{"id":36772,"date":"2024-04-22T09:35:26","date_gmt":"2024-04-22T01:35:26","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36772"},"modified":"2024-04-22T09:35:28","modified_gmt":"2024-04-22T01:35:28","slug":"%e5%b1%85%e7%84%b6%e8%bf%98%e8%83%bd%e4%bb%8e%e8%bf%99%e4%b8%aa%e8%a7%92%e5%ba%a6%e8%bf%9b%e8%a1%8cmr%e5%88%86%e6%9e%90%ef%bc%9f%e9%80%89%e9%a2%98%e9%80%89%e7%9a%84%e5%a5%bd%ef%bc%8c%e6%96%87-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=36772","title":{"rendered":"\u5c45\u7136\u8fd8\u80fd\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u8fdb\u884cMR\u5206\u6790\uff1f\u9009\u9898\u9009\u7684\u597d\uff0c\u6587\u7ae0\u8dd1\u4e0d\u4e86\uff01\u6d59\u5927\u4e00\u9644\u9662\u4e00\u533a\u65b0\u4f5c\u6765\u88ad\uff01"},"content":{"rendered":"

\"\"<\/p>\n

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\u4eca\u5929\u5c0f\u4e91\u5c31\u662f\u6765\u5e2e\u52a9\u5927\u5bb6\u4fee\u70bc\u751f\u4fe1\u5206\u6790\u65b9\u6cd5\u4e2d\u7684\u57fa\u672c\u529f\u2014\u2014\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u3002\u8fd9\u4e2a\u65b9\u6cd5\u7684\u91cd\u8981\u6027\u5c0f\u4e91\u4eca\u5929\u5c31\u4e0d\u8d58\u8ff0\u4e86\u54e6\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u4f7f\u7528MR\u8fdb\u884c\u7814\u7a76\u7684\u6587\u7ae0\u8d8a\u6765\u8d8a\u591a\uff0c\u5927\u5bb6\u662f\u4e0d\u662f\u611f\u89c9\u7814\u7a76\u89d2\u5ea6\u5df2\u7ecf\u88ab\u7528\u5b8c\u4e86\u5462\uff1fNo\uff0cNo\uff0cNo\uff0c\u6ca1\u6709\u7528\u5b8c\u7684\u89d2\u5ea6\u53ea\u6709\u4e0d\u52aa\u529b\u7684\u751f\u4fe1\u4eba\uff01<\/strong>\u6bd4\u5982\u4eca\u5929\u5c0f\u4e91\u5206\u4eab\u7684\u8fd9\u7bc7\u6587\u7ae0\u7684\u89d2\u5ea6\u5c31\u5f88\u7279\u522b\uff0c\u5c06\u996e\u9152\u4e0e\u7cbe\u795e\u969c\u788d\u5173\u8054\uff0c\u6ca1\u60f3\u5230\u8fd8\u80fd\u8fd9\u6837\u5173\u8054\u5427\uff1f\u90a3\u4e48\u73b0\u5728\u5c31\u8ddf\u7740\u5c0f\u4e91\u4e00\u8d77\u6765\u770b\u770b\u8fd9\u7bc7\u6d59\u5927\u4e00\u9644\u9662\u4f20\u67d3\u75c5\u8bca\u6cbb\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u674e\u660e\u5fb7\u7814\u7a76\u56e2\u961f\u7684\u65b0\u4f5c\u5427\uff01<\/p>\n

    \n
  1. \u7814\u7a76\u56e2\u961f\u91c7\u7528\u4e86\u591a\u7ec4\u5b66\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/strong>\u5206\u6790\u65b9\u6cd5\uff0c\u901a\u8fc7\u5229\u7528\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u8bc4\u4f30\u4e86\u996e\u9152\u5bf9\u7cbe\u795e\u969c\u788d<\/strong>\u7684\u5f71\u54cd\uff0c\u4ee5\u53caDNA\u7532\u57fa\u5316\u548c\u57fa\u56e0\u8868\u8fbe\u5728\u5176\u4e2d\u7684\u4f5c\u7528<\/strong>\u3002\u4e3a\u4e86\u9a8c\u8bc1\u7ed3\u679c\u7684\u53ef\u9760\u6027\uff0c\u7814\u7a76\u56e2\u961f\u8fdb\u884c\u4e86\u591a\u79cd\u654f\u611f\u6027\u548c\u9a8c\u8bc1\u5206\u6790\uff0c\u5305\u62ec\u5171\u5b9a\u4f4d\u5206\u6790\u3002<\/li>\n<\/ol>\n

    2. \u7814\u7a76\u56e2\u961f\u4ece\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u3001\u5c3c\u53e4\u4e01\u4f7f\u7528\u6d4b\u5e8f\u8054\u76df\uff08GSCAN\uff09\u3001DNA\u7532\u57fa\u5316\u9057\u4f20\u5b66\u8054\u76df\uff08GoDMC\uff09\u4ee5\u53ca\u7cbe\u795e\u75c5\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff08PGC\uff09<\/strong>\u83b7\u53d6\u6570\u636e\uff0c\u5305\u62ec941280\u6761\u4e00\u822c\u9152\u7cbe\u6444\u5165\u91cf\u6570\u636e\uff0c51710 ~ 500199\u6761\u7cbe\u795e\u75be\u75c5\u6570\u636e\u4ee5\u53ca9643\u4e2a\u9152\u7cbe\u76f8\u5173DNA\u7532\u57fa\u5316CpG\u4f4d\u70b9\u7b49\u6570\u636e\u3002<\/p>\n

    3. \u7814\u7a76\u53d1\u73b0\uff0c\u75c5\u7406\u6027\u996e\u9152\u884c\u4e3a\u4e0e\u7cbe\u795e\u75be\u75c5\u98ce\u9669\u589e\u52a0\u76f8\u5173<\/strong>\uff0c\u53bb\u9664\u5f02\u5e38\u503c\u6216\u63a7\u5236\u9152\u7cbe\u6444\u5165\u540e\u8fd9\u79cd\u5173\u8054\u4f9d\u7136\u5b58\u5728\u3002MR\u5206\u6790\u786e\u8ba4\u4e8610\u4e2a\u4e0e\u9152\u7cbe\u76f8\u5173\u7684CpG\u4f4d\u70b9\uff0c\u5b83\u4eec\u4e0e\u7cbe\u795e\u75be\u75c5\u5b58\u5728\u56e0\u679c\u5173\u7cfb\u3002<\/strong>\u6b64\u5916\uff0c\u5728\u5927\u8111\u76ae\u5c42\u7684\u5f15\u5bfc\u4e0b\uff0c\u8fd9\u4e9bCpG\u4f4d\u70b9\u76f8\u5173\u7684\u57fa\u56e0\uff08\u5305\u62ecRERE\u3001PTK6\u3001GATAD2B\u3001COG8\u3001PDF\u548cGAS5\uff09\u7684\u8868\u8fbe\u4e0e\u7cbe\u795e\u75be\u75c5\u663e\u8457\u76f8\u5173<\/strong>\u3002<\/p>\n

    4. \u672c\u7814\u7a76\u7684\u521b\u65b0\u4e4b\u5904\u5728\u4e8e\u91c7\u7528\u4e86\u591a\u7ec4\u5b66\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/strong>\u65b9\u6cd5\uff0c\u4ece\u9057\u4f20\u89d2\u5ea6\u63a2\u7a76\u4e86\u996e\u9152\u3001DNA\u7532\u57fa\u5316\u548c\u7cbe\u795e\u969c\u788d\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb<\/strong>\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u56e2\u961f\u80fd\u591f\u66f4\u51c6\u786e\u5730\u8bc4\u4f30\u8fd9\u4e9b\u56e0\u7d20\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u4e3a\u672a\u6765\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002\u5c0f\u4f19\u4f34\u4eec\u89c9\u5f97\u8fd9\u4e2a\u7814\u7a76\u89d2\u5ea6\u548c\u601d\u8def\u600e\u4e48\u6837\u5440\uff1f\u662f\u4e0d\u662f\u6709\u79cd\u4e00\u8bed\u60ca\u9192\u68a6\u4e2d\u4eba\u7684\u611f\u89c9\uff1f\u4f60\u4e5f\u60f3\u8981\u8fd9\u79cd\u521b\u65b0\u89d2\u5ea6\u548c\u601d\u8def\u5417\uff1f\u90a3\u5c31\u8d76\u7d27\u6765\u627e\u5c0f\u4e91\u4ea4\u6d41\u5b66\u4e60\u5427\uff01<\/strong><\/p>\n

    \"\"<\/p>\n

    <\/p>\n

    \u9898\u76ee\uff1a\u996e\u9152\u3001DNA\u7532\u57fa\u5316\u548c\u7cbe\u795e\u75be\u75c5\uff1a\u4e00\u9879\u591a\u7ec4\u5b66\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\uff0c\u4ee5\u8c03\u67e5\u56e0\u679c\u5173\u7cfb<\/p>\n

    \u6742\u5fd7\uff1aAddiction<\/p>\n

    \u5f71\u54cd\u56e0\u5b50\uff1aIF = 6.0<\/p>\n

    \u53d1\u8868\u65f6\u95f4\uff1a2024\u5e7403\u6708<\/p>\n

    \u7814\u7a76\u80cc\u666f<\/strong><\/p>\n

    \u8fc7\u53bb\u7684\u7814\u7a76\u5df2\u7ecf\u53d1\u73b0\u996e\u9152\u548c\u7cbe\u795e\u969c\u788d\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\uff0c\u4f46\u5177\u4f53\u7684\u56e0\u679c\u5173\u7cfb\u548c\u5206\u5b50\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u660e\u786e\u3002\u56e0\u6b64\uff0c\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u901a\u8fc7MR\u65b9\u6cd5\u6765\u8bc4\u4f30\u996e\u9152\u5bf9\u7cbe\u795e\u969c\u788d\u7684\u5f71\u54cd\uff0c\u4ee5\u53caDNA\u7532\u57fa\u5316\u548c\u57fa\u56e0\u8868\u8fbe\u5728\u5176\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u6df1\u5165\u7814\u7a76\u8fd9\u4e9b\u590d\u6742\u5173\u7cfb\uff0c\u7814\u7a76\u56e2\u961f\u5e0c\u671b\u4e3a\u7406\u89e3\u548c\u5904\u7406\u4e0e\u996e\u9152\u3001DNA\u7532\u57fa\u5316\u548c\u7cbe\u795e\u969c\u788d\u76f8\u5173\u7684\u95ee\u9898\u63d0\u4f9b\u65b0\u7684\u89c1\u89e3\u548c\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

    \u6570\u636e\u6765\u6e90<\/strong><\/p>\n

    \u7814\u7a76\u4eba\u5458\u4ece\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u3001\u5c3c\u53e4\u4e01\u4f7f\u7528\u6d4b\u5e8f\u8054\u76df\uff08GSCAN\uff09\u3001DNA\u7532\u57fa\u5316\u9057\u4f20\u5b66\u8054\u76df\uff08GoDMC\uff09\u4ee5\u53ca\u7cbe\u795e\u75c5\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff08PGC\uff09\u83b7\u53d6\u7814\u7a76\u6570\u636e\uff0c\u5305\u62ec\u4ee5\u4e0b\u90e8\u5206\uff1a<\/p>\n

      \n
    1. \u4e00\u822c\u9152\u7cbe\u6444\u5165\u91cf\u7684\u6c47\u603b\u6570\u636e\uff1a941 280\u6761<\/li>\n
    2. \u7cbe\u795e\u75be\u75c5\u76f8\u5173\u6570\u636e\uff1a51710 \uff5e 500199\u6761\uff0c\u5305\u62ec\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u91cd\u6027\u6291\u90c1\u75c7\u548c\u53cc\u76f8\u60c5\u611f\u969c\u788d<\/li>\n
    3. \u9152\u7cbe\u76f8\u5173DNA\u7532\u57fa\u5316CpG\u4f4d\u70b9\uff1a9643\u6761<\/li>\n
    4. \u75c5\u7406\u6027\u996e\u9152\u884c\u4e3a\uff1a313 959\u6761\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u6570\u636e\uff0c435563\u6761\u95ee\u9898\u6027\u9152\u7cbe\u4f7f\u7528\u6570\u636e<\/li>\n
    5. mQTL\u6570\u636e\uff1a27 750\u6761\u8840\u6db2\u6570\u636e\uff0c1160\u6761\u8111\u90e8\u6570\u636e<\/li>\n<\/ol>\n

      \u7814\u7a76\u601d\u8def<\/strong><\/p>\n

      \u672c\u7814\u7a76\u4f7f\u7528\u4e86\u4ece\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u3001\u5c3c\u53e4\u4e01\u4f7f\u7528\u6d4b\u5e8f\u8054\u76df\uff08GSCAN\uff09\u3001DNA\u7532\u57fa\u5316\u9057\u4f20\u5b66\u8054\u76df\uff08GoDMC\uff09\u4ee5\u53ca\u7cbe\u795e\u75c5\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff08PGC\uff09\u83b7\u53d6\u7684\u6570\u636e\u3002\u9996\u5148\uff0c\u7814\u7a76\u56e2\u961f\u5229\u7528MR\u786e\u5b9a\u4e86\u996e\u9152\u5bf9\u7cbe\u795e\u969c\u788d\u7684\u6f5c\u5728\u5f71\u54cd\u3002\u5176\u6b21\uff0c\u901a\u8fc7\u6574\u5408\u5927\u8111\u548c\u8840\u6db2\u8868\u8fbe\u91cfQTL\u6570\u636e\uff0c\u7ed3\u5408\u7532\u57fa\u5316MR\u548c\u5171\u5b9a\u4f4d\u5206\u6790\uff0c\u8bc6\u522b\u4e86\u5728\u9152\u7cbe\u4ecb\u5bfc\u7684\u7cbe\u795e\u969c\u788d\u75c5\u56e0\u4e2d\u8d77\u56e0\u679c\u4f5c\u7528\u7684CpG\u4f4d\u70b9\u53ca\u5176\u5bf9\u5e94\u7684\u57fa\u56e0\u3002\u6700\u540e\u901a\u8fc7\u6574\u5408\u6570\u636e\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u7cbe\u795e\u969c\u788d\u7684\u81f4\u75c5\u57fa\u56e0\u3002\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u8fd9\u4e9b\u5206\u6790\uff0c\u63ed\u793a\u4e86\u996e\u9152\u5bf9\u7cbe\u795e\u969c\u788d\u7684\u6f5c\u5728\u56e0\u679c\u5173\u7cfb\uff0c\u4ee5\u53ca\u4e0e\u4e4b\u76f8\u5173\u7684DNA\u7532\u57fa\u5316\u548c\u57fa\u56e0\u8868\u8fbe\u7684\u751f\u7269\u5b66\u673a\u5236\uff0c\u4e3a\u9ad8\u98ce\u9669\u4e2a\u4f53\u7684\u5e72\u9884\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002<\/p>\n

      <\/p>\n

      \u7814\u7a76\u4e3b\u8981\u6d41\u7a0b\u56fe<\/p>\n

      \u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n

        \n
      1. \u996e\u9152\u9057\u4f20\u503e\u5411\u5bf9\u7cbe\u795e\u75be\u75c5\u9884\u540e\u7684\u56e0\u679c\u5f71\u54cd<\/strong><\/li>\n<\/ol>\n

        MR\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u800c\u8a00\uff0c\u53bb\u9664\u5f02\u5e38\u503c\u540e\u53d1\u73b0\u6bcf\u5468\u996e\u9152\u5bf9\u5176\u6709\u663e\u8457\u7684\u56e0\u679c\u5f71\u54cd\uff0c\u5e76\u4e14\u57fa\u56e0\u9884\u6d4b\u7684\u9152\u7cbe\u4f7f\u7528\u969c\u788d\u548c\u95ee\u9898\u6027\u9152\u7cbe\u4f7f\u7528\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u98ce\u9669\u589e\u52a0\u76f8\u5173\uff1b\u5bf9\u4e8e\u91cd\u6027\u6291\u90c1\u75c7\u800c\u8a00\uff0c\u6bcf\u5468\u996e\u9152\u4e5f\u663e\u793a\u51fa\u5bf9\u5176\u6709\u663e\u8457\u5f71\u54cd\uff1b\u5bf9\u4e8e\u53cc\u76f8\u60c5\u611f\u969c\u788d\u800c\u8a00\uff0c\u6ca1\u6709\u53d1\u73b0\u663e\u8457\u56e0\u679c\u5173\u7cfb\u7684\u8bc1\u636e\u3002<\/p>\n

        <\/p>\n

        \u9152\u7cbe\u5bf9\u7cbe\u795e\u75be\u75c5\u9884\u540e\u7684\u5f71\u54cdMR\u5206\u6790\u56fe<\/p>\n

          \n
        1. \u9152\u7cbe\u76f8\u5173DNA\u7532\u57fa\u5316\u5bf9\u7cbe\u795e\u75be\u75c5\u9884\u540e\u7684\u56e0\u679c\u5f71\u54cd<\/strong><\/li>\n<\/ol>\n

          \u7814\u7a76\u4eba\u5458\u4f7f\u7528DNA\u7532\u57fa\u5316MR\u5206\u6790\u5bf9275\u4e2a\u4e0e\u9152\u7cbe\u76f8\u5173\u7684CpG\u4f4d\u70b9\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u53d1\u73b0\u5176\u4e2d13\u4e2a\u30018\u4e2a\u548c10\u4e2aCpG\u4f4d\u70b9\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u91cd\u6027\u6291\u90c1\u75c7\u548c\u53cc\u76f8\u60c5\u611f\u969c\u788d\u7684\u98ce\u9669\u76f8\u5173\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u663e\u793a\u90e8\u5206CpG\u4f4d\u70b9\u5f71\u54cd\u4e24\u79cd\u6216\u4e09\u79cd\u7cbe\u795e\u75be\u75c5\uff0c\u5e76\u901a\u8fc7\u5171\u5b9a\u4f4d\u5206\u6790\u786e\u5b9a\u4e86\u4e0e\u8fd9\u4e9b\u75be\u75c5\u76f8\u5173\u7684CpG\u4f4d\u70b9\u3002\u654f\u611f\u6027\u5206\u6790\u548c\u9a8c\u8bc1\u5206\u6790\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8fd9\u4e9b\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\u67d0\u4e9bCpG\u4f4d\u70b9\u7684\u7532\u57fa\u5316\u4e0e\u76f8\u5e94\u57fa\u56e0\u8868\u8fbe\u76f8\u5173\uff0c\u800c\u8fd9\u4e9b\u57fa\u56e0\u7684\u8868\u8fbe\u4e0e\u7cbe\u795e\u75be\u75c5\u7684\u98ce\u9669\u76f8\u5173\uff0c\u5c24\u5176\u662f\u5728\u7279\u5b9a\u8111\u533a\u57df\u3002<\/p>\n

          <\/p>\n

          MR\u548c\u5171\u5b9a\u4f4d\u7ed3\u679c\u8868\u660e\u9152\u7cbe\u76f8\u5173DNA\u7532\u57fa\u5316\u4e0e\u7cbe\u795e\u75be\u75c5\u98ce\u9669\u4e4b\u95f4\u5b58\u5728\u5173\u8054<\/p>\n

          <\/p>\n

          MR\u7ed3\u679c\u8868\u660e\u5df2\u8bc6\u522b\u57fa\u56e0\u7684\u8868\u8fbe\u4e0e\u7cbe\u795e\u75be\u75c5\u98ce\u9669\u4e4b\u95f4\u5b58\u5728\u5173\u8054<\/p>\n

          \u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n

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