{"id":36601,"date":"2024-06-10T09:16:51","date_gmt":"2024-06-10T01:16:51","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36601"},"modified":"2024-06-10T09:16:51","modified_gmt":"2024-06-10T01:16:51","slug":"%e6%af%95%e4%b8%9a%e6%95%91%e6%98%9f%e6%89%be%e5%88%b0%e4%ba%86%ef%bc%811%e4%b8%aa%e6%9c%88%e6%8e%a5%e6%94%b66%e5%88%86%e7%bd%91%e7%bb%9c%e8%8d%af%e7%90%86%e5%ad%a6%ef%bc%81%e5%8d%97%e5%bc%80","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36601","title":{"rendered":"\u6bd5\u4e1a\u6551\u661f\u627e\u5230\u4e86\uff011\u4e2a\u6708\u63a5\u65366\u5206+\u7f51\u7edc\u836f\u7406\u5b66\uff01\u5357\u5f00\u5927\u5b66\u5b89\u5b9a\u533b\u9662\u56e2\u961f\u65b0\u4f5c\uff0c0\u5b9e\u9a8c\u7684\u5929\u9009\u6a21\u677f\uff01"},"content":{"rendered":"<p>\u5c0f\u5854\u4eca\u5929\u642d\u5730\u94c1\u65f6\u65e0\u610f\u4e2d\u542c\u5230\u65c1\u8fb9\u7684\u5c0f\u4f19\u4f34\u6709\u4e9b\u7126\u8651\u7684\u8ba8\u8bba\uff1a\u90fd\u662f\u5b66\u533b\u7684\uff0c\u4f60\u770b\u4eba\u5bb6\u641e\u4e34\u5e8a\u7684\u90fd\u7528SEER\u3001NHANES\u7b49\u6570\u636e\u5e93\u4e0d\u505a\u5b9e\u9a8c\u5c31\u8f7b\u677e\u7684\u53d1\u4e0a\u597d\u51e0\u7bc7\u6587\u7ae0\u4e86\uff0c\u53ef\u54b1\u8fd9\u641e\u836f\u5b66\u7684\uff0c\u90fd\u5feb\u8981\u7b54\u8fa9\u4e86\uff0c\u6587\u7ae0\u8fd8\u6ca1\u8c31\u5462\uff01\u5c0f\u5854\u542c\u5b8c\u662f\u771f\u60f3\u4e00\u4e2a\u7bad\u6b65\u51b2\u4e0a\u53bb\u63b7\u5730\u6709\u58f0\u7684\u8bf4\uff1a\u641e\u836f\u5b66\u7684\u4e5f\u67090\u5b9e\u9a8c\u53d1\u6587\u7ae0\u7684\u79d8\u7c4d\u2014\u2014\u7f51\u836f\u5206\u6790\u5440\uff01<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"434\" height=\"352\" class=\"wp-image-36602\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-1.png?resize=434%2C352\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-1.png?w=434 434w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-1.png?resize=300%2C243 300w\" sizes=\"(max-width: 434px) 100vw, 434px\" data-recalc-dims=\"1\" 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decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"309\" class=\"wp-image-36603\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-2.png?resize=640%2C309\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-2.png?w=879 879w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-2.png?resize=300%2C145 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-2.png?resize=768%2C371 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-2.png?resize=600%2C290 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" 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Disord<\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=6.6<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e743\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u53cc\u76f8\u60c5\u611f\u969c\u788d\uff0c\u4ee5\u524d\u88ab\u79f0\u4e3a\u8e81\u72c2\u6291\u90c1\u75c7\uff0c\u662f\u4e00\u79cd\u6162\u6027\u548c\u590d\u53d1\u6027\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u8e81\u72c2\u548c\u6291\u90c1\u5faa\u73af\u53d1\u4f5c\uff0c\u55b9\u786b\u5e73\u662f\u4e00\u79cd\u4e8c\u82ef\u5e76\u567b\u5511\u7c7b\u884d\u751f\u7269\uff0c\u6700\u521d\u88ab\u6279\u51c6\u4e3a\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u3002\u76ee\u524d\u55b9\u786b\u5e73\u5355\u836f\u6cbb\u7597\u66f4\u662f\u63a8\u8350\u4f5c\u4e3a\u6025\u6027\u8e81\u72c2\u548c\u6025\u6027\u53cc\u76f8\u6291\u90c1\u75c7\u7684\u4e00\u7ebf\u9009\u62e9\u3002\u7136\u800c\uff0c\u55b9\u786b\u5e73\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002<a id=\"post-36601-_Hlk162445112\"><\/a>\u56e0\u6b64\u672c\u6587\u91c7\u7528\u7f51\u7edc\u836f\u7406\u5b66\u548c\u5206\u5b50\u5bf9\u63a5\u65b9\u6cd5\uff0c\u786e\u5b9a\u55b9\u786b\u5e73\u53cc\u5411\u8c03\u8282\u53cc\u76f8\u6291\u90c1\u548c\u8e81\u72c2\u75c7\u7684\u5206\u5b50\u673a\u5236\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u6570\u636e\u96c6\/\u961f\u5217<\/strong><\/td>\n<td><strong>\u6570\u636e\u5e93<\/strong><\/td>\n<td><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n<td><strong>\u8be6\u7ec6\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u55b9\u786b\u5e73\u7684\u9776\u57fa\u56e0<\/td>\n<td><a id=\"post-36601-_Hlk162446221\"><\/a> GeneCard\u3001SwissTargetPrediction\u3001DrugBank<\/td>\n<td>\u55b9\u786b\u5e73\u7684\u9776\u57fa\u56e0<\/td>\n<td>\u55b9\u786b\u5e73\u7684\u9776\u57fa\u56e0<\/td>\n<\/tr>\n<tr>\n<td>\u53cc\u76f8\u6291\u90c1\u548c\u53cc\u76f8\u8e81\u72c2\u7684\u6cbb\u7597\u9776\u6807<\/td>\n<td><a id=\"post-36601-_Hlk162446244\"><\/a> DisGeNET\u3001GeneCards<\/td>\n<td>\u53cc\u76f8\u6291\u90c1\u548c\u53cc\u76f8\u8e81\u72c2\u7684\u6cbb\u7597\u9776\u6807<\/td>\n<td>\u53cc\u76f8\u6291\u90c1\u548c\u53cc\u76f8\u8e81\u72c2\u7684\u6cbb\u7597\u9776\u6807<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p>\u4f5c\u8005\u9996\u5148\u4eceGeneCard\u3001SwissTargetPrediction\u548cDrugBank\u6570\u636e\u5e93\u4e2d\u6536\u96c6\u55b9\u786b\u5e73\u7684\u63a8\u5b9a\u9776\u57fa\u56e0\u3002\u4eceDisGeNET\u548cGeneCards\u6570\u636e\u5e93\u4e2d\u786e\u5b9a\u53cc\u76f8\u6291\u90c1\u548c\u53cc\u76f8\u8e81\u72c2\u7684\u6cbb\u7597\u9776\u6807\u3002\u63a5\u4e0b\u6765\u5229\u7528String\u6570\u636e\u5e93\u751f\u6210\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528(PPI)\u7f51\u7edc\uff0c\u5e76\u5bfc\u5165\u5230Cytoscape\u4e2d\u3002\u800c\u540e\u5229\u7528DAVID\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\u5bf9\u524d15\u4e2a\u6838\u5fc3\u9776\u70b9\u8fdb\u884cGO\u548cKEGG\u5206\u6790\u3002\u63a5\u4e0b\u91cc\u5229\u7528Cytoscape\u6784\u5efa\u4e86\u836f\u7269\u901a\u8def-\u9776\u70b9-\u75be\u75c5\u7f51\u7edc\u3002\u6700\u540e\uff0c\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\u4ee5\u8bc4\u4f30\u55b9\u786b\u5e73\u4e0e\u6f5c\u5728\u9776\u70b9\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"626\" class=\"wp-image-36604\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-3.png?resize=640%2C626\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-3.png?w=918 918w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-3.png?resize=300%2C293 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-3.png?resize=768%2C751 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36601-3.png?resize=600%2C587 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 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id=\"post-36601-OLE_LINK2\"><\/a>\u5171\u540c\u9776\u70b9\u7684\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528(PPI)\u7f51\u7edc<\/p>\n<p><strong>3.GO\u5bcc\u96c6\u5206\u6790\u548cKEGG\u5bcc\u96c6\u5206\u6790<\/strong><\/p>\n<p>\u63a5\u4e0b\u6765\u4f5c\u8005\u5bf9\u55b9\u786b\u5e73\u6cbb\u7597\u53cc\u76f8\u6291\u90c1\u75c7\u7684\u6838\u5fc3\u9776\u70b9\u8fdb\u884cGO\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff0c\u53d1\u73b0\u4e86166\u4e2aBP\u6761\u76ee\u300116\u4e2aCC\u6761\u76ee\u548c16\u4e2aMF\u6761\u76ee\uff0c\u56fe4A-C\u663e\u793a\u4e86\u524d10\u4e2a\u5bcc\u96c6\u7684BP\u3001CC\u548cMF\u9879\u3002\u800c\u5bf9\u55b9\u786b\u5e73\u6cbb\u7597\u53cc\u76f8\u72c2\u8e81\u7684\u6838\u5fc3\u9776\u70b9\u8fdb\u884cGO\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff0c\u53d1\u73b0\u4e8689\u4e2aBP\u6761\u76ee\u300117\u4e2aCC\u6761\u76ee\u548c14\u4e2aMF\u6761\u76ee\uff0c\u524d10\u4e2a\u5bcc\u96c6\u7684BP\u3001CC\u548cMF\u6761\u76ee\u5982\u56fe4E-G\u6240\u793a\u3002\u540c\u65f6\uff0c\u4e3a\u4e86\u63a2\u7d22\u55b9\u786b\u5e73\u6cbb\u7597\u53cc\u76f8\u6291\u90c1\u548c\u8e81\u72c2\u75c7\u7684\u6f5c\u5728\u4fe1\u53f7\u901a\u8def\uff0c\u4f5c\u8005\u8fdb\u884cKEGG\u901a\u8def\u5206\u6790\uff0c\u7ed3\u679c\u53d1\u73b0MAPK\u548cPI3K\/AKT\u80f0\u5c9b\u7d20\u4fe1\u53f7\u901a\u8def\u88ab\u5bcc\u96c6\uff0c\u8868\u660e\u55b9\u786b\u5e73\u53ef\u80fd\u901a\u8fc7\u8fd9\u4e24\u6761\u901a\u8def\u4f5c\u7528\u4e8e\u53cc\u76f8\u6291\u90c1\u75c7\uff08\u56fe4D\uff09\u3002\u800c\u6839\u636e\u55b9\u786b\u5e73\u6cbb\u7597\u53cc\u76f8\u8e81\u72c2\u7684\u6838\u5fc3\u9776\u70b9\uff0c\u4f5c\u8005\u901a\u8fc7KEGG\u5bcc\u96c6\u786e\u5b9a\u4e86\u76f8\u5e94\u7684\u524d10\u6761\u5bcc\u96c6\u901a\u8def\uff0c\u7ed3\u679c\u53d1\u73b0\u6838\u5fc3\u57fa\u56e0\u6570\u91cf\u6700\u591a\u7684\u662f\u795e\u7ecf\u6d3b\u6027\u914d\u4f53-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u4fe1\u53f7\u901a\u8def\uff0c\u8868\u660e\u55b9\u786b\u5e73\u53ef\u80fd\u901a\u8fc7\u8be5\u901a\u8def\u4f5c\u7528\u4e8e\u53cc\u76f8\u8e81\u72c2(\u56fe4H)\u3002<\/p>\n<p>\u56fe4 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