{"id":21591,"date":"2023-12-26T15:58:41","date_gmt":"2023-12-26T07:58:41","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21591"},"modified":"2023-12-26T15:58:42","modified_gmt":"2023-12-26T07:58:42","slug":"%e9%9c%87%e6%83%8a%ef%bc%81%e6%b3%9b%e7%99%8c%e5%88%86%e6%9e%90%e6%8b%bf%e4%b8%8b37-3%e5%88%86%ef%bc%81%e5%b1%b1%e4%b8%9c%e5%a4%a7%e5%ad%a6%e5%86%af%e5%bc%ba%e5%9b%a2%e9%98%9f%ef%bc%9a%e7%a9%ba","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=21591","title":{"rendered":"\u9707\u60ca\uff01\u6cdb\u764c\u5206\u6790\u62ff\u4e0b37.3\u5206\uff01\u5c71\u4e1c\u5927\u5b66\u51af\u5f3a\u56e2\u961f\uff1a\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u8054\u5408\u5355\u7ec6\u80de\uff0c\u628aCAF\u7ec6\u80de\u73a9\u51fa\u4e86\u82b1\uff01"},"content":{"rendered":"<p>\u5404\u4f4d\u5e38\u5e74\u505a\u751f\u4fe1\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u80fd\u5bf9\u6cdb\u764c\u5206\u6790\u5df2\u7ecf\u65e0\u6bd4\u719f\u7ec3\u4e86\uff0c\u5c0f\u4e91\u8fd9\u4e24\u5929\u5728\u901bpubmed\u7684\u65f6\u5019\uff0c\u7a81\u7136\u770b\u5230\u4e00\u7bc7\u9ad8\u8fbe37.3\u5206\u7684\u6587\u7ae0\uff0c\u8feb\u4e0d\u53ca\u5f85\u5730\u60f3\u5206\u4eab\u7ed9\u5c0f\u4f19\u4f34\u4eec\u3002\u5404\u4f4d\u5c0f\u4f19\u4f34\u4eec\u90fd\u77e5\u9053\uff0c\u6cdb\u764c\u5206\u6790\u6587\u7ae0\u5f88\u591a\uff0c\u4f46\u5927\u591a\u6570\u6587\u7ae0\u7684\u5206\u503c\u4e00\u822c\u572810\u5206\u4ee5\u4e0b\uff0c\u90a3\u8fd9\u7bc7\u6587\u7ae0\u51ed\u4ec0\u4e48\u62ff\u5230\u9ad8\u5206\u7684\u5462\uff1f<\/p>\n<p>\u5c0f\u4e91\u7ec6\u7ec6\u9605\u8bfb\u4e86\u8fd9\u7bc7\u6587\u7ae0\uff0c\u53d1\u73b0\u5176\u62ff\u5230\u9ad8\u5206\u7edd\u5bf9\u662f\u540d\u526f\u5176\u5b9e\uff01\u5176\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u70b9\uff1a<\/p>\n<ol>\n<li>\u672c\u7814\u7a76\u7684\u7814\u7a76\u5bf9\u8c61\u662f\u80bf\u7624\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de(CAF)\uff0cCAF\u7ec6\u80de\u662f\u8fd1\u51e0\u5e74\u56fd\u81ea\u7136\u7684\u65b0\u5ba0\u513f\uff0c\u5e76\u4e14\u8fd1\u51e0\u5e74\u5176SCI\u53d1\u6587\u91cf\u9010\u5e74\u4e0a\u5347\uff0c\u672c\u6587\u7d27\u8ddf\u70ed\u70b9\u8bdd\u9898\uff0c\u59a5\u59a5\u7684\u5438\u4eba\u773c\u7403\uff01<\/li>\n<li>\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u4e0e\u5355\u7ec6\u80de\u6570\u636e\u76f8\u7ed3\u5408\u3002\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u7ec6\u80de\u4e4b\u95f4\u7684\u7a7a\u95f4\u5173\u7cfb\u4ee5\u53ca\u57fa\u56e0\u5728\u6574\u4e2a\u751f\u7269\u4f53\u5185\u7684\u5b9a\u4f4d\uff0c\u800c\u5bf9\u67d0\u4e9b\u5177\u4f53\u7684\u7ec6\u80de\u7c7b\u578b\u53ef\u80fd\u4e86\u89e3\u4e0d\u591f\u3002\u7136\u800c\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u53ef\u4ee5\u63ed\u793a\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u3001\u72b6\u6001\u4ee5\u53ca\u529f\u80fd\u7684\u5dee\u5f02\uff0c\u53ef\u4ee5\u66f4\u597d\u5730\u7406\u89e3\u7ec6\u80de\u7684\u591a\u6837\u6027\u548c\u590d\u6742\u6027\u3002\u6240\u4ee5\u4e8c\u8005\u5f3a\u5f3a\u8054\u5408\uff0c\u4e5f\u4f7f\u5f97\u6587\u7ae0\u521b\u65b0\u6027\u77ac\u95f4\u63d0\u9ad8\uff01<\/li>\n<li>\u81ea\u6d4b\u6570\u636e\u4e0e\u516c\u5171\u6570\u636e\u76f8\u7ed3\u5408\uff0c\u5171\u540c\u63ed\u793a\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u4e32\u6270\uff0c\u4f7f\u6587\u7ae0\u7684\u8d28\u91cf\u77ac\u95f4\u63d0\u5347\uff0c\u518d\u4e5f\u4e0d\u6015\u5ba1\u7a3f\u4eba\u4ee5\u516c\u5171\u6570\u636e\u8bc4\u4f30\u4e0d\u51c6\u786e\u800c\u62d2\u7a3f\u5566\uff01<\/li>\n<li>\u672c\u7814\u7a76\u7684\u7814\u7a76\u601d\u8def\u65b0\u9896\u4e14\u6570\u636e\u91cf\u5927\u3002\u672c\u6587\u9996\u5148\u5206\u6790CAFs\u4e0d\u540c\u7684\u529f\u80fd\u4e9a\u7fa4\uff0c\u5e76\u7814\u7a76\u5176\u7a7a\u95f4\u5206\u5e03\u7279\u5f81\u3002\u53c8\u5728\u7a7a\u95f4\u80cc\u666f\u4e0b\u8fdb\u884c\u7684\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u5206\u6790\uff0c\u5f3a\u8c03\u57fa\u8d28CAFs (mCAFs)\u5728\u80bf\u7624\u8840\u7ba1\u751f\u6210\u548c\u708e\u75c7\u6027CAFs (iCAFs)\u5728\u5f62\u6210\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u4e00\u5957\u64cd\u4f5c\u4e0b\u6765\uff0c\u6df1\u5165\u7814\u7a76\u4e86\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u76f8\u4e92\u5f71\u54cd\uff0c\u8ba9\u4eba\u611f\u53f9\u601d\u8def\u4eae\u773c\uff0c\u903b\u8f91\u6e05\u6670\uff0c\u59a5\u59a5\u7684\u9ad8\u5206\u6587\u7ae0\uff01<\/li>\n<\/ol>\n<p>\u8fd9\u4e0d\u5c31\u662f\u6cdb\u764c\u9ad8\u5206SCI\u7684\u4f18\u79c0\u6a21\u677f\u5417\uff1f\u8fd9\u79cd\u7a7a\u95f4\u8f6c\u5f55\u7ec4+\u5355\u7ec6\u80de\u6d4b\u5e8f\u7684\u5957\u8def\u5728\u8fd1\u4e24\u5e74\u662f\u771f\u9999\u554a\uff01\u60f3\u8981\u53d1\u8868\u9ad8\u5206SCI\u7684\u5c0f\u4f19\u4f34\u4eec\u8fd8\u4e0d\u8d76\u5feb\u501f\u9274\u4e00\u4e0b\u672c\u6587\u7684\u7814\u7a76\u601d\u8def\uff0c\u6362\u4e2a\u201c\u7ec6\u80de\u201d\u8d76\u7d27\u4e0a\u8f66\uff01 <strong>(ps\uff1a\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff01\u8fd9\u91cc\u6709\u65b0\u9c9c\u51fa\u7089\u7684\u751f\u4fe1\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u4e00\u5927\u6ce2\u7684\u53ef\u590d\u73b0\u7684\u521b\u65b0\u601d\u8def\uff0c\u611f\u5174\u8da3\u7684\u76f4\u63a5\u626b\u7801\u8054\u7cfb\u6211\u5427\uff01)<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"171\" height=\"172\" class=\"wp-image-21592 aligncenter\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-1.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-1.png 171w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-1-150x150.png 150w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-1-100x100.png 100w\" sizes=\"(max-width: 171px) 100vw, 171px\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"865\" height=\"354\" class=\"wp-image-21593\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-2.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-2.png 865w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-2-300x123.png 300w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-2-768x314.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-2-600x246.png 600w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a \u6cdb\u764c\u7a7a\u95f4\u5355\u7ec6\u80de\u5206\u6790\u63ed\u793a\u4e86\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u4e32\u6270<\/li>\n<li>\u6742\u5fd7\uff1aMolecular Cancer<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=37.3<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7410\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de(CAFs)\u662f\u4e00\u79cd\u5f02\u8d28\u6027\u7ec6\u80de\u7fa4\uff0c\u5176\u5728\u534f\u8c03TME\u91cd\u7ec4\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u76ee\u524d\u5305\u62ec\u514d\u75ab\u6cbb\u7597\u548c\u5316\u7597\u5728\u5185\u7684\u5927\u591a\u6570\u6cbb\u7597\u65b9\u6cd5\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5ffd\u89c6\u4e86CAFs\u7684\u5173\u952e\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u65e8\u5728\u901a\u8fc7\u7efc\u5408\u7684\u6570\u636e\u8d44\u6e90\u4e3aTME\u4e2d\u9488\u5bf9CAFs\u7684\u6cbb\u7597\u7b56\u7565\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u548c\u6307\u5bfc\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u96c6\/\u961f\u5217<\/td>\n<td>\u6570\u636e\u5e93<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u8be6\u7ec6\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK7\"><\/a> GSE176078<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>26\u4f8b\u4e73\u817a\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK8\"><\/a> GSE166555<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>16\u4f8b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6b63\u5e38\u53ca\u90bb\u8fd1\u80bf\u7624\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK9\"><\/a> GSE149614<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>21\u4f8b\u809d\u7ec6\u80de\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK10\"><\/a> GSE184880<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>12\u4f8b\u5375\u5de2\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK11\"><\/a> GSE203612<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>\u6cdb\u764c\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK12\"><\/a> GSE207422<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>39\u4f8b NSCLC\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK13\"><\/a> GSE215120<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>11\u4f8b\u9ed1\u8272\u7d20\u7624\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK14\"><\/a> GSE181919<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>37\u4f8b\u5934\u9888\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>\u63a5\u53d7pembrolizumab\u6cbb\u7597\u7684BRCA\u60a3\u8005\u7684scRNA-seq\u6570\u636e<\/td>\n<td>VIB &#8211; KU LEUVEN CENTER FOR CANCER BIOLOGY<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>\u63a5\u53d7pembrolizumab\u6cbb\u7597\u7684BRCA\u60a3\u8005\u7684scRNA-seq\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK15\"><\/a> GSE176078<\/td>\n<td>GEO<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>26\u4f8b\u4e73\u817a\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td><a id=\"post-21591-OLE_LINK16\"><\/a> GSE203612<\/td>\n<td>GEO<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>\u6cdb\u764c\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>GSE91061<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>Gide\u961f\u5217<\/td>\n<td>TIDE<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>Nathanson\u961f\u5217<\/td>\n<td>TIDE<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/td>\n<\/tr>\n<tr>\n<td>22\u4e2a\u7ec4\u7ec7\u5207\u7247\u6574\u5408\u7684ST\u6570\u636e\u53ca\u5176\u76f8\u5e94\u7684scRNA-seq\u6570\u636e<\/td>\n<td>Synapse<\/td>\n<td>ST\u6570\u636e\u53ca\u5176\u76f8\u5e94\u7684scRNA-seq\u6570\u636e<\/td>\n<td><a id=\"post-21591-_Hlk152340681\"><\/a> 22\u4e2a\u7ec4\u7ec7\u5207\u7247\u6574\u5408\u7684ST\u6570\u636e\u53ca\u5176\u76f8\u5e94\u7684scRNA-seq\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>PRAD<\/td>\n<td>\u5728\u7ebf\u7f51\u7ad9\uff08<a href=\"http:\/\/www.pradcellatlas.com\/\">http:\/\/www.pradcellatlas.com\/<\/a>\uff09<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>PRAD\u7684scRNA-seq\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>CRC\u7684ST\u6570\u636e<\/td>\n<td>\u5728\u7ebf\u7f51\u7ad9\uff08http:\/\/www.cancerdiversity.asia\/scCRLM\/\uff09<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>CRC\u7684ST\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>LIHC1\u3001LIHC2\u3001LIHC3\u548cLIHC4\u7684ST\u6570\u636e<\/td>\n<td>\u5728\u7ebf\u7f51\u7ad9\uff08http:\/\/lifeome.net\/supp\/livercancer-st\/data.htm\uff09<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>LIHC1\u3001LIHC2\u3001LIHC3\u548cLIHC4\u7684ST\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>OVCA_10x\u7684ST\u6570\u636e<\/td>\n<td>10xgenomics<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>OVCA_10x\u7684ST\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>PRAD1\u7684ST\u6570\u636e<\/td>\n<td>10xgenomics<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>PRAD1\u7684ST\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>PRAD2\u7684ST\u6570\u636e<\/td>\n<td>10xgenomics<\/td>\n<td>ST\u6570\u636e<\/td>\n<td>PRAD2\u7684ST\u6570\u636e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p><a id=\"post-21591-_Hlk152275938\"><\/a> \u57fa\u4e8e\u516d\u79cd\u5e38\u89c1\u764c\u75c7\u7c7b\u578b\u7684\u7a7a\u95f4\u548c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\uff0c\u5206\u6790CAFs\u7684\u529f\u80fd\u4e9a\u7fa4\uff0c\u5e76\u63cf\u8ff0\u5b83\u4eec\u7684\u7a7a\u95f4\u5206\u5e03\u7279\u5f81\u3002\u5728\u7a7a\u95f4\u8303\u56f4\u5185\u8fdb\u884c\u7ec6\u80de\u4e0e\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u5206\u6790\uff0c\u6df1\u5165\u5206\u6790\u57fa\u8d28CAFs\uff08mCAFs\uff09\u5728\u80bf\u7624\u8840\u7ba1\u751f\u6210\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u4ee5\u53ca\u708e\u6027CAFs\uff08iCAFs\uff09\u5728\u5f62\u6210\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u5728\u63a5\u53d7\u6297PD-1\u514d\u75ab\u7597\u6cd5\u7684\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u5206\u6790iCAFs\u5728\u4fc3\u8fdb\u764c\u7ec6\u80de\u589e\u6b96\u3001\u4fc3\u8fdb\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u4ee5\u53ca\u5efa\u7acb\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u65b9\u9762\u7684\u4f5c\u7528\u3002<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. <\/strong><a id=\"post-21591-_Hlk152252764\"><\/a><strong>\u6cdb\u764c\u7a7a\u95f4\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31\u7684\u6784\u5efa<\/strong><\/p>\n<p>\u4e3a\u4e86\u5728\u6cdb\u764c\u4e2d\u5efa\u7acb\u7a7a\u95f4\u5355\u7ec6\u80de\u666f\u89c2\uff0c\u672c\u7814\u7a76\u4ece56\u4f8b\u8bca\u65ad\u4e3a6\u79cd\u5e38\u89c1\u764c\u75c7\u7c7b\u578b\u4e4b\u4e00\u7684\u60a3\u8005\u768469\u4e2a\u6837\u672c\u4e2d\u83b7\u53d6\u4e86scRNA-seq\u6570\u636e\uff0c\u4ee5\u53ca22\u4f8b\u60a3\u8005\u768422\u4e2a\u7ec4\u7ec7\u5207\u7247\u7684ST\u6570\u636e(\u56fe1a\u548cb)\u3002\u5176\u4e2d\uff0c10\u4e2a\u7ec4\u7ec7\u5207\u7247\u7684ST\u6570\u636e\u5177\u6709\u6765\u81ea\u540c\u4e00\u60a3\u8005\u7684\u76f8\u5e94\u7684scRNA-seq\u6570\u636e (\u56fe1c)\u3002\u672c\u7814\u7a76\u6536\u96c6\u7684\u6570\u636e\u5305\u62ec\u516d\u79cd\u7c7b\u578b\u7684\u764c\u75c7:\u4e73\u817a\u764c(BRCA)\u3001\u7ed3\u76f4\u80a0\u764c(CRC)\u3001\u809d\u764c(LIHC)\u3001\u5375\u5de2\u764c(OVCA)\u3001\u524d\u5217\u817a\u817a\u764c(PRAD)\u548c\u5b50\u5bab\u5185\u819c\u764c(UCEC)(\u56fe1a)\u3002\u4ee5CRC\u4e3a\u4f8b\uff0c\u91c7\u7528\u57fa\u4e8e\u56fe\u805a\u7c7b\u7684\u65b9\u6cd5\uff0c\u6839\u636e\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u5178\u578b\u6807\u8bb0\u7269\u8bc6\u522b\u51fa7\u4e2a\u4e3b\u8981\u805a\u7c7b\uff0c\u5305\u62ec\u4e0a\u76ae\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u3001T&amp;NK\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u9ad3\u6837\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de(\u56fe1e-f)\u3002\u6700\u540e\uff0c\u672c\u7814\u7a76\u83b7\u5f97\u4e00\u4e2a\u5305\u542b744289\u4e2a\u7ec6\u80de\u7684\u6cdb\u764c\u7a7a\u95f4\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31(\u56fe1d\u548cg)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"1920\" height=\"2480\" class=\"wp-image-21594\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3.png 1920w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-232x300.png 232w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-793x1024.png 793w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-768x992.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-1189x1536.png 1189w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-1586x2048.png 1586w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-3-600x775.png 600w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/> \u56fe1 \u6cdb\u764c\u7a7a\u95f4\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31\u7684\u6784\u5efa<\/p>\n<p><strong>2. \u6cdb\u764cCAF\u5f02\u8d28\u6027<\/strong><\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u672c\u7814\u7a76\u5206\u6790\u4e866\u79cd\u764c\u75c7\u7c7b\u578b\u7684scRNA-seq\u6570\u636e\u96c6\u4e2d\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u5f02\u8d28\u6027(\u56fe2a)\u3002\u6210\u7ea4\u7ef4\u7ec6\u80de\u7c07\u7684\u91cd\u65b0\u805a\u7c7b\u9274\u5b9a\u51fa\u56db\u79cdCAF\u4e9a\u578b\uff0c\u4ee5\u53ca\u5468\u7ec6\u80de\u548c\u5e73\u6ed1\u808c\u7ec6\u80de(\u56fe2a)\u3002CFD +\u6210\u7ea4\u7ef4\u7ec6\u80de\u663e\u793a\u9ad8\u8868\u8fbe\u8d8b\u5316\u56e0\u5b50(\u56fe2b)\u3002\u6807\u8bb0\u57fa\u56e0\u7684GO\u5bcc\u96c6\u5206\u6790\u663e\u793a\uff0c\u5b83\u4eec\u4e0e\u673a\u68b0\u523a\u6fc0\u3001\u6d3b\u6027\u6c27\u3001\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u3001\u514d\u75ab\u7cfb\u7edf\u548c\u7ec6\u80de\u8fc1\u79fb\u7684\u53cd\u5e94\u6709\u5173(\u56fe2c)\u3002POSTN +\u6210\u7ea4\u7ef4\u7ec6\u80de\u663e\u793a\u51faECM\u91cd\u5851\u57fa\u56e0\u9ad8\u8868\u8fbe(\u56fe2b\u548cc)\u3002\u63a5\u4e0b\u6765\uff0c\u4f7f\u7528AUCell\u7b97\u6cd5\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86CAFs\u7684\u5f02\u8d28\u6027(\u56fe2d)\u3002iCAFs\u5728\u514d\u75ab\u76f8\u5173\u529f\u80fd\u65b9\u9762\u8868\u73b0\u51fa\u6700\u9ad8\u7684\u6d3b\u6027\uff0c\u5305\u62ec\u8865\u4f53\u6fc0\u6d3b\u3001\u8d8b\u5316\u56e0\u5b50\u4ea7\u751f\u548c\u708e\u75c7\u53cd\u5e94(\u56fe2d)\u3002\u6b64\u5916\uff0c\u8840\u7ba1\u751f\u6210\u3001\u4f24\u53e3\u6108\u5408\u3001ECM\u7ec4\u7ec7\u8c03\u8282\u548c\u80f6\u539f\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u7b49\u90fd\u5728mCAFs\u4e2d\u5bcc\u96c6(\u56fe2d)\u3002\u5c3d\u7ba1\u57286\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\uff0ciCAFs\u548cmCAFs\u662f\u4e3b\u8981\u7684CAFs\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u4e0d\u540c\u4e9a\u578b\u7684CAFs\u4ecd\u7136\u8868\u73b0\u51fa\u660e\u663e\u7684\u764c\u75c7\u504f\u597d(\u56fe2e\u548cf)\u3002\u5e76\u4e14\u4e0e\u708e\u75c7\u76f8\u5173\u7684\u8c03\u8282\u86cb\u767dCDX2\u548c\u4e0eECM\u91cd\u5851\u76f8\u5173\u7684\u8c03\u8282\u86cb\u767dTCF12\u5206\u522b\u5728iCAFs\u548cmCAFs\u4e2d\u5bcc\u96c6(\u56fe2g)\u3002\u6b63\u5982\u9884\u671f\u7684\u90a3\u6837\uff0c\u7cd6\u9175\u89e3\u548c\u4e19\u916e\u9178\u5728meCAFs\u7684\u9876\u5c42\u4ee3\u8c22\u9014\u5f84\u4e2d\u5bcc\u96c6(\u56fe2h)\u3002\u901a\u8fc7Slingshot\u5206\u6790\uff0c\u63d0\u51fa\u4e86\u4ece\u5468\u7ec6\u80de\u5230iCAFs\u7684\u6f5c\u5728\u8fc7\u6e21\u9014\u5f84(\u56fe2i)\u3002GeneSwitches\u5206\u6790\u786e\u5b9a\u4e86\u4ece\u5468\u7ec6\u80de\u5230iCAFs\u7684\u9014\u5f84\u4e2d\u6fc0\u6d3b\u7684\u591a\u4e2a\u751f\u7269\u8fc7\u7a0b\uff0c\u5305\u62ec\u4f24\u53e3\u6108\u5408\u3001\u7ec6\u80de\u7c98\u9644\u8c03\u8282\u3001ECM\u3001\u8840\u7ba1\u751f\u6210\u3001\u80f6\u539f\u7ea4\u7ef4\u7ec4\u7ec7\u3001\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\u548c\u708e\u75c7\u53cd\u5e94(\u56fe2j)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"1944\" height=\"1160\" class=\"wp-image-21595\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4.png 1944w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4-300x179.png 300w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4-1024x611.png 1024w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4-768x458.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4-1536x917.png 1536w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-4-600x358.png 600w\" sizes=\"(max-width: 1944px) 100vw, 1944px\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"1944\" height=\"1123\" class=\"wp-image-21596\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5.png 1944w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5-300x173.png 300w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5-1024x592.png 1024w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5-768x444.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5-1536x887.png 1536w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-5-600x347.png 600w\" sizes=\"(max-width: 1944px) 100vw, 1944px\" \/><\/p>\n<p>\u56fe2 \u6cdb\u764cCAF\u5f02\u8d28\u6027<\/p>\n<p><strong>3. <\/strong><a id=\"post-21591-_Hlk152254781\"><\/a><strong>CAFs\u7684\u7a7a\u95f4\u5206\u5e03\u7279\u5f81<\/strong><\/p>\n<p>\u4e3a\u4e86\u786e\u5b9aCAFs\u7684\u7a7a\u95f4\u5206\u5e03\u7279\u5f81\uff0c\u672c\u7814\u7a76\u89c2\u5bdf\u5230iCAFs\u548cmCAFs\u7684\u9ad8\u5bc6\u5ea6\u533a\u57df\u4e4b\u95f4\u5b58\u5728\u7a7a\u95f4\u6392\u4ed6\u73b0\u8c61(\u56fe3a -d)\uff0c\u8fd9\u8868\u660eCAFs\u7684\u6fc0\u6d3b\u72b6\u6001\u4e0e\u5176\u5728TME\u4e2d\u7684\u4f4d\u7f6e\u6709\u5173\u3002\u672c\u7814\u7a76\u8ba1\u7b97\u4e86\u6bcf\u4e2a\u7ec4\u7ec7\u5207\u7247\u4e2d\u6240\u6709\u7ec6\u80de\u4e0e\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e9a\u7fa4\u4e4b\u95f4\u7684\u7a7a\u95f4k\u8ddd\u79bb\uff0c\u5e76\u4f7f\u7528RRA\u7b97\u6cd5\u5bf9\u5b83\u4eec\u8fdb\u884c\u6574\u5408\uff0c\u4ee5\u83b7\u5f97\u6240\u6709\u7ec6\u80de\u7684\u7efc\u5408\u6392\u540d\u3002\u7ecf\u5206\u6790\uff0c\u56db\u79cdCAFs\u4e9a\u578b\u4e4b\u95f4\u7684\u7a7a\u95f4k\u8ddd\u79bb\u6700\u5c0f\uff0c\u800c\u514d\u75ab\u7ec6\u80de\u4e9a\u578b\u7684\u6392\u5e8f\u6ca1\u6709\u663e\u8457\u5dee\u5f02(\u56fe3e- 1)\u3002\u5728\u6bcf\u4e00\u79cdCAF\u4e9a\u578b\u5468\u56f4\u90fd\u6709\u5176\u4ed6\u7c7b\u578b\u7684CAF\u4e9a\u578b\u7684\u5bcc\u96c6\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6240\u6709\u56db\u79cdCAF\u4e9a\u578b\u5468\u56f4\u4e0a\u76ae\u7ec6\u80de\u7684\u6bd4\u4f8b\u90fd\u4e0b\u964d\uff0c\u8fd9\u610f\u5473\u7740\u8fd9\u4e9b\u4e9a\u578b\u4f4d\u4e8e\u79bb\u4e0a\u76ae\u533a\u57df\u66f4\u8fdc\u7684\u5730\u65b9(\u56fe3m)\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660eCAF\u5728\u7a7a\u95f4\u5206\u5e03\u4e0a\u5b58\u5728\u660e\u663e\u5f02\u8d28\u6027\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"1944\" height=\"2240\" class=\"wp-image-21597\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6.png 1944w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-260x300.png 260w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-889x1024.png 889w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-768x885.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-1333x1536.png 1333w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-1777x2048.png 1777w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-6-600x691.png 600w\" sizes=\"(max-width: 1944px) 100vw, 1944px\" \/><\/p>\n<p>\u56fe3 CAFs\u7684\u7a7a\u95f4\u5206\u5e03\u7279\u5f81<\/p>\n<p><strong>4. <\/strong><a id=\"post-21591-_Hlk152267503\"><\/a><strong>CAFs\u901a\u8fc7\u65c1\u5206\u6ccc\u4fe1\u53f7\u5bf9TME\u7684\u5f71\u54cd<\/strong><\/p>\n<p>\u9274\u4e8emCAFs\u7684\u9ad8\u8840\u7ba1\u751f\u6210\u6d3b\u6027\uff0c\u672c\u7814\u7a76\u4f7f\u7528Spatalk\u6765\u63a2\u7d22mCAFs\u4e0e\u5185\u76ae\u7ec6\u80de\u5728\u7a7a\u95f4\u80cc\u666f\u4e0b\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u5728mCAFs\u4e2d\u9274\u5b9a\u7684\u914d\u4f53\u88ab\u53d1\u73b0\u5728\u5404\u79cd\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5305\u62ec\u8fc1\u79fb\u3001\u589e\u6b96\u3001\u51cb\u4ea1\u3001\u8d8b\u5316\u3001\u5206\u5316\u548c\u53d1\u80b2(\u56fe4a)\u3002\u672c\u7814\u7a76\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u4e00\u7cfb\u5217\u4e0e\u8840\u7ba1\u751f\u6210\u76f8\u5173\u7684\u914d\u4f53-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528(LRIs) (\u56fe4d)\u3002\u6b64\u5916\uff0c\u4eceiCAFs\u5230\u5de8\u566c\u7ec6\u80de\u7684\u914d\u4f53\u88ab\u53d1\u73b0\u663e\u8457\u5730\u4e30\u5bcc\u4e86\u5de8\u566c\u7ec6\u80de\u7684\u5404\u79cd\u529f\u80fd\uff0c\u5305\u62ec\u5206\u5316\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3001\u8d8b\u5316\u6027\u3001\u8fc1\u79fb\u548c\u6fc0\u6d3b(\u56fe4b)\u3002\u8003\u8651\u5230M2\u5de8\u566c\u7ec6\u80de\u6781\u5316\u4e0e\u80bf\u7624\u8fdb\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u672c\u7814\u7a76\u9274\u5b9a\u4e86\u4e00\u7cfb\u5217\u53c2\u4e0e\u8fd9\u4e00\u8fc7\u7a0b\u7684LRIs (\u56fe4e)\u3002CD8 + T\u7ec6\u80de\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u7814\u7a76\u53d1\u73b0\u7ed3\u5408CD8 + T\u7ec6\u80de\u7684iCAFs\u914d\u4f53\u5bcc\u542b\u5404\u79cdT\u7ec6\u80de\u76f8\u5173\u529f\u80fd\uff0c\u5305\u62ec\u8fc1\u79fb\u3001\u6fc0\u6d3b\u3001\u589e\u6b96\u3001\u8d8b\u5316\u3001\u5206\u5316\u3001\u5171\u523a\u6fc0\u3001\u51cb\u4ea1\u8fc7\u7a0b\u3001\u7a33\u6001\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3001T\u7ec6\u80de\u6781\u6027\u7684\u5efa\u7acb\u3001T\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u548c\u7ec6\u80de\u6bd2\u6027(\u56fe4c)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0ciCAFs\u53ef\u80fd\u901a\u8fc7LGALS1\u4e0eCD8 + T\u7ec6\u80dePTPRC\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u8bf1\u5bfcCD8 + T\u7ec6\u80de\u51cb\u4ea1\u5e76\u635f\u5bb3\u5176\u6297\u80bf\u7624\u529f\u80fd(\u56fe4f)\u3002\u672c\u7814\u7a76\u968f\u540e\u7684\u5206\u6790\u96c6\u4e2dLGALS1-PTPRC\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u5404\u79cd\u80bf\u7624\u7684ST\u7ec4\u7ec7\u5207\u7247\u4e2d\u89c2\u5bdf\u5230\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528(\u56fe4g)\u3002\u5728BRCA\u548cLIHC\u7684\u7ec4\u7ec7\u5fae\u9635\u5217\u4e0a\u8fdb\u884c\u7684\u514d\u75ab\u8367\u5149\u5b9e\u9a8c\u4e5f\u63ed\u793a\u4e86\u5927\u91cf\u7684\u4f8b\u5b50\uff0c\u5176\u4e2dCD\u9633\u6027\u7ec6\u80de\u548cCD8\u9633\u6027\u7ec6\u80de\u8868\u73b0\u51fa\u7a7a\u95f4\u63a5\u8fd1\u6027(\u56fe4h)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"674\" height=\"643\" class=\"wp-image-21598\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-7.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-7.png 674w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-7-300x286.png 300w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-7-600x572.png 600w\" sizes=\"(max-width: 674px) 100vw, 674px\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"674\" height=\"370\" class=\"wp-image-21599\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-8.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-8.png 674w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-8-300x165.png 300w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-8-600x329.png 600w\" sizes=\"(max-width: 674px) 100vw, 674px\" \/><\/p>\n<p>\u56fe4 CAFs\u901a\u8fc7\u65c1\u5206\u6ccc\u4fe1\u53f7\u5bf9TME\u7684\u5f71\u54cd<\/p>\n<p><strong>5. <\/strong><a id=\"post-21591-_Hlk152268104\"><\/a><strong>\u6297pd1\u6cbb\u7597\u5f71\u54cdiCAFs\u4e0eTME\u4e4b\u95f4\u7684\u901a\u8baf<\/strong><\/p>\n<p>\u4e3a\u4e86\u7814\u7a76\u6297pd1\u6cbb\u7597\u5bf9iCAFs\u7684\u5f71\u54cd\uff0c\u672c\u7814\u7a76\u5bf9\u6210\u7ea4\u7ef4\u7ec6\u80de\u8fdb\u884c\u805a\u7c7b\u540e\uff0c\u83b7\u5f97\u4e86\u4e0e\u6cdb\u764c\u4e00\u81f4\u7684CAF\u4e9a\u578b\u5206\u578b\u7ed3\u679c(\u56fe5a\u548cb)\u3002\u5728\u6cbb\u7597\u671f\u95f4\uff0c\u4e0e\u672a\u8fdb\u884c\u514b\u9686\u6269\u5f20\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u514b\u9686\u6269\u5f20\u60a3\u8005\u7684\u764c\u7ec6\u80de\u6bd4\u4f8b\u8f83\u4f4e\uff0c\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u6d3b\u6027\u7684T\u7ec6\u80de\u6570\u91cf\u589e\u52a0\u3002\u6b64\u5916\uff0c\u65e0\u8bba\u662f\u6cbb\u7597\u524d\u8fd8\u662f\u6cbb\u7597\u4e2d\uff0c\u63a5\u53d7\u514b\u9686\u6269\u5f20\u7684\u60a3\u8005\u4e2diCAFs\u7684\u6bd4\u4f8b\u59cb\u7ec8\u8f83\u4f4e(\u56fe5c-e)\u3002\u4e0e\u9884\u5904\u7406\u76f8\u6bd4\uff0ciCAFs\u5728\u6cbb\u7597\u671f\u95f4\u6291\u5236CD8+ T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3001\u589e\u6b96\u548c\u8fc1\u79fb (\u56fe5f\u548cg)\u3002\u5c3d\u7ba1iCAFs\u5728\u6cbb\u7597\u671f\u95f4\u4e0b\u8c03TGFB3\uff0c\u5b83\u4eec\u4ecd\u53ef\u80fd\u901a\u8fc7\u8fc7\u8868CSF-1\u4fc3\u8fdb\u5355\u6838\u7ec6\u80de\u5b58\u6d3b\u5e76\u5411\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u5206\u5316 (\u56fe5g\u548ch)\u3002\u603b\u4e4b\uff0c\u6297PD1\u6cbb\u7597\u589e\u5f3aiCAFs\u4fc3\u8fdb\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u5f62\u6210\u7684\u80fd\u529b\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"777\" height=\"968\" class=\"wp-image-21600\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-9.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-9.png 777w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-9-241x300.png 241w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-9-768x957.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-9-600x747.png 600w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><\/p>\n<p><a id=\"post-21591-_Hlk152268511\"><\/a> \u56fe5 \u6297pd1\u6cbb\u7597\u5f71\u54cdiCAF\u4e0eTME\u4e4b\u95f4\u7684\u901a\u8baf<\/p>\n<p><strong>6. <\/strong><a id=\"post-21591-_Hlk152268538\"><\/a><strong>iCAF\u8bc4\u5206\u4e0e\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173<\/strong><\/p>\n<p>\u8003\u8651\u5230TME\u4e2diCAFs\u4e0e\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u672c\u7814\u7a76\u53d1\u73b0\u5728\u6240\u6709\u961f\u5217\u4e2d\uff0ciCAF\u8bc4\u5206\u9ad8\u7684\u60a3\u8005\u8868\u73b0\u51fa\u8f83\u957f\u7684\u603b\u751f\u5b58\u671f(OS)\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS) (\u56fe6 a)\u3002\u63a5\u4e0b\u6765\uff0c\u6839\u636e\u4e2d\u4f4d\u6570\u5c06\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5206\u4e3a\u9ad8\u548c\u4f4eiCAF\u8bc4\u5206\u7ec4\uff0c\u5e76\u6bd4\u8f83\u4e24\u7ec4\u4e4b\u95f4ICB\u5e94\u7b54\u8005\u7684\u767e\u5206\u6bd4\u3002\u7ed3\u679c\u663e\u793a\uff0ciCAF\u8bc4\u5206\u9ad8\u7684\u60a3\u8005\u5bf9\u6297pd -1\u6cbb\u7597\u7684\u5e94\u7b54\u7387\u66f4\u9ad8(\u56fe6b)\u548c\u6297ctla -4\u6cbb\u7597(\u56fe6 c)\u3002\u63a5\u4e0b\u6765\uff0c\u672c\u7814\u7a76\u5206\u6790\u4e86\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u514d\u75ab\u666f\u89c2\uff0c\u53d1\u73b0\u4e86\u9ad8iCAF\u8bc4\u5206\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u514d\u75ab\u68c0\u67e5\u70b9\u57fa\u56e0\u7684\u8868\u8fbe\u66f4\u9ad8\uff0cCNV\u6269\u589e\u7684\u9891\u7387\u66f4\u9ad8(\u56fe6d)\u3002\u7531ESTIMATE\u7b97\u6cd5\u8ba1\u7b97\u7684\u514d\u75ab\u8bc4\u5206\u548c\u5148\u524d\u62a5\u9053\u7684\u514d\u75ab\u53cd\u5e94\u8bc4\u5206\uff0c\u4e5f\u53d1\u73b0iCAF\u8bc4\u5206\u9ad8\u7684\u60a3\u8005\u514d\u75ab\u53cd\u5e94\u8bc4\u5206\u66f4\u9ad8(\u56fe6e)\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u9ad8iCAF\u8bc4\u5206\u60a3\u8005\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u83b7\u76ca\u53ef\u80fd\u4f9d\u8d56\u4e8e\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u589e\u52a0\u548c\u514d\u75ab\u8c03\u8282\u5242\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"1214\" height=\"1350\" class=\"wp-image-21601\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10.png\" srcset=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10.png 1214w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10-270x300.png 270w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10-921x1024.png 921w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10-768x854.png 768w, http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-21591-10-600x667.png 600w\" sizes=\"(max-width: 1214px) 100vw, 1214px\" \/><\/p>\n<p>\u56fe6 iCAF\u8bc4\u5206\u4e0e\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173<\/p>\n<p><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u53ef\u8c13\u662f\u7d27\u8ddf\u5f53\u524d\u7814\u7a76\u6f6e\u6d41\uff0c\u9009\u62e9\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u8fd9\u4e2a\u70ed\u70b9\u8bdd\u9898\uff0c\u76f4\u63a5\u5438\u4eba\u773c\u7403\uff01\u540c\u65f6\u53c8\u4f7f\u7528\u4e86\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u548c\u5355\u7ec6\u80de\u6d4b\u5e8f\u8fd9\u4e24\u79cd\u5f53\u7ea2\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u521b\u65b0\u6027\u518d\u6b21\u63d0\u5347\u3002\u5bf9\u6cdb\u764c\u7a7a\u95f4\u548c\u5355\u7ec6\u80de\u6570\u636e\u7684\u7efc\u5408\u5206\u6790\u63ed\u793a\u4e86CAFs\u7684\u5f02\u8d28\u6027\uff0c\u63ed\u793a\u4e86\u5b83\u4eec\u7684\u7a7a\u95f4\u5206\u5e03\u6a21\u5f0f\u548c\u4e0eTME\u590d\u6742\u7684\u7ec6\u80de\u901a\u8baf\u3002\u672c\u7814\u7a76\u4e0d\u4ec5\u589e\u5f3a\u4e86\u5bf9CAF\u751f\u7269\u5b66\u7279\u6027\u7684\u7406\u89e3\uff0c\u800c\u4e14\u4e3a\u9488\u5bf9CAF\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u89c1\u89e3\u3002\u770b\u5230\u522b\u7684\u56e2\u961f\u8e6d\u8e6d\u8e6d\u5730\u53d1\u6587\uff0c\u4f60\u662f\u4e0d\u662f\u4e5f\u8feb\u4e0d\u53ca\u5f85\u51c6\u5907\u5927\u5c55\u8eab\u624b\u5566\uff1f\u60f3\u5728\u6cdb\u764c\u65b9\u5411\u505a\u70b9\u65b0\u4e1c\u897f\u7684\u5c0f\u4f19\u4f34\uff0c\u4e0d\u8981\u9519\u8fc7\u8fd9\u4e2a\u597d\u601d\u8def\uff0c<strong>\u60f3\u590d\u73b0\u7684\u5c0f\u4f19\u4f34\u4eec\u5feb\u5feb\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u5427\uff01<\/strong><\/p>\n<p><strong><img 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