{"id":22754,"date":"2023-12-29T17:29:36","date_gmt":"2023-12-29T09:29:36","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22754"},"modified":"2023-12-29T17:29:38","modified_gmt":"2023-12-29T09:29:38","slug":"%e4%bb%8e9%e5%88%86%e9%99%8d%e5%88%b06%e5%88%86%ef%bc%9f%e6%9c%9f%e5%88%8a%e5%bd%b1%e5%93%8d%e5%9b%a0%e5%ad%90%e7%bc%a9%e6%b0%b4%ef%bc%8c%e4%bd%86%e6%96%b0%e5%88%86%e6%9e%90%e6%80%9d%e8%b7%af%e4%bb%8d","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22754","title":{"rendered":"\u4ece9\u5206\u964d\u52306\u5206\uff1f\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u7f29\u6c34\uff0c\u4f46\u65b0\u5206\u6790\u601d\u8def\u4ecd\u7136\u503c\u5f97\u501f\u9274\uff01Q1\u533a\u7eaf\u751f\u4fe1\uff0c\u8d85\u65b0\u65b9\u5411\u7b49\u4f60\u4e0a\u8f66\uff01"},"content":{"rendered":"<p>\u8981\u8bf4\u6700\u8fd1\u79d1\u7814\u754c\u7684\u5927\u4e8b\u4ef6\uff0c\u7edd\u5bf9\u662f\u5f71\u54cd\u56e0\u5b50\u7684\u53d1\u5e03\uff01<\/p>\n<p>\u4ed4\u7ec6\u770b\u4e0d\u96be\u53d1\u73b0\u5f71\u54cd\u56e0\u5b50\u53d8\u6210\u4e86\u5c0f\u6570\u70b9\u540e1\u4f4d\uff0c\u800c\u4e14\u201c\u56db\u5927\u533b\u5b66\u671f\u520a\u4e2d3\u672cNEJM\u3001The Lancet\u3001JAMA\u90fd\u96c6\u4f53\u4e0b\u8dcc\uff0cBMJ\u7565\u6709\u4e0a\u6da8\u3002CNS\u671f\u520a\u7684 IF\u4e5f\u5168\u90e8\u4e0b\u8dcc\uff0cNature 64.8\u3001Cell 64.5\u3001Science 56.9\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"122\" class=\"wp-image-22759\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-1.png?resize=640%2C122\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-1.png?w=806 806w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-1.png?resize=300%2C57 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-1.png?resize=768%2C147 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-1.png?resize=600%2C115 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u5f53\u7136\u5c0f\u4e91\u8fd8\u662f\u6bd4\u8f83\u5173\u6ce8\u751f\u4fe1\u53cb\u597d\u671f\u520a\u7684\u5f71\u54cd\u56e0\u5b50\uff0c\u679c\u7136\u4e0d\u51fa\u6240\u6599\uff0c\u4e5f\u662f\u5448\u73b0\u5f71\u54cd\u56e0\u5b50\u666e\u904d\u4e0b\u964d\u7684\u60c5\u51b5\u3002<\/p>\n<p>\u5c31\u62ff\u4eca\u5929\u8981\u5206\u4eab\u7684\u8fd9\u7bc7\u6587\u7ae0\u6765\u8bf4\uff0c\u5728pubmed\u53d1\u73b0\u5b83\u7684\u65f6\u5019\uff0c\u6742\u5fd7\u5f71\u54cd\u56e0\u5b50\u8fd8\u57289.029\uff0c\u7ed3\u679c\u73b0\u5728\u5c31\u5df2\u7ecf\u964d\u4e3a6.6\u4e86\u2026<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"421\" height=\"412\" class=\"wp-image-22760\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-2.png?resize=421%2C412\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-2.png?w=421 421w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-2.png?resize=300%2C294 300w\" sizes=\"(max-width: 421px) 100vw, 421px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4e0d\u8fc7\u8fd9\u5e76\u4e0d\u80fd\u963b\u6b62\u5c0f\u4e91\u8981\u5206\u4eab\u5b83\u7684\u51b3\u5fc3\uff01\uff01\u6bd5\u7adf\u662f\u4e2a\u751f\u4fe1\u5206\u6790\u7684\u65b0\u601d\u8def\uff0c\u4e0d\u5206\u4eab\u7740\u5b9e\u53ef\u60dc~<\/p>\n<p><strong>\uff08\u4e0d\u77e5\u9053\u5982\u4f55\u627e\u65b0\u601d\u8def\u6216\u521b\u65b0\u5347\u7ea7\u7684\u53ef\u4ee5\u627e\u5c0f\u4e91\uff0c\u5404\u79cd\u4e2a\u6027\u5316\u5206\u6790\u601d\u8def\u7b49\u4f60\u6765\u6311~\uff09<\/strong><\/p>\n<p>\u63a5\u4e0b\u6765\u8ba9\u6211\u4eec\u6574\u7406\u4e00\u4e0b\u5fc3\u60c5\uff0c\u770b\u4e00\u4e0b\u57fa\u4e8e\u201c\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u57fa\u56e0\u201d\u8fdb\u884c\u5206\u6790\u7684\u7eaf\u751f\u4fe1\u601d\u8def\uff01\u4e00\u8d77\u6765\u5b66\u4e60\u4e00\u4e0b\u5427~<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"201\" class=\"wp-image-22761\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?resize=640%2C201\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?w=1092 1092w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?resize=300%2C94 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?resize=1024%2C322 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?resize=768%2C241 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-3.png?resize=600%2C188 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u9898\u76ee\uff1a\u4e0e\u514d\u75ab\u5fae\u73af\u5883\u548c\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u7684\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u7279\u5f81\u901a\u8fc7\u6574\u5408\u673a\u5668\u5b66\u4e60\u548c\u5355\u7ec6\u80de\u5206\u6790\u6765\u9884\u6d4b\u9884\u540e\u5e76\u63d0\u9ad8\u809d\u764c\u7684\u8bca\u65ad<\/p>\n<p>\u6742\u5fd7\uff1aHepatology international<\/p>\n<p>\u5f71\u54cd\u56e0\u5b50\uff1a6.6<\/p>\n<p>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e745\u6708<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22762\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-20.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><strong>\u6570\u636e\u4fe1\u606f<\/strong> <img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22763\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-21.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td>\u6570\u636e\u96c6\/\u961f\u5217<\/td>\n<td>\u6570\u636e\u5e93<\/td>\n<td>\u6570\u636e\u7c7b\u578b<\/td>\n<td>\u6837\u672c\u4fe1\u606f<\/td>\n<\/tr>\n<tr>\n<td>TCGA-\u809d\u764c\uff08HCC\uff09<\/td>\n<td>TCGA<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>374\u4e2aHCC\u80bf\u7624\u7ec4\u7ec7\u548c50\u4e2a\u76f8\u90bb\u7684\u914d\u5bf9\u975e\u80bf\u7624\u7ec4\u7ec7<\/td>\n<\/tr>\n<tr>\n<td>ICGC-LIRI<\/td>\n<td>ICGC<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>HCC\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>GSE89377<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>\u5305\u62ec13\u4e2a\u76f8\u90bb\u914d\u5bf9\u7684\u6b63\u5e38\u7ec4\u7ec7\u300120\u4e2a\u809d\u708e\u7ec4\u7ec7\u300112\u4e2a\u809d\u786c\u5316\u6837\u672c\u300122\u4e2a\u589e\u751f\u6837\u672c\u300114\u4e2aT1\u671fHCC\u6837\u672c\u300126\u4e2aT2\/T3\u671fHCC\u6837\u672c<\/td>\n<\/tr>\n<tr>\n<td>GSE149614<\/td>\n<td>GEO<\/td>\n<td>scRNA-seq\u6570\u636e<\/td>\n<td>10\u4f8bHCC\u539f\u53d1\u80bf\u7624\u548c8\u4f8b\u975e\u80bf\u7624\u7ec4\u7ec7\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e<\/td>\n<\/tr>\n<tr>\n<td>\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u57fa\u56e0(CARGs)<\/td>\n<td>GO\u548cKEGG\u6570\u636e\u5e93<\/td>\n<td>\u57fa\u56e0\u96c6<\/td>\n<td>653\u4e2a\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u57fa\u56e0(CARGs)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22764\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-22.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><strong>\u7814\u7a76\u601d\u8def<\/strong> <img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22765\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-23.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><\/p>\n<p><a id=\"post-22754-OLE_LINK2\"><\/a> \u4e2d\u5fc3\u4f53\u6269\u589e\u662f\u591a\u79cd\u6076\u6027\u80bf\u7624\u53d1\u751f\u548c\u53d1\u5c55\u7684\u4e00\u4e2a\u81f4\u764c\u9a71\u52a8\u56e0\u7d20\uff0c\u5e76\u4e0e\u80bf\u7624\u7684\u4fb5\u88ad\u6027\u3001\u8f6c\u79fb\u548c\u4e0d\u826f\u9884\u540e\u6709\u5173\u3002\u672c\u7814\u7a76\u57fa\u4e8eTCGA\u6570\u636e\u96c6\uff0c\u4f7f\u7528LASSO Cox\u56de\u5f52\u7b97\u6cd5\u8fdb\u884c\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u7279\u5f81\u7684\u6784\u5efa\uff0c\u83b7\u53d6ICGC\u6570\u636e\u96c6\u8fdb\u884c\u9a8c\u8bc1\u3002\u5bf9GSE149614\u7684\u5355\u7ec6\u80de\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u4ee5\u4e86\u89e3\u57fa\u56e0\u8868\u8fbe\u548c\u809d\u810f\u80bf\u7624\u4e2d\u7684\u5b9a\u4f4d\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22766\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-24.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><strong>\u4e3b\u8981\u7814\u7a76\u7ed3\u679c<\/strong> <img decoding=\"async\" loading=\"lazy\" width=\"50\" height=\"44\" class=\"wp-image-22767\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/unnamed-file-25.png?resize=50%2C44\" alt=\"\u56fe\u7247\" data-recalc-dims=\"1\" \/><\/p>\n<ol>\n<li><strong>HCC\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u9884\u540e\u57fa\u56e0\u7279\u5f81\u7684\u6784\u5efa\u548c\u9a8c\u8bc1<\/strong><\/li>\n<\/ol>\n<p>\u9996\u5148\u5206\u6790TCGA\u6570\u636e\u5e93\u4e2dHCC\u80bf\u7624\u7ec4\u7ec7\u548c\u76f8\u90bb\u914d\u5bf9\u975e\u80bf\u7624\u7ec4\u7ec7\u4e4b\u95f4\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0(DEGs)\uff0c\u5bf9\u4e0a\u8c03\u7684DEGs\u8fdb\u884cGO\u5bcc\u96c6\u5206\u6790\uff0c\u53d1\u73b0\u8fd9\u4e9bDEGs\u5927\u91cf\u4f4d\u4e8e\u4e2d\u5fc3\u7c92\uff0c\u5e76\u6620\u5c04\u5230\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u7684\u9014\u5f84\uff0c\u5305\u62ec\u4e2d\u5fc3\u4f53\u590d\u5236\u3001\u4e2d\u5fc3\u4f53\u5faa\u73af\u3001\u4e2d\u5fc3\u4f53\u5206\u79bb\u548c\u5fae\u7ba1\u6210\u6838(\u56fe1b)\uff0c\u8868\u660e\u4e2d\u5fc3\u4f53\u6269\u589e\u5728HCC\u7684\u764c\u53d8\u548c\u53d1\u5c55\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p>\u901a\u8fc7\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u7b5b\u9009\u9884\u540e\u76f8\u5173\u57fa\u56e0(PRGs)\u3002\u7136\u540e\uff0c\u6211\u4eec\u5bf9\u8fd9\u4e9b\u4e0a\u8c03\u7684deg\u8fdb\u884c\u4e86\u57fa\u56e0\u672c\u4f53(GO)\u5bcc\u96c6\u5206\u6790\uff0c\u4ee5\u4e86\u89e3\u4e0eHCC\u53d1\u5c55\u76f8\u5173\u7684\u6f5c\u5728\u5206\u5b50\u673a\u5236\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8fd9\u4e9b\u4e0a\u8c03\u7684deg\u5927\u91cf\u4f4d\u4e8e\u4e2d\u5fc3\u7c92\uff0c\u5e76\u6620\u5c04\u5230\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u7684\u9014\u5f84\uff0c\u5305\u62ec\u4e2d\u5fc3\u4f53\u590d\u5236\u3001\u4e2d\u5fc3\u4f53\u5faa\u73af\u3001\u4e2d\u5fc3\u4f53\u5206\u79bb\u3001\u5fae\u7ba1\u7ec4\u7ec7\u4e2d\u5fc3\u7ec4\u7ec7\u548c\u5fae\u7ba1\u6210\u6838(\u56fe1b)\uff0c\u8868\u660e\u4e2d\u5fc3\u4f53\u6269\u589e\u5728HCC\u7684\u764c\u53d8\u548c\u53d1\u5c55\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p>\u63a5\u4e0b\u6765\u4eceGO\u548cKEGG\u57fa\u56e0\u96c6\u4e2d\u6536\u96c6\u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u57fa\u56e0(CARGs)\u3002\u7136\u540e\uff0c\u5229\u7528Venn\u56fe\u5bf9653\u4e2aCARGs\u30017847\u4e2a\u4e0a\u8c03DEGs\u548c4770\u4e2aPRGs\u8fdb\u884c\u53ef\u89c6\u5316\u53d6\u4ea4\u96c6\uff0c\u7b5b\u9009\u51fa134\u4e2aCARGs(\u56fe1c)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"393\" class=\"wp-image-22768\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-10.png?resize=640%2C393\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-10.png?w=882 882w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-10.png?resize=300%2C184 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-10.png?resize=768%2C472 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-10.png?resize=600%2C369 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"471\" class=\"wp-image-22769\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-11.png?resize=640%2C471\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-11.png?w=913 913w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-11.png?resize=300%2C221 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-11.png?resize=768%2C565 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-11.png?resize=600%2C442 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1. \u4e2d\u5fc3\u4f53\u6269\u589e\u53ef\u80fd\u4fc3\u8fdb\u809d\u764c\u7684\u53d1\u751f\u53d1\u5c55<\/p>\n<p>\u5c06\u8fd9134\u4e2aCARGs\u7eb3\u5165LASSO Cox\u56de\u5f52\u5206\u6790\uff0c\u6700\u7ec8\u5efa\u7acb6\u4e2a\u57fa\u56e0\u7684\u9884\u540e\u7279\u5f81\u3002\u57fa\u4e8e\u8fd96\u4e2a\u57fa\u56e0\u8ba1\u7b97\u9884\u540e\u98ce\u9669\u8bc4\u5206\uff0c\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u98ce\u9669\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\u3002\u6563\u70b9\u56fe\u663e\u793a\uff0c\u4e2a\u4f53\u5f97\u5206\u8d8a\u9ad8\uff0c\u603b\u4f53\u751f\u5b58\u7ed3\u5c40(OS)\u8d8a\u5dee(\u56fe2d)\u3002\u540c\u6837\uff0cKaplan-Meier\u66f2\u7ebf\u548clog-rank\u68c0\u9a8c\u4e5f\u8868\u660e\uff0c\u9ad8\u98ce\u9669\u7ec4\u60a3\u8005\u7684OS\u660e\u663e\u5dee\u4e8e\u4f4e\u98ce\u9669\u7ec4(\u56fe2 e)\u3002\u7136\u540e\uff0c\u91c7\u7528\u65f6\u95f4\u4f9d\u8d56\u7684\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81(ROC)\u66f2\u7ebf\u6765\u8bc4\u4f30\u9884\u540e\u57fa\u56e0\u6807\u8bb0\u7684\u6027\u80fd\u548c\u6548\u7387\uff0c\u8868\u660e\u8be5\u9884\u540e\u6807\u8bb0\u5728\u9884\u6d4bOS\u65b9\u9762\u5177\u6709\u5f88\u9ad8\u7684\u654f\u611f\u6027\u548c\u7279\u5f02\u6027(\u56fe2f)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"257\" class=\"wp-image-22770\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=640%2C257\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?w=1546 1546w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=300%2C120 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=1024%2C411 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=768%2C308 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=1536%2C616 1536w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?resize=600%2C241 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-12.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"583\" class=\"wp-image-22771\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-13.png?resize=640%2C583\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-13.png?w=668 668w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-13.png?resize=300%2C274 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-13.png?resize=600%2C547 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2. \u4e2d\u5fc3\u4f53\u6269\u589e\u76f8\u5173\u57fa\u56e0(CARGs)\u6807\u8bb0\u7684\u5efa\u7acb\u548c\u9a8c\u8bc1<\/p>\n<ol>\n<li><strong>CARGs\u7684\u529f\u80fd\u5206\u6790<\/strong><\/li>\n<\/ol>\n<p>\u4f5c\u8005\u4f7f\u7528GSVA\u8fdb\u884c\u4e86\u529f\u80fd\u6ce8\u91ca\u3002GSVA-KEGG\u7ed3\u679c\u663e\u793a\u4e0e\u7ec6\u80de\u5468\u671f\u548cDNA\u4fee\u590d\u76f8\u5173\u7684\u9014\u5f84\uff08\u5982DNA\u590d\u5236\u3001\u540c\u6e90\u91cd\u7ec4\u3001\u9519\u914d\u4fee\u590d\u7b49\uff09\u5728\u9ad8\u98ce\u9669\u7ec4\u4e2d\u663e\u8457\u5bcc\u96c6 (\u56fe3a)\u3002\u6b64\u5916\uff0cGSVA-HALLMARK\u5bcc\u96c6\u5206\u6790\u663e\u793a\u7ec6\u80de\u5468\u671f\u76f8\u5173\u901a\u8def\u7684\u663e\u8457\u5bcc\u96c6\uff0c\u610f\u5473\u7740\u9ad8\u98ce\u9669\u7ec4\u7684\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\u589e\u5f3a(\u56fe5b)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u5982PI3K\/AKT\/mTOR\u3001mTORC1\u3001Wnt\/\u03b2-catenin\u548cTGF-\u03b2\u4fe1\u53f7\u5728\u9ad8\u98ce\u9669\u7ec4\u6bd4\u4f4e\u98ce\u9669\u7ec4\u66f4\u6d3b\u8dc3(\u56fe3b)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"389\" class=\"wp-image-22772\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?resize=640%2C389\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?w=1076 1076w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?resize=300%2C182 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?resize=1024%2C622 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?resize=768%2C467 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-14.png?resize=600%2C365 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"463\" class=\"wp-image-22773\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-15.png?resize=640%2C463\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-15.png?w=859 859w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-15.png?resize=300%2C217 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-15.png?resize=768%2C556 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-15.png?resize=600%2C434 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3. CARGs\u7279\u5f81\u7684\u529f\u80fd\u5bcc\u96c6<\/p>\n<ol>\n<li><strong>C<\/strong><a id=\"post-22754-OLE_LINK3\"><\/a><strong>ARGs\u7279\u5f81\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u7684\u76f8\u5173\u6027\u5206\u6790<\/strong><\/li>\n<\/ol>\n<p>\u56e0\u4e3a\u4e4b\u524d\u7684\u7814\u7a76\u53d1\u73b0\u4f4d\u4e8e\u4e2d\u5fc3\u4f53\u6269\u589e\u5c42\u7ea7\u9876\u7aef\u7684\u86cb\u767dCEP192\u4e0e\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\u5bc6\u5207\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u63a5\u4e0b\u6765\u57fa\u4e8eESTIMATE\u548cssGSEA\u7b97\u6cd5\uff0c\u63a2\u8ba8\u4e86CARGs\u7279\u5f81\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u9996\u5148\uff0cESTIMATE\u5206\u6790\u663e\u793a\uff0c\u9ad8\u98ce\u9669\u7ec4\u80bf\u7624\u7eaf\u5ea6\u9ad8\u4e8e\u4f4e\u98ce\u9669\u7ec4(\u56fe4a)\uff0c\u800c\u57fa\u8d28\u8bc4\u5206\u4e0eESTIMATE\u8bc4\u5206\u76f8\u53cd(\u56fe4b\u3001c)\u3002\u9ad8\u98ce\u9669\u7ec4\u514d\u75ab\u8bc4\u5206\u867d\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u5448\u4e0b\u964d\u8d8b\u52bf(\u56fe4d)\u3002\u6b64\u5916\uff0cssGSEA\u5206\u6790\u663e\u793a\uff0c\u591a\u79cd\u6297\u81f4\u7624\u6027\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u7684\u6bd4\u4f8b\u5728\u9ad8\u98ce\u9669\u7ec4\u4e2d\u663e\u8457\u964d\u4f4e(\u56fe4e)\u3002\u76f8\u53cd\uff0c\u514d\u75ab\u6291\u5236\u6027Th2\u548c\u603bCD4+ T\u7ec6\u80de\u5728\u9ad8\u98ce\u9669\u7ec4\u5927\u91cf\u5bcc\u96c6(\u56fe4e)\u3002\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u8868\u660e\uff0c\u9ad8\u98ce\u9669\u7ec4\u7684\u80bf\u7624\u53ef\u80fd\u5f62\u6210\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\uff0c\u635f\u5bb3\u6297\u80bf\u7624\u514d\u75ab\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002<\/p>\n<p><strong>\uff08ps\uff1a\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u5206\u6790\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1a<\/strong><a href=\"http:\/\/www.biocloudservice.com\/home.html\"><strong>http:\/\/www.biocloudservice.com\/home.html<\/strong><\/a><strong> \uff09<\/strong>\u3002<\/p>\n<p>\u8fdb\u4e00\u6b65\u91c7\u7528TIDE\u5de5\u5177\u6765\u8bc4\u4f30\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad(ICB)\u5728\u4e0d\u540c\u5371\u9669\u4eba\u7fa4\u4e2d\u7684\u6f5c\u5728\u4e34\u5e8a\u7597\u6548\u3002\u5982\u56fe4f\u6240\u793a\uff0c\u9ad8\u98ce\u9669\u7ec4\u7684TIDE\u8bc4\u5206\u660e\u663e\u5347\u9ad8\uff0c\u8bf4\u660e\u9ad8\u98ce\u9669\u7ec4\u60a3\u8005\u5bf9ICB\u7684\u53cd\u5e94\u8f83\u4f4e\u98ce\u9669\u7ec4\u5dee\u3002\u540c\u65f6\u53d1\u73b0\u9ad8\u98ce\u9669\u7ec4T\u7ec6\u80de\u6392\u65a5\u548c\u514d\u75ab\u6291\u5236\u8bc4\u5206(MDSC\u3001TAM\u548cCD274)\u8f83\u9ad8(\u56fe4g-j)\uff0c\u800c\u9ad8\u98ce\u9669\u7ec4\u95f4\u8d28\u8bc4\u5206(CAF)(\u56fe4k)\u3001T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u8bc4\u5206(\u56fe6l)\u548c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027(MSI)\u8bc4\u5206(\u56fe4m)\u8f83\u4f4e\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"142\" class=\"wp-image-22774\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=640%2C142\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?w=1667 1667w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=300%2C67 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=1024%2C227 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=768%2C170 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=1536%2C341 1536w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?resize=600%2C133 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-16.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"318\" class=\"wp-image-22775\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?resize=640%2C318\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?w=1381 1381w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?resize=300%2C149 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?resize=1024%2C509 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?resize=768%2C381 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?resize=600%2C298 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-17.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"268\" class=\"wp-image-22776\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=640%2C268\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?w=1636 1636w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=300%2C126 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=1024%2C429 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=768%2C322 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=1536%2C643 1536w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?resize=600%2C251 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-18.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4. 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srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?w=2032 2032w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=257%2C300 257w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=878%2C1024 878w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=768%2C895 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=1317%2C1536 1317w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=1757%2C2048 1757w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2023\/12\/word-image-22754-21.jpeg?resize=600%2C700 600w, 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