{"id":21569,"date":"2023-12-25T09:16:22","date_gmt":"2023-12-25T01:16:22","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21569"},"modified":"2023-12-25T09:16:24","modified_gmt":"2023-12-25T01:16:24","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%9611%e6%9c%88%e9%ab%98%e5%88%86%e6%96%87%e7%ab%a0%e5%a4%a7%e6%b1%87%e6%80%bb%ef%bc%81%e5%9b%bd%e4%ba%ba%e5%9b%a2%e9%98%9f-%e4%b8%b4%e5%ba%8a","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21569","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u531611\u6708\u9ad8\u5206\u6587\u7ae0\u5927\u6c47\u603b\uff01\u56fd\u4eba\u56e2\u961f\/\u4e34\u5e8a\u533b\u751f\u90fd\u5728\u62a2\u53d1\u7684\u9ad8\u5206\u7eaf\u751f\u4fe1,\u5feb\u5feb\u4e0a\u8f66!"},"content":{"rendered":"<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\u8fdb\u884c\u7684\u5982\u706b\u5982\u837c\uff0c\u6709\u4e9b\u56e2\u961f\u751a\u81f3\u902e\u4f4fMR\u5206\u6790\u628a\u9ad8\u5206\u6587\u7ae0\u53d1\u5230\u624b\u8f6f\uff0c\u770b\u5230\u8fd9\u4e48\u706b\u7206\u53d1\u6587\u5f62\u52bf\uff0c\u4f60\u8fd8\u80fd\u4e0d\u5fc3\u52a8\uff1f<\/p>\n<p>MR\u5206\u6790\u80fd\u8fd9\u4e48\u706b\u3001\u8fd9\u4e48\u53d7\u4e34\u5e8a\u533b\u751f\u9752\u7750\uff0c\u6709\u4e09\u5927\u539f\u56e0\uff0c\u4e00\u662f\uff1a\u53ea\u9700\u516c\u5171\u6570\u636e\u5e93\u5206\u6790\u30010\u5b9e\u9a8c\u9a8c\u8bc1\u3001\u6027\u4ef7\u6bd4\u9ad8\uff1b\u4e8c\u662f\uff1a\u9009\u9898\u65b9\u5411\u4e0e\u4e34\u5e8a\u95ee\u9898\u3001\u6d41\u884c\u75c5\u5b66\u66f4\u76f8\u8fd1\u3001\u66f4\u9002\u5408\u4e34\u5e8a\u533b\u751f\u4ee5\u53ca\u516c\u5171\u536b\u751f\u53e3\u7684\u7814\u7a76\u4eba\u5458\uff1b\u4e09\u662f\uff1aMR\u5206\u6790\u76ee\u524d\u8fd8\u6bd4\u8f83\u65b0\uff0c\u6574\u4f53\u53d1\u6587\u91cf\u8fdc\u4f4e\u4e8e\u5e38\u89c4\u751f\u4fe1\uff0c\u53ef\u9009\u7684\u5206\u6790\u65b9\u5411\u66f4\u591a\uff0c\u8fd8\u6709\u5927\u7247\u5f85\u5f00\u53d1\u7684\u84dd\u6d77\u9886\u57df\uff0c\u6240\u4ee5\u66f4\u5bb9\u6613\u53d1\u9ad8\u5206\u3002<\/p>\n<p>\u90a3\u4e48\u9488\u5bf9\u5982\u6b64\u5f62\u52bf\uff0c\u5c0f\u4e91\u4e5f\u51c6\u5907\u5f00\u8f9f\u4e00\u4e2a\u65b0\u7684\u7248\u5757\uff0c\u6bcf\u6708\u6c47\u603b\u6574\u7406\u524d\u4e00\u4e2a\u6708\u5185\u53d1\u8868\u7684MR\u5206\u6790\u9ad8\u5206\u6587\u7ae0\uff0c\u7ed9\u5c0f\u4f19\u4f34\u4eec\u4f20\u9012\u6700\u65b0\u53d1\u6587\u60c5\u51b5\uff0c\u54b1\u4eec\u4e00\u8d77\u505a\u5230\u77e5\u5df1\u77e5\u5f7c\uff0c\u53d1\u6587\u624d\u80fd\u767e\u6218\u4e0d\u6b86~ <strong>\u6709\u60f3\u6cd5\u3001\u6709\u5174\u8da3\u505a\u76f8\u5173\u8bfe\u9898\u7684\u670b\u53cb\u4e5f\u53ef\u4ee5\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u505a\u601d\u8def\u8bbe\u8ba1\/\u590d\u73b0\u6216\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u54df\uff0c\u6211\u4eec\u5c06\u63d0\u4f9b\u6700\u9002\u5408\u60a8\u7684\u53d1\u6587\u65b9\u6848~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-21570 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-1.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-1.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-1.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-1.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>11\u6708\u6574\u4f53\u53d1\u6587\u60c5\u51b5\uff1a<\/strong>\u4ecepubmed\u4e0a\u641c\u7d22\u201cMendelian randomization\u201d\uff0c\u53ef\u4ee5\u770b\u523011\u6708MR\u5206\u6790\u5171\u53d1\u6587<strong>423\u7bc7<\/strong>\uff0c\u4e0b\u9762\u5c0f\u4e91\u4ee510\u7bc7\u5178\u578b\u6587\u7ae0\u7ed9\u5c0f\u4f19\u4f34\u4eec\u5c55\u793a\u4e0b\u6700\u65b0\u53d1\u6587\u8fdb\u5c55\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"249\" class=\"wp-image-21571\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-2.png?resize=640%2C249\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-2.png?w=1011 1011w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-2.png?resize=300%2C117 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-2.png?resize=768%2C299 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-2.png?resize=600%2C233 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u56fd\u4eba\u56e2\u961f\u9ad8\u5206\u6587\u7ae0<\/strong><\/li>\n<\/ul>\n<p><strong>1. \u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u5f20\u4e50\u6559\u6388\u56e2\u961f\uff1a\u86cb\u767d\u7ec4\u5b66+\u836f\u7269\u9776\u70b9MR\u5206\u6790\uff08IF=15.3\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"305\" class=\"wp-image-21572\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-3.png?resize=640%2C305\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-3.png?w=715 715w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-3.png?resize=300%2C143 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-3.png?resize=600%2C286 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u4ece\u8840\u6d46\u548c\u8111\u810a\u6db2\u86cb\u767d\u8d28\u7ec4\u4e2d\u786e\u5b9a\u7f3a\u8840\u6027\u5352\u4e2d\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u9776\u70b9:\u4e00\u9879\u591a\u4e2d\u5fc3\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f<\/strong>\uff1a\u7f3a\u8840\u6027\u5352\u4e2d(IS)\u9010\u5e74\u589e\u591a\uff0c\u75c5\u60c5\u4e25\u91cd\uff0c\u9884\u540e\u5dee\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u3001\u6709\u6548\u7684\u548c\u5b89\u5168\u7684\u6cbb\u7597\u9776\u70b9\u3002\u5faa\u73af\u86cb\u767d\u662f\u6709\u5438\u5f15\u529b\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u672c\u7814\u7a76\u65e8\u5728\u4f7f\u7528\u591a\u4e2d\u5fc3MR\u65b9\u6cd5\uff0c\u5728\u8840\u6d46\u548c\u8111\u810a\u6db2(CSF)\u86cb\u767d\u4e2d\u8bc6\u522b\u7528\u4e8e\u9884\u9632\u548c\u6cbb\u7597IS\u7684\u6f5c\u5728\u836f\u7406\u5b66\u9776\u70b9\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def<\/strong>\uff1a\u9996\u5148\u901a\u8fc7MR\u8bc4\u4f30734\u4e2a\u8840\u6d46\u548c151\u4e2a\u8111\u810a\u6db2\u86cb\u767d\u7684\u5de5\u5177\u53d8\u91cf\u4e0eIS\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4ee5\u786e\u5b9a\u9884\u671f\u7684\u6cbb\u7597\u9776\u70b9\u3002\u7136\u540e\uff0c\u4f7f\u7528\u6765\u81eadeCODE\u8054\u76df\u548cFenland\u8054\u76df\u7684\u8840\u6d46\u86cb\u767d\u6570\u636e\uff0c\u4ee5\u53ca\u6765\u81eaFinnGen\u7fa4\u7ec4\u3001ISGC\u8054\u76df\u548cUKB\u7684GWAS\u6570\u636e\uff0c\u4f7f\u7528\u835f\u8403\u5206\u6790\u5bf9\u4e0a\u8ff0\u53ef\u80fd\u7684\u836f\u7406\u5b66\u9776\u70b9\u8fdb\u884c\u4e86\u5f7b\u5e95\u7684\u8bc4\u4f30\u3002\u7136\u540e\u901a\u8fc7\u4f7f\u7528\u591a\u79cd\u6280\u672f\u7684\u654f\u611f\u6027\u5206\u6790\u6765\u786e\u8ba4MR\u7ed3\u679c\u7684\u7a33\u5065\u6027\u3002\u6700\u540e\uff0c\u5229\u7528PPI\u7f51\u7edc\u6765\u7814\u7a76\u5047\u5b9a\u7684\u836f\u7269\u9776\u6807\u548c\u6cbb\u7597\u5242\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/li>\n<\/ul>\n<p><strong>2. \u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662\u738b\u73ae\u6559\u6388\u56e2\u961f\uff1a\u73af\u5883\u6c61\u67d3\u65b9\u5411MR\u5206\u6790\uff08IF=9.8\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"213\" class=\"wp-image-21573\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-4.png?resize=640%2C213\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-4.png?w=730 730w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-4.png?resize=300%2C100 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-4.png?resize=600%2C200 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u66b4\u9732\u4e8e\u73af\u5883\u7a7a\u6c14\u6c61\u67d3\u5bf9\u764c\u75c7\u98ce\u9669\u7684\u56e0\u679c\u5f71\u54cd:\u6765\u81ea\u9057\u4f20\u5b66\u8bc1\u636e\u7684\u89c1\u89e3<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f\uff1a<\/strong>\u7a7a\u6c14\u6c61\u67d3\u8d8a\u6765\u8d8a\u4e0e\u764c\u75c7\u98ce\u9669\u8054\u7cfb\u5728\u4e00\u8d77\u3002\u7136\u800c\uff0c\u7a7a\u6c14\u6c61\u67d3\u548c\u764c\u75c7\u98ce\u9669\u4e4b\u95f4\u7684\u9057\u4f20\u56e0\u679c\u5173\u7cfb\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def\uff1a<\/strong>\u91c7\u7528\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u65b9\u6cd5\u8fdb\u884c\u4e86\u5927\u89c4\u6a21\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff0c\u4ee5\u9610\u660e\u7a7a\u6c14\u6c61\u67d3(\u6c2e\u6c27\u5316\u5408\u7269\u3001\u4e8c\u6c27\u5316\u6c2e\u3001PM2.5\u3001\u7c97\u9897\u7c92\u7269\u548cPM10)\u572818\u79cd\u7279\u5b9a\u90e8\u4f4d\u764c\u75c7\u98ce\u9669\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"312\" class=\"wp-image-21574\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?resize=640%2C312\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?w=1300 1300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?resize=300%2C146 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?resize=1024%2C499 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?resize=768%2C374 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-5.png?resize=600%2C292 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>3. \u798f\u5efa\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662\u6797\u7acb\u822a\u3001\u97e9\u60a6\u6559\u6388\u56e2\u961f\uff1a\u53cc\u75be\u75c5\u65b9\u5411MR\u5206\u6790\uff08IF=9.3\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"231\" class=\"wp-image-21575\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-6.png?resize=640%2C231\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-6.png?w=709 709w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-6.png?resize=300%2C108 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-6.png?resize=600%2C217 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u7279\u5e94\u6027\u76ae\u708e\u5bf9\u76ae\u80a4\u764c\u98ce\u9669\u7684\u56e0\u679c\u5f71\u54cd:\u4e00\u9879\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f\uff1a<\/strong>\u89c2\u5bdf\u6027\u548c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u663e\u793a\u4e86\u7279\u5e94\u6027\u76ae\u708e\u548c\u76ae\u80a4\u764c\u4e4b\u95f4\u76f8\u4e92\u77db\u76fe\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u89c2\u5bdf\u6027\u7814\u7a76\u5bb9\u6613\u53d7\u5230\u53cd\u5411\u56e0\u679c\u5173\u7cfb\u548c\u6df7\u6742\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u65e0\u6cd5\u89e3\u91ca\u771f\u6b63\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u7279\u5e94\u6027\u76ae\u708e\u5bf9\u76ae\u80a4\u764c\u98ce\u9669\u7684\u56e0\u679c\u5f71\u54cd\u4ecd\u4e0d\u6e05\u695a\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def\uff1a<\/strong>\u57fa\u4e8e\u6b27\u6d32\u8840\u7edf\u7684\u516c\u5171\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u7684\u6c47\u603b\u6570\u636e\u96c6\u8fdb\u884c\u4e86\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u4ee5\u63a2\u8ba8\u7279\u5e94\u6027\u76ae\u708e\u4e0e\u76ae\u80a4\u764c(\u5305\u62ec\u76ae\u80a4\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u57fa\u5e95\u7ec6\u80de\u764c\u548c\u5149\u5316\u6027\u89d2\u5316\u75c5)\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u8d1f\u65b9\u5dee\u52a0\u6743\u6cd5\uff08IVW\uff09\u88ab\u7528\u4f5c\u4e3b\u8981\u5206\u6790\u65b9\u6cd5\uff0cMR\u2013Egger\u548c\u52a0\u6743\u4e2d\u503c\u65b9\u6cd5\u7528\u4e8e\u8865\u5145\u65b9\u5dee\u52a0\u6743\u7684\u7ed3\u679c\uff0c\u4e00\u7cfb\u5217\u7684\u654f\u611f\u6027\u5206\u6790\u88ab\u7528\u6765\u786e\u4fdd\u56e0\u679c\u5173\u7cfb\u4f30\u8ba1\u7684\u7a33\u5065\u6027\u3002<\/li>\n<\/ul>\n<p><strong>4. \u5317\u4eac\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u5f20\u5b66\u667a\u6559\u6388\u56e2\u961f\uff1a\u80a0\u9053\u83cc\u7fa4\u65b9\u5411\uff0c\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790+MR\u5206\u6790\uff08IF=12.2\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"248\" class=\"wp-image-21576\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-7.png?resize=640%2C248\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-7.png?w=710 710w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-7.png?resize=300%2C116 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-7.png?resize=600%2C232 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u865a\u5f31:\u6765\u81ea\u9057\u4f20\u76f8\u5173\u6027\u548c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u89c1\u89e3<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f\uff1a<\/strong>\u89c2\u5bdf\u7814\u7a76\u8868\u660e\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u4e0e\u865a\u5f31\u6709\u5173\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u8054\u7cfb\u662f\u5426\u662f\u56e0\u679c\u5173\u7cfb\u7684\u57fa\u7840\u8fd8\u4e0d\u6e05\u695a\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def\uff1a<\/strong>\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u6765\u81eaMiBioGen \u8054\u76df(N= 18,340)\u3002\u865a\u5f31\u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u6765\u81eaGWAS\u7684\u835f\u8403\u5206\u6790\uff0c\u5305\u62ecUKB\u548cTwinGene (N= 175,226)\u3002\u4f7f\u7528\u8fde\u9501\u4e0d\u5e73\u8861\u8bc4\u5206\u56de\u5f52(LDSC)\u548c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u8bc4\u4f30\u9057\u4f20\u9884\u6d4b\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u548c\u865a\u5f31\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\u548c\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"541\" class=\"wp-image-21577\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-8.png?resize=640%2C541\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-8.png?w=999 999w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-8.png?resize=300%2C253 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-8.png?resize=768%2C649 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-8.png?resize=600%2C507 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>5. \u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u4e09\u533b\u9662\u9633\u56fd\u5e73\u3001\u9646\u7476\u6559\u6388\u56e2\u961f\uff1a\u836f\u7269\u5e94\u7528\u65b9\u5411\uff0c\u89c2\u5bdf\u6027\u961f\u5217\u5206\u6790+MR\u5206\u6790\uff08IF=9.3\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"250\" class=\"wp-image-21578\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-9.png?resize=640%2C250\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-9.png?w=719 719w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-9.png?resize=300%2C117 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-9.png?resize=600%2C234 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u975e\u9009\u62e9\u6027\u03b2-\u80be\u4e0a\u817a\u7d20\u53d7\u4f53\u963b\u6ede\u5242\u7684\u4f7f\u7528\u4e0e\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\uff1a\u57fa\u4e8e\u591a\u4e2a\u771f\u5b9e\u4e16\u754c\u8bc1\u636e<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f\uff1a<\/strong>\u9ad8\u8840\u538b\u60a3\u8005\u53d1\u751f\u5e15\u91d1\u68ee\u75c5(PD)\u7684\u98ce\u9669\u8f83\u9ad8\uff0c\u6d41\u884c\u75c5\u5b66\u8bc1\u636e\u8868\u660e\uff0c\u591a\u79cd\u6297\u9ad8\u8840\u538b\u836f\u7269\u53ef\u80fd\u5f71\u54cdPD\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u4f46\u7ed3\u679c\u4e0d\u4e00\u81f4\u3002\u901a\u8fc7\u591a\u6e90\u6570\u636e\uff0c\u4f5c\u8005\u8bd5\u56fe\u786e\u5b9a\u7279\u5b9a\u7684\u6297\u9ad8\u8840\u538b\u836f\u7269\u7c7b\u522b\u662f\u5426\u4f1a\u589e\u52a0\u6216\u51cf\u5c11\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def\uff1a<\/strong>\u4f5c\u8005\u4f7f\u7528\u4e86\u4e00\u79cd\u6df7\u5408\u65b9\u6cd5\uff0c\u7ed3\u5408\u4e864\u79cd\u65b9\u6cd5\u7814\u7a76\u975e\u9009\u62e9\u6027\u03b2-\u80be\u4e0a\u817a\u7d20\u53d7\u4f53\u963b\u6ede\u5242\u4f7f\u7528\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u5f71\u54cd\u3002\u9996\u5148\uff0c\u4f7f\u7528\u57fa\u4e8eFDA\u836f\u7269\u8b66\u6212\u6570\u636e\u5e93(FAERS)\u4e2d\u5f15\u8d77\u4e0d\u826f\u4e8b\u4ef6\u7684\u62a5\u544a\u8fdb\u884c\u4e86\u975e\u6bd4\u4f8b\u5206\u6790\uff0c\u4ee5\u63a2\u8ba8\u4e0d\u540c\u7c7b\u522b\u7684\u6297\u9ad8\u8840\u538b\u836f\u7269\u5bf9PD\u98ce\u9669\u7684\u5f71\u54cd\uff1b\u7136\u540e\u57fa\u4e8eFAERS\u7684\u53d1\u73b0\uff0c\u8fdb\u884c\u835f\u8403\u5206\u6790\u548cUKB\u6570\u636e\u5e93\u961f\u5217\u5206\u6790\u8fdb\u4e00\u6b65\u8bc4\u4f30\u836f\u7269\u4f7f\u7528\u4e0e\u5e15\u91d1\u68ee\u75c5\u7684\u5173\u7cfb\uff1b\u6700\u540e\uff0c\u91c7\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5206\u6790\u6765\u9a8c\u8bc1\u836f\u7269\u9776\u70b9\u548c\u5e15\u91d1\u68ee\u75c5\u53d1\u751f\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"236\" class=\"wp-image-21579\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?resize=640%2C236\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?w=1364 1364w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?resize=300%2C111 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?resize=1024%2C378 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?resize=768%2C283 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?resize=600%2C221 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-10.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>6. \u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u65b0\u534e\u533b\u9662\u8303\u5efa\u9ad8\u3001\u8d75\u5065\u56e2\u961f\uff1a\u4ee3\u8c22\u65b9\u5411\uff0cMR\u5206\u6790\uff08IF=9.3\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"250\" class=\"wp-image-21580\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-11.png?resize=640%2C250\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-11.png?w=722 722w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-11.png?resize=300%2C117 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-11.png?resize=600%2C234 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u57fa\u56e0\u9884\u6d4b\u7684\u8840\u6d46\u6c28\u57fa\u9178\u6c34\u5e73\u4e0e\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u75c5\u98ce\u9669:\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f\uff1a<\/strong>\u65b0\u5174\u7684\u57fa\u4e8e\u4ee3\u8c22\u7ec4\u5b66\u7684\u7814\u7a76\u8868\u660e\uff0c\u6c28\u57fa\u9178\u4ee3\u8c22\u4e0e\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u8102\u80aa\u6027\u809d\u75c5(MAFLD)\u98ce\u9669\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\uff1b\u7136\u800c\uff0c\u662f\u5426\u5b58\u5728\u6c28\u57fa\u9178\u4ee3\u8c22\u5728MAFLD\u53d1\u5c55\u4e2d\u7684\u75c5\u56e0\u5b66\u4f5c\u7528\u4ecd\u7136\u672a\u77e5\u3002\u672c\u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4f30\u5faa\u73af\u4e2d\u6c28\u57fa\u9178\u6c34\u5e73\u548cMAFLD\u98ce\u9669\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def\uff1a<\/strong>\u4f7f\u7528\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76(GWAS)\u7684\u6982\u8981\u6c34\u5e73\u6570\u636e\u8fdb\u884c\u4e86\u4e00\u9879\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5206\u6790\uff0c\u4ee5\u8bc4\u4f30\u9057\u4f20\u9884\u6d4b\u7684\u5faa\u73af\u6c28\u57fa\u9178\u6c34\u5e73\u4e0eMAFLD\u98ce\u9669\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u5728\u53d1\u73b0 MR\u5206\u6790\u4e2d\uff0c\u4f7f\u7528\u4e86\u6765\u81ea\u6700\u5927\u7684GWAS (8434\u4f8b\u75c5\u4f8b\u548c770\uff0c180\u4f8b\u5bf9\u7167)\u7684\u6570\u636e\uff0c\u800c\u5728\u590d\u5236MR\u5206\u6790\u4e2d\uff0c\u4f7f\u7528\u4e86\u6765\u81eaMAFLD GWAS(1483\u4f8b\u75c5\u4f8b\u548c17\uff0c781\u4f8b\u5bf9\u7167)\u7684\u6570\u636e\uff0c\u5176\u4e2dMAFLD\u75c5\u4f8b\u662f\u901a\u8fc7\u809d\u6d3b\u68c0\u8bca\u65ad\u7684\u3002\u5728MR\u4e3b\u5206\u6790\u4e2d\u4f7f\u7528Wald\u6bd4\u7387\u6216\u9006\u65b9\u5dee\u52a0\u6743(IVW)\u65b9\u6cd5\uff0c\u5728\u654f\u611f\u6027\u5206\u6790\u4e2d\u4f7f\u7528\u52a0\u6743\u4e2d\u4f4d\u6570\u548cMR-Egger\u56de\u5f52\u5206\u6790\u3002\u6b64\u5916\uff0c\u8fd8\u8fdb\u884c\u4e86\u4fdd\u5b88\u7684MR\u5206\u6790\uff0c\u5c06\u5de5\u5177\u53d8\u91cf\u9650\u5236\u5728\u90a3\u4e9b\u76f4\u63a5\u53c2\u4e0e\u6c28\u57fa\u9178\u4ee3\u8c22\u9014\u5f84\u7684\u57fa\u56e0\u4e0a\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"574\" class=\"wp-image-21581\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-12.png?resize=640%2C574\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-12.png?w=967 967w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-12.png?resize=300%2C269 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-12.png?resize=768%2C689 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-12.png?resize=600%2C538 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u56fd\u5916\u56e2\u961f\u9ad8\u5206\u6587\u7ae0<\/strong><\/li>\n<\/ul>\n<p><strong>1. \u82f1\u56fd\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u56e2\u961f\uff1a\u53cc\u75be\u75c5\u65b9\u5411\uff0c\u89c2\u5bdf\u6027\u5206\u6790+ MR\u5206\u6790\uff08IF=24.3\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"251\" class=\"wp-image-21582\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-13.png?resize=640%2C251\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-13.png?w=718 718w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-13.png?resize=300%2C118 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-13.png?resize=600%2C236 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u54ee\u5598\u548c\u51a0\u5fc3\u75c5\u4e8b\u4ef6:\u4e00\u9879\u89c2\u5bdf\u6027\u5b5f\u5fb7\u5c14\u968f\u673a\u7814\u7a76<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f<\/strong>\uff1a\u89c2\u5bdf\u6027\u7814\u7a76\u8868\u660e\u54ee\u5598\u662f\u51a0\u5fc3\u75c5(CHD)\u7684\u4e00\u4e2a\u5371\u9669\u56e0\u7d20\uff0c\u6027\u522b\u6539\u53d8\u4e86\u8fd9\u4e00\u98ce\u9669\uff0c\u4f46\u5b83\u4eec\u53ef\u80fd\u53d7\u5230\u65b9\u6cd5\u5b66\u7684\u9650\u5236\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u95ee\u9898\uff0c\u4f5c\u8005\u91c7\u7528\u4e86\u201c\u4e09\u89d2\u6d4b\u91cf\u6cd5\u201d\uff0c\u5229\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\u548c\u4e0d\u540c\u7684\u6f5c\u5728\u504f\u5dee\u6765\u589e\u5f3a\u5bf9\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u4fe1\u5ea6\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def<\/strong>\uff1a\u9996\u5148\u4f7f\u7528\u82f1\u56fd\u533b\u7597\u8bb0\u5f55\u8fdb\u884c\u4e86\u4e00\u9879\u89c2\u5bdf\u6027\u7814\u7a76\uff0c\u5c06\u54ee\u5598\u60a3\u8005\u6309\u5e74\u9f84\u3001\u6027\u522b\u548c\u5168\u79d1\u533b\u751f(GP)\u64cd\u4f5c\u4e0e\u666e\u901a\u4eba\u7fa41:1\u5339\u914d\uff0c\u901a\u8fc7\u5e94\u7528\u6700\u5c0f\u5145\u5206\u8c03\u6574\u6d4b\u91cf\u54ee\u5598\u548c\u51a0\u5fc3\u75c5\u4e8b\u4ef6(\u5fc3\u808c\u6897\u6b7b:\u4f4f\u9662\/\u6b7b\u4ea1)\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u7136\u540e\u4f7f\u7528\u6765\u81eaUKB\u3001\u8de8\u56fd\u54ee\u5598\u9057\u4f20\u8054\u76df(TAGC)\u548cCARDIoGRAM\u7684\u6570\u636e\u8fdb\u884c\u4e86\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u7814\u7a76\uff0c\u4ee5\u54ee\u5598\u4f5c\u4e3a\u66b4\u9732\uff0c\u51a0\u5fc3\u75c5\u4f5c\u4e3a\u7ed3\u5c40\uff0c\u9009\u62e9\u4e0e\u66b4\u9732\uff08\u54ee\u5598\uff09\u76f8\u5173\u768464\u4e2aSNPs\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u901a\u8fc7\u53cd\u5411\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09\u835f\u8403\u5206\u6790\u548c\u8c03\u6574\u591a\u6548\u6027\u7684\u65b9\u6cd5\u6765\u8bc4\u4f30\u54ee\u5598\u5bf9\u51a0\u5fc3\u75c5\u7684\u5f71\u54cd\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"415\" class=\"wp-image-21583\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-14.png?resize=640%2C415\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-14.png?w=838 838w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-14.png?resize=300%2C195 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-14.png?resize=768%2C499 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-14.png?resize=600%2C389 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>2. \u54c8\u4f5b\u5927\u5b66\u8054\u5408\u5357\u4eac\u533b\u79d1\u5927\u5b66\u56e2\u961f\uff1aMR\u5206\u6790+\u8f6c\u5f55\u7ec4\u9a8c\u8bc1\uff08IF=38.9\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"223\" class=\"wp-image-21584\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-15.png?resize=640%2C223\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-15.png?w=706 706w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-15.png?resize=300%2C105 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-15.png?resize=600%2C209 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\u76f8\u5173\u57fa\u56e0\u8c31\u548c\u751f\u7269\u6807\u5fd7\u7269\u7684\u9274\u5b9a<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f<\/strong>\uff1a\u672c\u7814\u7a76\u7684\u76ee\u7684\u662f\u63cf\u8ff0\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81(ARDS)\u7684\u9057\u4f20\u81f4\u75c5\u56e0\u7d20\uff0c\u5e76\u65e9\u671f\u9884\u6d4b\u5177\u6709\u9ad8ARDS\u98ce\u9669\u7684\u60a3\u8005\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def<\/strong>\uff1a\u901a\u8fc7\u5bf9ARDS\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76(1250\u4f8b\u75c5\u4f8b\u548c1583\u4f8b\u6b27\u6d32\u8840\u7edf\u5bf9\u7167)\u548c33\uff0c150\u4e2a\u7279\u5f81\u7684\u6c47\u603b\u7edf\u8ba1\uff0c\u8fdb\u884c\u4e86\u5168\u8868\u578b\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\uff0c\u4ee5\u63a2\u7d22\u4e0eARDS\u53d1\u5c55\u6709\u6f5c\u5728\u56e0\u679c\u5173\u7cfb\u7684\u9057\u4f20\u81f4\u75c5\u7279\u5f81\u3002\u7136\u540e\u5229\u7528\u6765\u81ea\u4e34\u5e8a\u524d\u5c0f\u9f20\u6a21\u578b\u7684\u80ba\u7ec4\u7ec7\u8f6c\u5f55\u7ec4\u6570\u636e\u548c\u4eba\u7c7b\u8840\u6db2\u8f6c\u5f55\u7ec4\u6570\u636e\u6765\u9a8c\u8bc14\u4e2a\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\u7684\u8868\u8fbe\uff0c\u7136\u540e\u57fa\u4e8e4\u4e2a\u8840\u6db2\u57fa\u56e0\u548c5\u4e2a\u514d\u75ab\u7ec6\u80de\u6bd4\u4f8b\u8fdb\u4e00\u6b65\u6784\u5efa\u9884\u6d4b\u6a21\u578b\u548c\u5217\u7ebf\u56fe\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"478\" class=\"wp-image-21585\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-16.png?resize=640%2C478\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-16.png?w=733 733w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-16.png?resize=300%2C224 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-16.png?resize=600%2C448 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>3. \u7f8e\u56fd\u8303\u5fb7\u6bd4\u5c14\u7279\u5927\u5b66\u56e2\u961f\uff1a\u836f\u7269\u5e94\u7528\u65b9\u5411\uff0cMR\u5206\u6790\uff08IF=13.8\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"301\" class=\"wp-image-21586\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-17.png?resize=640%2C301\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-17.png?w=720 720w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-17.png?resize=300%2C141 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-17.png?resize=600%2C283 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\u57fa\u56e0\u66ff\u4ee3\u7269\u4e0e\u964d\u4f4e\u80be\u7ed3\u77f3\u98ce\u9669\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5206\u6790<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f<\/strong>\uff1a\u4e09\u5341\u591a\u5e74\u6765\uff0c\u567b\u55ea\u7c7b\u836f\u7269\u4e00\u76f4\u662f\u9884\u9632\u80be\u7ed3\u77f3\u590d\u53d1\u7684\u6807\u51c6\u836f\u7269\uff0c\u8fd9\u79cd\u5b9e\u8df5\u5efa\u7acb\u5728\u89c2\u5bdf\u6570\u636e\u96c6\u548c\u591a\u4e2a\u5c0f\u578b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u57fa\u7840\u4e0a\u3002\u7136\u800c\uff0c\u6700\u5927\u89c4\u6a21\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u672a\u80fd\u53d1\u73b0\u567b\u55ea\u7c7b\u836f\u7269\u5bf9\u80be\u7ed3\u77f3\u590d\u53d1\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u5bf9\u5176\u9884\u9632\u80be\u7ed3\u77f3\u7684\u529f\u6548\u63d0\u51fa\u4e86\u8d28\u7591\u3002\u672c\u7814\u7a76\u65e8\u5728\u786e\u5b9a\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\u7684\u57fa\u56e0\u66ff\u4ee3\u7269\u4e0e\u80be\u7ed3\u77f3\u98ce\u9669\u4e4b\u95f4\u662f\u5426\u5b58\u5728\u5173\u8054\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def<\/strong>\uff1a\u4f7f\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u65b9\u6cd5\u8bc4\u4f30\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\u7684\u57fa\u56e0\u66ff\u4ee3\u7269\u4e0e\u80be\u7ed3\u77f3\u98ce\u9669\u7684\u76f8\u5173\u6027\u3002\u66b4\u9732\u4e3a\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\u7684\u57fa\u56e0\u66ff\u4ee3\u7269\uff0c\u662f\u4e0e\u6536\u7f29\u538b\u76f8\u5173\u7684\u567b\u55ea\u7c7b\u654f\u611f\u6027\u6c2f\u5316\u94a0\u5171\u8f6c\u8fd0\u4f53\u57fa\u56e0\u7684\u9057\u4f20\u53d8\u5f02\u4f53\uff0c\u6765\u81ea\u56fd\u9645\u8840\u538b\u8054\u76df(ICBP)\u7684\u6536\u7f29\u538bGWAS\u6570\u636e\u3002\u4e3b\u8981\u7ed3\u679c\u662f\u80be\u7ed3\u77f3\u7684\u53d1\u75c5\u7387\uff0c\u6765\u81ea\u767e\u4e07\u9000\u4f0d\u519b\u4eba\u8ba1\u5212(MVP)\u3001\u82f1\u56fd\u751f\u7269\u94f6\u884c(UKB)\u548c\u82ac\u6839\u7814\u7a76(FinnGen) \u7684GWAS\u6570\u636e\u3002\u567b\u55ea\u7c7b\u5229\u5c3f\u5242\u7684\u57fa\u56e0\u66ff\u4ee3\u7269\u4e0e\u80be\u7ed3\u77f3\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5173\u8054\u5728\u6bcf\u4e2a\u961f\u5217\u4e2d\u5206\u522b\u8fdb\u884c\u8bc4\u4f30\uff0c\u7136\u540e\u5728\u968f\u673a\u6548\u5e94\u835f\u8403\u5206\u6790\u4e2d\u5408\u5e76\u3002<\/li>\n<\/ul>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"851\" class=\"wp-image-21587\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-18.png?resize=640%2C851\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-18.png?w=766 766w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-18.png?resize=226%2C300 226w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-18.png?resize=600%2C797 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>4. \u8036\u9c81\u5927\u5b66\u8054\u5408\u591a\u4e2a\u5927\u5b66\u56e2\u961f\uff1a\u7cbe\u795e\u75c5\u5b66\u65b9\u5411\uff0c\u9057\u4f20\u76f8\u5173\u6027+MR\u5206\u6790\uff08IF=25.8\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"291\" class=\"wp-image-21588\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-19.png?resize=640%2C291\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-19.png?w=721 721w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-19.png?resize=300%2C136 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-19.png?resize=600%2C273 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li><strong>\u9898\u76ee<\/strong>\uff1a\u521b\u4f24\u540e\u5e94\u6fc0\u969c\u788d\u75c7\u72b6\u7684\u9057\u4f20\u6613\u611f\u6027\u53ca\u5176\u4e0e\u5fc3\u810f\u4ee3\u8c22\u548c\u547c\u5438\u7ed3\u5c40\u7684\u76f8\u5173\u6027<\/li>\n<li><strong>\u7814\u7a76\u80cc\u666f<\/strong>\uff1a\u636e\u62a5\u9053\uff0c\u521b\u4f24\u540e\u5e94\u6fc0\u969c\u788d(PTSD)\u662f\u51e0\u79cd\u8eab\u4f53\u548c\u8eaf\u4f53\u75c7\u72b6\u7684\u5371\u9669\u56e0\u7d20\u3002\u7136\u800c\uff0cPTSD\u7684\u9057\u4f20\u5b66\u53ca\u5176\u4e0e\u533b\u7597\u7ed3\u679c\u7684\u6f5c\u5728\u5173\u8054\u4ecd\u4e0d\u6e05\u695a\u3002\u672c\u7814\u7a76\u65e8\u5728\u4ece\u7535\u5b50\u5065\u5eb7\u8bb0\u5f55(EHR)\u4e2d\u68c0\u67e5\u4e0ePTSD\u591a\u57fa\u56e0\u8bc4\u5206\u76f8\u5173\u7684\u75be\u75c5\u7c7b\u522b\u548c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u3002<\/li>\n<li><strong>\u7814\u7a76\u601d\u8def<\/strong>\uff1a\u8fd9\u9879\u9057\u4f20\u5173\u8054\u7814\u7a76\u4ece2021\u5e747\u670815\u65e5\u81f32023\u5e741\u670824\u65e5\u8fdb\u884c\uff0c\u4f7f\u7528\u4e86\u6765\u81ea4\u4e2a\u751f\u7269\u5e93\u53c2\u4e0e\u8005\u7684EHR\u6570\u636e\u3002PTSD\u75c7\u72b6\u4e25\u91cd\u7a0b\u5ea6\u7684\u591a\u57fa\u56e0\u8bc4\u5206(PGS-PTSD)\u4f7f\u7528BioVU\u3001MGB\u3001MGI\u548cUKBB\u4e2d\u6240\u6709\u53ef\u7528\u7684phecodes\u8fdb\u884c\u6d4b\u8bd5\u3002PTSD\u75c7\u72b6\u4e25\u91cd\u6027\u7684\u591a\u57fa\u56e0\u8bc4\u5206\u4f5c\u4e3a\u66b4\u9732\uff0c\u603b\u51711680\u4e2aphecodes(\u5373\uff0c\u56fd\u9645\u75be\u75c5\u5206\u7c7b)\u548c2\u4e2a\u751f\u7269\u5e93(BioVU\u548cMGB)\u7684490\u9879\u5b9e\u9a8c\u5ba4\u6d4b\u8bd5\u4f5c\u4e3a\u7ed3\u679c\u3002\u5bf9\u91cd\u8981\u7684\u533b\u7597\u7ed3\u679c\u8fdb\u884c\u4e86\u8d85\u6bd4\u4f8b\u75be\u75c5\u7c7b\u522b\u68c0\u6d4b\uff0c\u968f\u540e\u8fdb\u884c\u4e86\u9057\u4f20\u76f8\u5173\u6027\u548c\u4e24\u6837\u672cMR\u68c0\u6d4b\uff0c\u4ee5\u786e\u5b9a\u9057\u4f20\u76f8\u5173\u6027\u3002\u7136\u540e\u8fdb\u884c\u591a\u53d8\u91cfMR\u8bc4\u4f30PTSD\u4e0e\u5065\u5eb7\u7ed3\u679c\u7684\u76f8\u5173\u6027\u662f\u5426\u72ec\u7acb\u4e8e\u4f53\u91cd\u6307\u6570\u548c\u5438\u70df\u7684\u9057\u4f20\u6548\u5e94\u3002<\/li>\n<\/ul>\n<p><strong>\u5c0f\u7ed3<\/strong><\/p>\n<p>\u672c\u6b21\u6c47\u603b\u4e8610\u7bc7\u56fd\u5185\u5916\u56e2\u961f\u7684\u9ad8\u5206\u7ecf\u5178MR\u6587\u7ae0\uff0c\u6db5\u76d6\u4e86\u73af\u5883\u6c61\u67d3\u3001\u7cbe\u795e\u75be\u75c5\u3001\u53cc\u75be\u75c5\u3001\u4ee3\u8c22\u3001\u836f\u7269\u9776\u70b9\u7814\u7a76\u7b49\u51e0\u4e2a\u4e3b\u6d41\u5206\u6790\u65b9\u5411\uff0c\u8d76\u5feb\u5b66\u8d77\u6765~\u8fd8\u5728\u72b9\u8c6b\u89c2\u671b\u7684\u670b\u53cb\uff0c\u811a\u6b65\u8981\u5feb\u4e00\u70b9\u4e86\uff0c\u968f\u7740\u6587\u7ae0\u7684\u7206\u53d1\uff0c\u9ad8\u5206\u6587\u7ae0\u7684\u53d1\u6587\u96be\u5ea6\u80af\u5b9a\u4f1a\u53d8\u5927\uff0c\u5c3d\u65e9\u4e0a\u8f66\u624d\u597d\u62ff\u9ad8\u5206\u5440\uff01<strong>\u60f3\u5728\u4ee5\u4e0a\u65b9\u5411\u4e0a\u8fdb\u884cMR\u601d\u8def\u590d\u73b0\/\u8bbe\u8ba1\u6216\u5b9a\u5236\u5206\u6790\u7684\u670b\u53cb\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\uff0c\u591a\u79cd\u5206\u6790\u601d\u8def\u4efb\u541b\u9009\u62e9~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-21589\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-20.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-20.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-20.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21569-20.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p>1. 1\u4e2a\u591a\u6708\u63a5\u6536\uff0c24\u5206+\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff01\u53cc\u75be\u75c5\u5206\u6790\u8fd9\u4e48\u505a\uff0c0\u5b9e\u9a8c\u53d1\u9ad8\u5206\u5c31\u662f\u5982\u6b64\u7b80\u5355\uff01<\/p>\n<p>2. \u6b66\u6c49\u7cbe\u795e\u536b\u751f\u4e2d\u5fc3\u5218\u6770\u4f1f&amp;\u9093\u660e\u6e2f\u56e2\u961f\uff1a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5f3a\u52bf\u62ff\u4e0b13\u5206+Science\u5b50\u520a\uff01<\/p>\n<p>3. \u961c\u5916\u533b\u9662\u7aa6\u514b\u975e\u56e2\u961f15\u5206\u65b0\u6587\uff1aUKB+\u4e2d\u56fdCHARLS\uff0c2\u5927\u4e34\u5e8a\u6570\u636e\u5e93\u5206\u6790\u8054\u5408\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff0c2\u4e2a\u6708\u5373\u63a5\u6536\uff01<\/p>\n<p>4. \u80bf\u7624\u5206\u578b\u7eaf\u751f\u4fe1\u8fd8\u80fd\u53d17\u5206+\uff1f\u54c8\u533b\u5927\u674e\u971e\u6559\u6388\u56e2\u961f\uff1a\u72ec\u7279\u300e\u80bf\u7624\u751f\u6001\u300f\u89c6\u89d2\u548c6000+\u6837\u672c\u91cf\u73a9\u51fa\u751f\u4fe1\u65b0\u9ad8\u5ea6\uff01<\/p>\n<p>5. \u75c5\u7406\u56fe\u50cf\u516c\u5171\u6570\u636e\u5206\u6790\u8fd8\u80fd\u53d17\u5206+\u7eaf\u751f\u4fe1\uff1f\u53f0\u6e7e\u6210\u529f\u5927\u5b66\u8c22\u5b59\u6e90\u56e2\u961f\u7528\u6df1\u5ea6\u5b66\u4e60\u8d85\u5f3abuff\u65a9\u83b7\u9ad8\u5206\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\u8fdb\u884c\u7684\u5982\u706b\u5982\u837c\uff0c\u6709\u4e9b\u56e2\u961f\u751a\u81f3\u902e\u4f4fMR\u5206\u6790\u628a\u9ad8\u5206\u6587\u7ae0\u53d1\u5230\u624b\u8f6f\uff0c\u770b\u5230\u8fd9\u4e48\u706b\u7206\u53d1\u6587\u5f62\u52bf\uff0c\u4f60\u8fd8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21569"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21569"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21569\/revisions"}],"predecessor-version":[{"id":21651,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/21569\/revisions\/21651"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21569"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}