{"id":28020,"date":"2024-02-04T17:27:28","date_gmt":"2024-02-04T09:27:28","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=28020"},"modified":"2024-02-04T17:27:30","modified_gmt":"2024-02-04T09:27:30","slug":"%e5%a6%82%e4%bd%95%e8%bd%bb%e6%9d%be%e7%bb%98%e5%88%b6%e6%a3%92%e6%a3%92%e7%b3%96%e5%9b%be%ef%bc%9f3%e5%88%86%e9%92%9f%e6%95%99%e4%bd%a0%e5%ad%a6%e4%bc%9anature%e7%ba%a7%e5%88%ab%e7%9a%84%e6%95%b0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=28020","title":{"rendered":"\u5982\u4f55\u8f7b\u677e\u7ed8\u5236\u68d2\u68d2\u7cd6\u56fe\uff1f3\u5206\u949f\u6559\u4f60\u5b66\u4f1anature\u7ea7\u522b\u7684\u6570\u636e\u5904\u7406\uff01"},"content":{"rendered":"<p>\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u5e26\u6765\u7684\u6559\u7a0b\u662f\u68d2\u68d2\u7cd6\u56fe\u7684\u7ed8\u5236\u65b9\u6cd5\uff0c\u68d2\u68d2\u7cd6\u56fe\uff08Lollipop Chart\uff09\u662f\u4e00\u79cd\u6570\u636e\u53ef\u89c6\u5316\u7684\u56fe\u8868\u7c7b\u578b\uff0c\u662f\u67f1\u5f62\u56fe\u7684\u201c\u8d85\u7ea7\u53d8\u5f62\u201d\u7248\uff0c\u901a\u8fc7\u7528\u7ebf\u6761\u548c\u5706\u5708\u6765\u8868\u793a\u6570\u636e\u7684\u5927\u5c0f\u548c\u5206\u5e03\uff0c\u53ef\u4ee5\u6a2a\u5411\u6216\u7eb5\u5411\u5c55\u793a\u6570\u636e\uff0c\u7279\u522b\u9002\u5408\u5206\u7c7b\u53d8\u91cf\u8f83\u591a\u7684\u60c5\u51b5\u3002\u8bf4\u5230\u8fd9\u91cc\uff0c\u60f3\u5fc5\u5927\u5bb6\u90fd\u80fd\u60f3\u5230\u68d2\u68d2\u7cd6\u56fe\u662f\u4e00\u79cd\u975e\u5e38\u5951\u5408\u751f\u4fe1\u5206\u6790\u7684\u5c55\u793a\u65b9\u6cd5\uff01\u90a3\u4e48\u5e94\u8be5\u5982\u4f55\u7ed8\u5236\u68d2\u68d2\u7cd6\u56fe\u5462\uff1f\u5982\u4f55\u624d\u80fd\u7ed8\u5236\u597d\u4e00\u4e2a\u9876\u5c16\u7684\u68d2\u68d2\u7cd6\u56fe\u5462\uff1f\u5feb\u8ddf\u7740\u5c0f\u679c\u6765\u505a\u5427\uff01<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"522\" class=\"wp-image-28021\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?resize=640%2C522\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?w=1286 1286w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?resize=300%2C244 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?resize=1024%2C834 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?resize=768%2C626 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-1.png?resize=600%2C489 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> \u4e3a\u4e86\u4f53\u73b0\u5c0f\u679c\u7684\u4e13\u4e1a\u7a0b\u5ea6\uff0c\u5c0f\u679c\u7279\u5730\u6311\u9009\u4e86\u4e00\u7bc7\u53d1\u8868\u5728Nature communications\u4e0a\u7684\u6587\u7ae0\u2014\u2014Obesity-associated changes in molecular biology of primary breast cancer\u3002\u8fd9\u7bc7\u6587\u732e\u4f7f\u7528\u8d85\u8fc72000\u540d\u60a3\u8005\u7684\u6570\u636e\uff0c\u5bf9\u672a\u7ecf\u6cbb\u7597\u7684\u539f\u53d1\u6027\u4e73\u817a\u764c(BC)\u60a3\u8005\u7684\u751f\u7269\u5b66\u5dee\u5f02\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u786e\u5b9a\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u60a3\u8005\u4e0e\u7626\u5f31\u60a3\u8005\u4e4b\u95f4\u666e\u904d\u5b58\u5728\u7684\u51e0\u79cd\u4e0d\u540c\u7684\u57fa\u56e0\u7ec4\u6539\u53d8\uff0c\u901a\u8fc7\u5355\u7ec6\u80de\u8c31\u68c0\u6d4b\u4e0d\u540c\u7ec6\u80de\u533a\u5ba4\u4e2d\u660e\u663e\u7684\u53d8\u5316\uff0c\u6700\u7ec8\u53d1\u73b0\u660e\u80a5\u80d6\u4e0e\u708e\u75c7\u6837\u8868\u578b\u6709\u5173\uff0c\u60a3\u8005\u80a5\u80d6\u53ef\u80fd\u5728BC\u7684\u5f02\u8d28\u6027\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5e94\u8be5\u5728BC\u6cbb\u7597\u4e2d\u52a0\u4ee5\u8003\u8651\u3002<\/p>\n<p>\u5728\u8fd9\u7bc7\u6587\u7ae0\u5bf9\u6570\u636e\u5904\u7406\u7684\u521d\u6b65\u5904\u7406\u4e2d\uff0c\u4f7f\u7528\u4e86\u6570\u636e\u7684\u5173\u8054\u6027\u5206\u6790\uff0c\u800c\u5206\u6790\u7684\u7ed3\u679c\u5c31\u662f\u7528\u68d2\u68d2\u7cd6\u56fe\u5c55\u793a\u7684\u3002\u8003\u8651\u5230\u672c\u6b21\u590d\u73b0\u7684\u6570\u636e\u91cf\u6bd4\u8f83\u5927\uff0c\u5c0f\u679c\u63a8\u8350\u5927\u5bb6\u79df\u8d41\u6211\u4eec\u7684\u670d\u52a1\u5668\u8fdb\u884c\u672c\u6b21\u7684\u590d\u73b0\u5b66\u4e60\uff5e<\/p>\n<p>Step 1 \u5bfc\u5165ICGC\u6570\u636e<\/p>\n<p>ICGC\u662f\u6307\u56fd\u9645\u764c\u75c7\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff0c\u9996\u5148\u4ece\u8be5\u7f51\u7ad9\u7684\u6570\u636e\u5e93\u4e2d\u83b7\u53d6\u4e0eBC\u76f8\u5173\u7684\u57fa\u56e0\u6570\u636e\uff0c\u5728\u8fd9\u91cc\u5c0f\u679c\u5df2\u7ecf\u5e2e\u5927\u5bb6\u6574\u7406\u597d\u4e86\uff0c\u5173\u6ce8\u516c\u4f17\u53f7\u540e\u5373\u53ef\u9886\u53d6\u3002\u5728\u5bfc\u5165\u6570\u636e\u4e4b\u524d\uff0c\u5148\u5bfc\u5165\u672c\u6b21\u6570\u636e\u5904\u7406\u6240\u9700\u7684R\u5305\uff1adplyr\uff0cstringr\uff0copenxlsx\u3002\u7136\u540e\u5bfc\u5165\u4e34\u5e8a\u6570\u636e\u8868\u683cNik-Zainal_et-al_1_ClinicalPathology_withBMI.csv\uff0c\u68c0\u67e5BMI \u7684\u53ef\u7528\u6027\u548c\u5206\u7c7b\u53d8\u91cf\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff0c\u68c0\u67e5\u7ed3\u679c\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u662f\u5bf9BMI\u7684\u53ef\u7528\u6027\u8fdb\u884c\u7684\u76f8\u5173\u6027\u68c0\u9a8c\u3002\u63a5\u7740\u8fc7\u6ee4\u6570\u636e\uff0c\u5bfc\u5165\u7a81\u53d8\u6570\u636e\uff0c\u62f7\u8d1d\u6570\u53d8\u5f02\u6570\u636e\uff0c\u7a81\u53d8\u548c\u91cd\u6392\u7684\u7279\u5f81\u6570\u636e\uff0c\u7a81\u53d8\u8d1f\u8377\u6570\u636e\uff0c\u5355\u78b1\u57fa\u6d4b\u5e8f\u8870\u8001\u4e0a\u4e0b\u6587\u6570\u636e\uff08\u6240\u6709\u7684SBS\uff09\uff0c\u5355\u78b1\u57fa\u6d4b\u5e8f\u8870\u8001\u4e0a\u4e0b\u6587\u6570\u636e\uff08 BC\u57fa\u56e0\u4e2d\u7684\u81f4\u764c SBS \uff09\uff0c\u57fa\u56e0\u8868\u8fbe\u6570\u636e\uff0c\u81f3\u6b64\uff0c\u6240\u6709\u7684ICGC\u6570\u636e\u5bfc\u5165\u5b8c\u6bd5\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"471\" class=\"wp-image-28022\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?resize=640%2C471\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?w=1279 1279w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?resize=300%2C221 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?resize=1024%2C753 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?resize=768%2C565 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-2.png?resize=600%2C441 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>ICGC_clinpath_BMIavailability.csv<\/p>\n<p>Step 2 \u5bfc\u5165METABRIC\u6570\u636e<\/p>\n<p>METABRIC\u662f\u4e00\u4e2a\u56fd\u9645\u5408\u4f5c\u7684\u7814\u7a76\u9879\u76ee\uff0c\u65e8\u5728\u5bf9\u4e73\u817a\u764c\u8fdb\u884c\u6df1\u5165\u7684\u5206\u5b50\u5206\u7c7b\u548c\u751f\u7269\u5b66\u7814\u7a76\u3002METABRIC\u9879\u76ee\u7684\u6570\u636e\u5e93\u5bf9\u5927\u89c4\u6a21\u7684\u5206\u5b50\u5206\u6790\u548c\u4e34\u5e8a\u6570\u636e\u8fdb\u884c\u4e86\u6574\u5408\uff0c\u6240\u4ee5\u5728\u8fd9\u91cc\u6211\u4eec\u8fd8\u9700\u8981\u5bfc\u5165\u548cBC\u76f8\u5173\u7684\u6570\u636e\u3002\u8fd9\u91cc\u7684\u5bfc\u5165\u6d41\u7a0b\u548cICGC\u6570\u636e\u7684\u5bfc\u5165\u6d41\u7a0b\u662f\u76f8\u4f3c\u7684\uff0c\u76f8\u4fe1\u806a\u660e\u5982\u5c0f\u4f19\u4f34\u53ef\u4ee5\u81ea\u5df1\u5b8c\u6210\uff01\u5f53\u7136\uff0c\u5c0f\u679c\u4e5f\u6574\u7406\u597d\u4e86\u76f8\u5173\u7684\u4ee3\u7801\uff0c\u4e5f\u53ef\u4ee5\u6839\u636e\u5c0f\u679c\u6574\u7406\u7684\u4ee3\u7801\u5b8c\u6210\u3002\u8f93\u5165\u8f93\u51fa\u7684\u7ed3\u679c\u5982\u56fe\uff1a<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"472\" class=\"wp-image-28023\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?resize=640%2C472\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?w=1278 1278w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?resize=300%2C221 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?resize=1024%2C755 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?resize=768%2C566 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-3.png?resize=600%2C442 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><a id=\"post-28020-_Hlk155269451\"><\/a><a id=\"post-28020-_Hlk155269452\"><\/a> data_clinical_patient.txt<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"514\" class=\"wp-image-28024\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?resize=640%2C514\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?w=1278 1278w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?resize=300%2C241 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?resize=1024%2C822 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?resize=768%2C617 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-4.png?resize=600%2C482 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>METABRIC_clinpath_BMIavailability.csv<\/p>\n<p>data_clinical_patient.txt\u4e2d\u7684\u662f\u60a3\u6709BC\u7684\u75c5\u4eba\u7684\u4e34\u5e8a\u6570\u636e\uff0cMETABRIC_clinpath_BMIavailability.csv\u4e2d\u7684\u6570\u636e\u5219\u662fMETABRIC\u7684BMI\u6570\u636e\u7684\u53ef\u7528\u6027\u7684\u548c\u5206\u7c7b\u53d8\u91cf\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n<p>Step 3\u3000\u5bfc\u5165ELBC\u6570\u636e<\/p>\n<p>ELBC\u662f\u7531\u6b27\u6d32\u673a\u6784\u6536\u96c6\u7684\u539f\u53d1\u6027\u6d78\u6da6\u6027\u5c0f\u53f6\u764c\u6837\u672c(ELBC)\uff0c\u5176\u5bfc\u5165\u65b9\u5f0f\u548c\u524d\u4e24\u4e2a\u6b65\u9aa4\u4e5f\u662f\u76f8\u4f3c\u7684\uff0c\u5c0f\u4f19\u4f34\u4eec\u76f4\u63a5\u5957\u7528\u4ee3\u7801\u5373\u53ef\uff5e<\/p>\n<p>Step 4 \u5206\u6790\u57fa\u56e0\u8868\u8fbe\u548c\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u4e4b\u95f4\u7684\u5173\u8054\u6027<\/p>\n<p>\u5728\u5bfc\u5165\u6240\u9700\u7684\u6570\u636e\u4e4b\u540e\uff0c\u9700\u8981\u5bf9\u57fa\u56e0\u7684\u8868\u8fbe\u4ee5\u53ca\u4e34\u5e8a\u7684\u75c5\u7406\u7279\u5f81\u4e4b\u95f4\u8fdb\u884c\u5173\u8054\u6027\u5206\u6790\uff0c\u5728\u672c\u7bc7\u6587\u7ae0\u4e2d\u4f7f\u7528\u7684\u662fFisher\u68c0\u9a8c\u3002\u68c0\u9a8c\u7684\u7ed3\u679c\u5982\u4e0b\u56fe\uff0c\u901a\u8fc7p-value\u7684\u503c\u5373\u53ef\u5224\u65ad\u5173\u8054\u6027\u7684\u5927\u5c0f\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"456\" class=\"wp-image-28025\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?resize=640%2C456\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?w=1277 1277w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?resize=300%2C214 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?resize=1024%2C730 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?resize=768%2C547 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-5.png?resize=600%2C428 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>ICGC_clinpath_BMIcat.csv<\/p>\n<p>Step 5\u5206\u6790\u4e34\u5e8a\u7279\u5f81\u548c\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u5173\u8054\u6027<\/p>\n<p>\u8fd9\u4e00\u6b65\u9aa4\u4e2d\u9700\u8981\u5bf9\u4e0a\u8ff0\u4e09\u4e2a\u6570\u636e\u5e93\u4e2d\u5bfc\u5165\u7684\u6570\u636e\u8fdb\u884c\u548c\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u5173\u8054\u6027\u5206\u6790\uff0c\u9996\u5148\u5bf9<\/p>\n<p>METABRIC\u548cICGC\u6570\u636e\u5e93\u4e2d\u7684\u6570\u636e\u8fdb\u884c\u5904\u7406\uff1a\u8bfb\u53d6\u6570\u636e\uff0c\u5bf9BMI\u4e0e\u4f53\u7ec6\u80de\u57fa\u56e0\u7a81\u53d8\u8fdb\u884c\u5173\u8054\u6027\u5206\u6790\uff0c\u68c0\u7d22\u529f\u80fd\uff08\u86cb\u767d\u8d28\uff09\u57df\u6570\u636e\uff0c\u518d\u5bf9BMI \u4e0e\u70ed\u70b9\u7a81\u53d8\u8fdb\u884c\u5173\u8054\u6027\u5206\u6790\uff0c\u6700\u540e\u7ed8\u5236\u9891\u7387\u56fe\u4e0e\u6570\u91cf\u56fe\u3002<\/p>\n<p>\u6700\u540e\u5229\u7528\u68d2\u68d2\u7cd6\u56fe\u5bf9\u7ed3\u679c\u8fdb\u884c\u5c55\u793a\uff0c\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u662f\u6211\u4eec\u4f9d\u636e\u7a81\u53d8\u9891\u7387\u4ee5\u53ca\u7a81\u53d8\u6570\u91cf\u7ed8\u5236\u7684\u68d2\u68d2\u7cd6\u56fe\uff0c\u5c0f\u679c\u53ea\u622a\u53d6\u4e86\u5176\u4e2d\u7684\u4e00\u90e8\u5206\uff0c\u56fe\u7684\u7eb5\u8f74\u662f&#8221;Mutation frequency (lean &amp; overweight)&#8221;\u4e5f\u5c31\u662f\u7626\u4f53\u578b\u548c\u8d85\u91cd\u4f53\u578b\u7684\u7a81\u53d8\u9891\u7387\uff0c\u6a2a\u8f74\u662f\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u7279\u5b9a\u533a\u57df\u6216\u7279\u5f81\uff0c\u5bf9\u4e8e\u86cb\u767d\u8d28\u7684\u529f\u80fd\u548c\u76f8\u4e92\u4f5c\u7528\u5177\u6709\u91cd\u8981\u7684\u5f71\u54cd\uff0c\u4f8b\u5982\u56fe\u4e2d\u7684Notch,NOD domain\u5c31\u662f\u5bf9\u7ec6\u80de\u751f\u547d\u6d3b\u52a8\u6709\u5f71\u54cd\u7684\u7ed3\u6784\u57df\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"344\" class=\"wp-image-28026\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?resize=640%2C344\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?w=1269 1269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?resize=300%2C161 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?resize=1024%2C551 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?resize=768%2C413 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-6.png?resize=600%2C323 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>METABRIC_ICGC_LollipopPlot_NST_ERnHER2n_NOTCH1_count.pdf<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"345\" class=\"wp-image-28027\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?resize=640%2C345\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?w=1270 1270w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?resize=300%2C162 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?resize=1024%2C552 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?resize=768%2C414 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/02\/word-image-28020-7.png?resize=600%2C323 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>METABRIC_ICGC_LollipopPlot_NST_ERnHER2n_PIK3CA_count<\/p>\n<p>\u5c0f\u679c\u5728\u56fe\u4e2d\u4ec5\u4ec5\u5c55\u793a\u4e86METABRIC\u548cICGC\u6570\u636e\u5e93\u4e2d\u7684\u4e00\u90e8\u5206\u6570\u636e\u7ed8\u5236\u7684\u68d2\u68d2\u7cd6\u56fe\uff0c\u5c0f\u4f19\u4f34\u4eec\u6839\u636e\u7ed9\u5b9a\u7684\u4ee3\u7801\u53ef\u4ee5\u751f\u6210\u5176\u4ed6\u6570\u636e\u7684\u68d2\u68d2\u7cd6\u56fe\u54e6\u3002<\/p>\n<p>\u4eca\u5929\u7684\u68d2\u68d2\u7cd6\u56fe\u7684\u7ed8\u5236\u6559\u7a0b\u5c31\u5230\u8fd9\u91cc\u5566~\uff0c\u5c0f\u679c\u7528\u6587\u732e\u7684\u6570\u636e\u4f5c\u4e3a\u5b9e\u4f8b\uff0c\u624b\u628a\u624b\u6559\u5927\u5bb6\u7ed8\u5236\u4e86\u6587\u732e\u4e2d\u4f7f\u7528\u7684\u68d2\u68d2\u7cd6\u56fe\uff0c\u5927\u5bb6\u5728\u5b66\u4f1a\u4e4b\u540e\u53ef\u4ee5\u4f7f\u7528\u5176\u4ed6\u516c\u5f00\u7684\u6570\u636e\u5e93\u8fdb\u884c\u5c1d\u8bd5\u54e6\uff0c\u5982\u679c\u6709\u4efb\u4f55\u7591\u95ee\u6b22\u8fce\u5173\u6ce8\u5c0f\u679c\uff0c\u8bd5\u4e00\u8bd5\u6211\u4eec\u7684\u4e91\u751f\u4fe1\u5c0f\u5de5\u5177\u54df\uff0c\u53ea\u8981\u8f93\u5165\u5408\u9002\u7684\u6570\u636e\u5c31\u53ef\u4ee5\u76f4\u63a5\u7ed8\u5236\u60f3\u8981\u7684\u56fe\u5462\uff0c\u94fe\u63a5\uff1a<a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.biocloudservice.com\/home.html<\/a>\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u5e26\u6765\u7684\u6559\u7a0b\u662f\u68d2\u68d2\u7cd6\u56fe\u7684\u7ed8\u5236\u65b9\u6cd5\uff0c\u68d2\u68d2\u7cd6\u56fe\uff08Lollipop Chart\uff09\u662f\u4e00\u79cd\u6570\u636e\u53ef\u89c6\u5316\u7684\u56fe\u8868\u7c7b 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