{"id":22179,"date":"2024-01-08T15:56:23","date_gmt":"2024-01-08T07:56:23","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22179"},"modified":"2024-01-08T15:56:26","modified_gmt":"2024-01-08T07:56:26","slug":"8%e9%9d%9e%e8%82%bf%e7%98%a4%e7%ba%af%e7%94%9f%e4%bf%a1%ef%bc%81%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0%e7%ad%9b%e9%80%89%e5%85%b3%e9%94%ae%e5%9f%ba%e5%9b%a0%e7%9a%84%e6%96%87%e7%ab%a0%ef%bc%8c-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22179","title":{"rendered":"8+\u975e\u80bf\u7624\u7eaf\u751f\u4fe1\uff01\u673a\u5668\u5b66\u4e60\u7b5b\u9009\u5173\u952e\u57fa\u56e0\u7684\u6587\u7ae0\uff0c\u751f\u4fe1\u5c0f\u767d\u4e5f\u53ef\u590d\u73b0\uff01"},"content":{"rendered":"<p>\u673a\u5668\u5b66\u4e60\u4f5c\u4e3a\u4eba\u5de5\u667a\u80fd\u9886\u57df\u7684\u6838\u5fc3\u6280\u672f\u4e4b\u4e00\uff0c\u5728\u533b\u5b66\u79d1\u7814\u9886\u57df\u4e5f\u8868\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u548c\u5f71\u54cd\u529b\uff0c\u65e0\u8bba\u5728\u80bf\u7624\u8fd8\u662f\u975e\u80bf\u7624\u75be\u75c5\u4e2d\uff0c\u90fd\u4e3a\u65e0\u5b9e\u9a8c\u6570\u636e\u4eba\u5458\u53d1\u8868\u9ad8\u5206\u6587\u7ae0\uff0c\u63d0\u4f9b\u4e86\u66f4\u591a\u53ef\u80fd\u6027\uff01<\/p>\n<p>\u4eca\u5929\u5c0f\u4e91\u8ddf\u5c0f\u4f19\u4f34\u4eec\u5206\u4eab\u4e00\u7bc78.7\u5206\u7684\u673a\u5668\u5b66\u4e60\u7c7b\u6587\u7ae0\u3002\u8fd9\u7bc7\u6587\u7ae0\u91c7\u7528\u4e86\u5e38\u89c4\u7684\u975e\u80bf\u7624\u751f\u4fe1\u5206\u6790\u601d\u8def\uff08\u5dee\u5f02\u57fa\u56e0+WGCNA+\u673a\u5668\u5b66\u4e60+\u5916\u90e8\u9a8c\u8bc1+\u514d\u75ab\u6d78\u6da6\uff09\uff0c\u8fd9\u7bc7\u6587\u7ae0\u4e3a\u4ec0\u4e48\u80fd\u53d1\u88688\u5206+\u5462\uff1f\u8bf4\u5b9e\u8bdd\u7b2c\u4e00\u773c\u770b\u5230\u8fd9\u7bc7\u6587\u7ae0\u7684IF\uff0c\u5c0f\u4e91\u4e5f\u662f\u5927\u5403\u4e00\u60ca\uff0c\u4f46\u662f\u5b9a\u775b\u4e00\u770b\uff0c\u8fd9\u7bc7\u6587\u7ae0\u65e0\u8bba\u662f\u5728\u5206\u6790\u65b9\u6cd5\u8fd8\u662f\u9009\u520a\u65b9\u9762\u90fd\u662f\u6709\u4e00\u5b9a\u6280\u5de7\u7684\u5462\uff0c\u4e0b\u9762\u5c0f\u4e91\u5c31\u5e26\u5927\u5bb6\u4e00\u8d77\u63ed\u79d8\u4e00\u4e0b\u5427~<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"182\" height=\"184\" class=\"wp-image-22180 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-1.png?resize=182%2C184\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-1.png?w=182 182w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-1.png?resize=100%2C100 100w\" sizes=\"(max-width: 182px) 100vw, 182px\" data-recalc-dims=\"1\" \/><\/p>\n<ol>\n<li style=\"text-align: left;\">\u672c\u7814\u7a76\u6240\u7528\u7684\u516c\u5171\u6570\u636e\u5e93\u662f\u513f\u7ae5\u8113\u6bd2\u75c7\u7684\u6570\u636e\uff0c\u9009\u6295\u7684\u671f\u520a\u662f\u7531\u56fd\u5bb6\u513f\u7ae5\u5065\u5eb7\u4e0e\u75be\u75c5\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u4e2d\u5fc3\u3001\u56fd\u5bb6\u513f\u7ae5\u533a\u57df\u533b\u7597\u4e2d\u5fc3\u3001\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u513f\u7ae5\u533b\u9662\u4e3b\u529e\u7684\u300a\u4e16\u754c\u513f\u79d1\u6742\u5fd7\u300b\uff08World Journal of Pediatrics\uff0cWJP\uff09\u6700\u65b0\u5f71\u54cd\u56e0\u5b508.7\u5206\uff0c\u6b64\u671f\u520a\u5bf9\u56fd\u4eba\u53cb\u597d\uff0c\u513f\u79d1\u7684\u5c0f\u4f19\u4f34\u4eec\u4e5f\u53ef\u4ee5\u770b\u4e0b\u8fd9\u4e2a\u671f\u520a\u54e6\uff1b<\/li>\n<li>\u672c\u6587\u4f7f\u7528\u4e86\u4f7f\u7528\u4e24\u4e2aGEO\u6570\u636e\u96c6\u5408\u5e76\u540e\u505a\u540e\u7eed\u5206\u6790\uff0c\u589e\u52a0\u4e86\u6570\u636e\u91cf\uff0c\u4e30\u5bcc\u4e86\u7814\u7a76\u5185\u5bb9\uff0c\u540c\u65f6\u5229\u7528\u4e00\u4e2aGEO\u5916\u90e8\u6570\u636e\u96c6\u8fdb\u884c\u9a8c\u8bc1\u589e\u52a0\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u9760\u6027\uff1b<\/li>\n<li style=\"text-align: center;\">\u672c\u7814\u7a76\u9996\u6b21\u5229\u7528\u673a\u5668\u5b66\u4e60\u9274\u5b9a\u513f\u7ae5\u8113\u6bd2\u75c7\u76f8\u5173\u5173\u952e\u57fa\u56e0\uff0c\u7ed3\u679c\u663e\u793a\u8be5\u65b9\u6cd5\u5728\u8bc6\u522b\u513f\u7ae5\u8113\u6bd2\u75c7\u60a3\u8005\u65b9\u9762\u5177\u6709\u4f18\u52bf\uff0c\u80fd\u591f\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u51c6\u786e\u5730\u6cbb\u7597\u5efa\u8bae\u3002\u60f3\u8981\u53d1\u8868\u9ad8\u5206SCI\u7684\u5c0f\u4f19\u4f34\u4eec\u4e5f\u53ef\u4ee5\u501f\u9274\u4e00\u4e0b\u672c\u6587\u7684\u7814\u7a76\u601d\u8def\u4ee5\u53ca\u9009\u520a\u7b56\u7565\u54e6~<strong>(ps\uff1a\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff01\u8fd9\u91cc\u6709\u70ed\u6c14\u817e\u817e\u7684\u5c0f\u4f17\u751f\u4fe1\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u4e00\u832c\u63a5\u4e00\u832c\u7684\u53ef\u590d\u73b0\u521b\u65b0\u601d\u8def\uff0c\u611f\u5174\u8da3\u5c0f\u4f19\u4f34\u4eec\u7684\u76f4\u63a5\u626b\u7801\u8054\u7cfb\u6211\u5662\uff01)\u3002<img decoding=\"async\" loading=\"lazy\" class=\"alignnone  wp-image-22194\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?resize=164%2C165\" alt=\"\" width=\"164\" height=\"165\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?resize=100%2C100 100w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-3.png?w=568 568w\" sizes=\"(max-width: 164px) 100vw, 164px\" data-recalc-dims=\"1\" \/><\/strong><\/li>\n<\/ol>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"328\" class=\"wp-image-22181\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-2.png?resize=640%2C328\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-2.png?w=723 723w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-2.png?resize=300%2C154 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-2.png?resize=600%2C308 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u751f\u7269\u4fe1\u606f\u5b66\u4e0e\u673a\u5668\u5b66\u4e60\u76f8\u7ed3\u5408\u7684\u513f\u7ae5\u8113\u6bd2\u75c7\u8bca\u65ad\u6807\u5fd7\u7269\u53ca\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7279\u5f81\u5206\u6790\u4e0e\u9a8c\u8bc1<\/li>\n<li>\u6742\u5fd7\uff1aWorld J Pediatr<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=8.7<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e744\u6708<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u513f\u7ae5\u8113\u6bd2\u75c7\u662f\u4e00\u79cd\u590d\u6742\u7684\u75be\u75c5\uff0c\u5176\u7279\u70b9\u662f\u7531\u4e8e\u513f\u7ae5\u5bf9\u611f\u67d3\u7684\u5bbf\u4e3b\u53cd\u5e94\u5931\u8c03\u800c\u5bfc\u81f4\u5371\u53ca\u751f\u547d\u7684\u5668\u5b98\u8870\u7aed\u3002\u5b83\u4e0e\u9ad8\u53d1\u75c5\u7387\u548c\u9ad8\u6b7b\u4ea1\u7387\u6709\u5173\uff0c\u5e76\u5f3a\u8c03\u5feb\u901f\u68c0\u6d4b\u548c\u670d\u7528\u6297\u83cc\u5242\u3002\u672c\u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4ef7\u513f\u7ae5\u8113\u6bd2\u75c7\u7684\u8bca\u65ad\u6807\u5fd7\u7269\u548c\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u529f\u80fd\u7684\u5173\u7cfb\u672c\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u6570\u636e\u96c6<\/strong><\/td>\n<td><strong>\u6570\u636e\u5e93<\/strong><\/td>\n<td><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n<td><strong>\u8be6\u7ec6\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n<tr>\n<td>GSE26378<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>72\u4e2a\u513f\u7ae5\u8113\u6bd2\u75c7\u548c21\u4e2a\u6b63\u5e38\u5bf9\u7167\u8840\u6db2\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE26440<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>98\u4e2a\u513f\u7ae5\u8113\u6bd2\u75c7\u548c32\u4e2a\u6b63\u5e38\u5bf9\u7167\u8840\u6db2\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE13904<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>106\u4e2a\u513f\u7ae5\u8113\u6bd2\u75c7\u548c18\u4e2a\u6b63\u5e38\u5bf9\u7167\u8840\u6db2\u6837\u672c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center;\"><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u4f7f\u7528R\u8bed\u8a00\u5728\u4e24\u4e2aGEO\u6570\u636e\u96c6\u4e2d\u627e\u5230DEGs\u5e76\u8fdb\u884c\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\u3002\u968f\u540e\uff0c\u5c06DEGs\u4e0eWGCNA\u9009\u62e9\u7684\u5173\u952e\u6a21\u5757\u57fa\u56e0\u53d6\u4ea4\u96c6\u5f97\u5230\u4ea4\u96c6\u57fa\u56e0\uff0c\u57fa\u4e8e\u4ea4\u96c6\u57fa\u56e0\uff0c\u5229\u75283\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u9274\u5b9a\u51fa402\u4e2a\u67a2\u7ebd\u57fa\u56e0\u3002\u63a5\u7740\u4f7f\u7528ROC\u66f2\u7ebf\u548c\u5217\u7ebf\u56fe\u4ee5\u9a8c\u8bc1\u5019\u9009\u67a2\u7ebd\u57fa\u56e0\uff08CD177\u3001CYSTM1\u548cMMP8\uff09\u7684\u8bc6\u522b\u6027\u80fd\u548c\u6709\u6548\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7CIBERSORT\u7b97\u6cd5\uff0c\u4f7f\u7528\u7ec6\u80de\u7c7b\u578b\u9274\u5b9a\u8bc4\u4f30\u5c0f\u513f\u8d25\u8840\u75c7\u7684\u708e\u75c7\u548c\u514d\u75ab\u72b6\u6001\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u8bca\u65ad\u6807\u5fd7\u7269\u4e0e\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"781\" class=\"wp-image-22182\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?resize=640%2C781\" alt=\"12519_2023_717_Fig1_HTML\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?w=965 965w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?resize=246%2C300 246w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?resize=839%2C1024 839w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?resize=768%2C938 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig1_html-1.png?resize=600%2C732 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. DEGs\u7684\u9274\u5b9a<\/strong><\/p>\n<p>\u4f7f\u7528SVA\u5305\u5bf9\u6570\u636e\u8fdb\u884c\u5f52\u4e00\u5316\u5904\u7406\u5e76\u5408\u5e76\u6570\u636e\u96c6\uff0c\u4f7f\u7528Limma\u5305\u7b5b\u9009\u5408\u5e76\u540e\u7684\u6570\u636e\u96c6\u4e2d\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff0c\u53d6\u4ea4\u96c6\u540e\u83b7\u5f97556\u4e2aDEGs\uff0c\u5305\u62ec381\u4e2a\u4e0a\u8c03\u57fa\u56e0\u548c175\u4e2a\u4e0b\u8c03\u57fa\u56e0\uff0c\u4f7f\u7528\u201cheatmap\u201d\u7ed8\u5236\u70ed\u56fe\u548c\u201cggplot2\u201d\u5305\u7ed8\u5236\u706b\u5c71\u56fe\u5bf9\u7ed3\u679c\u8fdb\u884c\u53ef\u89c6\u5316\uff08\u56fe1a-b\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"520\" class=\"wp-image-22183\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-4.png?resize=640%2C520\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-4.png?w=776 776w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-4.png?resize=300%2C244 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-4.png?resize=768%2C624 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-4.png?resize=600%2C487 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"516\" class=\"wp-image-22184\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-5.png?resize=640%2C516\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-5.png?w=800 800w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-5.png?resize=300%2C242 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-5.png?resize=768%2C619 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-5.png?resize=600%2C484 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe1 DEGs\u7684\u9274\u5b9a<\/p>\n<ol>\n<li><strong>DEGs\u7684\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u548cPPI\u6784\u5efa<\/strong><\/li>\n<\/ol>\n<p>\u5bf9\u5c0f\u513f\u8d25\u8840\u75c7\u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u8fdb\u884cGSEA\u5206\u6790\uff0c\u7ed3\u679c\u663e\u793a\u5c0f\u513f\u8d25\u8840\u75c7\u60a3\u8005\u7684\u51dd\u8840\u3001\u8865\u4f53\u3001IL6-JAK-STAT3\u4fe1\u53f7\u4f20\u5bfc\u3001\u708e\u75c7\u53cd\u5e94\u548cNF-\u03baB\u4ecb\u5bfc\u7684TNF\u03b1\u4fe1\u53f7\u663e\u8457\u5bcc\u96c6\uff08\u56fe2a\uff09\uff1bDO\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cDEGs\u4e0e\u80ba\u90e8\u75be\u75c5\u3001\u52a8\u8109\u786c\u5316\u3001\u809d\u708e\u3001\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u52a8\u8109\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7ec6\u83cc\u6027\u4f20\u67d3\u75c5\u3001\u539f\u53d1\u6027\u7ec6\u83cc\u6027\u4f20\u67d3\u75c5\u3001\u963b\u585e\u6027\u80ba\u75c5\u3001\u7ed3\u6838\u75c5\u548c\u652f\u6c14\u7ba1\u75be\u75c5\u6709\u5173\uff08\u56fe2b\uff09\uff1bGO\u5bcc\u96c6\u5206\u6790\u8868\u660e\uff0cDEGs\u5177\u6709\u514d\u75ab\u5e94\u7b54\u8c03\u8282\u4fe1\u53f7\u901a\u8def\u3001\u514d\u75ab\u5e94\u7b54\u6d3b\u5316\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u6b63\u5411\u8c03\u8282\u3001\u767d\u7ec6\u80de\u4ecb\u5bfc\u514d\u75ab\u3001T\u7ec6\u80de\u6d3b\u5316\u548c\u9ad3\u7cfb\u767d\u7ec6\u80de\u6d3b\u5316\uff08\u56fe2c\uff09\uff1bKEGG\u5206\u6790\u8868\u660e\uff0cDEGs\u4e0e\u9020\u8840\u7ec6\u80de\u8c31\u7cfb\u3001\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u611f\u67d3\u3001Th1\u548cTh2\u7ec6\u80de\u5206\u5316\u4ee5\u53caTh17\u7ec6\u80de\u5206\u5316\u6709\u5173\uff08\u56fe2d\uff09\u3002\u6700\u540e\u4f7f\u7528STRING\u6570\u636e\u5e93\u8fdb\u884cPPI\u7f51\u7edc\u6784\u5efa\uff08\u56fe2e\uff09\u3002<strong>\uff08ps\uff1a\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u3001\u4ee5\u53ca\u540e\u9762\u7684\u514d\u75ab\u6d78\u6da6\u5206\u6790\u4e5f\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"547\" class=\"wp-image-22185\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-6.png?resize=640%2C547\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-6.png?w=801 801w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-6.png?resize=300%2C257 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-6.png?resize=768%2C657 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-6.png?resize=600%2C513 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"435\" height=\"438\" class=\"wp-image-22186\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-7.png?resize=435%2C438\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-7.png?w=435 435w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-7.png?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-7.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-7.png?resize=100%2C100 100w\" sizes=\"(max-width: 435px) 100vw, 435px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe2 DEGs\u7684\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u548cPPI\u6784\u5efa<\/p>\n<ol>\n<li><strong>WGCNA\u5206\u6790<\/strong><\/li>\n<\/ol>\n<p>\u5728\u5408\u5e76\u540e\u7684\u6570\u636e\u96c6\u4e2d\u8fdb\u884cWGCNA\u5206\u6790\uff0c\u9996\u5148\u5c06\u672c\u805a\u7c7b\uff0c\u5254\u9664\u79bb\u7fa4\u6837\u672c\uff08\u56fe3a\uff09\uff0c\u5176\u6b21\u9009\u62e9\u5408\u9002\u7684\u8f6f\u9608\u503c\u529f\u7387\u03b2\uff0c\u786e\u4fdd\u65e0\u6807\u5ea6\u7f51\u7edc\uff08\u56fe3b\uff0cc\uff09\uff0c\u7136\u540e\u901a\u8fc7\u5206\u5c42\u805a\u7c7b\u5206\u6790\u548c\u57fa\u56e0\u6811\u72b6\u56fe\u7684\u52a8\u6001\u5207\u5272\u65b9\u6cd5\uff0c\u5c06\u57fa\u56e0\u5206\u4e3a12\u4e2a\u6a21\u5757\uff08\u56fe3d\uff0ce\uff09\uff0c\u53d1\u73b0\u6d45\u9752\u8272\u3001\u84dd\u8272\u548c\u6d45\u7eff\u8272\u6a21\u5757\u4e0e\u513f\u7ae5\u8113\u6bd2\u75c7\u663e\u8457\u76f8\u5173\uff08\u56fe3f\uff09\uff0c\u6700\u540e\u57fa\u4e8eMM\u2009&gt;\u20090.8\uff0cGS\u2009&gt;\u20090.2\u7b5b\u9009\u4e861582\u4e2a\u5173\u952e\u6a21\u5757\u57fa\u56e0\uff08\u56fe3g-i\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"640\" class=\"wp-image-22187\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?resize=640%2C640\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?w=688 688w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?resize=600%2C600 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-8.png?resize=100%2C100 100w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"217\" class=\"wp-image-22188\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-9.png?resize=640%2C217\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-9.png?w=684 684w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-9.png?resize=300%2C102 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22179-9.png?resize=600%2C204 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe3 WGCNA\u5206\u6790<\/p>\n<ol>\n<li><strong>\u7279\u5f81\u57fa\u56e0\u7684\u8bc6\u522b<\/strong><\/li>\n<\/ol>\n<p>\u901a\u8fc7\u7ef4\u6069\u56fe\u5c06DEGs\u548c\u5173\u952e\u6a21\u5757\u57fa\u56e0\u53d6\u4ea4\u96c6\uff0c\u5f97\u5230402\u4e2a\u4ea4\u96c6\u57fa\u56e0\uff08\u56fe2a\uff09\u3002\u57fa\u4e8e\u4ea4\u96c6\u57fa\u56e0\uff0c\u4f7f\u7528\u4e09\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u6765\u8bc6\u522b\u7279\u5f81\u57fa\u56e0\uff1aSVM-RFE\uff08\u56fe2b\uff09\u3001\u968f\u673a\u68ee\u6797\uff08R\u5305\u201crandomForest\u201d\uff09(\u56fe2c, d)\u3001LASSO\u56de\u5f52\u5206\u6790\uff08R\u5305\u201cglmnet\u201d\uff09(\u56fe2e, f)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"839\" class=\"wp-image-22189\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=640%2C839\" alt=\"12519_2023_717_Fig2_HTML.webp\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?w=1770 1770w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=229%2C300 229w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=781%2C1024 781w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=768%2C1007 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=1172%2C1536 1172w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=1562%2C2048 1562w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?resize=600%2C786 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig2_html-webp-1.jpeg?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe4 \u7279\u5f81\u57fa\u56e0\u7684\u8bc6\u522b<\/p>\n<ol>\n<li><strong>\u5173\u952e\u57fa\u56e0\u7684\u9274\u5b9a\u4e0e\u8bc4\u4f30<\/strong><\/li>\n<\/ol>\n<p>\u4e09\u79cd\u7b97\u6cd5\u5f97\u5230\u7684\u57fa\u56e0\u53d6\u4ea4\u96c6\u5171\u83b7\u5f973\u4e2a\u5173\u952e\u57fa\u56e0\uff08CYSTM1\uff0cMMP8\u548cCD177\uff09\uff08\u56fe5a\uff09\uff0c\u4f7f\u7528rms\u8f6f\u4ef6\u5305\u5f00\u53d1\u57fa\u4e8e\u4e09\u4e2a\u5173\u952e\u57fa\u56e0\u8bca\u65ad\u513f\u7ae5\u8113\u6bd2\u75c7\u7684\u5217\u7ebf\u56fe\u6a21\u578b\uff08\u56fe5b\uff09\u3002\u6839\u636e\u51b3\u7b56\u66f2\u7ebf\u5206\u6790\uff08DCA\uff09\u7684\u7ed3\u679c\uff0c\u5217\u7ebf\u56fe\u6a21\u578b\u5177\u6709\u66f4\u597d\u7684\u4e34\u5e8a\u9884\u6d4b\u6027\u80fd\uff08\u56fe5c\uff09\u3002ROC\u66f2\u7ebf\u4e2d\u7684AUC\u5206\u522b\u4e3a0.988\u30010.973\u548c0.986\uff0c\u8868\u660e\u5173\u952e\u57fa\u56e0\u5177\u6709\u8f83\u9ad8\u7684\u9884\u6d4b\u51c6\u786e\u6027\uff08\u56fe5d\uff09\u3002\u540c\u65f6\u5728GSE13904\u9a8c\u8bc1\u96c6\u4e2d\u8fdb\u884c\u8868\u8fbe\u9a8c\u8bc1\u548cROC\u5206\u6790\uff0c\u7ed3\u679c\u8868\u660e\u513f\u7ae5\u8113\u6bd2\u75c7\u7ec4CYSTM1\u3001MMP8\u548cCD177\u7684\u8868\u8fbe\u660e\u663e\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff08\u56fe5e\uff09\uff0cROC\u66f2\u7ebf\u7684AUC\u5206\u522b\u4e3a0.968\u30010.964\u548c0.957\uff0c\u8868\u660e\u5173\u952e\u57fa\u56e0\u5728GSE13904\u9a8c\u8bc1\u96c6\u4e2d\u4e5f\u662f\u6709\u4ef7\u503c\u7684\uff08\u56fe5f\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"773\" class=\"wp-image-22190\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig3_html-webp-1.jpeg?resize=640%2C773\" alt=\"12519_2023_717_Fig3_HTML.webp\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig3_html-webp-1.jpeg?w=1768 1768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig3_html-webp-1.jpeg?resize=248%2C300 248w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig3_html-webp-1.jpeg?resize=848%2C1024 848w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/12519_2023_717_fig3_html-webp-1.jpeg?resize=768%2C927 768w, 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