{"id":36752,"date":"2024-04-22T09:31:43","date_gmt":"2024-04-22T01:31:43","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36752"},"modified":"2024-06-01T22:48:10","modified_gmt":"2024-06-01T14:48:10","slug":"nature-communications%ef%bc%81%e4%b8%8d%e8%a6%81%e5%91%bd%e4%ba%86%ef%bc%9f%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%bb%93%e5%90%88%e5%a4%9a%e7%a7%8d%e5%85%88%e8%bf%9b%e7%94%9f","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36752","title":{"rendered":"Nature Communications\uff01\u4e0d\u8981\u547d\u4e86\uff1f\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u5408\u591a\u79cd\u5148\u8fdb\u751f\u4fe1\u6280\u672f\uff01\u8fd9\u6ce2\u64cd\u4f5c\u7b80\u76f46\u5230\u98de\u8d77\uff01"},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone  wp-image-36510\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=640%2C137\" alt=\"\" width=\"640\" height=\"137\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=300%2C64 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=768%2C163 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=600%2C128 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?w=940 940w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" 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decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-36511 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/2.jpg?resize=298%2C300\" alt=\"\" width=\"298\" height=\"300\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/2.jpg?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/2.jpg?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/2.jpg?resize=100%2C100 100w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/2.jpg?w=568 568w\" sizes=\"(max-width: 298px) 100vw, 298px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"438\" class=\"wp-image-36753\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-1.png?resize=640%2C438\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-1.png?w=898 898w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-1.png?resize=300%2C205 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-1.png?resize=768%2C526 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-1.png?resize=600%2C411 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u5c06\u57fa\u56e0\u8c03\u63a7\u548c\u5355\u7ec6\u80de\u8868\u8fbe\u4e0e GWAS 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POAG\uff09\u662f\u4e00\u79cd\u5bfc\u81f4\u4e0d\u53ef\u9006\u6027\u5931\u660e\u7684\u4e3b\u8981\u539f\u56e0\u3002\u5c3d\u7ba1\u5df2\u77e5\u773c\u5185\u538b\u5347\u9ad8\u662fPOAG\u7684\u4e00\u4e2a\u4e3b\u8981\u98ce\u9669\u56e0\u7d20\uff0c\u4f46\u8bb8\u591a\u60a3\u8005\u773c\u5185\u538b\u6b63\u5e38\uff0c\u8fd9\u8868\u660e\u53ef\u80fd\u5b58\u5728\u5176\u4ed6\u5bfc\u81f4\u89c6\u795e\u7ecf\u635f\u4f24\u7684\u8fc7\u7a0b\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3POAG\u7684\u5206\u5b50\u57fa\u7840\uff0c\u7814\u7a76\u8005\u4eec\u8fdb\u884c\u4e86\u4e00\u9879\u7efc\u5408\u5206\u6790\uff0c\u7ed3\u5408\u4e86\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u3001\u8868\u8fbe\u91cf\u6027\u72b6\u4f4d\u70b9\uff08eQTLs\uff09\u548c\u526a\u63a5\u91cf\u6027\u72b6\u4f4d\u70b9\uff08sQTLs\uff09\u6570\u636e\uff0c\u4ee5\u53ca\u5355\u6838RNA\u6d4b\u5e8f\u6570\u636e\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u63ed\u793a\u4e86\u53ef\u80fd\u5bf9POAG\u53d1\u75c5\u673a\u5236\u4ea7\u751f\u8d21\u732e\u7684\u8c03\u63a7\u673a\u5236\u3001\u57fa\u56e0\u3001\u901a\u8def\u548c\u7ec6\u80de\u7c7b\u578b\u3002<\/p>\n<p><strong>\u7814\u7a76\u601d\u8def<\/strong><\/p>\n<p><strong><img decoding=\"async\" loading=\"lazy\" width=\"253\" height=\"342\" class=\"wp-image-36754\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-2.png?resize=253%2C342\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-2.png?w=253 253w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-36752-2.png?resize=222%2C300 222w\" sizes=\"(max-width: 253px) 100vw, 253px\" data-recalc-dims=\"1\" \/><\/strong><\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1\u3001\u901a\u8fc7\u5171\u5b9a\u4f4d\u5206\u6790\uff0c\u7814\u7a76\u8005\u8bc6\u522b\u4e86\u4e0ePOAG\u548cIOP\u76f8\u5173\u7684\u591a\u4e2a\u9057\u4f20\u4f4d\u70b9\u4e2d\u7684\u56e0\u679c\u57fa\u56e0\u3002<\/strong><\/p>\n<p>\u901a\u8fc7\u5e94\u7528\u5171\u5b9a\u4f4d\u5206\u6790\u65b9\u6cd5\uff0c\u7814\u7a76\u8005\u4eec\u5bf9\u539f\u53d1\u6027\u5f00\u89d2\u578b\u9752\u5149\u773c\uff08POAG\uff09\u548c\u773c\u5185\u538b\uff08IOP\uff09\u7684\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\u8fdb\u884c\u4e86\u6df1\u5165\u6316\u6398\u3002\u4ed6\u4eec\u5229\u7528\u4e86\u6765\u81eaGTEx\u9879\u76ee\u768449\u79cd\u7ec4\u7ec7\u7684\u8868\u8fbe\u91cf\u6027\u72b6\u4f4d\u70b9\uff08eQTLs\uff09\u548c\u526a\u63a5\u91cf\u6027\u72b6\u4f4d\u70b9\uff08sQTLs\uff09\u6570\u636e\uff0c\u4ee5\u53ca\u89c6\u7f51\u819c\u7684\u5355\u7ec6\u80de\u8868\u8fbe\u6570\u636e\u3002\u901a\u8fc7\u7ed3\u5408\u8fd9\u4e9b\u4e30\u5bcc\u7684\u6570\u636e\u8d44\u6e90\uff0c\u5e76\u8fd0\u7528eCAVIAR\u548cenloc\u4e24\u79cd\u8d1d\u53f6\u65af\u5171\u5b9a\u4f4d\u65b9\u6cd5\uff0c\u7814\u7a76\u8005\u6210\u529f\u5730\u8bc6\u522b\u4e86\u591a\u4e2a\u4e0ePOAG\u548cIOP\u76f8\u5173\u7684\u9057\u4f20\u4f4d\u70b9\u4e2d\u7684\u56e0\u679c\u57fa\u56e0\u3002\u8fd9\u4e00\u53d1\u73b0\u663e\u8457\u63a8\u8fdb\u4e86\u5bf9\u9752\u5149\u773c\u9057\u4f20\u57fa\u7840\u7684\u7406\u89e3\uff0c\u4e3a\u672a\u6765\u7684\u7cbe\u51c6\u533b\u7597\u548c\u65b0\u7597\u6cd5\u7684\u5f00\u53d1\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002\u5171\u5b9a\u4f4d\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c<strong>\u7ea660%\u7684POAG\u548cIOP GWAS\u4f4d\u70b9\u4e0e\u81f3\u5c11\u4e00\u4e2aeQTL\u6216sQTL\u663e\u8457\u5171\u5b9a\u4f4d<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"955\" class=\"wp-image-36755\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=640%2C955\" alt=\"Fig. 1\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?w=1269 1269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=201%2C300 201w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=686%2C1024 686w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=768%2C1146 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=1030%2C1536 1030w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-1.png?resize=600%2C895 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u56fe1 \u5171\u5b9a\u4f4d\u5206\u6790\u7ed3\u679c\u3002 <\/strong><\/p>\n<p><strong>2\u3001MR\u5206\u6790\u4e3a\u5171\u5b9a\u4f4d\u5206\u6790\u4e2d\u8bc6\u522b\u7684e\/sQTLs\u4e0ePOAG\u548cIOP\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u63d0\u4f9b\u4e86\u989d\u5916\u7684\u9057\u4f20\u5b66\u652f\u6301\u3002<\/strong><\/p>\n<p>\u7814\u7a76\u56e2\u961f\u91c7\u7528\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u65b9\u6cd5\u6765\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u5171\u5b9a\u4f4d\u5206\u6790\u4e2d\u8bc6\u522b\u7684\u8868\u8fbe\u91cf\u6027\u72b6\u4f4d\u70b9\uff08eQTLs\uff09\u548c\u526a\u63a5\u91cf\u6027\u72b6\u4f4d\u70b9\uff08sQTLs\uff09\u4e0e\u539f\u53d1\u6027\u5f00\u89d2\u578b\u9752\u5149\u773c\uff08POAG\uff09\u548c\u773c\u5185\u538b\uff08IOP\uff09\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u901a\u8fc7\u4f7f\u7528\u6b27\u6d32\u8840\u7edf\u7684POAG\u548cIOP\u7684GWAS\u6458\u8981\u7edf\u8ba1\u6570\u636e\uff0c\u7814\u7a76\u8005\u4eec\u5e94\u7528\u4e86\u4e24\u79cd\u6837\u672cMR\u65b9\u6cd5\uff0c\u4ee5\u8bc4\u4f30e\/sQTLs\u4e0e\u75be\u75c5\u6216\u6027\u72b6\u4e4b\u95f4\u7684\u6f5c\u5728\u56e0\u679c\u6548\u5e94\u3002\u7ed3\u679c\u663e\u793a\uff0c<strong>\u5927\u7ea675%\u7684\u5171\u5b9a\u4f4de\/sQTLs\u901a\u8fc7\u4e86MR\u5206\u6790\uff0c\u652f\u6301\u4e86\u5b83\u4eec\u4e0ePOAG\u548c\/\u6216IOP\u7684\u56e0\u679c\u5173\u8054<\/strong>\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u7406\u89e3\u9752\u5149\u773c\u7684\u9057\u4f20\u673a\u5236\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u9057\u4f20\u8bc1\u636e\uff0c\u5e76\u4e14\u5f3a\u8c03\u4e86e\/sQTLs\u5728\u63ed\u793a\u590d\u6742\u75be\u75c5\u7684\u5206\u5b50\u548c\u7ec6\u80de\u673a\u5236\u4e2d\u7684\u91cd\u8981\u4f5c\u7528<strong>\u3002<\/strong><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"855\" class=\"wp-image-36756\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=640%2C855\" alt=\"Fig. 2\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?w=1738 1738w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=224%2C300 224w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=766%2C1024 766w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=768%2C1027 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=1149%2C1536 1149w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=1532%2C2048 1532w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?resize=600%2C802 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-2.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><a id=\"post-36752-_Hlk157189163\"><\/a><strong>\u56fe2 \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u652f\u6301\u3002<\/strong><\/p>\n<p><strong>3\u3001ECLIPSER\u5206\u6790\u63ed\u793a\u4e86\u5728\u9752\u5149\u773c\u76f8\u5173\u7684\u773c\u7ec4\u7ec7\u4e2d\uff0c\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\uff08\u5982\u776b\u72b6\u808c\u7ea4\u7ef4\u7ec6\u80de\u3001\u89c6\u7f51\u819c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7b49\uff09\u4e2d\u5bcc\u96c6\u7684POAG\u548cIOP\u76f8\u5173\u57fa\u56e0\u3002<\/strong><\/p>\n<p>\u7814\u7a76\u56e2\u961f\u8fd0\u7528\u4e86ECLIPSER\u65b9\u6cd5\uff0c\u8fd9\u662f\u4e00\u79cd\u4e13\u95e8\u8bbe\u8ba1\u7528\u4e8e<strong>\u5355\u7ec6\u80de\u8868\u8fbe\u548c\u8c03\u63a7\u6570\u636e<\/strong>\u7684\u5206\u6790\u5de5\u5177\uff0c\u4ee5\u8bc6\u522b\u5728\u9752\u5149\u773c\u76f8\u5173\u773c\u7ec4\u7ec7\u4e2d\u5bcc\u96c6\u7684\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u57fa\u56e0\u3002\u901a\u8fc7\u5bf9\u6765\u81ea\u4e0d\u540c\u773c\u7ec4\u7ec7\uff08\u5305\u62ec\u524d\u6bb5\u3001\u89c6\u7f51\u819c\u3001\u89c6\u795e\u7ecf\u5934\u53ca\u5176\u5468\u56f4\u540e\u90e8\u7ec4\u7ec7\uff09\u7684\u5355\u6838RNA\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u6df1\u5165\u5206\u6790\uff0c\u7814\u7a76\u8005\u4eec\u63ed\u793a\u4e86<strong>\u4e0ePOAG\u548cIOP\u76f8\u5173\u7684\u57fa\u56e0\u5728\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u5bcc\u96c6\u6a21\u5f0f<\/strong>\u3002\u7ed3\u679c\u663e\u793a\uff0cPOAG\u76f8\u5173\u57fa\u56e0\u7279\u522b\u5bcc\u96c6\u5728\u89c6\u7f51\u819c\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548cM\u00fcller\u80f6\u8d28\u7ec6\u80de\u4e2d\uff0c\u800cIOP\u76f8\u5173\u57fa\u56e0\u5219\u5728\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u548c\u5468\u7ec6\u80de\u4e2d\u6709\u663e\u8457\u5bcc\u96c6\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e0d\u4ec5\u63ed\u793a\u4e86\u9752\u5149\u773c\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u7684\u5173\u952e\u7ec6\u80de\u7c7b\u578b\uff0c\u800c\u4e14\u4e3a\u672a\u6765\u9488\u5bf9\u8fd9\u4e9b\u7ec6\u80de\u7c7b\u578b\u7684\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u5206\u5b50\u9776\u70b9\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"932\" class=\"wp-image-36757\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=640%2C932\" alt=\"Fig. 6\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?w=1701 1701w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=206%2C300 206w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=703%2C1024 703w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=768%2C1119 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=1054%2C1536 1054w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=1406%2C2048 1406w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?resize=600%2C874 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-6.png?w=1280 1280w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u56fe3\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u8868\u8fbe\u3002<\/strong><\/p>\n<p><strong>4\u3001\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\u8868\u660e\uff0cPOAG\u548cIOP\u76f8\u5173\u57fa\u56e0\u5728\u7ec6\u80de\u5916\u57fa\u8d28\u7ec4\u7ec7\u3001\u7ec6\u80de\u7c98\u9644\u548c\u8840\u7ba1\u53d1\u80b2\u7b49\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u5bcc\u96c6\u3002<\/strong><\/p>\n<p>\u7814\u7a76\u8005\u4eec\u901a\u8fc7<strong>\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790<\/strong>\uff08Gene Set Enrichment Analysis\uff09\u63a2\u8ba8\u4e86POAG\u548cIOP\u76f8\u5173\u57fa\u56e0\u5728\u751f\u7269\u5b66\u8fc7\u7a0b\u548c\u901a\u8def\u4e2d\u7684\u53c2\u4e0e\u60c5\u51b5\u3002\u4ed6\u4eec\u5229\u7528\u4e86GeneEnrich\u8f6f\u4ef6\uff0c\u5c06\u5171\u5b9a\u4f4d\u5206\u6790\u4e2d\u8bc6\u522b\u7684\u57fa\u56e0\u4e0e\u591a\u4e2a\u751f\u7269\u4fe1\u606f\u6570\u636e\u5e93\u4e2d\u7684\u57fa\u56e0\u96c6\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u8bc4\u4f30\u8fd9\u4e9b\u57fa\u56e0\u5728\u7279\u5b9a\u751f\u7269\u5b66\u901a\u8def\u4e2d\u7684\u5bcc\u96c6\u7a0b\u5ea6\u3002\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0cPOAG\u76f8\u5173\u57fa\u56e0\u5728\u7ec6\u80de\u5916\u57fa\u8d28\u7ec4\u7ec7\u3001\u7ec6\u80de\u7c98\u9644\u548c\u8840\u7ba1\u53d1\u80b2\u7b49\u8fc7\u7a0b\u4e2d\u663e\u8457\u5bcc\u96c6\uff0c\u800c<strong>IOP\u76f8\u5173\u57fa\u56e0\u5219\u4e0e\u8c03\u63a7\u7ec6\u80de\u9aa8\u67b6\u7ec4\u7ec7\u3001\u7ec6\u80de-\u7ec6\u80de\u7c98\u9644\u548c\u8840\u7ba1\u5f62\u6001\u53d1\u751f\u7b49\u8fc7\u7a0b\u5bc6\u5207\u76f8\u5173<\/strong>\u3002\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86\u9752\u5149\u773c\u75c5\u7406\u8fc7\u7a0b\u4e2d\u6f5c\u5728\u7684\u5173\u952e\u751f\u7269\u5b66\u673a\u5236\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u53ef\u80fd\u7684\u5e72\u9884\u901a\u8def\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u4e0d\u4ec5\u52a0\u6df1\u4e86\u5bf9\u9752\u5149\u773c\u5206\u5b50\u57fa\u7840\u7684\u7406\u89e3\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"848\" class=\"wp-image-36758\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=640%2C848\" alt=\"Fig. 3\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?w=1269 1269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=226%2C300 226w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=773%2C1024 773w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=768%2C1018 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=1159%2C1536 1159w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-3.png?resize=600%2C795 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><a id=\"post-36752-_Hlk163118626\"><\/a><strong>\u56fe4 \u751f\u7269\u5b66\u8fc7\u7a0b\u548c\u901a\u8def\u7684\u5bcc\u96c6\u3002<\/strong><\/p>\n<p><strong>5\u3001\u7814\u7a76\u7ed3\u679c\u63d0\u51fa\u4e86\u53ef\u80fd\u7684\u65b0\u6cbb\u7597\u9776\u70b9\uff0c\u5305\u62ec\u4e0e\u8840\u7ba1\u53d1\u80b2\u548c\u795e\u7ecf\u4fdd\u62a4\u76f8\u5173\u7684\u57fa\u56e0\u548c\u7ec6\u80de\u7c7b\u578b\u3002<\/strong><\/p>\n<p>\u901a\u8fc7\u7efc\u5408\u5206\u6790<strong>GWAS\u6570\u636e\u3001eQTLs\u3001sQTLs\u4ee5\u53ca\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e<\/strong>\uff0c\u7814\u7a76\u8005\u4eec\u8bc6\u522b\u51fa\u4e86\u4e0e\u539f\u53d1\u6027\u5f00\u89d2\u578b\u9752\u5149\u773c\uff08POAG\uff09\u548c\u773c\u5185\u538b\uff08IOP\uff09\u76f8\u5173\u7684\u57fa\u56e0\u548c\u7ec6\u80de\u7c7b\u578b\u3002\u4ed6\u4eec\u7279\u522b\u5173\u6ce8\u4e86\u90a3\u4e9b\u5728IOP\u72ec\u7acb\u673a\u5236\u4e2d\u53ef\u80fd\u53d1\u6325\u4f5c\u7528\u7684\u57fa\u56e0\uff0c\u5982CDKN2B-AS1\u548cRERE\uff0c\u8fd9\u4e9b\u57fa\u56e0\u5728\u89c6\u7f51\u819c\u7684\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u4e2d\u8868\u8fbe\u589e\u52a0\uff0c\u53ef\u80fd\u901a\u8fc7\u5f71\u54cd\u7ec6\u80de\u5468\u671f\u548c\u7ec6\u80de\u51cb\u4ea1\u6765\u589e\u52a0POAG\u98ce\u9669\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\u4e0e\u8840\u7ba1\u53d1\u5c55\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u5982ANGPT1\u548cANGPT2\uff0c\u5b83\u4eec\u7684\u8868\u8fbe\u589e\u52a0\u53ef\u80fd\u6709\u52a9\u4e8e\u964d\u4f4eIOP\u6c34\u5e73\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"460\" class=\"wp-image-36759\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?resize=640%2C460\" alt=\"Fig. 5\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?w=1269 1269w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?resize=300%2C216 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?resize=1024%2C737 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?resize=768%2C553 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/fig-5.png?resize=600%2C432 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u56fe5 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