{"id":22410,"date":"2024-01-03T14:43:18","date_gmt":"2024-01-03T06:43:18","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22410"},"modified":"2024-01-03T14:43:20","modified_gmt":"2024-01-03T06:43:20","slug":"%e5%8c%97%e4%ba%ac%e5%8d%8f%e5%92%8c%e5%8c%bb%e9%99%a21%e5%8c%ba14-5%e5%88%86%e7%9a%84%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%a0%94%e7%a9%b6%ef%bc%81%e8%81%94%e5%90%88ppi%e7%bd%91-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22410","title":{"rendered":"\u5317\u4eac\u534f\u548c\u533b\u96621\u533a14.5\u5206\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\uff01\u8054\u5408PPI\u7f51\u7edc\u7b5b\u9009\u6f5c\u5728\u836f\u7269\u9776\u70b9\uff01"},"content":{"rendered":"

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u6700\u8fd1\u98ce\u5934\u6b63\u76db\uff0c\u9ad8\u5206SCI\u6587\u7ae0\u9891\u51fa\uff0c\u6027\u4ef7\u6bd4\u8d85\u9ad8\uff0c\u662f\u4e2a\u4e0d\u53ef\u591a\u5f97\u7684\u53d1\u6587\u597d\u9014\u5f84\u3002\u65e2\u7136\u5982\u6b64\u706b\u70ed\uff0c\u5c0f\u4e91\u4e5f\u4f1a\u65f6\u4e0d\u65f6\u5206\u4eab\u4e00\u4e0b\u6700\u65b0\u7684MR\u76f8\u5173\u7814\u7a76\uff0c\u7ed9\u5927\u5bb6\u62d3\u5c55\u4e00\u4e0b\u601d\u8def~<\/p>\n

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\uff08\u6ca1\u6709\u601d\u8def\u3001\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u627e\u5c0f\u4e91\uff0c\u8d85\u591a\u4e2a\u6027\u5316\u3001\u521b\u65b0\u6027\u9ad8\u7684\u5206\u6790\u601d\u8def\u4f9b\u4f60\u9009\u62e9\uff01\uff09<\/strong><\/p>\n

\"\"<\/p>\n

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\u6742\u5fd7\uff1aBrain : a journal of neurology<\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1a14.5<\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e748\u6708<\/p>\n

\"\u56fe\u7247\"\u7814\u7a76\u601d\u8def<\/strong> \"\u56fe\u7247\"<\/p>\n

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<\/p>\n

\u56fe1 \u6d41\u7a0b\u56fe<\/p>\n

\"\u56fe\u7247\"\u4e3b\u8981\u7814\u7a76\u7ed3\u679c<\/strong> \"\u56fe\u7247\"<\/p>\n

    \n
  1. \u7b5b\u9009\u591a\u53d1\u6027\u786c\u5316\u75c7\u81f4\u75c5\u86cb\u767d\u7684\u86cb\u767d\u8d28\u7ec4<\/strong><\/li>\n<\/ol>\n

    \u5728Bonferroni\u663e\u8457\u6027\u4e0b\uff0cMR\u5206\u6790\u663e\u793a\u4e866\u4e2a\u86cb\u767d- MS\u5bf9(\u88681\u548c\u56fe2A\u548cB)\uff0c\u5305\u62ec\u8840\u6d46\u4e2d\u7684Fc\u53d7\u4f53\u6837\u86cb\u767d3 (FCRL3)\u3001\u80f8\u82f7\u78f7\u9178\u5316\u9176(TYMP)\u548c\u03b1 -2- HS -\u7cd6\u86cb\u767d(AHSG)\uff0c\u4ee5\u53ca\u8111\u810a\u6db2\u4e2d\u7684\u819c\u91d1\u5c5e\u5185\u80bd\u9176\u68371 (MMEL1)\u3001\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u4fe1\u53f7\u5206\u5b50F7 (SLAMF7)\u548cCD5\u6297\u539f\u6837(CD5L)\u3002\u5177\u4f53\u6765\u8bf4\uff0cFCRL3\u3001TYMP\u3001AHSG\u3001SLAMF7\u548cCD5L\u7684\u5347\u9ad8\u964d\u4f4e\u4e86MS\u7684\u98ce\u9669\uff0c\u800cMMEL1\u7684\u5347\u9ad8\u5219\u589e\u52a0\u4e86MS\u7684\u98ce\u9669\u3002<\/p>\n

    <\/p>\n

    \u88681 Bonferroni\u6821\u6b63\u540e\u8840\u6d46\u548cCSF\u86cb\u767d\u4e0eMS\u663e\u8457\u76f8\u5173\u7684MR\u7ed3\u679c<\/p>\n

    <\/p>\n

    \u56fe2\u8840\u6d46\u548c\u8111\u810a\u6db2\u86cb\u767d\u7684MR\u7ed3\u679c\u4e0eMS\u7684\u98ce\u9669<\/p>\n

      \n
    1. \u591a\u53d1\u6027\u786c\u5316\u75c7\u81f4\u75c5\u86cb\u767d\u654f\u611f\u6027\u5206\u6790<\/strong><\/li>\n<\/ol>\n

      MR\u5206\u6790\u53d1\u73b0\u76846\u4e2a\u86cb\u767d\u4e2d\u67095\u4e2a\u88ab\u786e\u5b9a\u4e3aMS\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\uff0c\u5305\u62ecFCRL3\u3001TYMP\u3001AHSG\u3001MMEL1\u548cSLAMF7\u3002\u9996\u5148\uff0c\u53cc\u5411MR\u5206\u6790\u6ca1\u6709\u53d1\u73b0MS\u5bf96\u4e2a\u9274\u5b9a\u86cb\u767d\u6c34\u5e73\u7684\u56e0\u679c\u5f71\u54cd(\u88682)\u3002\u5176\u6b21\uff0c\u8d1d\u53f6\u65af\u5171\u5b9a\u4f4d\u5f3a\u70c8\u63d0\u793aFCRL3\u3001TYMP\u3001AHSG\u3001MMEL1\u548cSLAMF7\u4e0eMS\u5177\u6709\u76f8\u540c\u7684\u53d8\u5f02(\u88682)\u3002\u6700\u540e\uff0c\u7ecf\u8fc7\u8868\u578b\u626b\u63cf\uff0c\u53d1\u73b0FCRL3 (rs7528684)\u4e0e1\u578b\u7cd6\u5c3f\u75c5\u6709\u5173\u3002<\/p>\n

      <\/p>\n

      \u88682 6\u79cd\u6f5c\u5728\u56e0\u679c\u86cb\u767d\u7684\u53cd\u5411\u56e0\u679c\u68c0\u6d4b\u3001\u8d1d\u53f6\u65af\u5171\u5b9a\u4f4d\u5206\u6790\u548c\u8868\u578b\u626b\u63cf\u603b\u7ed3<\/p>\n

        \n
      1. \u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\u4e0e\u5f53\u524d\u591a\u53d1\u6027\u786c\u5316\u75c7\u836f\u7269\u7684\u5173\u8054<\/strong><\/li>\n<\/ol>\n

        PPI\u7f51\u7edc\u63ed\u793a\u4e86\u4e09\u79cd\u4f18\u5148\u86cb\u767d(FCRL3, TYMP\u548cSLAMF7)\u4e0e\u56db\u79cd\u5f53\u524dMS\u836f\u7269\u9776\u70b9\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u4f7f\u7528STRING\uff0c\u786e\u5b9aMS4A1-FCRL3\u548cPNP-TYMP\u5177\u6709\u6700\u53ef\u9760\u7684\u76f8\u4e92\u4f5c\u7528(\u5df2\u77e5\u76f8\u4e92\u4f5c\u7528)\u3002\u5177\u4f53\u6765\u8bf4\uff0cFCRL3\u4e0eb\u6dcb\u5df4\u7ec6\u80de\u6297\u539fCD20 (MS4A1)\u76f8\u5173\uff0c\u8fd9\u662focrelizumab\u548cofatumumab\u7684\u9776\u70b9\u3002<\/p>\n

        STRING\u8fd8\u63ed\u793a\u4e86FCRL3\u548cMS4A1\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u8868\u660e\u8fd9\u4e24\u4e2a\u86cb\u767d\u975e\u5e38\u63a5\u8fd1\uff0c\u4f46\u4e0d\u4e00\u5b9a\u76f4\u63a5\u63a5\u89e6\u3002SLAMF7\u4e0e\u963f\u4ed1\u5355\u6297\u7684\u9776\u70b9\uff0cCAMPAIGN-1\u6297\u539f(CD52)\u76f8\u5173(\u56fe3)\u3002\u4f5c\u8005\u8fd8\u5728Drugbank\u6570\u636e\u5e93\u4e2d\u641c\u7d22\u4e86\u76ee\u524d\u9488\u5bf9\u5df2\u786e\u5b9a\u7684\u6f5c\u5728\u56e0\u679c\u86cb\u767d\u7684\u836f\u7269\uff0c\u786e\u5b9a\u4e86\u4e24\u79cd\u53ef\u80fd\u6539\u53d8\u75be\u75c5\u7684\u836f\u7269:\u6c1f\u5c3f\u5b9a(\u4e00\u79cdTYMP\u8bf1\u5bfc\u5242)\u548celotuzumab(\u4e00\u79cdSLAMF7\u8c03\u8282\u5242)\u3002<\/p>\n

        <\/p>\n

        \u56fe3\u5f53\u524dMS\u836f\u7269\u9776\u70b9\u4e0e\u5df2\u786e\u5b9a\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/p>\n

          \n
        1. \u591a\u53d1\u6027\u786c\u5316\u75c7\u6f5c\u5728\u836f\u7269\u9776\u70b9\u7684\u5916\u90e8\u9a8c\u8bc1<\/strong><\/li>\n<\/ol>\n

          \u5728\u4e0d\u540c\u6570\u636e\u96c6\u4e2d\u4f7f\u7528\u76f8\u540c\u53d8\u5f02\u548c\u663e\u8457\u53d8\u5f02\u7b56\u7565\u6765\u91cd\u590d\u4e3b\u8981\u53d1\u73b0\uff0cMMEL1\u5728UK Biobank\u548cFinnGen\u961f\u5217\u4e2d\u4e5f\u88ab\u53d1\u73b0\u4e0eMS\u76f8\u5173\uff0c\u800cFCRL3\u4ec5\u5728UK Biobank\u4e2d\u4e0eMS\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u4f7f\u7528Ferkingstad\u7b49\u4eba\u62a5\u9053\u7684\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u53d8\u5f02\u4f5c\u4e3a\u9057\u4f20\u5de5\u5177\uff0c\u589e\u52a0FCRL3\u4f1a\u589e\u52a0MS\u7684\u98ce\u9669\u3002\u6b64\u5916\uff0c\u5728UK Biobank\u4e2d\uff0cAHSG\u5bf9MS\u6709\u8f7b\u5fae\u7684\u663e\u8457\u56e0\u679c\u6548\u5e94(\u56fe4)\u3002<\/p>\n

          <\/p>\n

          <\/p>\n

          \u56fe4 6\u79cd\u6f5c\u5728\u7684\u56e0\u679c\u86cb\u767d\u4e0eMS\u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\u7684\u5916\u90e8\u9a8c\u8bc1<\/p>\n

          \"\u56fe\u7247\"\u603b\u7ed3<\/strong> \"\u56fe\u7247\"<\/p>\n

          \u8fd9\u7bc7\u6587\u7ae0\u7684\u5206\u6790\u8868\u660e\uff0c FCRL3\u3001TYMP\u3001AHSG\u3001CSF MMEL1\u548cSLAMF7\u6c34\u5e73\u4e0e\u591a\u53d1\u6027\u786c\u5316\u98ce\u9669\u6709\u56e0\u679c\u5173\u7cfb\u3002\u8fd9\u4e94\u79cd\u86cb\u767d\u53ef\u80fd\u662f\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\uff0c\u503c\u5f97\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u7279\u522b\u662fFCRL3\u548cSLAMF7\u3002<\/p>\n

          \u8fd0\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5206\u6790\u65b9\u6cd5\uff0c3\u5f20\u7ed3\u679c\u56fe+2\u5f20\u8868\u683c\u5c31\u80fd\u53d1\u4e00\u7bc714\u5206+\u6587\u7ae0\uff0c\u4f60\u4e0d\u60f3\u8bd5\u8bd5\u5417\uff1f\u5982\u679c\u4f60\u6709\u5927\u6837\u672c\u7684\u5206\u6790\u9700\u6c42\uff0c\u6216\u8005\u60f3\u5728\u4e34\u5e8a\u3001\u6d41\u884c\u75c5\u5b66\u65b9\u5411\u53d1\u9ad8\u5206\u6587\u7ae0\uff0c\u4e0d\u59a8\u8bd5\u8bd5\u8fd9\u4e2a\u7701\u94b1\u7701\u65f6\u53c8\u7701\u529b\u7684\u601d\u8def\u5427\uff01<\/p>\n

          \u5982\u679c\u4f60\u8fd8\u82e6\u607c\u4e8e\u751f\u4fe1\u5206\u6790\u6ca1\u6709\u601d\u8def\uff0c\u6216\u8005\u5acc\u5206\u6790\u65b9\u6cd5\u592a\u8fc7\u7b80\u5355\u3001\u592a\u8fc7\u8001\u5957\uff0c\u60f3\u8981\u521b\u65b0\u601d\u8def\u7684\uff0c\u6216\u8005\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u5feb\u6765\u8054\u7cfb\u5c0f\u4e91\u5427\uff01<\/p>\n

          (\u6b64\u5904\u9700\u8981\u6dfb\u52a0\u76f8\u5173\u94fe\u63a5)<\/strong><\/p>\n

          <\/a> Nat Commun | 17\u5206+\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u957f\u5565\u6837\uff1f\u4e5f\u4e0d\u8fc77\u5f20\u4e3b\u56fe\uff01\u96f6\u57fa\u7840\u96f6\u5b9e\u9a8c\u53d1\u9ad8\u5206\u7684\u7edd\u4f73\u795e\u5668~\u8fd8\u4e0d\u5fc3\u52a8\u5417\uff1f<\/p>\n

          2\u5f20\u56fe\u5c31\u641e\u5b9a\u67f3\u53f6\u5200\u5b50\u520a\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff01\u9999\u6e2f\u5927\u5b66\u6700\u65b0\u7814\u7a76\u8bc1\u660e\u300c\u795e\u836f\u300d\u4e8c\u7532\u53cc\u80cd\u8fd8\u80fd\u6297\u8870\u8001\uff1f<\/p>\n

          \u8d85\u9ad8\u6027\u4ef7\u6bd4\u7684\u201c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u201d\u6765\u5566\uff01\u516c\u5171\u6570\u636e\u6316\u6398\uff0c\u7b80\u53554\u5f20\u56fe\u641e\u5b9a6\u5206+\uff0c1\u4e2a\u6708\u5c31\u63a5\u6536\uff01\u8d70\u8fc7\u8def\u8fc7\u5343\u4e07\u4e0d\u8981\u9519\u8fc7<\/p>\n

          1\u56fe1\u8868\u62ff\u4e0b7.9\u5206+\u6587\u7ae0!\u201c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u201d\u5343\u4e07\u4e0d\u8981\u9519\u8fc7\uff0c\u7eaf\u6570\u636e\u6316\u6398\uff0c0\u9a8c\u8bc1\u5b9e\u9a8c\uff0c\u5fc3\u52a8\u4e0d\u5982\u884c\u52a8\u54e6\uff01<\/p>\n

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