{"id":26885,"date":"2024-01-29T17:29:19","date_gmt":"2024-01-29T09:29:19","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=26885"},"modified":"2024-01-29T17:29:20","modified_gmt":"2024-01-29T09:29:20","slug":"%e8%8d%af%e7%89%a9%e5%88%86%e5%ad%90%e8%ae%be%e8%ae%a1part2%ef%bc%9a%e5%85%a8%e7%bd%91%e6%9c%80%e5%85%a8%e8%bf%bd%e6%a0%b9%e6%ba%af%e6%ba%90%ef%bc%81%e5%8d%81%e5%88%86%e9%92%9f%e6%89%8b%e6%8a%8a","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=26885","title":{"rendered":"\u836f\u7269\u5206\u5b50\u8bbe\u8ba1part2\uff1a\u5168\u7f51\u6700\u5168\u8ffd\u6839\u6eaf\u6e90\uff01\u5341\u5206\u949f\u624b\u628a\u624b\u8bb2\u6e05\u86cb\u767d\u7ed3\u6784\u5904\u7406\u7684\u524d\u56e0\u540e\u679c"},"content":{"rendered":"

\u5728\u4e0a\u4e00\u6b21\u7684\u5206\u4eab\u4e2d\uff0c\u5c0f\u679c\u7ed9\u5927\u5bb6\u6f14\u793a\u4e86\u5982\u4f55\u4f7f\u7528Discovery Studio\u8bbe\u8ba1\u53ca\u4f18\u5316\u5c0f\u5206\u5b50\u914d\u4f53\u7ed3\u6784\uff0c\u90a3\u4e48\u8fd9\u4e00\u6b21\uff0c\u5c0f\u679c\u5c31\u6765\u7ed9\u5927\u5bb6\u5206\u4eab\u4e00\u4e0b\u5982\u4f55\u4f7f\u7528Discovery Studio\u6765\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4f7f\u5176\u53ef\u4ee5\u5728\u540e\u7eed\u4e0e\u6211\u4eec\u8bbe\u8ba1\u597d\u7684\u5c0f\u5206\u5b50\u914d\u4f53\u8fdb\u884c\u5bf9\u63a5\u7b49\u4e00\u7cfb\u5217\u64cd\u4f5c\u3002\u5e9f\u8bdd\u4e0d\u591a\u8bf4\uff0c\u8ddf\u4e0a\u5c0f\u679c\u76f4\u63a5\u5f00\u59cb\u5427\uff01<\/p>\n

<\/a>\u4e3a\u4ec0\u4e48\u8981\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\uff1f<\/h2>\n

\u5982\u679c\u60f3\u8981\u771f\u6b63\u7406\u89e3\u836f\u7269\u8bbe\u8ba1\u7684\u6d41\u7a0b\uff0c\u4e0d\u80fd\u53ea\u77e5\u9053\u8be5\u5982\u4f55\u64cd\u4f5c\uff0c\u8fd8\u8981\u7406\u89e3\u6bcf\u4e00\u6b65\u7684\u610f\u4e49\u4f55\u5728\u3002\u53ef\u80fd\u6709\u4e9b\u5c0f\u4f19\u4f34\u8fd8\u4e0d\u77e5\u9053\u4e3a\u4ec0\u4e48\u8981\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\u4ee5\u53ca\u4f18\u5316\u540e\u7684\u86cb\u767d\u8d28\u6709\u4ec0\u4e48\u7528\u5904\uff0c\u4e0b\u9762\u5c0f\u679c\u5c31\u7ed9\u5927\u5bb6\u8be6\u7ec6\u5730\u4ecb\u7ecd\u4e00\u4e0b\uff1a<\/p>\n

<\/a>\u5904\u7406\u540e\u7684\u86cb\u767d\u8d28\u7528\u9014<\/h3>\n

\u5f53\u5904\u7406\u540e\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u5e94\u7528\u4e8e\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u9886\u57df\u65f6\uff0c\u5b83\u53ef\u4ee5\u53d1\u6325\u4ee5\u4e0b\u4f5c\u7528\uff1a<\/p>\n

    \n
  1. \u836f\u7269\u6a21\u5f0f\u8bc6\u522b<\/strong>\uff1a\u5373\u786e\u5b9a\u86cb\u767d\u8d28\u4e0e\u836f\u7269\u7ed3\u5408\u76f8\u5173\u7684\u7ed3\u6784\u6a21\u5f0f\u3002\u901a\u8fc7\u8ba1\u7b97\u548c\u6a21\u62df\u5206\u6790\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u4e0e\u836f\u7269\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u5173\u952e\u6c28\u57fa\u9178\u6b8b\u57fa\u6216\u7ed3\u6784\u57df\uff0c\u8fd9\u6709\u52a9\u4e8e\u6307\u5bfc\u836f\u7269\u5206\u5b50\u7684\u8bbe\u8ba1\uff0c\u4f7f\u5176\u80fd\u591f\u5728\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u4f4d\u70b9\u4e0a\u5b9e\u73b0\u6700\u4f73\u7ed3\u5408\uff0c\u5e76\u53d1\u6325\u6cbb\u7597\u6548\u679c\u3002<\/li>\n
  2. \u836f\u7269\u5076\u8054\u7269\u8bbe\u8ba1<\/strong>\uff1a\u5982\u8bbe\u8ba1\u6297\u4f53\u836f\u7269\u6216\u8f7d\u4f53\u3002\u901a\u8fc7\u4e86\u89e3\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u7279\u5b9a\u533a\u57df\u548c\u4f4d\u70b9\uff0c\u53ef\u4ee5\u5c06\u836f\u7269\u5206\u5b50\u8fde\u63a5\u5230\u9002\u5f53\u7684\u8f7d\u4f53\u4e0a\uff0c\u5b9e\u73b0\u836f\u7269\u7cbe\u786e\u8f93\u9001\u3001\u9776\u5411\u91ca\u653e\u7b49\u529f\u80fd\u3002\u8fd9\u6709\u52a9\u4e8e\u63d0\u9ad8\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\u548c\u9488\u5bf9\u6027\uff0c\u51cf\u8f7b\u5242\u91cf\u548c\u526f\u4f5c\u7528\u3002<\/li>\n
  3. \u836f\u7269\u4ee3\u8c22\u9884\u6d4b<\/strong>\uff1a\u901a\u8fc7\u6a21\u62df\u836f\u7269\u4e0e\u4ee3\u8c22\u9176\u7684\u7ed3\u5408\uff0c\u53ef\u4ee5\u9884\u6d4b\u836f\u7269\u7684\u4ee3\u8c22\u9014\u5f84\u3001\u4ee3\u8c22\u4ea7\u7269\u4ee5\u53ca\u4ee3\u8c22\u901f\u7387\u3002\u8fd9\u5bf9\u4e8e\u8bc6\u522b\u6f5c\u5728\u7684\u4ee3\u8c22\u95ee\u9898\uff0c\u4f18\u5316\u836f\u7269\u7684\u4ee3\u8c22\u7a33\u5b9a\u6027\u548c\u4ee3\u8c22\u7279\u6027\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/li>\n
  4. \u836f\u7269\u526f\u4f5c\u7528\u8bc4\u4f30<\/strong>\uff1a\u901a\u8fc7\u5206\u6790\u836f\u7269\u4e0e\u975e\u9776\u86cb\u767d\u8d28\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u53ef\u4ee5\u53d1\u73b0\u53ef\u80fd\u5f15\u8d77\u526f\u4f5c\u7528\u7684\u7ed3\u6784\u7279\u5f81\u6216\u4eb2\u548c\u6027\u3002\u8fd9\u6709\u52a9\u4e8e\u63d0\u524d\u8bc6\u522b\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u4e3a\u836f\u7269\u4f18\u5316\u548c\u526f\u4f5c\u7528\u7ba1\u7406\u63d0\u4f9b\u6307\u5bfc\u3002<\/li>\n
  5. \u836f\u7269\u6297\u6027\u673a\u5236\u7814\u7a76<\/strong>\uff1a\u901a\u8fc7\u5206\u6790\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u53d8\u5f02\u4f4d\u70b9\u548c\u7a81\u53d8\u6a21\u5f0f\uff0c\u53ef\u4ee5\u63ed\u793a\u836f\u7269\u6297\u6027\u6240\u6d89\u53ca\u7684\u7ed3\u6784\u548c\u529f\u80fd\u53d8\u5316\u3002\u8fd9\u6709\u52a9\u4e8e\u7406\u89e3\u836f\u7269\u5931\u6548\u7684\u539f\u56e0\uff0c\u5e76\u4e3a\u514b\u670d\u836f\u7269\u6297\u6027\u63d0\u4f9b\u7b56\u7565\u548c\u6307\u5bfc\u3002<\/li>\n<\/ol>\n

    \u603b\u4e4b\uff0c\u901a\u8fc7\u5206\u6790\u9884\u6d4b\u5904\u7406\u540e\u7684\u86cb\u767d\u8d28\u4e0e\u836f\u7269\u7684\u5404\u79cd\u4f5c\u7528\u6548\u679c\u80fd\u591f\u4e3a\u836f\u7269\u7684\u8bbe\u8ba1\u548c\u4f18\u5316\u63d0\u4f9b\u5173\u952e\u4fe1\u606f\uff0c\u786e\u4fdd\u836f\u7269\u7684\u9ad8\u6548\u6027\u3001\u9009\u62e9\u6027\u548c\u5b89\u5168\u6027\uff0c\u56e0\u6b64\u5904\u7406\u86cb\u767d\u662f\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u4e2d\u4e0d\u53ef\u7f3a\u5c11\u7684\u4e00\u73af\u3002<\/p>\n

    <\/a>\u4e3a\u4ec0\u4e48\u4e00\u5b9a\u8981\u5904\u7406\uff1f<\/h3>\n

    \u901a\u8fc7\u4e0a\u9762\u7684\u5206\u6790\uff0c\u5c0f\u679c\u76f8\u4fe1\u5c0f\u4f19\u4f34\u4eec\u5df2\u7ecf\u7406\u89e3\u4e86\u86cb\u767d\u8d28\u5728\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u90a3\u4e48\u53ef\u80fd\u4f1a\u6709\u5c0f\u4f19\u4f34\u95ee\u5230\uff0c\u4e3a\u4ec0\u4e48\u4e00\u5b9a\u8981\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u5904\u7406\u5462\uff1f\u53ef\u4e0d\u53ef\u4ee5\u4e0d\u5904\u7406\uff1f\u5982\u679c\u4e0d\u5904\u7406\u4f1a\u600e\u4e48\u6837\u5462\uff1f\u5584\u4e8e\u601d\u8003\u662f\u4e00\u9879\u975e\u5e38\u597d\u7684\u4f18\u70b9\uff0c\u4e0b\u9762\u5c0f\u679c\u5c31\u7ed9\u5927\u5bb6\u89e3\u7b54\u7591\u60d1\uff1a<\/p>\n

    \u9700\u8981\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u4f18\u5316\u7684\u539f\u56e0\u5982\u4e0b\uff1a<\/p>\n

      \n
    1. \u63d0\u9ad8\u836f\u7269\u7684\u4eb2\u548c\u529b<\/strong>\uff1a\u901a\u8fc7\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u836f\u7269\u4e0e\u9776\u86cb\u767d\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u4ee5\u88ab\u6539\u5584\u3002\u8fd9\u6709\u52a9\u4e8e\u589e\u52a0\u836f\u7269\u5bf9\u76ee\u6807\u86cb\u767d\u7684\u4eb2\u548c\u529b\uff0c\u63d0\u9ad8\u836f\u7269\u4e0e\u9776\u6807\u7684\u7ed3\u5408\u6548\u7387\u548c\u7a33\u5b9a\u6027\u3002<\/li>\n
    2. \u589e\u52a0\u836f\u7269\u7684\u9009\u62e9\u6027<\/strong>\uff1a\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u4f18\u5316\u53ef\u4ee5\u5e2e\u52a9\u8bbe\u8ba1\u5177\u6709\u66f4\u9ad8\u9009\u62e9\u6027\u7684\u836f\u7269\u3002\u901a\u8fc7\u4e86\u89e3\u9776\u86cb\u767d\u7684\u7ed3\u6784\u7ec6\u8282\uff0c\u53ef\u4ee5\u4e3a\u836f\u7269\u8bbe\u8ba1\u63d0\u4f9b\u6307\u5bfc\uff0c\u4f7f\u5176\u80fd\u591f\u66f4\u7cbe\u786e\u5730\u4e0e\u76ee\u6807\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff0c\u51cf\u5c11\u4e0e\u5176\u4ed6\u975e\u9776\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u964d\u4f4e\u975e\u7279\u5f02\u6027\u526f\u4f5c\u7528\u3002<\/li>\n
    3. \u6539\u8fdb\u836f\u7269\u4ee3\u8c22\u548c\u7a33\u5b9a\u6027<\/strong>\uff1a\u901a\u8fc7\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u53ef\u4ee5\u6539\u53d8\u836f\u7269\u4e0e\u4ee3\u8c22\u9176\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5f71\u54cd\u836f\u7269\u7684\u4ee3\u8c22\u9014\u5f84\u3001\u4ee3\u8c22\u901f\u7387\u548c\u534a\u8870\u671f\u3002\u8fd9\u6709\u52a9\u4e8e\u6539\u5584\u836f\u7269\u7684\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u5ef6\u957f\u836f\u7269\u5728\u4f53\u5185\u7684\u505c\u7559\u65f6\u95f4\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002<\/li>\n
    4. \u51cf\u8f7b\u836f\u7269\u526f\u4f5c\u7528<\/strong>\uff1a\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\u53ef\u4ee5\u5e2e\u52a9\u9884\u6d4b\u548c\u8bc4\u4f30\u836f\u7269\u7684\u526f\u4f5c\u7528\u3002\u901a\u8fc7\u5206\u6790\u836f\u7269\u4e0e\u975e\u9776\u86cb\u767d\u8d28\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u4ee5\u53d1\u73b0\u53ef\u80fd\u5f15\u8d77\u526f\u4f5c\u7528\u7684\u7ed3\u6784\u7279\u5f81\u6216\u4eb2\u548c\u6027\u3002\u4ece\u800c\u53ef\u4ee5\u63d0\u524d\u8bc6\u522b\u6f5c\u5728\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u5e76\u4e3a\u836f\u7269\u8bbe\u8ba1\u548c\u526f\u4f5c\u7528\u7ba1\u7406\u63d0\u4f9b\u6307\u5bfc\u3002<\/li>\n
    5. \u514b\u670d\u836f\u7269\u6297\u6027<\/strong>\uff1a\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u4f18\u5316\u6709\u52a9\u4e8e\u7814\u7a76\u548c\u514b\u670d\u836f\u7269\u6297\u6027\u7684\u673a\u5236\u3002\u901a\u8fc7\u5206\u6790\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u53d8\u5f02\u4f4d\u70b9\u548c\u7a81\u53d8\u6a21\u5f0f\uff0c\u53ef\u4ee5\u63ed\u793a\u836f\u7269\u6297\u6027\u6240\u6d89\u53ca\u7684\u7ed3\u6784\u548c\u529f\u80fd\u53d8\u5316\u3002\u8fd9\u6709\u52a9\u4e8e\u5bfb\u627e\u5bf9\u6297\u836f\u7269\u6297\u6027\u7684\u7b56\u7565\uff0c\u91cd\u65b0\u8bbe\u8ba1\u836f\u7269\u5206\u5b50\u4ee5\u6062\u590d\u6cbb\u7597\u6548\u679c\u3002<\/li>\n<\/ol>\n

      \u7efc\u4e0a\u6240\u8ff0\uff0c\u901a\u8fc7\u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u4eb2\u548c\u529b\u548c\u9009\u62e9\u6027\uff0c\u6539\u5584\u836f\u7269\u4ee3\u8c22\u548c\u7a33\u5b9a\u6027\uff0c\u51cf\u8f7b\u836f\u7269\u526f\u4f5c\u7528\uff0c\u5e76\u514b\u670d\u836f\u7269\u6297\u6027\u3002\u8fd9\u4e9b\u4f18\u5316\u63aa\u65bd\u6709\u52a9\u4e8e\u63d0\u9ad8\u836f\u7269\u7597\u6548\u3001\u964d\u4f4e\u4e0d\u826f\u53cd\u5e94\uff0c\u56e0\u6b64\u662f\u81f3\u5173\u91cd\u8981\u3001\u4e0d\u53ef\u7701\u7565\u7684\u6b65\u9aa4\u3002<\/p>\n

      <\/a>\u5982\u4f55\u83b7\u5f97\u86cb\u767d\u8d28\u7ed3\u6784\uff1f<\/h2>\n

      \u5c0f\u4f19\u4f34\u4eec\u770b\u5230\u8fd9\u91cc\u4e00\u5b9a\u5df2\u7ecf\u7406\u89e3\u4e86\u4f18\u5316\u86cb\u767d\u8d28\u7684\u91cd\u8981\u6027\uff0c\u73b0\u5728\u662f\u4e0d\u662f\u5df2\u7ecf\u8feb\u4e0d\u53ca\u5f85\u5730\u60f3\u770b\u4e00\u770b\u5982\u4f55\u64cd\u4f5c\u4e86\u5462\uff1f\u4f46\u662f\u4e0d\u8981\u5fd8\u8bb0\uff0c\u5728\u6211\u4eec\u5904\u7406\u4e4b\u524d\uff0c\u9700\u8981\u5148\u83b7\u5f97\u86cb\u767d\u8d28\u7ed3\u6784\u624d\u53ef\u4ee5\uff0c\u4e0d\u7136\u6211\u4eec\u5904\u7406\u4ec0\u4e48\u5462\uff1f\u83b7\u53d6\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5c0f\u679c\u4e00\u822c\u4f1a\u9009\u62e9\u5728RCSB PDB\u4e2d\u8fdb\u884c\u641c\u7d22\u548c\u4e0b\u8f7d\u3002\u4e0b\u9762\u5c31\u8ba9\u5c0f\u679c\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u8fd9\u4e2a\u5b9e\u7528\u7684\u6570\u636e\u5e93\u5427\uff1a<\/p>\n

      <\/p>\n

      PDB\uff08Protein Data Bank\uff09\u662f\u4e00\u4e2a\u56fd\u9645\u77e5\u540d\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u5e93\uff0c\u81f4\u529b\u4e8e\u6536\u96c6\u3001\u5b58\u50a8\u548c\u5206\u53d1\u751f\u7269\u5927\u5206\u5b50\uff08\u5c24\u5176\u662f\u86cb\u767d\u8d28\uff09\u7684\u4e09\u7ef4\u7ed3\u6784\u6570\u636e\u3002\u4f5c\u4e3a\u5168\u7403\u79d1\u5b66\u754c\u7684\u91cd\u8981\u8d44\u6e90\uff0c\u5b83\u4e3a\u7814\u7a76\u8005\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5e7f\u6cdb\u548c\u53ef\u9760\u7684\u5e73\u53f0\uff0c\u4ee5\u4fbf\u8fdb\u884c\u751f\u7269\u5927\u5206\u5b50\u7ed3\u6784\u7684\u7814\u7a76\u3001\u5206\u6790\u548c\u89e3\u91ca\u3002PDB\u5728\u5168\u7403\u6709\u591a\u4e2a\u5206\u7ad9\uff0c\u5176\u4e2dRCSB PDB\uff08Research Collaboratory for Structural Bioinformatics Protein Data Bank\uff09\u662f\u7f8e\u56fd\u5206\u7ad9\uff0c\u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb\u3002<\/p>\n

      RCSB PDB\u7684\u6570\u636e\u6765\u6e90\u975e\u5e38\u591a\u6837\uff0c\u5176\u4e2d\u5305\u62ec\u4e86\u901a\u8fc7X\u5c04\u7ebf\u6676\u4f53\u5b66\u3001\u6838\u78c1\u5171\u632f\u7b49\u5b9e\u9a8c\u6280\u672f\u83b7\u5f97\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\uff0c\u4e5f\u5c31\u662f\u8bf4\u8fd9\u4e9b\u6570\u636e\u5747\u901a\u8fc7\u5b9e\u9645\u5b9e\u9a8c\u5f97\u6765\u800c\u975e\u4ec5\u4ec5\u6a21\u62df\u9884\u6d4b\u3002\u8fd9\u4e9b\u6570\u636e\u4ee5PDB\u6587\u4ef6\u683c\u5f0f\u8fdb\u884c\u5b58\u50a8\uff0c\u5176\u4e2d\u5305\u542b\u4e86\u5173\u4e8e\u539f\u5b50\u5750\u6807\u3001\u7ed3\u6784\u62d3\u6251\u3001\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u7b49\u91cd\u8981\u4fe1\u606f\uff0c\u80fd\u591f\u63cf\u8ff0\u86cb\u767d\u8d28\u5206\u5b50\u5728\u7a7a\u95f4\u4e2d\u7684\u7acb\u4f53\u6784\u8c61\u3002<\/p>\n

      RCSB PDB\u63d0\u4f9b\u4e86\u591a\u79cd\u5de5\u5177\u548c\u8d44\u6e90\uff0c\u5e2e\u52a9\u7814\u7a76\u8005\u4eec\u8fdb\u884c\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u53ef\u89c6\u5316\u3001\u6a21\u62df\u8ba1\u7b97\u548c\u529f\u80fd\u6ce8\u91ca\u3002\u7814\u7a76\u8005\u4eec\u53ef\u4ee5\u4f7f\u7528PDB ID\u6216\u5173\u952e\u8bcd\u8fdb\u884c\u641c\u7d22\uff0c\u83b7\u53d6\u611f\u5174\u8da3\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\uff0c\u5e76\u53ef\u901a\u8fc7\u5728\u7ebf\u5de5\u5177\u8fdb\u884c\u7ed3\u6784\u53ef\u89c6\u5316\u3001\u7ed3\u6784\u6bd4\u5bf9\u548c\u7ed3\u6784\u5206\u6790\u7b49\u64cd\u4f5c\u3002\u6b64\u5916\uff0cRCSB PDB\u8fd8\u63d0\u4f9b\u4e86\u9ad8\u8d28\u91cf\u7684\u6559\u80b2\u8d44\u6e90\uff0c\u7528\u4e8e\u57f9\u8bad\u548c\u6559\u5b66\uff0c\u4ee5\u63a8\u5e7f\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u5b66\u4e60\u548c\u5e94\u7528\u3002<\/p>\n

      \u975e\u5e38\u503c\u5f97\u63a8\u5d07\u7684\u4e00\u70b9\u662f\uff0cPDB\u6570\u636e\u5e93\u4e2d\u7684\u6570\u636e\u5747\u4e3a\u5171\u7528\u6570\u636e\uff0c\u4f7f\u7528\u8d77\u6765\u4e0d\u9700\u8981\u62c5\u5fc3\u8457\u4f5c\u6743\u7684\u95ee\u9898\uff0c\u56e0\u6b64\u5c0f\u679c\u975e\u5e38\u63a8\u8350\u5927\u5bb6\u4f7f\u7528\u3002<\/p>\n

      \u770b\u5230\u8fd9\u91cc\u76f8\u4fe1\u5927\u5bb6\u5df2\u7ecf\u7406\u89e3\u4e86RCSB PDB\u7684\u5389\u5bb3\u4e4b\u5904\uff0c\u90a3\u4e48\u6211\u4eec\u8be5\u5982\u4f55\u4f7f\u7528\u5b83\u5462\uff1f\u5728\u53f3\u4e0a\u89d2\u6211\u4eec\u53ef\u4ee5\u76f4\u63a5\u8f93\u5165\u611f\u5174\u8da3\u7684\u86cb\u767d\u8d28\u540d\u79f0\u3001PDB ID\u6216\u5173\u952e\u8bcd\u6765\u641c\u7d22\uff0c\u751a\u81f3\u6211\u4eec\u53ef\u4ee5\u76f4\u63a5\u8f93\u5165\u914d\u4f53\u7684\u540d\u79f0\u6765\u68c0\u7d22\u7ed3\u6784\u4e2d\u5305\u542b\u6709\u8be5\u914d\u4f53\u7684\u86cb\u767d\u8d28\u3002<\/p>\n

      \u9664\u4e86\u76f4\u63a5\u641c\u7d22\u4ee5\u5916\u8fd8\u6709\u4e00\u4e2a\u975e\u5e38\u5b9e\u7528\u7684\u529f\u80fd\u5c31\u662f\u9ad8\u7ea7\u641c\u7d22\uff08advanced search\uff09\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u8fdb\u4e00\u6b65\u7f29\u5c0f\u641c\u7d22\u5f97\u5230\u7684\u8303\u56f4\uff1a<\/p>\n

      <\/p>\n

      \u5173\u4e8e\u9ad8\u7ea7\u641c\u7d22\u5982\u4f55\u4f7f\u7528\u4ee5\u53ca\u5176\u4ed6\u7528\u6cd5\u5982\u5982\u4f55\u67e5\u770b\u7ed3\u679c\u9875\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\u5728\u9875\u9762\u4e2d\u7ed9\u51fa\u4e86Help\u6309\u94ae\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u70b9\u8fdb\u53bb\u4e86\u89e3\u4e00\u4e0b\uff0c\u5b98\u65b9\u7ed9\u7684\u4f7f\u7528\u65b9\u6cd5\u8fd8\u662f\u975e\u5e38\u8be6\u7ec6\u7684\uff0c\u5c0f\u679c\u5728\u8fd9\u91cc\u5c31\u4e0d\u8d58\u8ff0\u5566\u3002<\/p>\n

      <\/p>\n

      <\/p>\n

      \u5f53\u6211\u4eec\u6b63\u786e\u641c\u7d22\u5e76\u4ece\u7ed3\u679c\u9875\u5de6\u4fa7\u7b5b\u9009\u51fa\u6211\u4eec\u60f3\u67e5\u8be2\u7684\u7269\u8d28\u65f6\uff0c\u6211\u4eec\u53ef\u4ee5\u76f4\u63a5\u70b9\u8fdb\u53bb\u67e5\u770b\u5b83\u7684\u5404\u79cd\u4fe1\u606f\u5e76\u4e0b\u8f7d\u5b83\u7684\u7ed3\u6784\u4fe1\u606f\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5982\u679c\u60f3\u5bfc\u5165\u5230Discovery Studio\u4e2d\u8fdb\u884c\u5206\u6790\u7684\u8bdd\u4e00\u822c\u4e0b\u8f7d\u7684\u662fPDB \u683c\u5f0f\u3002\uff08PDB gz\u4e3a\u538b\u7f29\u540e\u7684PDB\u683c\u5f0f\uff09<\/p>\n

      <\/p>\n

      <\/p>\n

      \u9664\u4e86\u4e0b\u8f7d\u540e\u4eceDiscovery Studio\u6253\u5f00\u6587\u4ef6\u8fd9\u79cd\u65b9\u6cd5\uff0cDiscovery Studio\u8fd8\u63d0\u4f9b\u4e86\u901a\u8fc7PDB\u7f16\u53f7\u76f4\u63a5\u8f7d\u5165\u8be5\u7ed3\u6784\u7684\u65b9\u6cd5\uff1a\u70b9\u51fb\u83dc\u5355\u680fFile->Open URL\uff0c\u968f\u540e\u8f93\u5165\u7f16\u53f7\u7b49\u5f85\u4e00\u4f1a\u5373\u53ef\u6253\u5f00\u3002<\/p>\n

      <\/p>\n

      <\/p>\n

      <\/a>\u5982\u4f55\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u4f18\u5316\uff1f<\/h2>\n

      \u4f18\u5316\u86cb\u767d\u8d28\u7ed3\u6784\u53ef\u80fd\u4f1a\u6709\u4ec0\u4e48\u6b65\u9aa4\u5462\uff0c\u4e0b\u9762\u5c0f\u679c\u5c31\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\uff1a<\/p>\n

        \n
      1. \u6784\u5efa\u86cb\u767d\u8d28\u6a21\u578b<\/strong>\uff1a\u9488\u5bf9\u76ee\u6807\u86cb\u767d\u8d28\uff0c\u53ef\u80fd\u9700\u8981\u6839\u636e\u5df2\u6709\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u3001\u5e8f\u5217\u4fe1\u606f\u6216\u76f8\u5173\u6a21\u677f\u8fdb\u884c\u86cb\u767d\u8d28\u6a21\u578b\u7684\u6784\u5efa\u3002\u8fd9\u6709\u52a9\u4e8e\u7406\u89e3\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u5e76\u63d0\u4f9b\u4e00\u4e2a\u57fa\u7840\u6846\u67b6\u7528\u4e8e\u540e\u7eed\u7684\u8ba1\u7b97\u548c\u6a21\u62df\u3002<\/li>\n
      2. \u86cb\u767d\u8d28\u7ed3\u6784\u4fee\u590d<\/strong>\uff1a\u5bf9\u4e8e\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u5b58\u5728\u7684\u7f3a\u5931\u3001\u9519\u8bef\u6216\u4e0d\u5b8c\u6574\u7684\u90e8\u5206\uff0c\u9700\u8981\u8fdb\u884c\u4fee\u590d\u548c\u4f18\u5316\u3002\u8fd9\u5305\u62ec\u4fee\u590d\u7f3a\u5931\u7684\u539f\u5b50\u3001\u4fee\u6b63\u4e0d\u5408\u7406\u7684\u6784\u8c61\u3001\u4fee\u590d\u7ed3\u6784\u9519\u8bef\u7b49\uff0c\u4ee5\u786e\u4fdd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u662f\u51c6\u786e\u548c\u53ef\u9760\u7684\u3002<\/li>\n
      3. \u6d3b\u6027\u4f4d\u70b9\u8bc6\u522b<\/strong>\uff1a\u6d3b\u6027\u4f4d\u70b9\u662f\u86cb\u767d\u8d28\u4e0a\u4e0e\u914d\u4f53\u7ed3\u5408\u5e76\u53d1\u6325\u751f\u7269\u6d3b\u6027\u7684\u533a\u57df\u3002\u901a\u8fc7\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u5206\u6790\u548c\u9884\u6d4b\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u6f5c\u5728\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u8fd9\u6709\u52a9\u4e8e\u5728\u836f\u7269\u8bbe\u8ba1\u4e2d\u9009\u62e9\u548c\u4f18\u5316\u76f8\u4e92\u4f5c\u7528\u7684\u533a\u57df\u3002<\/li>\n
      4. \u6c34\u5408\u5242\u5904\u7406<\/strong>\uff1a\u86cb\u767d\u8d28\u5728\u751f\u7269\u4f53\u5185\u901a\u5e38\u662f\u6c34\u5408\u72b6\u6001\u7684\u3002\u5728\u5bf9\u86cb\u767d\u8d28\u8fdb\u884c\u8ba1\u7b97\u548c\u6a21\u62df\u65f6\uff0c\u9700\u8981\u5bf9\u6c34\u5206\u5b50\u8fdb\u884c\u5904\u7406\uff0c\u5305\u62ec\u6dfb\u52a0\u3001\u5220\u9664\u6216\u4f18\u5316\u6c34\u5408\u5242\u7684\u4f4d\u7f6e\u548c\u6784\u8c61\u3002\u8fd9\u6709\u52a9\u4e8e\u66f4\u51c6\u786e\u5730\u6a21\u62df\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u8fc7\u7a0b\u3002<\/li>\n
      5. \u6676\u4f53\u7ed3\u6784\u5904\u7406\uff1a<\/strong>\u5982\u679c\u76ee\u6807\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u662f\u901a\u8fc7X\u5c04\u7ebf\u6676\u4f53\u5b66\u5f97\u5230\u7684\uff0c\u53ef\u80fd\u9700\u8981\u8fdb\u884c\u4e00\u4e9b\u989d\u5916\u6b65\u9aa4\u6765\u5904\u7406\u6676\u4f53\u7ed3\u6784\uff0c\u5982\u53bb\u9664\u6eb6\u5242\u5206\u5b50\u3001\u4fee\u590d\u7ed3\u6676\u4e2d\u7684\u539f\u5b50\u9519\u8bef\u7b49\u3002<\/li>\n<\/ol>\n

        \u5c06\u86cb\u767d\u7ed3\u6784\u5bfc\u5165Discovery Studio\u540e\uff0c\u9664\u975e\u6709\u7279\u6b8a\u9700\u6c42\uff0c\u4e00\u822c\u9996\u5148\u5c06\u6c34\u5206\u5b50\u53bb\u9664\uff08\u60f3\u53bb\u9664\u54ea\u4e00\u90e8\u5206\u76f4\u63a5\u5c06\u52fe\u9009\u53d6\u6d88\u5373\u53ef\uff09\uff0c\u56e0\u4e3a8EF5\u4e2d\u6ca1\u6709\u6c34\u5206\u5b50\uff0c\u56e0\u6b64\u5c0f\u679c\u6253\u5f00\u53e6\u4e00\u4e2a\u5206\u5b50\u7ed9\u5927\u5bb6\u5c55\u793a\u5982\u4f55\u53bb\u9664\u6c34\u5206\u5b50\uff08\u6807\u9ec4\u90e8\u5206\uff09\u3002\uff08\u4f7f\u7528Ctrl H\u548cCtrl T\u53ef\u76f4\u63a5\u6253\u5f00\u7cfb\u7edf\u89c6\u56fe\u53ca\u8868\u683c\u89c6\u56fe\uff09<\/p>\n

        <\/p>\n

        \u968f\u540e\uff0c\u6211\u4eec\u4e00\u822c\u4f7f\u7528Discovery Studio\u4e2d\u5feb\u6377\u7684Macromolecules>Prepare Protein>Clean Protein\u529f\u80fd\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u5904\u7406\uff0c\u5373\u4fee\u590d\u548c\u4f18\u5316\u86cb\u767d\u8d28\u7684\u539f\u5b50\u5750\u6807\uff0c\u4ee5\u786e\u4fdd\u5176\u7b26\u5408\u5408\u7406\u7684\u51e0\u4f55\u5b66\u7ea6\u675f\uff0c\u5e76\u63d0\u9ad8\u540e\u7eed\u8ba1\u7b97\u548c\u6a21\u62df\u7684\u51c6\u786e\u6027\u3002\u5b83\u6267\u884c\u4ee5\u4e0b\u4e3b\u8981\u529f\u80fd\uff1a<\/p>\n

          \n
        1. \u53bb\u9664\u975e\u6807\u51c6\u6b8b\u57fa\uff1a\u4f8b\u5982\u6c34\u5206\u5b50\u3001\u79bb\u5b50\u548c\u5c0f\u5206\u5b50\u914d\u4f53\u3002<\/li>\n
        2. \u6821\u6b63\u6c28\u57fa\u9178\u672b\u7aef\uff1a\u4fee\u590d\u6c28\u57fa\u9178\u672b\u7aef\u6b8b\u57fa\u7684\u7f3a\u5931\u6216\u4e0d\u5b8c\u6574\uff0c\u786e\u4fdd\u6240\u6709\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u90fd\u5177\u6709\u6b63\u786e\u7684\u8fde\u63a5\u548c\u539f\u5b50\u5750\u6807\u3002<\/li>\n
        3. \u4fee\u590d\u526a\u5207\u8fde\u63a5\uff1a\u526a\u5207\u8fde\u63a5\u662f\u7531\u4e8e\u5b9e\u9a8c\u6216\u8ba1\u7b97\u8bef\u5dee\u800c\u5bfc\u81f4\u7684\u86cb\u767d\u8d28\u94fe\u65ad\u5f00\u7684\u60c5\u51b5\uff0c\u8be5\u529f\u80fd\u80fd\u591f\u81ea\u52a8\u68c0\u6d4b\u548c\u4fee\u590d\u8fd9\u4e9b\u65ad\u5f00\u7684\u8fde\u63a5\u3002<\/li>\n
        4. \u4f18\u5316\u539f\u5b50\u5750\u6807\uff1a\u8be5\u5de5\u5177\u4f7f\u7528\u5206\u5b50\u529b\u5b66\u529b\u573a\u5bf9\u86cb\u767d\u8d28\u7684\u539f\u5b50\u5750\u6807\u8fdb\u884c\u6700\u5c0f\u5316\u6216\u4f18\u5316\uff0c\u4ee5\u63d0\u9ad8\u5176\u51e0\u4f55\u5b66\u8d28\u91cf\u3002\u8fd9\u53ef\u4ee5\u901a\u8fc7\u514b\u670d\u539f\u5b50\u95f4\u7684\u8fc7\u5ea6\u91cd\u53e0\u3001\u4fee\u6b63\u626d\u66f2\u6784\u8c61\u548c\u4f18\u5316\u6c22\u952e\u7b49\u65b9\u5f0f\u6765\u5b9e\u73b0\u3002<\/li>\n<\/ol>\n

          <\/p>\n

          \u5728Clean Protein\u6309\u94ae\u4e0b\u9762\u6709\u663e\u793a\u76f8\u5e94\u62a5\u544a\u7684\u6309\u94ae\uff1a<\/p>\n

          <\/p>\n

          \u9664\u4e86\u6700\u4fbf\u6377\u6700\u5e38\u7528\u7684Clean Protein\u529f\u80fd\u5916\uff0cDiscovery Studio\u8fd8\u63d0\u4f9b\u4e86\u975e\u5e38\u591a\u7684\u5176\u4ed6\u529f\u80fd\u6765\u4f18\u5316\u86cb\u767d\u7ed3\u6784\uff0c\u4f8b\u5982\u4e3b\u83dc\u5355\u680fstructure->clean geometry\uff0c\u5b83\u53ef\u4ee5\u6e05\u9664\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u51e0\u4f55\u9519\u8bef\u6216\u4e0d\u826f\u51e0\u4f55\u7279\u5f81\uff0c\u4fee\u590d\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u6784\u8c61\u95ee\u9898\uff0c\u4f8b\u5982\u4e0d\u6b63\u5e38\u7684\u952e\u957f\u3001\u952e\u89d2\u6216\u626d\u8f6c\u89d2\u3002<\/p>\n

          <\/p>\n

          \u901a\u8fc7\u53f3\u952eMacromolecules\u7684tools\u65f6\u5f39\u51fa\u7684\u83dc\u5355\u6211\u4eec\u53ef\u4ee5\u5f88\u76f4\u89c2\u5730\u611f\u53d7\u5230Discovery Studio\u7684\u529f\u80fd\u4e4b\u5f3a\u5927\u548c\u4e30\u5bcc\uff1a<\/p>\n

          <\/p>\n

          <\/p>\n

          \u5c0f\u679c\u5728\u8fd9\u91cc\u7ed9\u5927\u5bb6\u7ffb\u8bd1\u6210\u4e2d\u6587\uff0c\u8ba9\u5927\u5bb6\u770b\u7740\u66f4\u52a0\u65b9\u4fbf\uff1a<\/p>\n

          \u5bf9\u5c0f\u5206\u5b50\u8fdb\u884c\u5bf9\u9f50;
          \n\u5206\u6790\u86cb\u767d\u8d28\u4fdd\u5b88\u6027\u6a21\u5f0f;
          \n\u5206\u6790\u5e8f\u5217;
          \n\u5206\u6790\u8f68\u8ff9;
          \n\u5206\u6790\u8de8\u819c\u86cb\u767d;
          \n\u6784\u5efa\u6570\u636e\u5e93;
          \n\u6784\u5efa\u7247\u6bb5;
          \n\u6784\u5efa\u548c\u7f16\u8f91\u6838\u9178;
          \n\u6784\u5efa\u548c\u7f16\u8f91\u86cb\u767d\u8d28;
          \n\u6784\u5efa\u548c\u6539\u8fdbX\u5c04\u7ebf\u7ed3\u6784;
          \n\u8ba1\u7b97\u5206\u5b50\u6027\u8d28;
          \n\u66f4\u6539\u529b\u573a;
          \n\u6bd4\u8f83\u836f\u6548\u56e2;
          \n\u521b\u5efa\u540c\u6e90\u6a21\u578b;
          \n\u81ea\u52a8\u751f\u6210\u836f\u6548\u56e2;
          \n\u624b\u52a8\u521b\u5efa\u836f\u6548\u56e2;
          \n\u521b\u5efaQSAR\u6a21\u578b;
          \n\u81ea\u5b9a\u4e49\u836f\u6548\u56e2\u7279\u5f81;
          \n\u5b9a\u4e49\u548c\u7f16\u8f91\u7ed3\u5408\u4f4d\u70b9;
          \n\u5b9a\u4e49\u548c\u7f16\u8f91\u7ed3\u5408\u4f4d\u70b9\uff08\u9ad8\u7ea7\uff09;
          \n\u8bbe\u8ba1\u86cb\u767d\u8d28;
          \n\u8bbe\u8ba1\u548c\u5206\u6790\u5e93;
          \n\u5bf9\u914d\u4f53\u8fdb\u884c\u5bf9\u63a5;
          \n\u5bf9\u63a5\u548c\u5206\u6790\u86cb\u767d\u8d28\u590d\u5408\u7269;
          \n\u7f16\u8f91X\u5c04\u7ebf\u7ed3\u6784;
          \n\u7f16\u8f91\u548c\u805a\u7c7b\u7279\u5f81;
          \n\u57fa\u4e8e\u7247\u6bb5\u7684\u8bbe\u8ba1;
          \n\u5f15\u5bfc\u4f18\u5316;
          \n\u6700\u5c0f\u5316\u914d\u4f53;
          \n\u6700\u5c0f\u5316\u548c\u6539\u8fdb\u86cb\u767d\u8d28;
          \n\u5efa\u6a21\u6297\u4f53;
          \n\u5206\u5b50\u6d4f\u89c8\u5668;
          \n\u6d4f\u89c8\u548c\u6807\u8bb03D\u7ed3\u6784;
          \n\u653e\u7f6e\u548c\u6539\u8fdbX\u5c04\u7ebf\u914d\u4f53;
          \n\u9884\u6d4b\u86cb\u767d\u8d28\u805a\u96c6;
          \n\u51c6\u5907\u86cb\u767d\u8d28;
          \n\u51c6\u5907\u6216\u7b5b\u9009\u914d\u4f53;
          \n\u86cb\u767d\u8d28\u62a5\u544a\u548c\u5206\u6790;
          \n\u67e5\u8be2\u5728\u7ebf\u6570\u636e\u5e93;
          \n\u8fd0\u884c\u81ea\u7531\u80fd\u6a21\u62df;
          \n\u8fd0\u884c\u6a21\u62df;
          \n\u901a\u8fc7\u76f8\u4f3c\u6027\u641c\u7d22\u5e8f\u5217\uff1b
          \n\u641c\u7d22\u4fa7\u94feRotamer\u3002<\/p>\n

          \u4e0a\u9762\u6709\u4e00\u4e9b\u540d\u8bcd\u5c0f\u4f19\u4f34\u53ef\u80fd\u4e0d\u592a\u719f\u6089\uff0c\u5c0f\u679c\u5728\u8fd9\u91cc\u7ed9\u5927\u5bb6\u7a0d\u5fae\u89e3\u91ca\u4e00\u4e0b\uff0c\u6bd4\u5982\uff1a<\/p>\n

            \n
          1. QSAR\u6a21\u578b\u4ee3\u8868\u5b9a\u91cf\u6784\u6548\u5173\u7cfb\uff08Quantitative Structure-Activity Relationship\uff09\uff0c\u662f\u4e00\u79cd\u7528\u4e8e\u9884\u6d4b\u5316\u5408\u7269\u6d3b\u6027\u548c\u6027\u8d28\u7684\u8ba1\u7b97\u6a21\u578b\u3002\u5b83\u5efa\u7acb\u4e86\u5316\u5408\u7269\u7ed3\u6784\u4e0e\u5176\u751f\u7269\u6d3b\u6027\u4e4b\u95f4\u7684\u5b9a\u91cf\u5173\u7cfb\uff0c\u901a\u8fc7\u5206\u6790\u548c\u91cf\u5316\u5206\u5b50\u7ed3\u6784\u7684\u5316\u5b66\u7279\u5f81\uff0c\u9884\u6d4b\u5176\u6d3b\u6027\u6216\u5176\u4ed6\u76f8\u5173\u6027\u8d28\u3002<\/li>\n
          2. \u836f\u6548\u56e2\uff08Pharmacophore\uff09\u662f\u6307\u5728\u836f\u7269\u5206\u5b50\u4e2d\u5bf9\u7279\u5b9a\u751f\u7269\u6d3b\u6027\u8d77\u5173\u952e\u4f5c\u7528\u7684\u529f\u80fd\u57fa\u56e2\u6216\u7ed3\u6784\u6a21\u5f0f\u3002\u5b83\u662f\u901a\u8fc7\u5206\u6790\u548c\u603b\u7ed3\u4e00\u7cfb\u5217\u5177\u6709\u76f8\u4f3c\u751f\u7269\u6d3b\u6027\u7684\u5316\u5408\u7269\uff0c\u786e\u5b9a\u51fa\u5bf9\u6d3b\u6027\u8d21\u732e\u6700\u663e\u8457\u7684\u5171\u540c\u7279\u5f81\u3002<\/li>\n
          3. \u4fa7\u94feRotamer\u662f\u6307\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\uff0c\u6c28\u57fa\u9178\u4fa7\u94fe\u7684\u4e0d\u540c\u6784\u8c61\u6216\u65cb\u8f6c\u72b6\u6001\u3002\u6bcf\u4e2a\u6c28\u57fa\u9178\u4fa7\u94fe\u90fd\u53ef\u4ee5\u91c7\u53d6\u591a\u79cd\u4e0d\u540c\u7684\u6784\u8c61\uff0c\u8fd9\u4e9b\u6784\u8c61\u4e4b\u95f4\u7684\u65cb\u8f6c\u548c\u7a7a\u95f4\u6392\u5e03\u5b58\u5728\u5dee\u5f02\u3002\u4fa7\u94feRotamer\u63cf\u8ff0\u4e86\u4fa7\u94fe\u7684\u4e0d\u540c\u6784\u8c61\uff0c\u5e76\u901a\u8fc7\u547d\u540d\u548c\u5206\u7c7b\u4e0d\u540c\u7684\u65cb\u8f6c\u72b6\u6001\u6765\u8868\u793a\u3002\u901a\u8fc7\u641c\u7d22\u4fa7\u94feRotamer\uff0c\u53ef\u4ee5\u627e\u5230\u5408\u9002\u7684\u86cb\u767d\u8d28\u4fa7\u94fe\u6784\u8c61\uff0c\u7528\u4e8e\u86cb\u767d\u8d28\u7684\u6a21\u62df\u3001\u8bbe\u8ba1\u548c\u5206\u6790\u7b49\u5e94\u7528\u3002<\/li>\n<\/ol>\n

            \u603b\u800c\u8a00\u4e4b\uff0cDiscovery Studio\u662f\u4e00\u6b3e\u529f\u80fd\u5f3a\u5927\u4e14\u4e30\u5bcc\u7684\u8f6f\u4ef6\uff0c\u5c0f\u679c\u5728\u8fd9\u91cc\u662f\u8ddf\u5927\u5bb6\u4ecb\u7ecd\u4e0d\u5b8c\u7684\uff0c\u60f3\u8981\u6df1\u5165\u5b66\u4e60\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u81ea\u5df1\u67e5\u770bhelp\u6587\u6863\u5e76\u4eb2\u81ea\u591a\u5c1d\u8bd5\u5c1d\u8bd5\uff0c\u6bd5\u7adf\u5b9e\u8df5\u624d\u80fd\u51fa\u771f\u77e5\u3002\u672c\u6b21\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\u5566\uff0c\u5982\u679c\u5c0f\u4f19\u4f34\u4eec\u5e73\u65f6\u5728\u751f\u4fe1\u5206\u6790\u7684\u64cd\u4f5c\u8fc7\u7a0b\u4e2d\u9047\u5230\u56f0\u96be\uff0c\u6b22\u8fce\u5927\u5bb6\u4f7f\u7528\u5c0f\u679c\u5f00\u53d1\u7684\u751f\u4fe1\u5de5\u5177\u5e73\u53f0http:\/\/www.biocloudservice.com\/home.html<\/a>\u54e6\u3002<\/p>\n

            \u90a3\u4e48\u6211\u4eec\u4e0b\u6b21\u518d\u89c1\u5566\uff0c\u671f\u5f85\u4e0e\u5c0f\u4f19\u4f34\u4eec\u7ee7\u7eed\u5171\u540c\u6210\u957f\u54e6\uff0c\u62dc\u62dc\u250f(\uff3e0\uff3e)\u251b~<\/p>\n","protected":false},"excerpt":{"rendered":"

            \u5728\u4e0a\u4e00\u6b21\u7684\u5206\u4eab\u4e2d\uff0c\u5c0f\u679c\u7ed9\u5927\u5bb6\u6f14\u793a\u4e86\u5982\u4f55\u4f7f\u7528Discovery Studio\u8bbe\u8ba1\u53ca\u4f18\u5316\u5c0f\u5206\u5b50\u914d\u4f53\u7ed3\u6784\uff0c\u90a3\u4e48\u8fd9\u4e00\u6b21 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/26885"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26885"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/26885\/revisions"}],"predecessor-version":[{"id":26914,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/26885\/revisions\/26914"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26885"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}