{"id":22092,"date":"2023-12-26T17:23:13","date_gmt":"2023-12-26T09:23:13","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22092"},"modified":"2023-12-26T17:23:14","modified_gmt":"2023-12-26T09:23:14","slug":"%e5%9b%bd%e8%87%aa%e7%84%b6%e5%bf%85%e8%bf%bd%e7%83%ad%e7%82%b9-%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e8%81%94%e5%90%88101%e7%a7%8d%e7%bb%84%e5%90%88%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22092","title":{"rendered":"\u56fd\u81ea\u7136\u5fc5\u8ffd\u70ed\u70b9-\u5de8\u566c\u7ec6\u80de\u8054\u5408\u201c101\u79cd\u7ec4\u5408\u673a\u5668\u5b66\u4e60\u201d\u62ff\u4e0b7.7\u5206\u7eaf\u751f\u4fe1\u6587\u7ae0\uff0c\u6293\u7d27\u4e0a\u8f66\uff01"},"content":{"rendered":"<p>\u5de8\u566c\u7ec6\u80de\u662f\u4e00\u79cd\u4f4d\u4e8e\u7ec4\u7ec7\u5185\u7684\u767d\u8840\u7403\uff0c\u6e90\u81ea\u5355\u6838\u7ec6\u80de\uff0c\u800c\u5355\u6838\u7ec6\u80de\u53c8\u6765\u6e90\u4e8e\u9aa8\u9ad3\u4e2d\u7684\u524d\u4f53\u7ec6\u80de\u3002\u6709\u4e24\u79cd\u53d1\u6325\u4e0d\u540c\u529f\u80fd\u7684\u578b\uff0c\u5206\u522b\u662f\u5177\u6709\u4fc3\u708e\u4f5c\u7528\u7684M1\u578b\u548c\u5177\u6709\u6297\u708e\u4f5c\u7528\u7684M2\u578b\uff0c\u5b83\u4eec\u5728\u673a\u4f53\u7684\u67d0\u4e9b\u5668\u5b98\u6216\u4ee3\u8c22\u53cd\u5e94\u4e2d\u53ef\u80fd\u53d1\u6325\u76f8\u53cd\u7684\u4f5c\u7528\u3002\u56e0\u6b64\u5de8\u566c\u7ec6\u80de\u7684\u4ee3\u8c22\u4e0e\u529f\u80fd\u7684\u53d8\u5316\u5bf9\u591a\u79cd\u75be\u75c5\u6216\u8005\u80bf\u7624\u7684\u53d1\u751f\u6216\u6cbb\u7597\u6709\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u8fd1\u5e74\u6765\uff0c\u6709\u5173\u5de8\u566c\u7ec6\u80de\u7684\u7814\u7a76\u5df2\u7ecf\u6210\u4e3a\u70ed\u70b9\u4e4b\u4e00\uff0c\u5e76\u5f97\u5230\u5927\u91cf\u56fd\u5bb6\u57fa\u91d1\u8d44\u52a9\u3002\u5bf9\u5de8\u566c\u7ec6\u80de\u8fdb\u884c\u76f8\u5173\u7814\u7a76\u7684\u9ad8\u5206\u6587\u7ae0\u4e5f\u5c42\u51fa\u4e0d\u7a77\uff0c\u60f3\u53d1\u9ad8\u5206\u6587\u7ae0\u7684\u5c0f\u4f19\u4f34\u8fd8\u4e0d\u6293\u4f4f\u8fd9\u4e2a\u673a\u4f1a\u5feb\u5feb\u4e0a\u8f66\uff01\uff01\uff01<\/p>\n<p>\u4eca\u5929\u5c0f\u4e91\u8ddf\u5c0f\u4f19\u4f34\u4eec\u5206\u4eab\u4e00\u7bc77.7\u5206\u5de8\u566c\u7ec6\u80de\u7ed3\u5408\u673a\u5668\u5b66\u4e60\u7684\u7eaf\u751f\u4fe1\u6587\u7ae0\uff0c\u7eaf\u751f\u4fe1\u6587\u7ae0\u4e3a\u4ec0\u4e48\u80fd\u53d1\u52307.7\u5206\u5462\uff1f\u5c0f\u4e91\u5e26\u5c0f\u4f19\u4f34\u4eec\u4e00\u8d77\u63a2\u7d22\u4e00\u4e0b\u5427~<\/p>\n<ol>\n<li>\u672c\u7814\u7a76\u6293\u4f4f\u5de8\u566c\u7ec6\u80de\u8fd9\u4e2a\u56fd\u81ea\u7136\u5927\u70ed\u70b9\u5c31\u5df2\u7ecf\u6293\u4f4f\u9ad8\u5206\u6587\u7ae0\u7684\u5c3e\u5df4\u5566~<\/li>\n<li>\u672c\u6587\u4f7f\u7528\u7ec4\u540810\u79cd\u673a\u5668\u5b66\u4e60\u7684\u65b9\u5f0f\uff08\u5171101\u79cd\u7ec4\u5408\uff09\u5728\u8bad\u7ec3\u96c6\u548c\u6d4b\u8bd5\u96c6\u4e2d\u6311\u9009\u6700\u4f73\u7b97\u6cd5\u7ec4\u5408\u7684\u65b9\u5f0f\uff0c\u4e0d\u4f46\u5927\u5e45\u63d0\u5347\u4e86\u5de5\u4f5c\u91cf\uff0c\u4e5f\u8ba9\u5ba1\u7a3f\u4eba\u773c\u524d\u4e00\u4eae\u3002<\/li>\n<\/ol>\n<p>\u636e\u5c0f\u4e91\u4e86\u89e3\uff0c\u76ee\u524d\u5df2\u6709\u51e0\u7bc7\u9ad8\u5206\u6587\u7ae0\u91c7\u7528\u8fd9\u79cd\u65b9\u6cd5\u6216\u7c7b\u4f3c\u601d\u8def\uff0c\u8bc1\u660e\u65b9\u6cd5\u867d\u590d\u6742\u4f46\u8fd8\u662f\u6613\u590d\u73b0\u7684\uff0c\u751f\u4fe1\u5c0f\u767d\u770b\u5230\u8fd9\u4e48\u591a\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e5f\u4e0d\u8981\u88ab\u529d\u9000\u54e6~\u52c7\u5f80\u76f4\u524d\u7684\u501f\u9274\u8fd9\u79cd\u7814\u7a76\u601d\u8def\u53bb\u53d1\u8868\u9ad8\u5206SCI\u5427~<strong>(ps\uff1a\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff01\u8fd9\u91cc\u6709\u6700\u65b0\u7684\u751f\u4fe1\u7814\u7a76\u65b9\u5411\uff0c\u8fd8\u6709\u4e00\u5927\u6ce2\u7684\u53ef\u590d\u73b0\u7684\u521b\u65b0\u601d\u8def\uff0c\u611f\u5174\u8da3\u7684\u76f4\u63a5\u626b\u7801\u8054\u7cfb\u6211\u5662\uff01)\u3002<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"299\" height=\"302\" class=\"wp-image-22117\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-1-2.png?resize=299%2C302\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-1-2.png?w=299 299w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-1-2.png?resize=297%2C300 297w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-1-2.png?resize=100%2C100 100w\" sizes=\"(max-width: 299px) 100vw, 299px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"291\" class=\"wp-image-22118\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-2-2.png?resize=640%2C291\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-2-2.png?w=705 705w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-2-2.png?resize=300%2C137 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-2-2.png?resize=600%2C273 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u7ec4\u5408\u5f00\u53d1\u9884\u6d4b\u80ba\u817a\u764c\u9884\u540e\u548c\u514d\u75ab\u7597\u6cd5\u53cd\u5e94\u7684\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u6a21\u578b<\/li>\n<li>\u6742\u5fd7\uff1aArchives of Medical Research<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.7<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u80ba\u764c\u662f\u786e\u8bca\u7387\u7b2c\u4e8c\u9ad8\u7684\u6076\u6027\u80bf\u7624\uff0c\u4e5f\u662f2020\u5e74\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u7ea6\u5360\u786e\u8bca\u764c\u75c7\u75c5\u4f8b\u768411.4%\uff0c\u5360\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u75c5\u4f8b\u768418%\u3002\u5728\u6240\u6709\u80ba\u764c\u75c5\u4f8b\u4e2d\uff0c\u7ea640%\u4e3a\u80ba\u817a\u764c\uff08LUAD\uff09\u3002\u5de8\u566c\u7ec6\u80de\u5728LUAD\u7684\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff08TIME\uff09\u5f62\u6210\u548c\u764c\u75c7\u8fdb\u5c55\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5f88\u5c11\u6709\u7814\u7a76\u5168\u9762\u7cfb\u7edf\u5730\u63cf\u8ff0LUAD\u4e2d\u5de8\u566c\u7ec6\u80de\u7684\u7279\u5f81\u3002\u672c\u7814\u7a76\u65e8\u5728\u5229\u7528\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u6784\u5efaLUAD\u7684\u5171\u8bc6MRI\u3002\u5bf9LUAD\u8fdb\u884c\u98ce\u9669\u5206\u5c42\u3001\u9884\u540e\u5224\u65ad\u548c\u836f\u7269\u9884\u6d4b\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u6570\u636e\u96c6\/\u6570\u636e\u96c6<\/strong><\/td>\n<td><strong>\u6570\u636e\u5e93<\/strong><\/td>\n<td><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n<td><strong>\u8be6\u7ec6\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n<tr>\n<td>TCGA-LUAD<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>507\u4e2a\u80ba\u817a\u764c\u764c\u7ec4\u7ec7\u6837\u672c\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u9884\u540e\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>GSE189487<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>6\u4e2a\u80ba\u817a\u764c\u764c\u7ec4\u7ec7\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE30219<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>88\u4e2a\u80ba\u817a\u764c\u764c\u7ec4\u7ec7\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE31210<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>226\u4e2a\u80ba\u817a\u764c\u764c\u7ec4\u7ec7\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE72094<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>398\u4e2a\u80ba\u817a\u764c\u764c\u7ec4\u7ec7\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE91061<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>98\u4e2a\u63a5\u53d7\u6297PD-L1\u548c\u6297CTLA4\u836f\u7269\u6cbb\u7597\u7684\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u548c\u4e34\u5e8a\u6570\u636e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u5229\u7528GSE189487\u6570\u636e\u96c6\u4e2d\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u786e\u5b9a703\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\uff0c\u5728TCGA\u3001GSE30219\u3001GSE31210\u548cGSE72094\u6570\u636e\u96c6\u4e2d\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e10\u79cd\u7b97\u6cd5\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u4ee5\u6784\u5efa\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u6307\u6570\uff08MRI\uff09\u3002\u4f7f\u7528\u591a\u79cd\u7b97\u6cd5\u8bc4\u4f30\u4e86MRI\u4e0eTIME\u548c\u514d\u75ab\u7597\u6cd5\u76f8\u5173\u751f\u7269\u6807\u8bb0\u7269\u7684\u5173\u7cfb\u3002\u5229\u7528GSE91061\u6570\u636e\u96c6\u8bc4\u4f30MRI\u5728\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"375\" class=\"wp-image-22119\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?resize=640%2C375\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?w=1035 1035w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?resize=300%2C176 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?resize=1024%2C600 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?resize=768%2C450 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-3-2.png?resize=600%2C351 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. \u5355\u7ec6\u80de\u5206\u6790\u9274\u5b9a\u7ec6\u80de\u7c7b\u7fa4\u548c\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0<\/strong><\/p>\n<p>\u9996\u5148\uff0c\u5229\u7528\u201cSeurat\u201d\u5305\u5bf9scRNA-seq\u6570\u636e\u8fdb\u884c\u8d28\u63a7\u540e\uff0c\u83b7\u5f9717,579\u4e2a\u9ad8\u8d28\u91cf\u7684\u7ec6\u80de\u7528\u4e8e\u540e\u7eed\u5206\u6790\uff08\u56fe1A\uff09\uff1b\u5176\u6b21\uff0c\u4f7f\u7528Seurat\u5305\u4e2d\u7684\u201cLogNormalize\u201d\u51fd\u6570\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\u5904\u7406\uff08\u56fe1B\uff09\uff1b\u63a5\u7740\uff0c\u4e3a\u4e86\u53ef\u89c6\u5316\u7ec6\u80de\u7fa4\uff0c\u4f7f\u7528UMAP\u5206\u6790\u5bf9\u7ec6\u80de\u8fdb\u884c\u805a\u7c7b\uff0c\u5f97\u523011\u4e2a\u7c7b\u7fa4\uff08\u56fe1C\uff09\uff1b\u7136\u540e\uff0c\u4f7f\u7528\u201cSingleR\u201d\u5305\u6ce8\u91ca\u7ec6\u80de\u7c7b\u578b\uff0c\u7ed3\u679c\u663e\u793a\uff0c0\u30012\u30013\u30014\u30017\u30018\u548c10\u7fa4\u88ab\u786e\u5b9a\u4e3a\u5de8\u566c\u7ec6\u80de\uff0c1\u30015\u548c9\u7fa4\u88ab\u786e\u5b9a\u4e3a\u4e0a\u76ae\u7ec6\u80de\uff08\u56fe1D\uff09\u3002\u6700\u540e\u4f7f\u7528Seurat\u5305\u7684\u201cFindAllMarkers\u201d\u51fd\u6570\u8bc6\u522b\u6bcf\u4e2a\u7c7b\u7fa4\u7684\u6807\u8bb0\u57fa\u56e0\uff0c\u5f97\u5230703\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u3002<strong>\uff08ps\uff1a\u5355\u7ec6\u80de\u5206\u6790\u4e5f\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"437\" class=\"wp-image-22120\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-4-2.png?resize=640%2C437\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-4-2.png?w=933 933w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-4-2.png?resize=300%2C205 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-4-2.png?resize=768%2C524 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-4-2.png?resize=600%2C410 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 \u5355\u7ec6\u80de\u5206\u6790\u9274\u5b9a\u7ec6\u80de\u7c7b\u7fa4\u548c\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0<\/p>\n<p><strong>2. WGCNA\u9274\u5b9a\u5173\u952e\u6a21\u5757<\/strong><\/p>\n<p>\u5229\u7528R\u5305\u201cWGCNA\u201d\u57fa\u4e8e703\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u6784\u5efaWGCNA\uff0c\u4ee5\u786e\u5b9a\u4e0eLUAD\u60a3\u8005\u751f\u5b58\u72b6\u6001\u548c\u751f\u5b58\u65f6\u95f4\u76f8\u5173\u7684\u5173\u952e\u6a21\u5757\u3002\u8bbe\u5b9a\u8f6f\u9608\u503c\u03b2\u4e3a0.85\uff08\u56fe2A\uff09\uff0c\u5171\u751f\u6210\u4e86\u4e94\u4e2a\u6a21\u5757\u4f9b\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u6bcf\u4e2a\u6a21\u5757\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u5982\u56fe2B\u6240\u793a\uff0c\u4e94\u4e2a\u4e0d\u540c\u989c\u8272\u6a21\u5757\u7684\u805a\u7c7b\u6811\u89c1\u56fe2C\u3002\u9009\u62e9\u4e86\u4e0eLUAD\u60a3\u8005\u9884\u540e\u6b63\u76f8\u5173\u6027\u548c\u8d1f\u76f8\u5173\u6027\u6700\u9ad8\u7684\u7eff\u677e\u77f3\u6a21\u5757\uff08212\u4e2a\u57fa\u56e0\uff09\u548c\u7070\u8272\u6a21\u5757\uff0846\u4e2a\u57fa\u56e0\uff09\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff08\u56fe2D\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"599\" class=\"wp-image-22121\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-5-2.png?resize=640%2C599\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-5-2.png?w=809 809w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-5-2.png?resize=300%2C281 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-5-2.png?resize=768%2C719 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-5-2.png?resize=600%2C561 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 WGCNA\u9274\u5b9a\u5173\u952e\u6a21\u5757<\/p>\n<p><strong>3. LUAD\u4e2d\u4e0e\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u4e9a\u578b\u7684\u9274\u5b9a<\/strong><\/p>\n<p>\u6839\u636eWGCNA\u7b5b\u9009\u7684258\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\uff0c\u5728TCGA-LUAD\u6570\u636e\u96c6\u4e2d\u91c7\u7528NMF\u805a\u7c7b\u7b97\u6cd5\u5bf9LUAD\u60a3\u8005\u8fdb\u884c\u5206\u5b50\u4e9a\u578b\u5206\u7c7b\u3002K=2\u88ab\u786e\u5b9a\u4e3a\u6700\u4f73\u503c\uff08\u56fe3A\uff09\u3002\u56fe3B\u663e\u793a\u4e86\u5171\u8bc6\u77e9\u9635\u7684\u70ed\u56fe\u3002\u5728TCGA\u6570\u636e\u96c6\u4e2d\uff0c\u4e9a\u7ec41\u4e2d\u7684LUAD\u60a3\u8005\u7684\u603b\u751f\u5b58\u7387\u9ad8\u4e8e\u4e9a\u7ec42\u4e2d\u7684\u60a3\u8005\uff08\u56fe3C\uff09\u3002GSE30219\u3001GSE31210\u548cGSE72094\u6570\u636e\u96c6\u4e2d\u4e5f\u5f97\u5230\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u56fe3D\u30013F\u548c3H\u663e\u793a\u4e86\u76f8\u5e94\u7684\u5171\u8bc6\u77e9\u9635\u7684\u70ed\u56fe\uff0c\u8fdb\u4e00\u6b65\u8fdb\u884c\u751f\u5b58\u5206\u6790\u8868\u660e\uff0c\u5728GSE30219\uff08\u56fe4E\uff09\u3001GSE31210\uff08\u56fe4G\uff09\u548cGSE72094\uff08\u56fe4I\uff09\u6570\u636e\u96c6\u4e2d\uff0c\u4e0e\u4e9a\u7ec42\u76f8\u6bd4\uff0c\u4e9a\u7ec41\u4e0eLUAD\u66f4\u597d\u7684\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"418\" class=\"wp-image-22122\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?resize=640%2C418\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?w=1036 1036w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?resize=300%2C196 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?resize=1024%2C669 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?resize=768%2C502 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-6-2.png?resize=600%2C392 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"380\" class=\"wp-image-22123\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?resize=640%2C380\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?w=1040 1040w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?resize=300%2C178 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?resize=1024%2C608 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?resize=768%2C456 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-7-2.png?resize=600%2C357 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 LUAD\u4e2d\u4e0e\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u4e9a\u578b\u7684\u9274\u5b9a<\/p>\n<ol>\n<li><strong>\u673a\u5668\u5b66\u4e60<\/strong><\/li>\n<\/ol>\n<p>\u901a\u8fc7\u5355\u53d8\u91cfCox\u5206\u6790\uff0c\u83b7\u5f9762\u4e2a\u4e0eLUAD\u9884\u540e\u663e\u8457\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\uff0c\u57fa\u4e8e\u8fd962\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u9884\u540e\u57fa\u56e0\u8fdb\u884c\u673a\u5668\u5b66\u4e60\uff0c\u5e76\u5efa\u7acbMR\u6a21\u578b\u3002\u5728TCGA-LUAD\u6570\u636e\u96c6\u4e2d\uff0c\u901a\u8fc7leave-one-out\u4ea4\u53c9\u9a8c\u8bc1\u6846\u67b6\u62df\u5408\u4e86101\u79cd\u9884\u6d4b\u6a21\u578b\u3002\u7ed3\u679c\u8868\u660e\uff0c\u7531Lasso\u548cplsRCox\u65b9\u6cd5\u7ec4\u5408\u5efa\u7acb\u7684\u9884\u540e\u6a21\u578b\u662f\u6700\u4f73\u6a21\u578b\uff08\u56fe4A\uff09\uff0c\u504f\u5dee\u6982\u7387\u5728Lasso\u56de\u5f52\u4e2d\u8fbe\u5230\u6700\u5c0f\u503c\uff08\u56fe4B\uff09\u3002\u5bf9Lasso\u7cfb\u6570\u4e0d\u4e3a\u96f6\u768422\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u8fdb\u884cplsRCox\u56de\u5f52\uff08\u56fe4C\uff09\u3002\u6839\u636e\u8fd922\u4e2a\u5de8\u566c\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u7684\u56de\u5f52\u7cfb\u6570\u53ca\u5176\u8868\u8fbe\u6a21\u5f0f\uff0c\u8ba1\u7b97\u51fa\u4e86\u6bcf\u4f4dLUAD\u60a3\u8005\u7684MRI\u8bc4\u5206\uff0c\u4ee5MRI\u8bc4\u5206\u7684\u5e73\u5747\u503c\u4e3a\u5206\u754c\u70b9\uff0c\u5c06LUAD\u60a3\u8005\u5206\u4e3aMRI\u8bc4\u5206\u9ad8\u548c\u4f4e\u4e24\u7ec4\uff0c\u53d1\u73b0TCGA\u6570\u636e\u96c6\uff08\u56fe4D\uff09\u3001GSE30219\u6570\u636e\u96c6\uff08\u56fe4E\uff09\u3001GSE31210\u6570\u636e\u96c6\uff08\u56fe4F\uff09\u548cGSE72094\u6570\u636e\u96c6\uff08\u56fe4G\uff09\u4e2d\uff0c\u9ad8MRI\u8bc4\u5206\u7ec4\u7684LUAD\u60a3\u8005\u603b\u751f\u5b58\u7387\u4f4e\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"474\" class=\"wp-image-22124\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-8-2.png?resize=640%2C474\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-8-2.png?w=942 942w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-8-2.png?resize=300%2C222 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-8-2.png?resize=768%2C569 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-8-2.png?resize=600%2C445 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"661\" class=\"wp-image-22125\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-9-2.png?resize=640%2C661\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-9-2.png?w=726 726w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-9-2.png?resize=290%2C300 290w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-9-2.png?resize=600%2C620 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 \u673a\u5668\u5b66\u4e60<\/p>\n<ol>\n<li><strong>\u514d\u75ab\u5fae\u73af\u5883\u5206\u6790<\/strong><\/li>\n<\/ol>\n<p>\u5bf9\u516d\u79cd\u80bf\u7624\u514d\u75ab\u4e9a\u578b\u7814\u7a76\u663e\u793a\uff0c\u5728\u4f4eMRI\u8bc4\u5206\u7ec4\u4e2d\uff0cC3\u4e9a\u578b\u6240\u5360\u6bd4\u4f8b\u6700\u5927\uff0c\u800c\u5728\u9ad8MRI\u8bc4\u5206\u7ec4\u4e2d\uff0cC2\u4e9a\u578b\u6240\u5360\u6bd4\u4f8b\u6700\u9ad8\uff08\u56fe5A\uff09\u3002ESTIMATE\u7b97\u6cd5\u7528\u4e8e\u8bc4\u4f30\u9ad8MRI\u8bc4\u5206\u7ec4\u548c\u4f4eMRI\u8bc4\u5206\u7ec4\u7684\u514d\u75ab\u8bc4\u5206\u3001ESTIMATE\u8bc4\u5206\u548c\u57fa\u8d28\u8bc4\u5206\uff08\u56fe5B\uff09\u3002\u4f4eMRI\u8bc4\u5206\u7ec4\u4e2dB\u7ec6\u80de\u3001iDCs\u3001\u80a5\u5927\u7ec6\u80de\u3001T\u8f85\u52a9\u7ec6\u80de\u548cTILs\u7684\u5f97\u5206\u5747\u9ad8\u4e8e\u9ad8MRI\u8bc4\u5206\u7ec4\uff08\u56fe5D\uff09\u3002\u4f4eMRI\u8bc4\u5206\u7ec4\u4e0eAPC-co-inhibition\u3001MHC-class-I\u3001parainflammation\u548ctype-I-IFN-reponse\u76f8\u5173\uff0c\u800c\u9ad8MRI\u8bc4\u5206\u7ec4\u4e0eT-cell co-stimulation\u548ctype-II-IFN-reponse\u76f8\u5173\uff08\u56fe5E\uff09\u3002 <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"462\" class=\"wp-image-22126\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-10-2.png?resize=640%2C462\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-10-2.png?w=658 658w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-10-2.png?resize=300%2C217 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-10-2.png?resize=600%2C433 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"698\" class=\"wp-image-22127\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-11-2.png?resize=640%2C698\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-11-2.png?w=670 670w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-11-2.png?resize=275%2C300 275w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22092-11-2.png?resize=600%2C655 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 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