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    MR\u5206\u6790\u4e2d\u4ea7\u751f\u663e\u8457p\u503c\u76847\u79cd\u708e\u75c7\u6807\u5fd7\u7269\u7684\u56e0\u679c\u4f30\u8ba1\u548c\u76f8\u5e94\u768495%\u7f6e\u4fe1\u533a\u95f4<\/p>\n

      \n
    1. CRP\u4f5c\u4e3a\u7cbe\u795e\u5206\u88c2\u75c7\u89e6\u53d1\u708e\u75c7\u6807\u5fd7\u7269\u5bf9\u4e0d\u540c\u8111\u533a\u7eb5\u5411\u5f62\u6001\u53d8\u5316\u7684\u5f71\u54cd<\/strong><\/li>\n<\/ol>\n

      \u7814\u7a76\u53d1\u73b0\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\uff08SCZ\uff09\u60a3\u8005\u4f53\u5185\u7684\u708e\u75c7\u6807\u5fd7\u7269\uff0c\u5305\u62ecCRP\u3001IL-8\u548cGROA\uff08CXCL1\uff09\uff0c\u4e0e\u5927\u8111\u7ed3\u6784\u957f\u671f\u53d8\u5316\u76f8\u5173\u3002\u5177\u4f53\u6765\u8bf4\uff0cCRP\u4e0e\u5927\u8111\u767d\u8d28\u3001\u82cd\u767d\u7403\u548c\u8868\u9762\u79ef\u7684\u53d8\u5316\u7387\u5448\u663e\u8457\u5173\u8054\u3002IL-8\u4e0e\u5927\u8111\u767d\u8d28\u548c\u674f\u4ec1\u6838\u7684\u53d8\u5316\u7387\u4e5f\u5b58\u5728\u76f8\u5173\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u63d0\u793a\uff0c\u708e\u75c7\u53ef\u80fd\u5728SCZ\u7684\u53d1\u75c5\u548c\u8fdb\u5c55\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u708e\u75c7\u901a\u8fc7\u5f71\u54cd\u5927\u8111\u7ed3\u6784\u7684\u957f\u671f\u53d8\u5316\uff0c\u53ef\u80fd\u5bfc\u81f4SCZ\u60a3\u8005\u51fa\u73b0\u8ba4\u77e5\u548c\u60c5\u7eea\u529f\u80fd\u969c\u788d<\/p>\n

      <\/p>\n

      CRP\u4f5c\u4e3a\u7cbe\u795e\u5206\u88c2\u75c7\u89e6\u53d1\u708e\u75c7\u6807\u5fd7\u7269\u5bf9\u4e0d\u540c\u8111\u533a\u7eb5\u5411\u5f62\u6001\u53d8\u5316\u7684\u56e0\u679c\u5f71\u54cd\u8bf4\u660e\u56fe<\/p>\n

      \u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n

      \u8fd9\u7bc7\u6587\u7ae0\u5229\u7528\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u708e\u75c7\u76f8\u5173\u7684\u57fa\u56e0\u578b\u6570\u636e\uff0c\u7ed3\u5408\u5927\u8111\u7ed3\u6784\u53d8\u5316\u7684\u957f\u671f\u6570\u636e\uff0c\u63a2\u8ba8\u4e86\u708e\u75c7\u56e0\u5b50\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u75c5\u53ca\u5927\u8111\u5f62\u6001\u53d8\u5316\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u591a\u4e2a\u708e\u75c7\u6807\u5fd7\u7269\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u53d1\u75c5\u6709\u5173\uff0c\u5e76\u4e14C-\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u663e\u8457\u5f71\u54cd\u5927\u8111\u5f62\u6001\u7684\u7ebf\u6027\u53d8\u5316\uff0c\u5c24\u5176\u662f\u5728\u5927\u8111\u767d\u8d28\u7684\u53d8\u5316\u4e2d\u5177\u6709\u663e\u8457\u6027\u3002\u7814\u7a76\u56e2\u961f\u4f7f\u7528\u5168\u57fa\u56e0\u7ec4\u6a21\u578b\uff0c\u800c\u4e0d\u662f\u4f20\u7edf\u7684MR\u65b9\u6cd5\u3002\u6211\u4eec\u90fd\u77e5\u9053\uff0c\u5728\u4f20\u7edf\u7684MR\u65b9\u6cd5\u4e2d\uff0c\u7814\u7a76\u8005\u901a\u5e38\u9009\u62e9\u4e00\u7ec4\u7279\u5b9a\u7684SNP\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff08IVs\uff09\uff0c\u7528\u4e8e\u8bc4\u4f30\u67d0\u4e2a\u56e0\u7d20\u5bf9\u7279\u5b9a\u8868\u578b\u7684\u56e0\u679c\u5f71\u54cd\u3002\u7136\u800c\uff0c\u7531\u4e8e\u590d\u6742\u75be\u75c5\u5982\u7cbe\u795e\u5206\u88c2\u75c7\u53ef\u80fd\u6d89\u53ca\u591a\u4e2a\u57fa\u56e0\u548c\u57fa\u56e0\u7ec4\u533a\u57df\uff0c\u4f20\u7edf\u7684MR\u65b9\u6cd5\u53ef\u80fd\u65e0\u6cd5\u5168\u9762\u8003\u8651\u5230\u6240\u6709\u6f5c\u5728\u7684\u57fa\u56e0\u5f71\u54cd\u3002<\/p>\n

      \u7814\u7a76\u56e2\u961f\u5bf9\u751f\u4fe1\u6570\u636e\u5206\u6790\u65b9\u6cd5\u7684\u9009\u53d6\u89d2\u5ea6\u975e\u5e38\u503c\u5f97\u6211\u4eec\u5b66\u4e60\u54e6\uff0c\u5c31\u50cf\u5c0f\u4e91\u524d\u6587\u6240\u8bf4\u7684\uff0c\u7d27\u6293\u70ed\u70b9\u5e76\u4e14\u6839\u636e\u7814\u7a76\u5bf9\u8c61\u9009\u62e9\u5408\u9002\u7684\u7814\u7a76\u65b9\u6cd5\u4e0e\u89d2\u5ea6\uff0c\u8fd9\u624d\u662f\u8ffd\u8e2a\u70ed\u70b9\u7684\u6b63\u786e\u65b9\u5f0f\u54e6\uff01\u5982\u679c\u4f60\u5bf9\u8fd9\u65b9\u9762\u8fd8\u6709\u4ec0\u4e48\u7591\u95ee\u7684\u8bdd\uff0c\u53ef\u4ee5\u591a\u6765\u627e\u5c0f\u4e91\u804a\u804a\uff5e\u5f88\u591a\u65b9\u6cd5\u4e0e\u521b\u65b0\u70b9\u90fd\u662f\u5728\u4ea4\u6d41\u78b0\u649e\u4e2d\u4ea7\u751f\u7684\u54e6\uff01\u98ce\u91cc\u96e8\u91cc\uff0c\u5c0f\u4e91\u5728\u8fd9\u91cc\u7b49\u4f60\uff5e<\/strong><\/p>\n

      \"\"<\/p>\n

      \u539f\u6587\u94fe\u63a5\uff1aLiu Y, Ren H, Zhang Y, Deng W, Ma X, Zhao L, Li X, Sham P, Wang Q, Li T. Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study. Psychol Med. 2024 Mar 6:1-9. <\/strong><\/p>\n

      doi: 10.1017\/S003329172400014X.<\/strong><\/p>\n

      PMID: 38445386<\/strong><\/p>\n\n\n

      <\/p>\n","protected":false},"excerpt":{"rendered":"

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