{"id":22982,"date":"2024-01-02T17:08:42","date_gmt":"2024-01-02T09:08:42","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22982"},"modified":"2024-01-02T17:08:44","modified_gmt":"2024-01-02T09:08:44","slug":"cldn6%e5%9f%ba%e5%9b%a0%e7%9a%84%e5%8d%95%e5%9f%ba%e5%9b%a0%e5%88%86%e6%9e%90%e8%bf%98%e8%83%bd%e5%8f%91%e5%88%b07%e5%88%86%ef%bc%9f%e8%87%aa%e6%9c%89%e5%a4%a7%e9%98%9f%e5%88%97%e9%aa%8c%e8%af%81","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=22982","title":{"rendered":"CLDN6\u57fa\u56e0\u7684\u5355\u57fa\u56e0\u5206\u6790\u8fd8\u80fd\u53d1\u52307\u5206+\uff1f\u81ea\u6709\u5927\u961f\u5217\u9a8c\u8bc1\u6765\u5e2e\u5fd9\uff0c\u5e72\u6e7f\u7ed3\u5408\u7684\u6548\u679c\u4e0d\u8981\u592a\u8d5e\u54e6"},"content":{"rendered":"<p>\u80bf\u7624\u7684\u4e2a\u4f53\u6cbb\u7597\u4ee5\u53ca\u9884\u540e\u4e0d\u826f\u4e00\u76f4\u90fd\u662f\u7814\u7a76\u70ed\u70b9\uff0c\u5c0f\u4e91\u4eca\u5929\u5c31\u5728\u6700\u65b0\u53d1\u8868\u7684\u6587\u7ae0\u91cc\u6dd8\u5230\u4e86\u4e00\u4efd\u5b9d\u85cf\uff0c<strong>\uff08ps\uff1a\u6700\u8fd1\u624d\u53d1\u8868\u7684\u70ed\u4e4e\u4e4e\u7684\u6587\u7ae0\u54e6\uff0c\u5c0f\u4e91\u53ef\u662f\u7acb\u9a6c\u5c31\u60f3\u548c\u5927\u5bb6\u5206\u4eab\u4e86\uff09<\/strong>\uff0c\u4e0b\u9762\u5c0f\u4e91\u5c31\u6162\u6162\u4e3a\u5927\u5bb6\u89e3\u6790\u8fd9\u7bc77\uff0b\u7684\u6587\u7ae0\u7684\u7814\u7a76\u601d\u8def\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"640\" class=\"wp-image-22983\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?resize=640%2C640\" alt=\"5497c39d5f689fd1b71ffce957ad5f8\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?w=663 663w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?resize=600%2C600 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/5497c39d5f689fd1b71ffce957ad5f8.jpeg?resize=100%2C100 100w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u9996\u5148\u5c0f\u4e91\u53d1\u73b0\u4f5c\u8005\u7d27\u7d27\u6293\u4f4f\u4e86\u70ed\u70b9\uff0c\u9009\u62e9\u4e86\u4e00\u4e2a\u5728\u80bf\u7624\u7814\u7a76\u4e0a\u524d\u4e0d\u4e45\u624d\u88ab\u8bc1\u5b9e\u4e0e\u80bf\u7624\u589e\u6b96\u548c\u4fb5\u88ad\u6709\u5173\u7684\u57fa\u56e0\uff08CLDN6\uff09<strong>\uff08ps\uff1a\u6240\u4ee5\u5927\u5bb6\u8fd8\u662f\u9700\u8981\u65f6\u65f6\u4e86\u89e3\u65b0\u7684\u7814\u7a76\u6210\u679c\u7684\uff0c\u5982\u679c\u5927\u5bb6\u5e73\u65f6\u65f6\u95f4\u4e0d\u591f\u7684\u8bdd\uff0c\u53ef\u4ee5\u5173\u6ce8\u5c0f\u4e91\u54e6\uff0c\u5c0f\u4e91\u4f1a\u65f6\u65f6\u5206\u4eab\u4e00\u4e9b\u6700\u65b0\u53d1\u8868\u7684\u6587\u7ae0\u4f9b\u5927\u5bb6\u5b66\u4e60\u7684\uff09<\/strong>\uff0c\u7814\u7a76\u601d\u8def\u4e0a\u5462\uff0c\u5176\u5b9e\u7b97\u662f\u6bd4\u8f83\u7ecf\u5178\u7684\u5206\u6790\u601d\u8def\uff0c\u540c\u65f6\u505a\u4e86\u9884\u540e\u5206\u6790\uff0c\u4f46\u662f\u5229\u7528\u7684\u4e0d\u662f\u6570\u636e\u5e93\u7684\u6570\u636e\uff0c\u8fd9\u7bc7\u6587\u7ae0\u662f\u81ea\u6709\u5927\u961f\u5217\u5206\u6790\u8fd8\u7ed3\u5408\u4e86\u4e34\u5e8a\u7684\u6570\u636e\u3002\u6574\u4e2a\u6587\u7ae0\u867d\u7136\u9009\u62e9\u7684\u75c5\u75c7\u4e0d\u662f\u70ed\u95e8\uff0c\u4f46\u5728\u7814\u7a76\u601d\u8def\u4e0a\u5374\u505a\u51fa\u4e86\u521b\u65b0\u4e0d\u4ec5\u4ec5\u662f\u5229\u7528\u4e86\u5355\u57fa\u56e0\u7684\u5206\u6790\u66f4\u662f\u7ed3\u5408\u81ea\u6709\u5927\u961f\u5217\u9a8c\u8bc1\u4e0e\u4ee5\u53ca\u4e34\u5e8a\u7684\u6570\u636e\uff0c\u8fd9\u624d\u59a5\u59a5\u7684\u62ff\u4e0b\u4e867+\u7684\u5206\u6570\uff01<strong>\uff08ps\uff1a\u5bf9\u8fd9\u4e2a\u5206\u6790\u601d\u8def\u611f\u5174\u8da3\uff0c\u4f46\u662f\u590d\u73b0\u5206\u6790\u6709\u56f0\u96be\u7684\u7c89\u4e1d\uff0c\u53ef\u4ee5\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\uff0c\u5c0f\u4e91\u4e00\u76f4\u7b49\u5019\u60a8\u54e6\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"307\" class=\"wp-image-22984\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-2.png?resize=640%2C307\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-2.png?w=735 735w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-2.png?resize=300%2C144 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-2.png?resize=600%2C288 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u7d27\u5bc6\u8fde\u63a5\u86cb\u767dclaudin6\u662f\u98df\u7ba1\u548c\u80c3\u817a\u764c\u60a3\u8005\u4e2a\u4f53\u5316\u6cbb\u7597\u4e0e\u9884\u540e\u4e0d\u826f\u7684\u6f5c\u5728\u9776\u6807<\/li>\n<li>\u6742\u5fd7\uff1a<em>Journal of Translational Medicine.<\/em><\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.4<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e748\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u98df\u7ba1\u817a\u764c\uff08EAC\uff09\u548c\u80c3\u817a\u764c\uff08GAC\uff09\u662f\u4e0a\u6d88\u5316\u9053\u6700\u5e38\u89c1\u7684\u4e24\u79cd\u764c\u75c7\uff0cEAC\u548cGAC\u7684\u9884\u540e\u4ecd\u7136\u8f83\u5dee\uff0c\u76ee\u524d\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002Claudin 6\uff08CLDN6\uff09\u662f\u4e00\u79cd\u764c\u80ce\u6297\u539f\uff0c\u5df2\u88ab\u786e\u5b9a\u4e3a\u51e0\u79cd\u764c\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\uff0c\u4e14\u5728GAC\u4e2d\uff0c\u6709\u7814\u7a76\u9996\u6b21\u8868\u660e\uff0cCLDN6\u7684\u8868\u8fbe\u4e0e\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u548c\u4fb5\u88ad\u6027\u589e\u52a0\u6709\u5173\uff0c\u8fd9\u4f7fCLDN6\u6210\u4e3a\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u9776\u70b9\u3002\u56e0\u6b64\uff0c\u7814\u7a76CLDN6\u5728GAC\u548cEAC\u4e2d\u80bf\u7624\u53d1\u751f\u7684\u751f\u7269\u5b66\u529f\u80fd\u548c\u9884\u540e\u5f71\u54cd\u5341\u5206\u91cd\u8981\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<p>\u88681 TCGA EAC\u548cGAC\u60a3\u8005\u6570\u636e<\/p>\n<p><strong><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"545\" class=\"wp-image-22985\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?resize=640%2C545\" alt=\"3a2714c17881da2c2be2a114d5d0ffd\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?w=1349 1349w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?resize=300%2C256 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?resize=1024%2C872 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?resize=768%2C654 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?resize=600%2C511 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/3a2714c17881da2c2be2a114d5d0ffd.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/strong><\/p>\n<p>\u88682 EAC\u548cGAC\u514d\u75ab\u7ec4\u5316\u5b66\u60a3\u8005\u6570\u636e<\/p>\n<p><strong><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"1612\" class=\"wp-image-22986\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=640%2C1612\" alt=\"155efd8061b2439ad1aef64056490af\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?w=924 924w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=119%2C300 119w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=406%2C1024 406w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=768%2C1935 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=610%2C1536 610w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=813%2C2048 813w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/155efd8061b2439ad1aef64056490af.png?resize=600%2C1512 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/strong><\/p>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u4ece89\u4f8bEAC\u548c371\u4f8bGAC\u7684RNA-Seq\u6570\u636e\u4e2d\u83b7\u5f97\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff0c\u5e76\u4e14\u57fa\u4e8e\u751f\u5b58\u5206\u6790\u901a\u8fc7CLDN6 mRNA\u8868\u8fbe\u5bf9EAC \/ GAC\u75c5\u4f8b\u8fdb\u884c\u5206\u6790\u3002\u5bf9\u4e8eCLDN6\u8868\u8fbe\u9ad8\u4e8e\u6216\u4f4e\u4e8e\u6b64\u4e34\u754c\u503c\u7684\u7ec4\uff0c\u4f7f\u7528DESeq\u8fdb\u884c\u5dee\u5f02\u57fa\u56e0\u8868\u8fbe\u5206\u6790\uff0c\u5e76\u4f7f\u7528Enrichr\u5de5\u5177\u9274\u5b9a\u5931\u8c03\u7684\u751f\u7269\u901a\u8def\u3002\u6b64\u5916\uff0c\u4f7f\u7528CLDN6\u7279\u5f02\u6027\u514d\u75ab\u7ec4\u5316\u6297\u4f53\uff08\u514b\u968658-4B-2\uff09\u9274\u5b9a\u4e86800\u591a\u4f8bEAC\u548c\u8fd1600\u4f8bGAC\u4e2d\u7684CLDN6\u86cb\u767d\u8868\u8fbe\uff0c\u4ee5\u9274\u5b9aCLDN6\u9633\u6027\u80bf\u7624\u60a3\u8005\u3002<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. EAC\u548cGAC\u4e2dCLDN6 mRNA\u7684\u9884\u540e\u5206\u6790<\/strong><\/p>\n<p>EAC\u548cGAC TCGA\u961f\u5217\u6839\u636eCLDN6 mRNA\u8868\u8fbe\u7684\u9ad8\u4f4e\uff08TPM\uff0cRSEM\u6807\u51c6\u5316\uff09\u8fdb\u884c\u5206\u7ec4\u6bd4\u8f83\u4e24\u7ec4\u4e4b\u95f4\u7684\u603bOS\u3002\u5f53\u6839\u636eCLDN6\u8868\u8fbe\u4e2d\u503c\u5bf9EAC\u548cGAC\u961f\u5217\u8fdb\u884c\u5206\u7ec4\u65f6\uff0c\u672a\u68c0\u6d4b\u5230OS\u7684\u663e\u7740\u5dee\u5f02\uff08\u56fe1C\uff09\u3002\u4f46\u5bf9\u4e8eEAC\uff0c\u5229\u7528Cutoff Finder\u5de5\u5177\u786e\u5b9a\u4e86CLDN6 mRNA\u8868\u8fbe\u4e0eOS\u76f8\u5173\u7684\u6700\u4f73\u4e34\u754c\u503c\uff08TPM=113.5\uff09\u3002\u6309\u6b64\u503c\u7ec6\u5206\uff0cCLDN6\u8868\u8fbe\u9ad8\u4e8e\u4e34\u754c\u503c\u7684\u60a3\u8005\uff08n=14\uff09\u7684OS\u660e\u663e\u77ed\u4e8eCLDN6 \u8868\u8fbe\u4f4e\u4e8e\u4e34\u754c\u503c\u7684\u60a3\u8005\uff08n= 75\uff09\uff08\u56fe1B\uff09\u3002<\/p>\n<p>\u5728EAC\u7684TCGA\u961f\u5217\u4e2d\uff0c\u9ad8\u6c34\u5e73\u7684CLDN6\u5728\u5355\u53d8\u91cf\u5206\u6790\u4e2d\u662f\u4e00\u4e2a\u4e0d\u5229\u7684\u9884\u540e\u56e0\u7d20\uff0c\u4f46\u5728\u591a\u53d8\u91cf\u5206\u6790\u4e2d\u4e0d\u662f\uff08\u88683\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"596\" class=\"wp-image-22987\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?resize=640%2C596\" alt=\"e44b9def1f8fe65d0aa14c380d102fb\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?w=1241 1241w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?resize=300%2C279 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?resize=1024%2C954 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?resize=768%2C715 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/e44b9def1f8fe65d0aa14c380d102fb.png?resize=600%2C559 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 EAC\u548cGAC\u4e2dCLDN6 \u7684\u9884\u540e\u5206\u6790<\/p>\n<p>\u88683 EAC\u548cGAC\u4e2dCLDN6 mRNA\u8868\u8fbe\u7684\u591a\u53d8\u91cf\u5206\u6790<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"115\" class=\"wp-image-22988\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-6.png?resize=640%2C115\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-6.png?w=948 948w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-6.png?resize=300%2C54 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-6.png?resize=768%2C138 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/word-image-22982-6.png?resize=600%2C108 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>2. CLDN6 mRNA\u8868\u8fbe\u9ad8\u548c\u4f4e\u7684EAC\u548cGAC\u75c5\u4f8b\u5dee\u5f02\u57fa\u56e0\u7684\u5bcc\u96c6\u5206\u6790<\/strong><\/p>\n<p>\u5229\u7528DESeq\u5bf9CLDN6\u8868\u8fbe\u9ad8\u4e8e\u6216\u4f4e\u4e8e\u6700\u4f73\u4e34\u754c\u503c\u7684EAC\u548cGAC\u4e9a\u7ec4\u8fdb\u884c\u5dee\u5f02\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u3002\u5229\u7528Enrichr\u5e73\u53f0\u5c06CLDN6\u9ad8\u8868\u8fbe\u6216\u4f4e\u7684EAC\u548cGAC\u4e9a\u7ec4\u7684\u5dee\u5f02\u57fa\u56e0\u8fdb\u884c\u5bcc\u96c6\u5206\u6790\uff08\u56fe2\u548c\u56fe3\uff09\u3002\u53d1\u73b0GAC\u548cEAC\u4e00\u6837\uff0cCLDN6\u6c34\u5e73\u8f83\u9ad8\u7684\u7ec4\u4e2dAFP\u548cERBB2\uff08Her2\uff09\u5747\u53d1\u751f\u4e86\u4e0a\u8c03\u3002CLDN6\u6c34\u5e73\u8f83\u4f4e\u7684\u7ec4\u4e2d\uff0c\u5dee\u5f02\u57fa\u56e0\u4e3b\u8981\u5728\u5206\u6ccc\u901a\u8def\u4ee5\u53ca\u86cb\u767d\u8d28\u4ee3\u8c22\u901a\u8def\u4e2d\u4e0b\u8c03\uff0c\u4ee5\u53ca\u5728\u8c03\u8282\u8102\u80aa\u4ee3\u8c22\u7684\u57fa\u56e0\u548c\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u6fc0\u6d3b\u53d7\u4f53\u901a\u8def\u4e2d\u4e0b\u8c03\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"792\" class=\"wp-image-22989\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=640%2C792\" alt=\"ee32d08caa055361f61254a915c5945\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?w=1394 1394w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=242%2C300 242w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=828%2C1024 828w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=768%2C950 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=1241%2C1536 1241w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/ee32d08caa055361f61254a915c5945.png?resize=600%2C742 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 EAC\u751f\u4fe1\u5206\u6790<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"787\" class=\"wp-image-22990\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=640%2C787\" alt=\"47e78cd2ffc3eb0f4aecbac20e0574c\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?w=1385 1385w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=244%2C300 244w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=832%2C1024 832w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=768%2C945 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=1248%2C1536 1248w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/47e78cd2ffc3eb0f4aecbac20e0574c.png?resize=600%2C738 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 GAC\u751f\u4fe1\u5206\u6790<\/p>\n<p><strong>3. \u514d\u75ab\u7ec4\u5316<\/strong><\/p>\n<p>\u5bf9EAC\u548cGAC\u6837\u54c1\u8fdb\u884cCLDN6\u86cb\u767d\u8868\u8fbe\u7684\u514d\u75ab\u7ec4\u5316\u7684\u67d3\u8272\uff0c\u5927\u591a\u6570 EAC \u548c GAC\u6837\u54c1\u5bf9CLDN6\u5448\u9634\u6027\uff0c\u53ea\u670967\u4f8bEAC\u6807\u672c\uff088.3%\uff09\u548c18\u4f8bGAC\u6807\u672c\uff083.0%\uff09\u663e\u793a\u6709CLDN6\u8868\u8fbe\uff08\u56fe4\uff0c\u88685\uff09\u3002<\/p>\n<p>\u5728\u6240\u6709EAC\u4ee5\u53caGAC\u7684\u5206\u6790\u4e2d\uff0c\u65e0\u8bba\u662f\u6cbb\u7597\u524d\u6216\u662f\u6cbb\u7597\u540e\uff0c\u4f5c\u8005\u53d1\u73b0CLDN6\u7684\u8868\u8fbe\u4e0e\u60a3\u8005\u7684\u5e74\u9f84\u548c\u6027\u522b\u65e0\u5173\uff0c\u4e14CLDN6\u8868\u8fbe\u4e0e\u80bf\u7624\u5206\u671f\uff08pT\uff09\u3001\u6dcb\u5df4\u7ed3\u5206\u671f\uff08pN\uff09\u3001\u6dcb\u5df4\u7ba1\u3001\u8840\u7ba1\u548c\u795e\u7ecf\u5468\u56f4\u4fb5\u72af\u6216\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u5e94\u7528\u4e4b\u95f4\u4e0d\u5b58\u5728\u4efb\u4f55\u76f8\u4e92\u4f9d\u5b58\u5173\u7cfb\u3002\u5728 Her2\u72b6\u6001\uff08ERBB\uff09\u4e0eCLDN6 \u8868\u8fbe\u4e4b\u95f4\u672a\u89c2\u5bdf\u5230\u76f8\u5173\u6027\u3002<\/p>\n<p><strong>\uff08ps\uff1a\u8fd9\u91cc\u4f5c\u8005\u52a0\u5165\u4e86\u4e34\u5e8a\u4e0a\u7684\u6570\u636e\uff0c\u7b97\u662f\u4e00\u4e2a\u4e0d\u9519\u7684\u521b\u65b0\u70b9\u4e86\u3002\uff09<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"428\" class=\"wp-image-22991\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?resize=640%2C428\" alt=\"32eb0ce2a8f1a864e414907492a2784\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?w=1122 1122w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?resize=300%2C201 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?resize=1024%2C684 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?resize=768%2C513 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/32eb0ce2a8f1a864e414907492a2784.png?resize=600%2C401 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 \u514d\u75ab\u7ec4\u5316\u56fe<\/p>\n<p>\u88684 \u514d\u75ab\u7ec4\u5316\u6570\u636e\u7edf\u8ba1\u8868<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"390\" class=\"wp-image-22992\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/6f0d9a3d67f20eee3176b7c87143264.jpeg?resize=640%2C390\" alt=\"6f0d9a3d67f20eee3176b7c87143264\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/6f0d9a3d67f20eee3176b7c87143264.jpeg?w=723 723w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/6f0d9a3d67f20eee3176b7c87143264.jpeg?resize=300%2C183 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/6f0d9a3d67f20eee3176b7c87143264.jpeg?resize=600%2C366 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>4. EAC\u548cGAC\u4e2dCLDN6\u86cb\u767d\u8868\u8fbe\u7684\u9884\u540e\u5206\u6790<\/strong><\/p>\n<p>\u5728EAC\u548cGAC\u4e2d\u4f5c\u8005\u89c2\u5bdf\u5230CLDN6\u9633\u6027\u80bf\u7624\u60a3\u8005\u7684OS\u660e\u663e\u77ed\u4e8e CLDN6\u9634\u6027\u80bf\u7624\u60a3\u8005\uff08\u56fe5A\uff09\uff0c\u5728EAC\u4e2d\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u7ed3\u679c\u4e0e\u5176\u4e5f\u4e00\u81f4\uff0c\u4f46\u4e0d\u540c\u7684\u662f\u5728GAC\u4e2d\u5728\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u60a3\u8005\u7fa4\u4e2d\uff0c\u53ea\u67094\u4e2a\u80bf\u7624\u8868\u8fbeCLDN6\uff0c\u4e14\u672a\u663e\u793aOS\u7684\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08\u56fe5F\uff09\u3002\u7ecf\u8fc7\u5206\u6790\u540e\u4f5c\u8005\u5f97\u51fa\u4e86CLDN6\u7684\u8868\u8fbe\u5728\u5355\u53d8\u91cf\u5206\u6790\u548c\u591a\u53d8\u91cf\u5206\u6790\u4e2d\u4e5f\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u76f8\u5173\uff0c\u5728\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\u7684EAC\u4e9a\u7ec4\u4e2d\uff0c\u7ed3\u679c\u4e5f\u4e00\u81f4\uff0c\u4f46\u4e0eEAC\u961f\u5217\u4e0d\u540c\u7684\u662f\uff0c\u5728\u5355\u53d8\u91cf\u5206\u6790\u4e2d\uff0cCLDN6\u7684\u8868\u8fbe\u4e0e\u6cbb\u7597\u65e0\u6548\u60a3\u8005\u7684\u8f83\u5dee\u9884\u540e\u76f8\u5173\uff0c\u800c\u5728\u9884\u5904\u7406\u4e9a\u7ec4\u4e2d\uff0c\u5b83\u4e0d\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u9884\u540e\u56e0\u7d20\u3002\u5728\u591a\u53d8\u91cf\u5206\u6790\u4e2dCLDN6\u8868\u8fbe\u4e0e\u6cbb\u7597\u524d\u60a3\u8005\u961f\u5217\u7684\u4e0d\u826f\u9884\u540e\u663e\u8457\u76f8\u5173\uff08\u88686\uff09\u3002<\/p>\n<p><strong>\uff08ps\uff1a\u8fd9\u91cc\u4f5c\u8005\u6536\u96c6\u4e86\u5927\u91cf\u7684\u6570\u636e\u4f5c\u4e3a\u652f\u6491\uff0c\u5927\u5bb6\u8981\u60f3\u53d1\u9ad8\u5206\u6587\u7ae0\u5c3d\u91cf\u591a\u6536\u96c6\u6570\u636e\u54e6\u3002\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"420\" class=\"wp-image-22993\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?resize=640%2C420\" alt=\"cbd17cbac499880015966c2af364ed8\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?w=1391 1391w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?resize=300%2C197 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?resize=1024%2C671 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?resize=768%2C504 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?resize=600%2C393 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/cbd17cbac499880015966c2af364ed8.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 CLDN6\u86cb\u767d\u8868\u8fbe\u4e0eEAC\u548cGAC\u4e2d\u4f4eOS\u7684\u5173\u7cfb<\/p>\n<p>\u88685 EAC\u548cGAC\u4e2d CLDN6\u8868\u8fbe\u7684\u591a\u53d8\u91cf\u5206\u6790<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"537\" class=\"wp-image-22994\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?resize=640%2C537\" alt=\"d7552400bee46fb7031b6387221a698\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?w=1438 1438w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?resize=300%2C252 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?resize=1024%2C860 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?resize=768%2C645 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?resize=600%2C504 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/01\/d7552400bee46fb7031b6387221a698.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" 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