{"id":22527,"date":"2023-12-29T09:32:36","date_gmt":"2023-12-29T01:32:36","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22527"},"modified":"2023-12-29T09:32:38","modified_gmt":"2023-12-29T01:32:38","slug":"%e5%b9%bf%e4%b8%9c%e5%8c%bb%e5%a4%a7%e5%9b%a2%e9%98%9f7%e5%88%86-%e6%96%b0%e4%bd%9c%ef%bc%81%e7%bd%91%e7%bb%9c%e8%8d%af%e7%90%86%e5%ad%a6%e7%a1%ae%e5%ae%9a%e7%96%be%e7%97%85%e9%9d%b6%e7%82%b9","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22527","title":{"rendered":"\u5e7f\u4e1c\u533b\u5927\u56e2\u961f7\u5206 +\u65b0\u4f5c\uff01\u7f51\u7edc\u836f\u7406\u5b66\u786e\u5b9a\u75be\u75c5\u9776\u70b9\u548c\u751f\u7269\u6807\u5fd7\u7269"},"content":{"rendered":"<p>\u5927\u5bb6\u597d\uff01 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Cox\u5206\u6790\u4ece\u4e2d\u786e\u5b9a\u9884\u540e\u6807\u5fd7\uff0c\u8fdb\u4e00\u6b65\u4f7f\u7528Cytoscape\u8f6f\u4ef6\u6784\u5efa\u4e86\u72ec\u7279\u7684\u8349\u836f-\u5316\u5408\u7269-\u9776\u70b9\u7f51\u7edc\u56fe\uff0c\u6b64\u5916\uff0c\u4e3a\u4e86\u63a2\u7d22\u9884\u540e\u57fa\u56e0\u6cbb\u7597\u4e2d\u7684\u5206\u5b50\u673a\u5236\u548c\u9a8c\u8bc1\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9884\u540e\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u56e2\u961f\u8fd8\u8fdb\u884c\u4e86KEGG\u548c\u5355\u7ec6\u80de\u5206\u6790\u3002<\/p>\n<p>\u663e\u7136\uff0c\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u4e3a\u5229\u7528<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7ec6\u80de<\/a>\u6d78\u6da6\u7279\u6027\u5bfb\u627e\u75be\u75c5\u7684\u53ef\u9760\u9776\u70b9\u548c\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u800c\u4e14\u8bc1\u660e\u4e86\u8be5\u4e2d\u836f\u5728CRC\u60a3\u8005\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u5206\u5b50\u673a\u5236\u3002\u7c7b\u4f3c\u7684\uff0c\u7ed3\u5408\u836f\u7406\u5b66\u5206\u6790\u624b\u6bb5\u6765\u63a2\u7d22\u75be\u75c5\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5e76\u6784\u5efa\u9884\u6d4b\u6a21\u578b\u7684\u8fd9\u79cd\u65b9\u6cd5\u7b80\u5355\u9ad8\u6548\uff0c\u53d1\u6587\u601d\u8def\u975e\u5e38\u503c\u5f97\u540c\u5b66\u4eec\u53c2\u8003\u548c\u638c\u63e1\uff01\u5982\u679c\u4f60\u5bf9\u6b64\u611f\u5174\u8da3\uff0c\u4e0d\u59a8\u4e00\u8d77\u6765\u4e86\u89e3\u4e00\u4e0b\uff01 (<strong>ps\uff1a\u5982\u679c\u4f60\u6709\u4efb\u4f55\u60f3\u6cd5\uff0c\u4e0d\u8bba\u662f\u627e\u4e0d\u5230\u521b\u65b0\u65b9\u5411\u8fd8\u662f\u5176\u4ed6\u95ee\u9898\uff0c\u90fd\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff01)<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-22536 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?resize=157%2C158\" alt=\"\" width=\"157\" height=\"158\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?resize=100%2C100 100w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801-10.png?w=568 568w\" sizes=\"(max-width: 157px) 100vw, 157px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"372\" class=\"wp-image-22528\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?resize=640%2C372\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?w=1093 1093w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?resize=300%2C174 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?resize=1024%2C595 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?resize=768%2C446 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-1.png?resize=600%2C349 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u7ed3\u5408\u7f51\u7edc\u836f\u7406\u5b66\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u63a2\u8ba8\u6613YYFZBJS\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u53d1\u708e\u8868\u578b\u7684\u6f5c\u5728\u673a\u5236<\/li>\n<li>\u6742\u5fd7\uff1a<em>Computers in Biology and Medicine<\/em><\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.7<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u53d1\u5c55\u548c\u8fdb\u5c55\u4e0e\u5176\u590d\u6742\u7684<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/tumor-microenvironment&quot; \\o &quot;Learn more about tumor microenvironment from ScienceDirect's AI-generated Topic Pages\">\u80bf\u7624\u5fae\u73af\u5883<\/a>\uff08TME\uff09\u5bc6\u5207\u76f8\u5173\uff0c\u8bc4\u4f30<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7ec6\u80de<\/a>\u6d78\u6da6\uff08ICI\uff09\u7684\u6539\u826f\u6a21\u5f0f\u5c06\u6709\u52a9\u4e8e\u589e\u52a0\u6709\u5173TME\u6d78\u6da6\u7279\u5f81\u7684\u77e5\u8bc6\u3002\u858f\u82e1\u9644\u5b50\u8d25\u9171\u6563\uff08YYFZBJS\uff09\u5df2\u88ab\u8bc1\u660e\u5bf9\u7ed3\u76f4\u80a0\u764c\u514d\u75ab<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/microenvironment&quot; \\o &quot;Learn more about microenvironment from ScienceDirect's AI-generated Topic Pages\">\u5fae\u73af\u5883\u7684<\/a>\u8c03\u8282\u6709\u79ef\u6781\u4f5c\u7528\uff0c\u7136\u800c\u5176<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/pharmacological-target\">\u836f\u7406\u5b66\u9776\u70b9<\/a>\u548c\u5206\u5b50\u673a\u5236\u4ecd\u6709\u5f85\u9610\u660e\u3002\u672c\u6587\u4eceYYFZBJS\u9776\u6807\u4e2d\u786e\u5b9a\u4e86CRC IIP\u60a3\u8005\u768411\u4e2a\u9884\u540e\u57fa\u56e0\uff0c\u53d1\u73b0YYFZBJS\u6fc0\u6d3b\u4e86IIP\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u53cd\u5e94\u5e76\u51cf\u5c11\u4e86\u708e\u75c7\uff0c\u672c\u7814\u7a76\u4e3aCRC\u514d\u75ab\u53d1\u708e\u8868\u578b\u7684\u51c6\u786e\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u8bfe\u9898\u548c\u4f9d\u636e\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u5e93<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u8be6\u7ec6\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>42\u4e2a\u6b63\u5e38\u6837\u672c\u548c480\u4e2aCRC\u75c5\u4f8b\uff08TPM\u683c\u5f0f\uff09<\/td>\n<\/tr>\n<tr>\n<td>TCMSP<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>YYFZBJS\u7684\u6d3b\u6027\u5316\u5408\u7269<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center;\"><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u672c\u6587\u9996\u5148\u901a\u8fc7\u65e0\u76d1\u7763\u805a\u7c7b\u5c06480\u4e2a\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u6837\u672c\u5206\u4e3a\u4e09\u4e2a\u4e0d\u540c\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff08ICI\uff09\u6a21\u5f0f\uff0c\u5e76\u6839\u636essGSEA\u548cGSVA\u5206\u6790\u786e\u5b9a\u4e86\u8fd9\u4e09\u4e2a\u7c07\u7684\u514d\u75ab\u7279\u5f81\uff0c\u5e76\u8fdb\u884c\u5dee\u5f02\u5206\u6790\uff0c\u9274\u5b9a\u4e86\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u76f8\u5173\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEGs\uff09\u3002\u901a\u8fc7\u7f51\u7edc\u836f\u7406\u5206\u6790\uff0c\u5bf9\u57fa\u56e0\u96c6\u8fdb\u884c\u4ea4\u53c9\u5904\u7406\uff0c\u83b7\u5f9711\u4e2aYYFZBJS\u5728CRC\u7684TME\u4e2d\u5dee\u5f02\u8868\u8fbe\u7684\u9776\u70b9\uff0c\u7136\u540e\u901a\u8fc7LASSO Cox\u5206\u6790\u5efa\u7acb\u9884\u540e\u6a21\u578b\uff0c\u8fdb\u4e00\u6b65\u7684\u751f\u5b58\u5206\u6790\u786e\u5b9a\u8be5\u9884\u540e\u6a21\u578b\u7684\u9884\u6d4b\u6027\u80fd\u3002\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u5206\u6790\u5c55\u793a\u4e86\u4e0e\u9884\u540e\u6a21\u578b\u76f8\u5173\u7684\u57fa\u56e0\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u968f\u540e\u8fdb\u884c\u4e86KEGG\u901a\u8def\u5206\u6790\u4ee5\u9610\u660e\u76ee\u7684\u57fa\u56e0\u7684\u529f\u80fd\u3002\u6b64\u5916\uff0c\u5bf9\u72ec\u7acb\u6570\u636e\u96c6CRC_EMTAB8107\u7684\u5355\u7ec6\u80de\u5206\u6790\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u76f8\u5173\u7ec6\u80de\u4e2d\u9884\u540e\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u672c\u7814\u7a76\u65e8\u5728\u901a\u8fc7\u9884\u540e\u9884\u6d4b\u3001\u901a\u8def\u5bcc\u96c6\u548c\u5355\u7ec6\u80de\u5206\u6790\uff0c\u4eceYYFZBJS\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u4e2d\u63a2\u7d22\u4e00\u79cd\u65b0\u7684\u9884\u540e\u6807\u5fd7\u7269\uff0c\u5728CRC IIP\u60a3\u8005\u4e2d\u63d0\u4f9b\u5bf9YYFZBJS\u6cbb\u7597\u673a\u5236\u7684\u65b0\u89c6\u89d2\uff0c\u5e76\u5b9e\u73b0\u5bf9CRC\u60a3\u8005\u7684\u7cbe\u786e\u6cbb\u7597\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"912\" class=\"wp-image-22529\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=640%2C912\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?w=1796 1796w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=210%2C300 210w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=718%2C1024 718w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=768%2C1095 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=1077%2C1536 1077w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=1436%2C2048 1436w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?resize=600%2C855 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-2-scaled.jpeg?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe 1 \u7528\u4e8e\u4eceCRC\u5fae\u73af\u5883\u4e2dYYFZBJS\u5dee\u5f02\u8868\u8fbe\u9776\u6807\u9274\u5b9a\u9884\u540e\u57fa\u56e0\u7684\u5206\u6790\u8fc7\u7a0b<\/p>\n<p style=\"text-align: center;\"><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. \u7ed3\u76f4\u80a0\u764c\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u7279\u5f81<\/strong><\/p>\n<p>\u901a\u8fc7\u65e0\u76d1\u7763\u805a\u7c7b\u9274\u5b9a\u4e86\u4e09\u79cd\u4e0d\u540c\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff08ICI\uff09\u6a21\u5f0f\uff0c\u5305\u62ecA\u7c07\uff08284\u4e2a\u6837\u672c\uff09\u3001B\u7c07\uff0873\u4e2a\u6837\u672c\uff09\u548cC\u7c07\uff08123\u4e2a\u6837\u672c\uff09\uff08\u56fe2A\uff09\u3002TME\u7ec6\u80de\u6d78\u6da6\u5206\u6790\u663e\u793aA\u7c07\u8868\u73b0\u51fa\u660e\u663e\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff0c B\u7c07\u5177\u6709\u6700\u4f4e\u7684ICI\u5f97\u5206\uff0cC\u7c07\u76f8\u6bd4A\u7c07\u663e\u793a\u51fa\u66f4\u9ad8\u6c34\u5e73\u7684\u5de8\u566c\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u6d78\u6da6\uff08\u56fe2B\uff09\u3002GSVA\u5bcc\u96c6\u5206\u6790\u786e\u5b9a\u4e86\u4e0d\u540cICI\u6a21\u5f0f\u7684\u751f\u7269\u7279\u5f81\uff0cA\u7c07\u5bcc\u96c6\u4e0e\u5b8c\u5168\u514d\u75ab\u6fc0\u6d3b\u76f8\u5173\u7684\u901a\u8def\uff0c\u800cB\u7c07\u4e0e\u8d8b\u5316\u56e0\u5b50\u4fe1\u53f7\u901a\u8def\u548c\u80a0\u9053\u514d\u75ab\u7f51\u7edc\uff08IGA\u4ea7\u751f\uff09\u5448\u8d1f\u76f8\u5173\uff08\u56fe2C\uff09\uff0cC\u7c07\u5728\u57fa\u8d28\u548c\u764c\u53d8\u6fc0\u6d3b\u901a\u8def\u65b9\u9762\u663e\u8457\u5bcc\u96c6\uff08\u56fe2D\uff09\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u8fd9\u4e09\u79cdICI\u6a21\u5f0f\u5177\u6709TME\u7ec6\u80de\u6d78\u6da6\u7684\u72ec\u7279\u7279\u5f81\uff0c\u6211\u4eec\u53ef\u4ee5\u5c06A\u7c07\u8f7b\u677e\u5f52\u7c7b\u4e3a\u514d\u75ab\u6fc0\u6d3b\u548c\u9002\u5e94\u6027ICI\u7279\u5f81\u7684IIP\uff0c\u5c06B\u7c07\u5f52\u7c7b\u4e3a\u514d\u75ab\u6c99\u6f20\u8868\u578b\uff0c\u5177\u6709\u514d\u75ab\u6291\u5236\u7279\u5f81\uff0c\u5c06C\u7c07\u5f52\u7c7b\u4e3a\u514d\u75ab\u6392\u65a5\u8868\u578b\uff0c\u5177\u6709\u5148\u5929\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u548c\u57fa\u8d28\u6fc0\u6d3b\u7279\u5f81\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"920\" class=\"wp-image-22530\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=640%2C920\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?w=1780 1780w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=209%2C300 209w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=712%2C1024 712w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=768%2C1105 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=1068%2C1536 1068w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=1424%2C2048 1424w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?resize=600%2C863 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-3-scaled.jpeg?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe2 ICI\u6a21\u5f0f\u548c\u6bcf\u79cd\u6a21\u5f0f\u7684\u751f\u7269\u5b66\u7279\u6027<\/p>\n<p>(A) k=3\u65f6\u7684\u4e00\u81f4\u805a\u7c7b\u77e9\u9635\uff1b(B) 3\u79cdICI\u4fee\u9970\u6a21\u578b\u4e2d23\u4e2aTME\u76f8\u5173\u7ec6\u80de\u7684\u514d\u75ab\u6d78\u6da6\uff1b\u68c0\u6d4b\u7edf\u8ba1\u5dee\u5f02\uff1b\u70ed\u56fe\u4e3a\u4e0d\u540cICI\u7c07\u751f\u7269\u901a\u8def\u7684\u6fc0\u6d3b\u72b6\u6001\uff0c\u7ea2\u8272\u8868\u793a\u6fc0\u6d3b\u72b6\u6001\uff0c\u84dd\u8272\u8868\u793a\u6291\u5236\u72b6\u6001\uff1a(C) ICI\u96c6\u7fa4A \u4e0eB; (D) ICI\u96c6\u7fa4A\u4e0e C<\/p>\n<p><strong>2. YYFZBJS\u9776\u5411CRC\u7684\u80bf\u7624\u5fae\u73af\u5883<\/strong><\/p>\n<p>\u4e3a\u4e86\u9610\u660e\u4e0d\u540cTME\u72b6\u6001\u7684\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\uff0c\u8fdb\u4e00\u6b65\u786e\u5b9a\u4e86\u5728\u514d\u75ab\u8bc4\u5206\u9ad8\u4f4e\u7ec4\u548c\u57fa\u8d28\u8bc4\u5206\u9ad8\u4f4e\u7ec4\u4e4b\u95f4\u663e\u8457\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\u96c6\u3002\u5728CRC\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9274\u5b9a\u51fa1328\u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEGs\uff09\u3002\u63a5\u4e0b\u6765\uff0c\u4ece\u4e2d\u836f\u7cfb\u7edf\u836f\u7406\u5b66\u6570\u636e\u5e93\uff08TCMSP\uff09\u548cSwiss Target Prediction\u6570\u636e\u5e93\u4e2d\u9884\u6d4b\u51fa\u4e86744\u4e2aYYFZBJS\u7684\u9776\u70b9\uff0c\u4eceDisGeNET\u6570\u636e\u5e93\u68c0\u7d22\u5230\u4e862832\u4e2a\u4e0eCRC\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u4eceDigSee\u6570\u636e\u5e93\u68c0\u7d22\u5230\u4e862092\u4e2a\u4e0eCRC\u76f8\u5173\u7684\u57fa\u56e0\u3002\u6700\u7ec8\uff0c\u5171\u9274\u5b9a\u51faCRC\u7684\u80bf\u7624\u5fae\u73af\u5883\uff081328\u4e2a\u57fa\u56e0\uff09\u3001YYFZBJS\u7684\u9776\u70b9\uff08744\u4e2a\u57fa\u56e0\uff09\u548cCRC\uff081008\u4e2a\u57fa\u56e0\uff09\u76f8\u5173\u768435\u4e2a\u57fa\u56e0\uff08\u56fe3A\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"535\" height=\"738\" class=\"wp-image-22531\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-4.jpeg?resize=535%2C738\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-4.jpeg?w=535 535w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-4.jpeg?resize=217%2C300 217w\" sizes=\"(max-width: 535px) 100vw, 535px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe3 IIP\u60a3\u8005\u9884\u540e\u57fa\u56e0\u4e0eOS\u9884\u540e\u8bc4\u4ef7<\/p>\n<p>(A) CRC\u5fae\u73af\u5883\u4e2dYYFZBJS\u9776\u70b9\u3001CRC\u76f8\u5173\u57fa\u56e0\u548cDEGs\u7684\u7ef4\u6069\u56fe\uff1b(B)\u9884\u540e\u57fa\u56e0\u68ee\u6797\u56fe\uff1b(C)\u8bad\u7ec3\u961f\u5217\u4e2d\u9ad8\u5371\u7ec4\u548c\u4f4e\u5371\u7ec4\u751f\u5b58\u9884\u6d4b\u6a21\u578b\u7684\u751f\u5b58\u66f2\u7ebf\u548cROC\u66f2\u7ebf\uff1b(D)\u8bd5\u9a8c\u961f\u5217\u4e2d\u9ad8\u5371\u7ec4\u548c\u4f4e\u5371\u7ec4\u751f\u5b58\u9884\u6d4b\u6a21\u578b\u7684\u751f\u5b58\u66f2\u7ebf\u548cROC\u66f2\u7ebf<\/p>\n<p><strong>3. \u514d\u75ab\u6fc0\u6d3b\u8868\u578b\u7684\u9884\u540e\u6a21\u578b<\/strong><\/p>\n<p>\u4e3a\u63a2\u7d22IIP\u60a3\u8005\u7684\u9884\u540e\u57fa\u56e0\u5efa\u7acb\u4e86\u4e00\u4e2a\u9884\u540e\u751f\u5b58\u76f8\u5173\u6a21\u578b\u3002274\u540d\u5177\u6709\u751f\u5b58\u4fe1\u606f\u7684IIP\u60a3\u8005\u8fdb\u4e00\u6b65\u5206\u4e3a\u8bad\u7ec3\u961f\u5217\uff08194\u4e2a\u6837\u672c\uff09\u548c\u6d4b\u8bd5\u961f\u5217\uff0880\u4e2a\u6837\u672c\uff09\uff0c\u5176\u4e2d\u8bad\u7ec3\u961f\u5217\u7528\u4e8e\u4f18\u5316\u6a21\u578b\u53c2\u6570\uff0c\u6d4b\u8bd5\u961f\u5217\u7528\u4e8e\u6d4b\u8bd5\u6a21\u578b\u6027\u80fd\u3002\u5efa\u7acb\u4e86\u4e00\u4e2a\u7531\u8fd916\u4e2a\u57fa\u56e0\u4e2d\u768411\u4e2a\u7ec4\u6210\u7684\u591a\u5143Cox\u98ce\u9669\u6a21\u578b\uff08\u88681\uff09\u3002\u5176\u4e2d\uff0c PTGS2\u3001HPGDS\u548cPRF1\u7684\u4e0a\u8c03\u4e0e\u826f\u597d\u7684\u9884\u540e\u76f8\u5173\uff0c\u800cC5AR1\u3001IDO1\u3001PIK3CG\u3001CAV1\u548cSERPINE1\u7684\u4e0a\u8c03\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\uff0c\u800c\u5176\u4ed6\u4e09\u4e2a\u57fa\u56e0\u5728CRC\u7684\u9884\u540e\u6548\u5e94\u4e0a\u6ca1\u6709\u663e\u793a\u51fa\u663e\u8457\u6027\uff08\u56fe3B\uff09\u3002ROC\u66f2\u7ebf\u663e\u793a\u9884\u540e\u6a21\u578b\u5177\u6709\u8f83\u9ad8\u7684\u654f\u611f\u6027\u3001\u7279\u5f02\u6027\u548c\u53ef\u9760\u6027\uff0cAUC\u503c\u4e3a0.84\uff08\u56fe3C\uff09\u3002\u5728\u6d4b\u8bd5\u961f\u5217\u4e2d\uff0c\u9ad8\u98ce\u9669\u7ec4\u7684\u751f\u5b58\u7387\u4e5f\u663e\u8457\u77ed\u4e8e\u4f4e\u98ce\u9669\u7ec4\uff0cAUC\u503c\u4e3a0.793\uff08\u56fe3D\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"456\" class=\"wp-image-22532\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-5.png?resize=640%2C456\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-5.png?w=836 836w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-5.png?resize=300%2C214 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-5.png?resize=768%2C547 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-5.png?resize=600%2C427 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u88681 \u7ed3\u76f4\u80a0\u764cIIP\u60a3\u800511\u4e2a\u9884\u540e\u57fa\u56e0\u7684\u76f8\u5173\u7edf\u8ba1\u53c2\u6570<\/p>\n<p><strong>4. PPI\u7f51\u7edc\u5206\u6790<\/strong><\/p>\n<p>PPI\u7f51\u7edc\u4e2d11\u4e2a\u9884\u540e\u57fa\u56e0\u4e4b\u95f4\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u63ed\u793a\u4e86\u8fd9\u4e9b\u9884\u540e\u57fa\u56e0\u4e4b\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u5e76\u5171\u540c\u5f71\u54cdIIP\u60a3\u8005\u7684\u9884\u540e\uff08\u56fe4A\uff09\u3002MCODE\u5206\u6790\u663e\u793aMMP9\u3001TGFB1\u3001CAV1\u3001PTGS2\u548cSERPINE1\u6784\u6210\u4e86PPI\u7f51\u7edc\u7684\u6838\u5fc3\u6a21\u5757\uff08\u56fe4B\uff09\uff0c\u8868\u660e\u8fd9\u4e9b\u6838\u5fc3\u57fa\u56e0\u5728\u7f51\u7edc\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002KEGG\u5bcc\u96c6\u5206\u6790\u8868\u660e\uff0c\u9884\u540e\u57fa\u56e0\u4e3b\u8981\u5bcc\u96c6\u5728\u764c\u75c7\u4e2d\u7684\u86cb\u767d\u805a\u7cd6\u3001\u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22\u3001\u4ee3\u8c22\u9014\u5f84\u548cIL-17\u4fe1\u53f7\u901a\u8def\uff08\u56fe4B\uff09\u3002<\/p>\n<p>\u56fe4C\u663e\u793a\u4e86\u8349\u836f-\u5316\u5408\u7269-\u9776\u70b9\u7f51\u7edc\uff0c\u5b83\u6e05\u6670\u5730\u63cf\u8ff0\u4e86\u4e09\u79cd\u8349\u836f\u3001YYFZBJS\u768424\u4e2a\u5173\u952e\u5316\u5408\u7269\u548c11\u4e2a\u9884\u540e\u57fa\u56e0\u4e4b\u95f4\u7684\u591a\u8fb9\u96b6\u5c5e\u548c\u9776\u5411\u5173\u7cfb\uff0c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u76f4\u63a5\u63a2\u7d22\u8fd9\u79cd\u4e2d\u836f\u5728\u6cbb\u7597CRC\u60a3\u8005\u4e2d\u7684\u836f\u6548\u7269\u8d28\u57fa\u7840\uff0c\u5176\u4e2d\uff0cC5AR1\u3001HPGDS\u3001IDO1\u3001PRF1\u3001CXCR2\u548cSERPINE1\u3001CAV1\u548cTGFB1\u662f\u5916\u56f4\u9776\u70b9\uff0c\u5176\u7279\u70b9\u662f\u6765\u81ea\u858f\u82e1\u4ec1\u3001\u9644\u5b50\u548c\u8d25\u9171\u8349\u4e2d\u7684\u6d3b\u6027\u5316\u5408\u7269\u5177\u6709\u5355\u5411\u9776\u5411\u5173\u7cfb\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"871\" class=\"wp-image-22533\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=640%2C871\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?w=1881 1881w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=220%2C300 220w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=752%2C1024 752w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=768%2C1045 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=1128%2C1536 1128w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=1505%2C2048 1505w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?resize=600%2C817 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-6-scaled.jpeg?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe4 \u836f\u7269\u9776\u70b9\u4e0e\u9884\u540e\u76f8\u5173\u7684\u7269\u8d28\u57fa\u7840\u548c\u673a\u5236 (A) PPI\u7f51\u7edc (B)\u57fa\u56e0\u901a\u8def\u7f51\u7edc (C)\u8349\u836f-\u5316\u5408\u7269-\u9776\u6807\u7f51\u7edc<\/p>\n<p><strong>5. \u9884\u540e\u57fa\u56e0\u5bcc\u96c6\u60c5\u51b5<\/strong><\/p>\n<p>\u901a\u8fc7\u5355\u7ec6\u80de\u5206\u6790\u8c03\u67e5<a id=\"post-22527-_Hlk146295100\"><\/a>\u9884\u540e\u57fa\u56e0\u7684\u5bcc\u96c6\u60c5\u51b5\u3002\u56fe5\u4e3a\u9884\u540e\u57fa\u56e0\u5728TME\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u88682\u663e\u793aPRF1\u548cPIK3CG\u4e3b\u8981\u5bcc\u96c6\u5728CD4\/CD8 T\u7ec6\u80de\u4e2d\uff0c\u800cC5AR1\u548cMMP9\u4e3b\u8981\u8868\u8fbe\u5728\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\u4e2d\uff0cHPGDS\u548cPTGS2\u4e3b\u8981\u5728\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u4e2d\uff0cSERPINE1\u5728\u5185\u76ae\u7ec6\u80de\u548c\u80a0\u80f6\u8d28\u7ec6\u80de\u4e2d\u663e\u8457\u8868\u8fbe\uff0cCAV1\u548cTGFB1\u8fd8\u5728\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAV1\uff09\u548cCD4\/CD8 T\u7ec6\u80de\u4ee5\u53ca\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\uff08TGFB1\uff09\u4e2d\u660e\u663e\u8868\u8fbe\u3002\u4e14\u4e00\u4e9b\u9884\u540e\u57fa\u56e0\uff08PIK3CG\u3001CAV1\u548cTGFB1\uff09\uff0c\u5728TME\u7684\u5176\u4ed6\u7ec6\u80de\uff08\u6d46\u7ec6\u80de\u548cB\u7ec6\u80de\uff09\u4e2d\u7565\u6709\u8868\u8fbe\u3002\u7efc\u4e0a\uff0c\u9664IDO1\u548cCXCR2\u4e4b\u5916\uff0c\u6240\u6709\u9884\u540e\u57fa\u56e0\u5728\u8be5\u6570\u636e\u96c6\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e2d\u90fd\u68c0\u6d4b\u5230\u4e86\u5bcc\u96c6\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"924\" class=\"wp-image-22534\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=640%2C924\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?w=1773 1773w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=208%2C300 208w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=709%2C1024 709w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=768%2C1109 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=1064%2C1536 1064w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=1418%2C2048 1418w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?resize=600%2C866 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-7-scaled.jpeg?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u56fe5 \u5728CRC_EMTAB8107\u6570\u636e\u96c6\u4e2d\uff0c\u7528\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u63a2\u7d22\u4e8611\u4e2a\u9884\u540e\u57fa\u56e0\u4e2d9\u4e2a\u5728\u4e0d\u540cTME\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u5206\u5e03<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"475\" class=\"wp-image-22535\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-8.png?resize=640%2C475\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-8.png?w=887 887w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-8.png?resize=300%2C223 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-8.png?resize=768%2C571 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22527-8.png?resize=600%2C446 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\">\u88682 \u663e\u793a\u9884\u540e\u57fa\u56e0\u8868\u8fbe\u7684TME\u7ec6\u80de\u7c07<\/p>\n<p><strong>6. \u8ba8\u8bba<\/strong><\/p>\n<p>\u672c\u7814\u7a76\u4ece480\u540dCRC\u60a3\u8005\u4e2d\u786e\u5b9a\u4e86284\u540dIIP\u60a3\u8005\uff0c\u5171\u8bc6\u57fa\u56e0\u4e2d\u5171\u670935\u4e2a\u57fa\u56e0\u88ab\u786e\u5b9a\u4e3aYYFZBJS\u5728CRC\u60a3\u8005\u7684\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u9776\u70b9\uff0c\u4ece\u4e2d\u786e\u5b9a\u4e86\u5305\u62ec11\u4e2a\u57fa\u56e0\u9884\u540e\u6807\u5fd7\uff0c\u8bad\u7ec3\u7ec4\u548c\u6d4b\u8bd5\u7ec4\u7684\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\uff08ROC\uff09\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08AUC\uff09\u5206\u522b\u4e3a0.84\u548c0.793\u3002\u6b64\u5916\uff0c\u5728\u8349\u836f-\u5316\u5408\u7269-\u9776\u70b9\u7f51\u7edc\u4e2d\uff0c\u663e\u793a\u670924\u79cd\u5316\u5408\u7269\u4e0e\u8fd911\u4e2a\u9884\u540e\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u4e9b\u5316\u5408\u7269\u5728IL-17\u4fe1\u53f7\u901a\u8def\u3001\u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22\u548c\u4ee3\u8c22\u9014\u5f84\u4e2d\u5bcc\u96c6\u3002\u6700\u540e\uff0c\u9884\u540e\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u6790\u8bc1\u5b9e\u5b83\u4eec\u7684\u5f02\u5e38\u8868\u8fbe\u4e0eCRC\u7684\u80bf\u7624\u5fae\u73af\u5883\u76f8\u5173\u3002<\/p>\n<p style=\"text-align: center;\"><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n<p><a id=\"post-22527-OLE_LINK2\"><\/a> \u672c\u6587\u5c06\u7f51\u7edc\u836f\u7406\u5b66\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u7ed3\u5408\uff0c\u4eceYYFZBJS\u7684\u9776\u70b9\u4e0a\u9274\u5b9a\u4e86\u7ed3\u76f4\u80a0\u764cIIP\u60a3\u8005\u7684\u9884\u540e\u57fa\u56e0\uff0c\u8be5\u65b9\u6cd5\u4e3a\u5bfb\u627e\u65b0\u7684\u4e2d\u836f\u6cbb\u7597\u9776\u70b9\u548c\u4e2d\u836f\u9776\u5411\u764c\u75c7\u7684\u51c6\u786e\u8bca\u65ad\u6307\u6807\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\uff01\u8fd9\u7bc7\u6587\u7ae0\u7684\u7814\u7a76\u601d\u8def\u6e05\u6670\u660e\u4e86\uff0c\u7b80\u660e\u627c\u8981\u4e14\u51c6\u786e\u65e0\u8bef\uff0c\u5404\u79cd\u5206\u6790\u90fd\u7d27\u5bc6\u56f4\u7ed5\u7740\u4e3b\u7ebf\u601d\u8def\u5c55\u5f00\u3002\u5982\u679c\u4f60\u5bf9\u6784\u5efa\u9884\u6d4b\u6a21\u578b\u611f\u5174\u8da3\uff0c\u5343\u4e07\u522b\u9519\u8fc7\u8fd9\u7bc7\u6587\u7ae0\uff0c\u540c\u65f6\uff0c\u8be5\u6587\u7ae0\u4e2d\u5229\u7528\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\u6765\u786e\u5b9a<a href=\"https:\/\/www-sciencedirect-com-443.webvpn.sust.edu.cn\/topics\/medicine-and-dentistry\/immunocompetent-cell\">\u514d\u75ab\u7ec6\u80de<\/a>\u6d78\u6da6\u7279\u6027\u7684\u65b9\u6cd5\u975e\u5e38\u503c\u5f97\u5b66\u4e60\u548c\u53c2\u8003\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u8d76\u7d27\u884c\u52a8\u8d77\u6765\u5427\uff01<\/p>\n<p style=\"text-align: center;\"><strong>\u5c0f\u7f16\u6709\u8bdd\u8bf4<\/strong><\/p>\n<p><strong>\u5c0f\u4e91\u516c\u4f17\u53f7\u6301\u7eed\u4e3a\u5927\u5bb6\u5e26\u6765\u6700\u65b0\u751f\u4fe1\u601d\u8def\uff0c\u8bf7\u52a1\u5fc5\u5173\u6ce8\u672c\u516c\u4f17\u53f7\u540e\u7eed\u7684\u6587\u7ae0\uff0c\u9700\u8981\u590d\u73b0\u6216\u5b9a\u5236\u5206\u6790\u601d\u8def\u7684\u670b\u53cb\u6b22\u8fcecall\u5c0f\u4e91\uff0c\u98ce\u91cc\u96e8\u91cc\u5c0f\u4e91\u516c\u4f17\u53f7\u7b49\u4f60\uff01<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-22536 aligncenter\" 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