{"id":22072,"date":"2023-12-26T17:20:29","date_gmt":"2023-12-26T09:20:29","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22072"},"modified":"2023-12-26T17:20:30","modified_gmt":"2023-12-26T09:20:30","slug":"9%e5%88%86%e7%9a%84%e7%ba%af%e7%94%9f%e4%bf%a1%e9%95%bf%e4%bb%80%e4%b9%88%e6%a0%b7%e6%98%86%e6%98%8e%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e5%94%90%e6%96%87%e5%a6%82%e5%9b%a2%e9%98%9f%e7%9e%84","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22072","title":{"rendered":"9\u5206+\u7684\u7eaf\u751f\u4fe1\u957f\u4ec0\u4e48\u6837?\u6606\u660e\u7406\u5de5\u5927\u5b66\u5510\u6587\u5982\u56e2\u961f\u7784\u51c6\u201c\u5e72\u7ec6\u80de\u201d\uff0c\u642d\u8f7d\u836f\u7269\u7b5b\u9009+\u5355\u7ec6\u80de\u6210\u529f\u51fa\u5708\uff01"},"content":{"rendered":"<p>\u80bf\u7624\u76f8\u5173\u751f\u4fe1\u73b0\u5728\u7ade\u4e89\u8fd9\u4e48\u6fc0\u70c8\uff0c\u8be5\u600e\u4e48\u62ff\u9ad8\u5206\u5462\uff1f2023\u5e74\u5373\u5c06\u7ed3\u675f\uff0c\u73b0\u5728\u56de\u5934\u770b\u770b\uff0c\u6709\u6ca1\u6709\u53d1\u73b09\u5206\u4ee5\u4e0a\u7684\u751f\u4fe1\u6587\u7ae0\u5df2\u7ecf\u88ab\u201c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u201d\u3001\u201c\u4e34\u5e8a\u6570\u636e\u5e93\u5206\u6790\u201d\u3001\u201c\u5f71\u50cf\u7ec4\u5b66\u201d\u7b49\u65b0\u5174\u65b9\u5411\u5360\u9886\u4e86\u5927\u90e8\u5206\u5730\u76d8\uff0c\u90a3\u8981\u505a\u5e38\u89c4\u751f\u4fe1\u53c8\u8be5\u4ece\u54ea\u91cc\u7a81\u7834\u5462\uff1f<\/p>\n<p>\u8fd9\u4f60\u53ef\u95ee\u5bf9\u4eba\u4e86\uff0c\u5c0f\u4e91\u6240\u5728\u56e2\u961f\u505a\u4e86\u8fd9\u4e48\u591a\u80bf\u7624\u76f8\u5173\u751f\u4fe1\u601d\u8def\u8bbe\u8ba1\u548c\u5b9a\u5236\u5206\u6790\uff0c\u5f88\u591a\u505a\u60f3\u7ee7\u7eed\u5728\u5e38\u89c4\u751f\u4fe1\u9886\u57df\u6df1\u8015\u7684\u670b\u53cb\u90fd\u4f1a\u6709\u8fd9\u4e2a\u7591\u8651\uff0c<strong>\u5c0f\u4e91\u8fd8\u662f\u63a8\u8350\u5c0f\u4f19\u4f34\u4eec\u8ddf\u7740\u56fd\u81ea\u7136\u70ed\u70b9\u8d70\uff0c\u4f46\u53ef\u4ee5\u9002\u5f53\u7ed5\u8fc7\u4e00\u4e9b\u5927\u5bb6\u90fd\u6324\u7834\u5934\u3001\u7ade\u4e89\u6bd4\u8f83\u5927\u7684\u65b9\u5411\uff08\u6bd4\u5982\u80bf\u7624\u514d\u75ab\u7248\u5757\u7b49\uff09\uff0c\u5efa\u8bae\u770b\u770b\u4e00\u4e9b\u4e2d\u7b49\u70ed\u5ea6\u7684\u56fd\u81ea\u7136\u70ed\u70b9\uff08\u6bd4\u5982\u5e72\u7ec6\u80de\u65b9\u5411\uff09\u3002<\/strong>\u4e0b\u9762\u5c31\u7528\u4e00\u7bc7<strong>\u6606\u660e\u7406\u5de5\u5927\u5b66\u5510\u6587\u5982\u6559\u6388\u56e2\u961f<\/strong>\u65b0\u53d1\u76849\u5206+\u7684\u201c\u5e72\u7ec6\u80de\u201d\u65b9\u5411\u7eaf\u751f\u4fe1\u6587\u7ae0\u5b9e\u4f8b\u5c55\u793a\u4e00\u4e0b\uff1a<\/p>\n<p><strong>1\uff09\u9009\u9898\u65b9\u5411\u5b9a\u4f4d\u597d\uff1a\u907f\u5f00\u4e86\u7ade\u4e89\u8f83\u5927\u7684\u80bf\u7624\u514d\u75ab\u7248\u5757\uff0c\u7784\u51c6\u201c\u5e72\u7ec6\u80de\u201d<\/strong>\uff0c\u6b64\u65b9\u5411\u65e2\u662f\u56fd\u81ea\u7136\u70ed\u70b9\u65b9\u5411\uff0c\u6709\u70ed\u5ea6\u6709\u5173\u6ce8\u5ea6\uff0c\u53c8\u4e0e\u4e34\u5e8a\u5173\u8054\u5bc6\u5207\uff0c\u4f46\u53d1\u6587\u7ade\u4e89\u76f8\u5bf9\u5c0f\uff0c\u66f4\u5bb9\u6613\u51fa\u5708\u53d1\u9ad8\u5206\uff1b<\/p>\n<p><strong>2\uff09\u5206\u6790\u65b9\u6cd5\u8981\u521b\u65b0\uff1a\u5e94\u7528\u5206\u5b50\u5bf9\u63a5\u6280\u672f\u8fdb\u884c\u9776\u5411\u836f\u7269\u7b5b\u9009\uff0c\u540c\u65f6\u8fdb\u884c\u5355\u7ec6\u80de\u6570\u636e\u5206\u6790\uff0c<\/strong>\u5206\u5b50\u5bf9\u63a5\u836f\u7269\u7b5b\u9009\u5728\u80bf\u7624\u751f\u4fe1\u5206\u6790\u4e2d\u51fa\u73b0\u8f83\u5c11\uff0c\u65b0\u9896\u5ea6\u52a0\u500d\uff0c\u5728\u5e38\u89c4\u5957\u8def\u8fd9\u4e2d\uff0c\u5206\u6790\u65b9\u6cd5\u7684\u521b\u65b0\u53ef\u4ee5\u5927\u5927\u63d0\u9ad8\u6587\u7ae0\u6c34\u5e73\uff0c\u7edd\u5bf9\u7684\u4e0a\u5206\u795e\u5668\uff1b<\/p>\n<p>\u6574\u4f53\u6765\u770b\uff0c\u4f5c\u8005\u9996\u5148\u9009\u62e9\u4ee5\u201c\u5e72\u7ec6\u80de\u201d\u5206\u6790\u65b9\u5411\u51b2\u51fb\u751f\u4fe1\u9ad8\u5730\uff0c\u642d\u8f7d\u201c\u836f\u7269\u7b5b\u9009\u201d\u548c\u201c\u5355\u7ec6\u80de\u5206\u6790\u201d\u4e24\u5927\u52a9\u63a8\u5668\uff0c\u51c6\u786e\u7684\u9009\u9898+\u4e30\u5bcc\u7684\u914d\u7f6e\uff0c\u7b80\u5355\u7684\u5206\u6790\u4e5f\u80fd\u6210\u529f\u51fa\u5708\u62ff\u4e0b9\u5206+\u7eaf\u751f\u4fe1\uff0c\u8981\u590d\u73b0\u7684\u5feb\u6765\u5566~\u53e6\u5916\uff0c<strong>\u590d\u73b0\u6216\u8bbe\u8ba1\u601d\u8def\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u4e5f\u53ef\u4ee5\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u54e6\uff0c\u6211\u4eec\u53ef\u4ee5\u63d0\u4f9b\u6700\u4f18\u7684\u53d1\u6587\u65b9\u6848~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-22073\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-1.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-1.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-1.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-1.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"224\" class=\"wp-image-22074\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-2.png?resize=640%2C224\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-2.png?w=692 692w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-2.png?resize=300%2C105 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-2.png?resize=600%2C210 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u4e09\u9634\u6027\u4e73\u817a\u764c\u5e72\u7ec6\u80de\u7279\u5f81\u548c\u9776\u5411\u6cbb\u7597\u836f\u7269\u8bc6\u522b<\/li>\n<li>\u6742\u5fd7\uff1aScientific Data<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=9.8<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u662f\u4e73\u817a\u764c\u4e2d\u6700\u5177\u4fb5\u88ad\u6027\u7684\u4e9a\u578b\uff0c\u9884\u540e\u6700\u5dee\uff0c\u5176\u7279\u5f81\u662f\u7f3a\u4e4f\u5b55\u916e\u3001\u96cc\u6fc0\u7d20\u548cHER2\u57fa\u56e0\u8868\u8fbe\u3002\u764c\u75c7\u5e72\u7ec6\u80de\u5728\u4e73\u817a\u764c\u7684\u751f\u957f\u3001\u8f6c\u79fb\u548c\u8010\u836f\u6027\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5df2\u6709\u7814\u7a76\u63ed\u793a\u4e86\u4e0d\u540c\u764c\u75c7\u4e2d\u7684mRNAsi\u76f8\u5173\u7279\u5f81\uff0c\u5173\u4e8e\u4e09\u9634\u6027\u4e73\u817a\u764c\u5e72\u6027\u6307\u6570\u7684\u7814\u7a76\u5374\u5f88\u5c11\u3002\u672c\u7814\u7a76\u65e8\u5728\u5206\u6790\u764c\u75c7\u5e72\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u7279\u5f81\uff0c\u4ee5\u786e\u5b9a\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u98ce\u9669\u5206\u5c42\u548c\u9884\u540e\u7279\u5f81\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th><strong>\u6570\u636e\u96c6\/\u961f\u5217<\/strong><\/th>\n<th><strong>\u6570\u636e\u5e93<\/strong><\/th>\n<th><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/th>\n<th><strong>\u6837\u672c\u4fe1\u606f<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>TCGA-BRCA<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>1217\u4e2a\u6837\u672c\uff0c\u5305\u62ec127\u4e2aTNBC\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>METABRIC (Breast Cancer)<\/td>\n<td>METABRIC<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u6570\u636e<\/td>\n<td>2509\u4e2a\u6837\u672c\uff0c\u5305\u62ec320\u4e2aTNBC\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE176078<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e+\u4e34\u5e8a\u6570\u636e<\/td>\n<td>10\u4e2aTNBC\u6837\u672c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u6d41\u7a0b<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u57fa\u4e8eTCGA-BRCA\u961f\u5217\u4e2d\u7684127\u4e2aTNBC\u6837\u672c\u4f7f\u7528\u4e00\u7c7b\u903b\u8f91\u56de\u5f52(OCLR)\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u8ba1\u7b97TNBC\u60a3\u8005\u7684\u5e72\u7ec6\u80de\u6307\u6570\uff08mRNAsi\uff09\uff0c\u5229\u7528ESTIMATE\u7b97\u6cd5\u8ba1\u7b97\u514d\u75ab\u8bc4\u5206\u5e76\u5206\u6790\u4e86\u514d\u75ab\u6d78\u6da6\u548cmRNAsi\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7136\u540e\uff0c\u7b5b\u9009\u9ad8\u548c\u4f4emRNAsi\u7ec4\u95f4\u7684DEGs\uff0c\u5e76\u8fdb\u884c\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u3002\u968f\u540e\u57fa\u4e8e\u8fd9\u4e9bDEGs\u8fdb\u884c\u4e00\u81f4\u6027\u805a\u7c7b\u5c06TNBC\u60a3\u8005\u5206\u4e3a\u4e24\u4e2a\u5e72\u6027\u4e9a\u578b\uff0c\u540c\u65f6\u901a\u8fc7Cox\u548cLASSO\u56de\u5f52\u5206\u6790\u5efa\u7acb\u4e86\u4e00\u4e2a\u57fa\u4e8e16\u4e2a\u57fa\u56e0\u7684\u9884\u540e\u6a21\u578b\uff0c\u5e76\u5728\u5916\u90e8\u9a8c\u8bc1\u961f\u5217\u4e2d\u9a8c\u8bc1\u5176\u9884\u6d4b\u6027\u80fd\u3002\u57fa\u4e8e\u5355\u7ec6\u80de\u6570\u636e\u96c6\u63a2\u7d22\u4e86\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff0c\u5e76\u5206\u6790\u4e8616\u79cd\u57fa\u56e0\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u8868\u8fbe\u3002\u4f7f\u7528HPA\u6570\u636e\u5e93\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u9884\u540e\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u6700\u540e\uff0c\u5bf916\u4e2a\u57fa\u56e0\u8fdb\u884c\u4e86\u5206\u5b50\u5bf9\u63a5\u7814\u7a76\uff0c\u4ee5\u7b5b\u9009\u6297\u5e72\u6027\u5316\u5408\u7269\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"362\" class=\"wp-image-22075\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?resize=640%2C362\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?w=1218 1218w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?resize=300%2C169 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?resize=1024%2C578 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?resize=768%2C434 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-3.png?resize=600%2C339 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 \u5206\u6790\u6d41\u7a0b\u56fe<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c <\/strong><\/p>\n<p><strong>1. mRNAsi\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u7684\u76f8\u5173\u6027\u3001\u5dee\u5f02\u6027\u548c\u529f\u80fd\u5bcc\u96c6\u6027\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u4f7f\u7528OCLR\u548cESTIMATE\u7b97\u6cd5\u8ba1\u7b97\u4e86127\u4f8b\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u5e72\u7ec6\u80de\u6307\u6570\u548c\u514d\u75ab\u8bc4\u5206\uff0c\u5e76\u5bf9\u60a3\u8005\u8fdb\u884c\u6392\u5e8f\u4ee5\u7814\u7a76mRNAsi\u548c\u4e34\u5e8a\u7279\u5f81\u4e4b\u95f4\u7684\u5173\u7cfb\uff08\u56fe2A, B\uff09\u3002\u4e3a\u4e86\u63a2\u7d22mRNAsi\u4e0e\u514d\u75ab\u6d78\u6da6\u7684\u76f8\u5173\u6027\uff0c\u4f5c\u8005\u5206\u522b\u5229\u7528ssGSEA\u65b9\u6cd5\u3001ESTIMATE\u548cCIBERSORT\u7b97\u6cd5\u5206\u6790\u4e86\u514d\u75ab\u6d78\u6da6\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4f4emRNAsi\u7ec4\u7684\u514d\u75ab\u6d3b\u6027\u9ad8\u4e8e\u9ad8mRNAsi\u7ec4\uff08\u56fe3a\uff09\uff0cmRNAsi\u4e0e\u514d\u75ab\u8bc4\u5206\u3001\u95f4\u8d28\u8bc4\u5206\u548cESTIMATE\u8bc4\u5206\u663e\u8457\u8d1f\u76f8\u5173\uff08\u56fe3b-d\uff09\uff0cmRNAsi\u4e0e\u6ee4\u6ce1\u8f85\u52a9T\u7ec6\u80de\u3001CD4\u8bb0\u5fc6\u6fc0\u6d3bT\u7ec6\u80de\u548cM1\u5de8\u566c\u7ec6\u80de\u663e\u8457\u6b63\u76f8\u5173\uff08\u56fe3e\uff09\u3002\u7531\u4e8e\u6309mRNAsi\u4e2d\u503c\u5206\u7ec4\u7684\u6837\u672c\u4e4b\u95f4\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u4f5c\u8005\u53c8\u57fa\u4e8e\u201csurvminer\u201d\u5206\u6790\u7684\u7ed3\u679c\u5c06127\u540dTNBC\u60a3\u8005\u91cd\u65b0\u5206\u7c7b\u4e3a\u9ad8\u6216\u4f4emRNAsi\u7ec4\uff0c\u5e76\u4ece\u4e24\u7ec4\u95f4\u7b5b\u9009\u5f97\u52302228\u4e2aDEGs\uff08\u56fe3g\uff09\uff0c\u9488\u5bf9DEGs\u8fd8\u8fdb\u884c\u4e86\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff08\u56fe3i\uff09\u3002\u6700\u540e\u5229\u7528KM\u66f2\u7ebf\u8bc4\u4f30\u4e24\u7ec4\u95f4\u7684\u9884\u540e\u5dee\u5f02\uff0c\u663e\u793amRNAsi\u8bc4\u5206\u9ad8\u7684\u60a3\u8005\u603b\u4f53\u751f\u5b58\u72b6\u51b5\u8f83\u5dee\uff08\u56fe3j\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"263\" class=\"wp-image-22076\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-4.png?resize=640%2C263\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-4.png?w=640 640w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-4.png?resize=300%2C123 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-4.png?resize=600%2C247 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"260\" class=\"wp-image-22077\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-5.png?resize=640%2C260\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-5.png?w=654 654w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-5.png?resize=300%2C122 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-5.png?resize=600%2C244 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 mRNAsi\u548c\u514d\u75ab\u8bc4\u5206\u7684\u8ba1\u7b97<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"360\" class=\"wp-image-22078\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-6.png?resize=640%2C360\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-6.png?w=959 959w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-6.png?resize=300%2C169 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-6.png?resize=768%2C432 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-6.png?resize=600%2C337 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"214\" class=\"wp-image-22079\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?resize=640%2C214\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?w=1140 1140w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?resize=300%2C101 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?resize=1024%2C343 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?resize=768%2C257 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-7.png?resize=600%2C201 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"245\" class=\"wp-image-22080\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-8.png?resize=640%2C245\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-8.png?w=841 841w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-8.png?resize=300%2C115 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-8.png?resize=768%2C294 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-8.png?resize=600%2C230 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"464\" height=\"371\" class=\"wp-image-22081\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-9.png?resize=464%2C371\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-9.png?w=464 464w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-9.png?resize=300%2C240 300w\" sizes=\"(max-width: 464px) 100vw, 464px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"442\" height=\"554\" class=\"wp-image-22082\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-10.png?resize=442%2C554\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-10.png?w=442 442w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-10.png?resize=239%2C300 239w\" sizes=\"(max-width: 442px) 100vw, 442px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 mRNAsi\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u7684\u76f8\u5173\u6027\u3001\u5dee\u5f02\u6027\u548c\u529f\u80fd\u5bcc\u96c6\u6027\u5206\u6790<\/p>\n<p><strong>2. TNBC\u5e72\u6027\u4e9a\u578b\u7684\u9274\u5b9a<\/strong><\/p>\n<p>\u4f5c\u8005\u6839\u636e2228\u4e2aDEGs\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u4e86\u4e00\u81f4\u6027\u805a\u7c7b\u5206\u6790\uff0c\u5c06127\u540d\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u5206\u4e3a\u4e24\u4e2a\u5e72\u6027\u4e9a\u578b\uff0c\u5305\u62ecI\u578b(67\u4f8b\uff0c53.7%)\u548cII\u578b(60\u4f8b\uff0c47.2%)\uff08\u56fe4a\uff09\u3002\u5229\u7528ESTIMATE\u548cCIBERSORT\u7b97\u6cd5\u6765\u9610\u660e\u4e24\u79cd\u4e0d\u540c\u5e72\u7ec6\u80de\u4e9a\u578b\u7684\u4e0d\u540c\u514d\u75ab\u6d78\u6da6\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e9a\u578bI\u7684\u95f4\u8d28\u8bc4\u5206\u3001\u514d\u75ab\u8bc4\u5206\u548c\u8bc4\u4f30\u8bc4\u5206\u5747\u4f4e\u4e8e\u4e9a\u578bII\uff08\u56fe4c-e\uff09\uff0c\u514d\u75ab\u6d78\u6da6\u5305\u62ecB\u7ec6\u80de\u3001CD4+\u7ec6\u80de\u4e9a\u7fa4\u3001\u5355\u6838\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u5728\u5e72\u6027\u4e9a\u578bII\u4e2d\u660e\u663e\u66f4\u4e30\u5bcc\uff08\u56fe4i\uff09\u3002\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\uff0c\u4e9a\u578bI\u6bd4\u4e9a\u578bII\u66f4\u5177\u514d\u75ab\u539f\u6027\uff0c\u4e9a\u578bI\u7684\u60a3\u8005\u53ef\u80fd\u5bf9\u514d\u75ab\u7597\u6cd5\u8868\u73b0\u51fa\u66f4\u597d\u7684\u53cd\u5e94\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"314\" class=\"wp-image-22083\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-11.png?resize=640%2C314\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-11.png?w=837 837w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-11.png?resize=300%2C147 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-11.png?resize=768%2C376 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-11.png?resize=600%2C294 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"249\" class=\"wp-image-22084\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-12.png?resize=640%2C249\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-12.png?w=929 929w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-12.png?resize=300%2C117 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-12.png?resize=768%2C299 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-12.png?resize=600%2C234 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"348\" class=\"wp-image-22085\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-13.png?resize=640%2C348\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-13.png?w=803 803w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-13.png?resize=300%2C163 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-13.png?resize=768%2C418 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-13.png?resize=600%2C327 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 TNBC\u5e72\u6027\u4e9a\u578b\u7684\u9274\u5b9a<\/p>\n<p><strong>3. \u5e72\u6027\u76f8\u5173\u9884\u540e\u6a21\u578b\u7684\u5efa\u7acb\u548c\u8bc4\u4f30<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u4f7f\u7528METABERIC\u548cTCGA-BRCA\u5408\u5e76\u6570\u636e\u96c6\uff0c\u63d0\u53d6447\u4e2a\u4e09\u9634\u6027\u4e73\u817a\u764c\u6837\u672c\uff0c\u5206\u6210\u8bad\u7ec3\u548c\u6d4b\u8bd5\u96c6\u3002\u57fa\u4e8e2228 DEGs\u8fdb\u884cCox\u56de\u5f52\u548cLasso\u56de\u5f52\u5206\u6790\uff0c\u83b7\u5f9716\u4e2a\u9884\u540e\u57fa\u56e0\uff0c\u4ee5\u6784\u5efa\u9884\u540e\u98ce\u9669\u6a21\u578b\uff08\u56fe5a\uff09\u3002\u968f\u540e\u8ba1\u7b97\u4e86\u6bcf\u4e2a\u60a3\u8005\u7684\u98ce\u9669\u8bc4\u5206\uff0c\u5e76\u5c06\u4ed6\u4eec\u5206\u4e3a\u4f4e\u98ce\u9669\u7ec4\u6216\u9ad8\u98ce\u9669\u7ec4\uff0c\u8fdb\u884cKM\u751f\u5b58\u5206\u6790\u548c\u9884\u540e\u6027\u80fd\u8bc4\u4f30\uff0c\u663e\u793a\u5728\u8bad\u7ec3\u548c\u6d4b\u8bd5\u961f\u5217\u4e2d\u4f4e\u98ce\u9669\u7ec4\u7684\u9884\u540e\u5747\u660e\u663e\u597d\u4e8e\u9ad8\u98ce\u9669\u7ec4\uff08\u56fe5b\uff0cd\uff09\uff0cROC\u66f2\u7ebf\u663e\u793a\u6a21\u578b\u53ef\u4ee5\u51c6\u786e\u5730\u9884\u6d4bTNBC\u60a3\u8005\u7684\u9884\u540e\uff08\u56fe5c\uff0ce\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"269\" class=\"wp-image-22086\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?resize=640%2C269\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?w=1225 1225w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?resize=300%2C126 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?resize=1024%2C430 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?resize=768%2C323 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-14.png?resize=600%2C252 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 \u9884\u540e\u6a21\u578b\u7684\u5efa\u7acb\u548c\u8bc4\u4f30<\/p>\n<p><strong>4. \u9884\u540e\u57fa\u56e0\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u5206\u5b50\u5bf9\u63a5\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u901a\u8fc7CTD\u6570\u636e\u5e93\u3001PubChem\u6570\u636e\u5e93\u548cUniport\u6570\u636e\u5e93\u7b5b\u9009\u4e0e16\u4e2a\u9884\u540e\u57fa\u56e0\u76f8\u5173\u7684\u9776\u5411\u836f\u7269\uff0c\u7136\u540e\u4f7f\u7528Autodock\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\uff0c\u4ee5\u7814\u7a76\u4e0e\u9884\u540e\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u6700\u540e\u7b5b\u9009\u51fa\u4e8610\u4e2a\u6709\u5229\u4e8e\u6539\u5584\u753116\u4e2a\u57fa\u56e0\u5f15\u8d77\u7684\u9884\u540e\u4e0d\u826f\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u4e3a\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u9776\u5411\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u601d\u8def\uff08\u56fe6\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"371\" class=\"wp-image-22087\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?resize=640%2C371\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?w=1241 1241w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?resize=300%2C174 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?resize=1024%2C594 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?resize=768%2C446 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-15.png?resize=600%2C348 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe6 \u9776\u5411\u836f\u7269\u7b5b\u9009<\/p>\n<p><strong>5. <\/strong><a id=\"post-22072-_Hlk153206860\"><\/a><strong>\u9884\u540e\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u6790<\/strong><\/p>\n<p>\u57fa\u4e8e\u5355\u7ec6\u80de\u6570\u636e\u96c6GSE176078\uff0c\u603b\u5171\u6ce8\u91ca\u5f97\u523021\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u7fa4\uff08\u56fe7a\uff09\u3002\u89c2\u5bdf\u4e8621\u79cd\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e2d16\u79cd\u57fa\u56e0\u7684\u8868\u8fbe\u5dee\u5f02\uff08\u56fe7c\uff09\uff0c\u663e\u793aBMP4\u5728\u4e0a\u76ae\u7ec6\u80de\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\uff0cCCBE1\u5728\u95f4\u8d28\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"505\" class=\"wp-image-22088\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-16.png?resize=640%2C505\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-16.png?w=656 656w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-16.png?resize=300%2C237 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-16.png?resize=600%2C474 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"564\" class=\"wp-image-22089\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-17.png?resize=640%2C564\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-17.png?w=1024 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-17.png?resize=300%2C265 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-17.png?resize=768%2C677 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-17.png?resize=600%2C529 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe7 \u9884\u540e\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u6790<\/p>\n<p><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u601d\u8def\u5f88\u6e05\u6670\u5206\u6790\u5f88\u7b80\u5355\uff0c\u4f9d\u9760\u201c\u5e72\u7ec6\u80de\u201d\u56fd\u81ea\u7136\u70ed\u70b9\u9009\u9898\uff0c\u8f85\u4ee5\u836f\u7269\u7b5b\u9009\u3001\u5355\u7ec6\u80de\u5206\u6790\u7684\u521b\u65b0\u5206\u6790\u65b9\u6cd5\uff0c\u6210\u529f\u62ff\u4e0b9\u5206+\u7eaf\u751f\u4fe1\uff01\u601d\u8def\u8d85\u7ea7\u5bb9\u6613\u590d\u73b0\uff0c\u6027\u4ef7\u6bd4\u8fd8\u9ad8\uff0c\u5e38\u89c4\u751f\u4fe1\u60f3\u53d1\u9ad8\u5206\u7684\u53ef\u4ee5\u5b66\u8d77\u6765\u4e86\uff0c\u6362\u4e2a\u764c\u79cd\u6216\u8005\u518d\u6362\u4e2a\u5c0f\u4f17\u65b9\u5411\u5c31\u80fd\u590d\u73b0\uff0c\u9ad8\u5206\u6587\u7ae0\u5728\u5411\u4f60\u62db\u624b\u5566\uff01\u53e6\u5916\uff0c<strong>\u60f3\u8981\u590d\u73b0\/\u8bbe\u8ba1\u601d\u8def\u6216\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u7684\u670b\u53cb\u6b22\u8fce\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\uff0c\u98ce\u91cc\u96e8\u91cc\u4e00\u76f4\u5728\u7b49\u4f60~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-22090\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-18.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-18.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-18.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22072-18.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u80bf\u7624\u76f8\u5173\u751f\u4fe1\u73b0\u5728\u7ade\u4e89\u8fd9\u4e48\u6fc0\u70c8\uff0c\u8be5\u600e\u4e48\u62ff\u9ad8\u5206\u5462\uff1f2023\u5e74\u5373\u5c06\u7ed3\u675f\uff0c\u73b0\u5728\u56de\u5934\u770b\u770b\uff0c\u6709\u6ca1\u6709\u53d1\u73b09\u5206\u4ee5\u4e0a\u7684\u751f\u4fe1\u6587\u7ae0\u5df2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/22072"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22072"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/22072\/revisions"}],"predecessor-version":[{"id":22091,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/22072\/revisions\/22091"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22072"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}