fe1\u4e0d\u5728\u8bdd\u4e0b\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7ec6\u80de\u6b7b\u4ea1\u751f\u4fe1OUT\u4e86\uff1f\u5e38\u89c4\u80bf\u7624\u9884\u540e\u601d\u8defOUT\u4e86\uff1f \u7ec6\u80de\u6b7b\u4ea1+\u80bf\u7624\u9884\u540e\u601d\u8def\u73a9\u817b\u4e86\uff1f 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