{"id":22711,"date":"2023-12-29T17:22:52","date_gmt":"2023-12-29T09:22:52","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22711"},"modified":"2023-12-29T17:22:54","modified_gmt":"2023-12-29T09:22:54","slug":"%e5%8d%97%e6%98%8c%e5%a4%a7%e5%ad%a6%e4%b8%80%e9%99%84%e9%99%a2%e8%b0%a2%e5%8b%87%e5%9b%a2%e9%98%9f%ef%bc%9a%e5%a0%aa%e6%af%94%e8%91%a3%e5%ae%87%e8%be%89%e7%9a%847%e5%88%86%e5%8d%95%e5%9f%ba%e5%9b%a0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22711","title":{"rendered":"\u5357\u660c\u5927\u5b66\u4e00\u9644\u9662\u8c22\u52c7\u56e2\u961f\uff1a\u582a\u6bd4\u8463\u5b87\u8f89\u76847\u5206+\u5355\u57fa\u56e0\u751f\u4fe1\uff01\u94c1\u6b7b\u4ea1+\u591a\u7ec4\u5b66+\u673a\u5668\u5b66\u4e60+\u5355\u7ec6\u80de\uff0cbuff\u591a\u5230\u653e\u4e0d\u4e0b\u00b7\u00b7\u00b7"},"content":{"rendered":"<p>\u770b\u4e86\u90a3\u4e48\u591a\u751f\u4fe1\u6587\u7ae0\uff0c\u5c0f\u4e91\u4f9d\u65e7\u8ba4\u4e3a\uff1a\u5355\u57fa\u56e0\u5206\u6790\u4e4b\u4e8e\u751f\u4fe1\uff0c\u5c31\u50cf\u8463\u5b87\u8f89\u4e4b\u4e8e\u4e1c\u65b9\u7504\u9009\uff0c\u5b83\u5c31\u662f\u751f\u4fe1\u601d\u8def\u5927\u519b\u4e2d\u7684\u57fa\u77f3~<\/p>\n<p>\u5355\u57fa\u56e0\u5206\u6790\u56e0\u5176\u201c\u5206\u6790\u601d\u8def\u6bd4\u8f83\u7b80\u5355\u3001\u65b0\u624b\u5c0f\u767d\u597d\u4e0a\u624b\u201d\uff0c\u88ab\u9996\u63a8\u4e3a\u65b0\u624b\u6751\u9009\u624b\u7684\u5165\u95e8\u601d\u8def\uff0c\u540c\u65f6\u4e5f\u56e0\u4e3a\u5b83\u201c\u8fdb\u53ef\u653b\uff08\u751f\u4fe1\u5355\u72ec\u6210\u6587\uff09\u9000\u53ef\u5b88\uff08\u751f\u4fe1\u7ed3\u5408\u6e7f\u5b9e\u9a8c\u5f62\u6210\u5927\u8bfe\u9898\uff09\u201d\uff0c\u53c8\u6210\u4e3a\u5f88\u591a\u5927\u8bfe\u9898\u7684\u9ec4\u91d1\u914d\u89d2\uff0c\u601d\u8def\u5e94\u7528\u76f8\u5f53\u5e7f\u6cdb\uff0c\u52a9\u529b\u5c0f\u4f19\u4f34\u4eec\u8f7b\u8f7b\u677e\u677e\u5b9e\u73b0\u7701\u94b1\u63d0\u5206\u5927\u8ba1\uff01<strong>\uff08ps\uff1a\u5c0f\u4e91\u524d\u9762\u5df2\u7ecf\u5206\u4eab\u8fc7\u4e86\u591a\u79cd\u5355\u57fa\u56e0\u5206\u6790\u601d\u8def\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u8fdb\u5165\u516c\u4f17\u53f7\u641c\u7d22\u6216\u70b9\u51fb\u6587\u672b\u94fe\u63a5\u89c2\u770b\u54e6\uff09<\/strong><\/p>\n<p>\u65e2\u7136\u5982\u6b64\uff0c\u5c0f\u4e91\u4eca\u5929\u5c31\u5206\u4eab\u4e00\u4e0b<strong>\u5357\u660c\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u8c22\u52c7\u6559\u6388\u56e2\u961f<\/strong>\u6700\u65b0\u53d1\u8868\u7684\u4e00\u7bc7\u201c\u582a\u6bd4\u8463\u5b87\u8f89\u201d\u76847\u5206+\u5355\u57fa\u56e0\u5206\u6790\u6587\u7ae0\uff0c\u4e3a\u4ec0\u4e48\u8bf4\u5b83\u582a\u6bd4\u8463\u5b87\u8f89\uff0c\u8ddf\u7740\u5c0f\u4e91\u5f80\u4e0b\u770b\uff1a<\/p>\n<p><strong>1\uff09\u9009\u9898\u521b\u65b0\uff1a<\/strong>\u6587\u7ae0\u5c06\u80c3\u764c\u81f4\u75c5\u56e0\u7d20\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u4e0e\u94c1\u6b7b\u4ea1\u70ed\u70b9\u7ed3\u5408\uff0c\u9009\u9898\u65e2\u4e0e\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u53c8\u7d27\u8d34\u70ed\u70b9\uff0c\u521b\u65b0\u6027\u6ee1\u5206\uff1b<\/p>\n<p><strong>2\uff09\u5206\u6790\u65b9\u6cd5\u521b\u65b0\uff1a<\/strong>\u5e94\u7528\u591a\u7ec4\u5b66\u5206\u6790\u3001\u5206\u5b50\u5bf9\u63a5\u300110\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u548c\u5355\u7ec6\u80de\u5206\u6790\u7b49\uff0c\u5206\u6790\u65b9\u6cd5\u4e4b\u4e30\u5bcc\uff0cbuff\u591a\u5230\u5ba1\u7a3f\u4eba\u90fd\u79f0\u7edd\uff1b<\/p>\n<p><strong>3\uff09\u5e72\u6e7f\u7ed3\u5408\uff1a<\/strong>\u5229\u7528\u4e34\u5e8a\u7ec4\u7ec7\u6837\u672c\u8fdb\u884c\u57fa\u56e0\u7684\u8868\u8fbe\u9a8c\u8bc1\uff0c\u5e72\u6e7f\u7ed3\u5408\u7b26\u5408\u751f\u4fe1\u5927\u8d8b\u52bf\uff0c\u66f4\u53d7\u6742\u5fd7\u9752\u7750\u3002<\/p>\n<p>\u8fd9\u4e48\u770b\u6765\uff0c\u6587\u7ae0\u65e2\u6709\u5927\u70ed\u70b9\u3001\u6709\u5173\u6ce8\u5ea6\uff0c\u53c8\u6709\u8d85\u7ea7\u4e30\u5bcc\u7684\u5206\u6790\u65b9\u6cd5\u53e0buff\uff0c\u8fd8\u6709\u5907\u53d7\u6742\u5fd7\u559c\u7231\u7684\u5e72\u6e7f\u7ed3\u5408\u9a8c\u8bc1\uff0c\u662f\u4e0d\u662f\u50cf\u6781\u4e86\u5927\u53d7\u5e7f\u5927\u201c\u4e08\u6bcd\u5a18\u201d\u559c\u7231\u3001\u535a\u5b66\u591a\u8bc6\u7684\u8463\u5b87\u8f89\u8001\u5e08\u5462\uff01<strong>\u60f3\u8981\u5355\u57fa\u56e0\u601d\u8def\u7684\u5c0f\u4f19\u4f34\u8d76\u5feb\u6765\u5b66\u4e60\u5566\uff0c\u8fd9\u4e2a\u601d\u8def\u590d\u73b0\u51fa\u6765\u4f60\u4e5f\u53ef\u4ee5\u8f7b\u677e\u62ff\u9ad8\u5206\uff0c\u9700\u8981\u590d\u73b0\/\u8bbe\u8ba1\u601d\u8def\u6216\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u7684\u670b\u53cb\uff0c\u6b22\u8fce\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u54e6~<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"186\" height=\"187\" class=\"wp-image-22712\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-1.png?resize=186%2C187\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-1.png?w=186 186w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-1.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-1.png?resize=100%2C100 100w\" sizes=\"(max-width: 186px) 100vw, 186px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"263\" class=\"wp-image-22713\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-2.png?resize=640%2C263\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-2.png?w=708 708w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-2.png?resize=300%2C123 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-2.png?resize=600%2C247 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u901a\u8fc7\u591a\u7ec4\u5b66\u6574\u5408\u3001\u5206\u5b50\u5bf9\u63a5\u548c\u673a\u5668\u5b66\u4e60\u7efc\u5408\u5206\u6790\u80c3\u764c\u4e2d\u5e7d\u95e8\u87ba\u6746\u83cc\u76f8\u5173\u94c1\u6b7b\u4ea1\u57fa\u56e0YWHAE\u7684\u529f\u80fd<\/li>\n<li>\u6742\u5fd7\uff1aApoptosis<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.2<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u80c3\u764c\u4e0e\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u5bc6\u5207\u76f8\u5173\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u80cc\u666f\u4e0b\u80c3\u764c\u53d1\u751f\u7684\u5206\u5b50\u673a\u5236\uff0c\u5c24\u5176\u662f\u4e0e\u94c1\u6b7b\u4ea1\u76f8\u5173\u7684\u5206\u5b50\u673a\u5236\uff0c\u4ecd\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u96c6<\/td>\n<td>\u6765\u6e90<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u6837\u672c\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>PRJNA703469<\/td>\n<td>NCBI<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>\u5e7d\u95e8\u87ba\u6746\u83cc\u76f8\u5173\u80c3\u708e(32\u4efd\u5e7d\u95e8\u87ba\u6746\u83cc\u9633\u6027\u6837\u672c\u548c8\u4efd\u5e7d\u95e8\u87ba\u6746\u83cc\u9634\u6027\u6837\u672c)\u4ee5\u53ca\u80c3\u764c(32\u4efd\u5e7d\u95e8\u87ba\u6746\u83cc\u9633\u6027\u6837\u672c\u548c8\u4efd\u5e7d\u95e8\u87ba\u6746\u83cc\u9634\u6027\u6837\u672c)<\/td>\n<\/tr>\n<tr>\n<td>GSE13195<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>25\u4efd\u80c3\u764c\u6837\u672c\u548c25\u4efd\u6b63\u5e38\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>TCGA-STAD<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>\u80c3\u764c\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0<\/td>\n<td>ferry db V2<\/td>\n<td>\u57fa\u56e0\u96c6<\/td>\n<td>564\u4e2a\u94c1\u6b7b\u4ea1\u57fa\u56e0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p><a id=\"post-22711-_Hlk149223017\"><\/a> \u4f5c\u8005\u9996\u5148\u57fa\u4e8ePRJNA703469\u961f\u5217\u8fdb\u884c\u5dee\u5f02\u57fa\u56e0\u5206\u6790\uff0c\u5f97\u5230\u80c3\u764c\u548c\u80c3\u708e\u4e2d\u5e7d\u95e8\u87ba\u6746\u83cc\u76f8\u5173DEGs\uff0c\u7136\u540e\u518d\u4e0e\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u53d6\u4ea4\u96c6\uff0c\u5f97\u5230YWHAE\u57fa\u56e0\uff0c\u5e76\u5728GEPIA2\u548cGSE13195\u6570\u636e\u96c6\u4e2d\u9a8c\u8bc1\u5176\u8868\u8fbe\u3002\u63a5\u4e0b\u6765\u8fdb\u884cYWHAE\u7684\u6cdb\u764c\u5206\u6790\uff0c\u5229\u7528TIMER2.0\u6570\u636e\u5e93\u5206\u6790\u6cdb\u764c\u8868\u8fbe\uff0c\u901a\u8fc7TISCH\u6570\u636e\u5e93\u5206\u6790YWHAE\u4e0e\u751f\u5b58\u7ed3\u679c\u7684\u76f8\u5173\u6027\uff0c\u5229\u7528GSCA\u6570\u636e\u5e93\u8bc4\u4f30\u5176\u57fa\u56e0\u7ec4\u6539\u53d8\u3002\u57fa\u4e8eTISCH\u6570\u636e\u5e93\u7684\u5355\u7ec6\u80de\u6570\u636e\u5206\u6790YWHAE\u5728\u7ec6\u80de\u6c34\u5e73\u7684\u8868\u8fbe\u3002\u5728TCGA-STAD\u961f\u5217\u4e2d\u7b5b\u9009YWHAE\u76f8\u5173\u57fa\u56e0\u5e76\u6784\u5efaPPI\u7f51\u7edc\uff0c\u5229\u752810\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u8bc4\u4f30YWHAE\u76f8\u5173\u57fa\u56e0\u7684\u9884\u540e\u610f\u4e49\uff0c\u5efa\u7acb\u9884\u540e\u6a21\u578b\u5e76\u8fdb\u884c\u8bc4\u4f30\u548c\u9a8c\u8bc1\u3002\u5229\u7528cibersort\u7b49\u7b97\u6cd5\u5206\u6790YWHAE\u9ad8\u4f4e\u8868\u8fbe\u7ec4\u95f4\u7684\u514d\u75ab\u6d78\u6da6\u60c5\u51b5\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5dee\u5f02\u3002\u6bd4\u8f83\u4e24\u7ec4\u95f4\u7684\u836f\u654f\u6027\uff0c\u7b5b\u9009\u6cbb\u7597\u836f\u7269\u5e76\u4e0eYWHAE\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\u5206\u6790\u3002\u6700\u540e\uff0c\u5728\u4e34\u5e8a\u7ec4\u7ec7\u6837\u672c\u548cHPA\u6570\u636e\u5e93\u4e2d\u9a8c\u8bc1YWHAE\u57fa\u56e0\u8868\u8fbe\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"582\" class=\"wp-image-22714\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-3.png?resize=640%2C582\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-3.png?w=942 942w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-3.png?resize=300%2C273 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-3.png?resize=768%2C698 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-3.png?resize=600%2C545 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 \u7814\u7a76\u6d41\u7a0b\u56fe<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. YWHAE\u57fa\u56e0\u7684\u9274\u5b9a<\/strong><\/p>\n<p>\u9996\u5148\u57fa\u4e8ePRJNA703469\u961f\u5217\u8fdb\u884c\u5dee\u5f02\u57fa\u56e0\u5206\u6790\uff0c\u5206\u522b\u5f97\u5230380\u4e2a\u80c3\u708e\u4e2d\u5e7d\u95e8\u87ba\u6746\u83cc\u76f8\u5173DEGs\uff0c586 \u4e2a\u80c3\u764c\u5e7d\u95e8\u87ba\u6746\u83cc\u76f8\u5173DEGs\uff0c\u7136\u540e\u518d\u4e0e564\u4e2a\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u53d6\u4ea4\u96c6\uff0c\u5f97\u5230YWHAE\u57fa\u56e0\uff08\u56fe2A\uff09\uff0c\u5e76\u5728GEPIA2\uff08\u56fe2B\uff09\u548cGSE13195\u6570\u636e\u96c6\uff08\u56fe2C\uff09\u4e2d\u9a8c\u8bc1\u5176\u8868\u8fbe\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"304\" class=\"wp-image-22715\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?resize=640%2C304\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?w=1069 1069w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?resize=300%2C143 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?resize=1024%2C487 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?resize=768%2C365 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-4.png?resize=600%2C285 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 YWHAE\u57fa\u56e0\u7684\u9274\u5b9a<\/p>\n<p><strong>2. YWHAE\u57fa\u56e0\u7684\u6cdb\u764c\u5206\u6790<\/strong><\/p>\n<p>\u57fa\u4e8eTimer 2.0\u3001TISCH\u548cGSCA\u6570\u636e\u5e93\uff0c\u4f5c\u8005\u5bf9YWHAE\u57fa\u56e0\u8fdb\u884c\u6cdb\u764c\u5206\u6790\u3002Timer 2.0\u6570\u636e\u5e93\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cYWHAE\u57fa\u56e0\u5728\u8180\u80f1\u5c3f\u8def\u4e0a\u76ae\u764c\uff08BLCA\uff09\u7b49\u591a\u4e2a\u764c\u79cd\u4e2d\u8868\u8fbe\u4e0a\u8c03\uff08\u56fe3A\uff09\uff0cTISCH\u4e2d\u7684\u751f\u5b58\u5206\u6790\u663e\u793aYWHAE \u57fa\u56e0\u8868\u8fbe\u662f\u80c6\u7ba1\u764c\uff08CHOL\uff09\u3001\u8089\u7624\uff08SARC\uff09\u548c\u80ba\u817a\u764c\uff08LUAD\uff09\u60a3\u8005\u7684\u9884\u540e\u98ce\u9669\u56e0\u7d20\uff08\u56fe3B\uff09\u3002\u57fa\u4e8eGSCA\u6570\u636e\u5e93\u7684\u57fa\u56e0\u7ec4\u6539\u53d8\u5206\u6790\u663e\u793a\uff0c\u6709 29 \u79cd\u764c\u75c7\u7684 CNV \u4e0e YWHAE \u57fa\u56e0\u8868\u8fbe\u5448\u6b63\u76f8\u5173\uff08\u56fe3D\uff09\uff0c\u5728 28 \u79cd\u764c\u79cd\u4e2d\u7532\u57fa\u5316\u4e0e YWHAE \u57fa\u56e0\u8868\u8fbe\u5448\u8d1f\u76f8\u5173\uff08\u56fe3F\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"335\" class=\"wp-image-22716\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-5.png?resize=640%2C335\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-5.png?w=776 776w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-5.png?resize=300%2C157 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-5.png?resize=768%2C402 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-5.png?resize=600%2C314 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"349\" class=\"wp-image-22717\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-6.png?resize=640%2C349\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-6.png?w=707 707w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-6.png?resize=300%2C164 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-6.png?resize=600%2C328 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"291\" class=\"wp-image-22718\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-7.png?resize=640%2C291\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-7.png?w=982 982w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-7.png?resize=300%2C137 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-7.png?resize=768%2C350 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-7.png?resize=600%2C273 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"450\" class=\"wp-image-22719\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-8.png?resize=640%2C450\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-8.png?w=795 795w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-8.png?resize=300%2C211 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-8.png?resize=768%2C540 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-8.png?resize=600%2C422 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 YWHAE\u57fa\u56e0\u7684\u6cdb\u764c\u5206\u6790<\/p>\n<p><strong>3. YWHAE\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u6790<\/strong><\/p>\n<p>\u5229\u7528 TISCH \u6570\u636e\u5e93\u4e2d\u7684 GSE134520 \u6570\u636e\u96c6\u5206\u6790\u4e86 YWHAE \u57fa\u56e0\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u200b\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5171\u9274\u5b9a\u51fa9\u4e2a\u7ec6\u80de\u7fa4\uff08\u56fe4A\uff09\uff0cYWHAE \u4e3b\u8981\u5728\u51f9\u5751\u7c98\u6db2\u7ec6\u80de\u3001\u6076\u6027\u7ec6\u80de\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u8868\u8fbe\uff08\u56fe4B\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u6bd4\u8f83\u4e86\u6309\u6837\u672c\u6765\u6e90\u5206\u5c42\u540e\u4e0d\u540c\u7ec6\u80de\u7fa4\u4e2d YWHAE \u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u56fe 4C \u663e\u793a\u4e86\u5728 DC \u7ec6\u80de\u4e2d YWHAE \u6709\u663e\u8457\u5dee\u5f02\u8868\u8fbe\u3002\u6309\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u5206\u5c42\u540e\uff0c \u663e\u793a\u4e86 YWHAE \u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u7b49\u4e2d\u6709\u663e\u8457\u5dee\u5f02\u8868\u8fbe\uff08\u56fe 4D\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"451\" class=\"wp-image-22720\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?resize=640%2C451\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?w=1260 1260w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?resize=300%2C211 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?resize=1024%2C722 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?resize=768%2C541 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-9.png?resize=600%2C423 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 YWHAE\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u6790<\/p>\n<p><strong>4. \u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u5229\u7528 TCGA-STAD \u6837\u672c\u8fdb\u884c\u4e86Spearman\u76f8\u5173\u6027\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u4e0e YWHAE \u5173\u7cfb\u6700\u5bc6\u5207\u7684\u524d 20 \u4e2a\u57fa\u56e0\uff0c\u5e76\u6784\u5efaPPI\u7f51\u7edc\uff08\u56fe5A\uff09\u3002\u7136\u540e\u6839\u636e YWHAE \u5728 STAD \u4e2d\u7684\u4e2d\u4f4d\u8868\u8fbe\u6c34\u5e73\u5c06\u6837\u672c\u5206\u4e3a\u9ad8\u3001\u4f4e\u8868\u8fbe\u7ec4\uff0c\u7ec4\u95f4\u5dee\u5f02\u5206\u6790\u5f97\u5230265\u4e2aDEGs\uff0c\u9488\u5bf9DEGs\u8fdb\u884cGO\u548cKEGG\u5bcc\u96c6\u5206\u6790\uff0c\u663e\u793a\u5bcc\u96c6\u4e8e&#8221;PI3K-Akt &#8220;\u548c &#8220;ECM-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528 &#8220;\u7b49\u901a\u8def\uff08\u56fe 5D\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"541\" height=\"421\" class=\"wp-image-22721\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-10.png?resize=541%2C421\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-10.png?w=541 541w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-10.png?resize=300%2C233 300w\" sizes=\"(max-width: 541px) 100vw, 541px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"599\" height=\"431\" class=\"wp-image-22722\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-11.png?resize=599%2C431\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-11.png?w=599 599w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-11.png?resize=300%2C216 300w\" sizes=\"(max-width: 599px) 100vw, 599px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 \u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/p>\n<p><strong>5. \u836f\u654f\u6027\u5206\u6790\u548c\u5206\u5b50\u5bf9\u63a5<\/strong><\/p>\n<p>\u4f5c\u8005\u6bd4\u8f83\u4e86\u5e38\u7528\u5316\u7597\u836f\u7269\u5728YWHAE\u9ad8\u3001\u4f4e\u8868\u8fbe\u7ec4\u4e4b\u95f4\u7684\u7597\u6548\u5dee\u5f02\uff0c\u663e\u793a\u4f4e\u8868\u8fbe\u7ec4\u4e2d\u535a\u6765\u9709\u7d20\u3001\u987a\u94c2\u3001\u4f9d\u6258\u6cca\u82f7\u548c\u7d22\u62c9\u975e\u5c3c\u7684 IC50 \u503c\u660e\u663e\u66f4\u9ad8\uff08\u56fe6A\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u5c06\u4e24\u7ec4\u4e4b\u95f4\u7684DEGs\u5217\u8868\u4e0a\u4f20\u5230 Clue \u5e73\u53f0\uff0c\u4ece\u800c\u9884\u6d4b\u51fa\u516d\u79cd\u5728 STAD \u6cbb\u7597\u4e2d\u5177\u6709\u6f5c\u5728\u4f5c\u7528\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269(\u56fe6B-F)\u3002\u5bf9\u4e94\u79cd\u5173\u952e\u836f\u7269\uff08CI-1040\u3001\u5c3c\u7f57\u66ff\u5c3c\u3001PD-0325901\u3001RDEA119\u548cSelumetinib\uff09\u4e0eYWHAE\u8fdb\u884c\u4e86\u5206\u5b50\u5bf9\u63a5\uff08\u56fe6G-H\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"618\" class=\"wp-image-22723\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?resize=640%2C618\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?w=1260 1260w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?resize=300%2C290 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?resize=1024%2C988 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?resize=768%2C741 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-12.png?resize=600%2C579 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe6 \u836f\u654f\u6027\u5206\u6790\u548c\u5206\u5b50\u5bf9\u63a5<\/p>\n<p><strong>6. \u514d\u75ab\u6d78\u6da6\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5206\u6790<\/strong><\/p>\n<p>\u4f5c\u8005\u5728TCGA-STAD\u6570\u636e\u96c6\u4e2d\u91c7\u7528cibersort\u3001mcp\u3001xcell\u548cquantiseq\u7b49\u7b97\u6cd5\u5206\u6790YWHAE\u4e0e\u514d\u75ab\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u5173\u8054\u3002\u7ed3\u679c\u663e\u793aYWHAE\u9ad8\u3001\u4f4e\u8868\u8fbe\u7ec4\u95f4\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e9a\u578b\u5b58\u5728\u4e0d\u540c\u6bd4\u4f8b\uff0c\u8868\u660e\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u7684\u7ec4\u6210\u5b58\u5728\u5dee\u5f02\uff08\u56fe7C\uff09\u3002\u6b64\u5916\uff0c\u91c7\u7528\u4e86ESTIMATE\u7b97\u6cd5\u6765\u8bc4\u4f30\u80bf\u7624\u5fae\u73af\u5883\u8bc4\u5206\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u9ad8\u8868\u8fbe\u7ec4\u76f8\u6bd4\uff0c\u4f4e\u8868\u8fbe\u7ec4\u7684\u57fa\u8d28\u548cESTIMATE\u5f97\u5206\u660e\u663e\u66f4\u9ad8\uff0c\u800c\u4f4e\u8868\u8fbe\u7ec4\u7684\u80bf\u7624\u7eaf\u5ea6\u8f83\u4f4e\uff08\u56fe7D\uff09\u3002\u8fdb\u4e00\u6b65\u8bc4\u4f30\u9ad8\u3001\u4f4e\u8868\u8fbe\u7ec4\u7684 TIDE \u8bc4\u5206\u3001\u529f\u80fd\u969c\u788d\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u548c\u6392\u5f02\u6027\uff0c\u53d1\u73b0\u4e24\u7ec4\u5728 MSI \u548c\u529f\u80fd\u969c\u788d\u65b9\u9762\u5b58\u5728\u5dee\u5f02\uff08\u56fe 7E\uff09\u3002\u6700\u540e\uff0c\u6bd4\u8f83\u9ad8\u3001\u4f4e\u8868\u8fbe\u7ec4\u95f4\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5dee\u5f02\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u9ad8\u8868\u8fbe\u7ec4\u7684 CR\/PR\uff08\u5b8c\u5168\u5e94\u7b54\/\u90e8\u5206\u5e94\u7b54\uff09\u6bd4\u4f8b\u9ad8\u4e8e\u4f4e\u8868\u8fbe\u7ec4\uff08\u56fe7I\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"628\" height=\"498\" class=\"wp-image-22724\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-13.png?resize=628%2C498\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-13.png?w=628 628w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-13.png?resize=300%2C238 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-13.png?resize=600%2C476 600w\" sizes=\"(max-width: 628px) 100vw, 628px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"328\" class=\"wp-image-22725\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-14.png?resize=640%2C328\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-14.png?w=1067 1067w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-14.png?resize=300%2C154 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-14.png?resize=1024%2C525 1024w, 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\u514d\u75ab\u6d78\u6da6\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5206\u6790<\/p>\n<p><strong>7. \u673a\u5668\u5b66\u4e60\u5efa\u7acbYWHAE\u76f8\u5173\u9884\u540e\u6a21\u578b<\/strong><\/p>\n<p>\u901a\u8fc7Spearman\u76f8\u5173\u6027\u5206\u6790\uff0c\u5171\u53d1\u73b0 557 \u4e2a\u57fa\u56e0\u4e0e STAD \u4e2d\u7684 YWHAE \u5448\u6b63\u76f8\u5173\uff0c\u5176\u4e2d\u5305\u542b31 \u4e2a\u4e0e\u9884\u540e\u76f8\u5173\u7684\u57fa\u56e0\u3002\u968f\u540e\u4ee5TCGA-STAD\u4e3a\u8bad\u7ec3\u96c6\uff0c\u4ee5GSE62254\u7b49\u4e3a\u9a8c\u8bc1\u96c6\uff0c\u5e94\u752810\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u548c101\u79cd\u6574\u5408\u7ec4\u5408\uff08\u5305\u62ec\u5f39\u6027\u7f51\u7edc\uff08Enet\uff09\u3001Lasso\u3001\u968f\u673a\u751f\u5b58\u68ee\u6797\u7b49\uff09\u5efa\u7acb\u4e86\u9884\u540e\u6a21\u578b\u3002\u6839\u636e\u8bc4\u4ef7\u6307\u6807 C-index\uff0c\u4f5c\u8005\u9009\u62e9 Enet[0.2] \u4f5c\u4e3a\u6700\u7ec8\u7b97\u6cd5\uff08\u56fe 8A\uff09\uff0c\u5e76\u5229\u7528 Enet[0.2] 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src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?resize=640%2C215\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?w=1253 1253w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?resize=300%2C101 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?resize=1024%2C344 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?resize=768%2C258 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22711-19.png?resize=600%2C202 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe9 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