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    \n
  1. \u672c\u7814\u7a76\u7efc\u5408\u5e94\u7528\u4e86\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f<\/strong>\u548c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790<\/strong>\uff0c\u9996\u6b21<\/strong>\u63ed\u793a\u4e86\u80a5\u80d6\u76f8\u5173\u7ed3\u76f4\u80a0\u764c\u7279\u6709\u7684\u5fae\u751f\u7269\u548c\u4ee3\u8c22\u7279\u5f81\uff0c\u63d0\u51fa\u4e86\u65b0\u7684\u80bf\u7624\u53d1\u751f\u673a\u5236\u5047\u8bbe\uff0c\u8fd9\u79cd\u591a\u7ec4\u5b66\u6574\u5408<\/strong>\u7684\u65b9\u6cd5\u5168\u9762\u63ed\u793a\u5fae\u751f\u7269\u7fa4\u843d\u548c\u4ee3\u8c22\u7269\u4e4b\u95f4\u7684\u590d\u6742\u4ea4\u4e92\u4f5c\u7528\u3002<\/li>\n
  2. \u672c\u7814\u7a76\u53d1\u73b0\u80a5\u80d6\u76f8\u5173\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u843d\u4e0e\u4ee3\u8c22\u8f6e\u5ed3\u7684\u663e\u8457\u53d8\u5316\uff0c\u5982Peptostreptococcus stomatis\u7684\u4e30\u5ea6\u589e\u52a0\u3002<\/li>\n
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    \"\"<\/p>\n

    <\/strong><\/p>\n

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    \u6742\u5fd7\uff1aCell Rep Med<\/p>\n

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      \n
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        \n
      1. \u6b63\u5e38\u4f53\u91cd\u3001\u8d85\u91cd\u548c\u80a5\u80d6\u7ec4\u4e2d\u6574\u4f53\u5fae\u751f\u7269\u7ec4\u6210\u7684\u6539\u53d8<\/li>\n<\/ol>\n

        \u5728\u6b63\u5e38\u4f53\u91cd\u3001\u8d85\u91cd\u548c\u80a5\u80d6\u7ec4\u4e2d\uff0c\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u76f8\u8f83\u4e8e\u5065\u5eb7\u5bf9\u7167\u7ec4\uff0c\u5176\u80a0\u9053\u5fae\u751f\u7269\u7684\u03b1\u591a\u6837\u6027\uff08\u901a\u8fc7Shannon\u6307\u6570\u8861\u91cf\uff09\u663e\u8457\u964d\u4f4e\uff0c\u7279\u522b\u662f\u5728\u6b63\u5e38\u4f53\u91cdCRC\u7ec4\uff08N-CRC\uff09\u4e0e\u6b63\u5e38\u4f53\u91cd\u5bf9\u7167\u7ec4\uff08N-CTRL\uff09\u76f8\u6bd4\uff08\u56fe1B\uff09\u3002\u6b63\u5e38\u4f53\u91cdCRC\u7ec4\uff08N-CRC\uff09\u7684\u03b1\u591a\u6837\u6027\u4e0e\u6b63\u5e38\u4f53\u91cd\u5bf9\u7167\u7ec4\uff08N-CTRL\uff09\u76f8\u6bd4\u663e\u8457\u964d\u4f4e\uff08\u56fe1B\uff09\u3002<\/p>\n

        \u901a\u8fc7Bray-Curtis\u8ddd\u79bb\u8ba1\u7b97\u7684\u4e3b\u5750\u6807\u5206\u6790\uff08PCoA\uff09\u663e\u793a\uff0c\u4e0d\u540cBMI\u7ec4\u4e4b\u95f4\u7684CRC\u548c\u5bf9\u7167\u7ec4\u7fa4\u843d\u7ec4\u6210\u5b58\u5728\u663e\u8457\u53d8\u5316\uff08\u56fe1C\uff09\u3002PCoA\u8fd8\u9002\u7528\u4e8e\u7caa\u4fbf\u4ee3\u8c22\u7269\uff0c\u5c55\u793a\u4e86\u4e09\u4e2aBMI\u7ec4\u4e4b\u95f4\u7684\u4e00\u81f4\u53d8\u5316\uff08\u56fe1D\uff09\u3002\u5728\u6240\u6709BMI\u7ec4\u7684CRC\u4e2d\uff0c\u62df\u6746\u83cc\u95e8\uff08Bacteroidetes\uff09\u6bd4\u4f8b\u4e0b\u964d\uff0c\u800c\u539a\u58c1\u83cc\u95e8\uff08Firmicutes\uff09\u6bd4\u4f8b\u589e\u52a0\uff08\u56feS1A\uff09\u3002<\/p>\n

        \u7efc\u5408\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u4e0d\u540cBMI\u7ec4\u7684CRC\u5728\u591a\u6837\u6027\u548c\u5fae\u751f\u7269\u8ddd\u79bb\u6307\u6807\u4e0a\u4e0e\u76f8\u5e94\u7684\u5bf9\u7167\u7ec4\u5b58\u5728\u5dee\u5f02\uff0cOv-CRC\u548cOb-CRC\u663e\u793a\u51fa\u03b1\u591a\u6837\u6027\u7684\u964d\u4f4e\u3002<\/strong><\/p>\n

          \n
        1. \u80a5\u80d6CRC\u4e0e\u975e\u80a5\u80d6CRC\u7684\u5fae\u751f\u7269\u5206\u7c7b\u5b66\u7279\u5f81<\/li>\n<\/ol>\n

          \u672c\u7814\u7a76\u5728\u4e0d\u540cBMI\u7ec4\u7684CRC\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u9274\u5b9a\u51fa\u5dee\u5f02\u4e30\u5bcc\u7684\u7269\u79cd\uff0c\u5e76\u53d1\u73b0N-CRC\u548cOv-CRC\u4e2d\u5b58\u5728\u66f4\u591a\u5dee\u5f02\u7269\u79cd\uff0c\u8fd9\u4e9b\u7269\u79cd\u4e0eOb-CRC\u6709\u660e\u663e\u533a\u522b\uff08\u56feS1B\uff09\u3002\u6b64\u5916\uff0c\u672c\u7814\u7a76\u8fd8\u5c55\u793a\u4e86296\u79cd\u7ec6\u83cc\u7269\u79cd\u7684\u5dee\u5f02\u4e30\u5bcc\u7279\u5f81\uff08\u56fe2A\uff1b\u8868S3\uff09\uff0c\u4ee5\u53ca\u5728\u7269\u79cd\u6c34\u5e73\u4e0a\u7684\u5206\u7c7b\u5b66\u70ed\u56fe\uff08\u56feS1C\uff09\u3002<\/p>\n

          \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u6b63\u5e38\u4f53\u91cd\u3001\u8d85\u91cd\u548c\u80a5\u80d6\u7ec4\u7684CRC\u4e2d\uff0c\u4f5c\u8005\u786e\u5b9a\u4e86\u4e00\u4e9b\u4e00\u81f4\u53d8\u5316\u7684\u5e38\u89c1\u7279\u5f81\u3002\u5177\u4f53\u800c\u8a00\uff0c\u672c\u7814\u7a76\u89c2\u5bdf\u5230P. stomatis \u548c F. nucleatum \u5728CRC\u4e2d\u76f8\u5bf9\u5e94\u7684\u5bf9\u7167\u7ec4\u4e2d\u88ab\u5bcc\u96c6\uff0c\u800cP. stomatis\u7684\u4e30\u5ea6\u53d8\u5316\u8d8b\u52bf\u5728\u4e09\u7ec4\u4e2d\u9010\u6e10\u589e\u52a0\u3002\u76f8\u5173\u6027\u5206\u6790\u663e\u793a\uff0c\u5728\u5bf9\u7167\u7ec4\u4e2dP. stomatis\u7684\u4e30\u5ea6\u4e0eBMI\u5448\u8d1f\u76f8\u5173\uff0c\u4f46\u5728CRC\u4e2d\u5448\u6b63\u76f8\u5173\uff08\u56feS1D\uff09\u3002\u4f46\u662f\uff0c\u5728CRC\u6216\u5bf9\u7167\u7ec4\u4e2d\u6ca1\u6709\u89c2\u5bdf\u5230F. nucleatum\u4e0eBMI\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08\u56feS1D\uff09\u3002\u7279\u522b\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4f5c\u4e3a\u76ca\u751f\u83cc\u7684F. prausnitzii\u5728CRC\u548c\u5bf9\u7167\u7ec4\u4e2d\u90fd\u4e0eBMI\u5448\u6b63\u76f8\u5173\uff08\u56feS1D\uff09\u3002\u672c\u7814\u7a76\u8fd8\u53d1\u73b0\u4e86\u4ec5\u5728Ob-CRC\u4e2d\u6539\u53d8\u7684\u80a5\u80d6\u7279\u5f81\uff0c\u5305\u62ec\u4e30\u5bcc\u7684E. sulci \u548c S. oralis\u4ee5\u53ca\u51cf\u5c11\u7684C. butyricum\u3002<\/p>\n

          \u672c\u6587\u8fdb\u4e00\u6b65\u5bf9\u8bc6\u522b\u51fa\u7684\u5fae\u751f\u7269\u6807\u8bb0\u8fdb\u884c\u4e86\u5171\u73b0\u5206\u6790\uff0c\u63a2\u7d22\u4e86\u8de8\u7269\u79cd\u95f4\u6f5c\u5728\u7684\u7ec6\u83cc\u76f8\u4e92\u4f5c\u7528\uff08\u56fe2B\uff09\u3002\u5728\u4e09\u4e2aBMI\u7ec4\u4e2d\uff0cF. prausnitzii\u3001R. inulinivorans\u548cD. formicigenerans\u4e4b\u95f4\u5b58\u5728\u7a33\u5b9a\u7684\u5171\u751f\u5173\u7cfb\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u6b63\u5e38\u4f53\u91cd\u548c\u8d85\u91cd\u7ec4\u4e2d\uff0c\u89c2\u5bdf\u5230\u4e86\u5bcc\u96c6\u4e8e\u80bf\u7624\u7684\u7269\u79cdP. stomatis\u4e0e\u88ab\u80bf\u7624\u6d88\u8017\u7684\u7269\u79cdF. prausnitzii\u4e4b\u95f4\u7684\u7ade\u4e89\u5173\u7cfb\u3002<\/p>\n

          \u672c\u7814\u7a76\u7ed3\u679c\u663e\u793a\u4e86\u4e0d\u540cBMI\u7ec4CRC\u4e2d\u72ec\u7279\u7684\u5fae\u751f\u7269\u8c31\u548c\u7ec6\u83cc\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u4e0eOb-CRC\u4e2d\u80bf\u7624\u53d1\u5c55\u7684\u673a\u5236\u6709\u5173\u3002<\/strong><\/p>\n

          <\/p>\n

          \u56fe2 \u4e0d\u540c\u4f53\u91cd\u6307\u6570\u7ec4\u4e2d\u7684\u4e0d\u540c\u7269\u79cd\u4ee5\u53ca CRC \u60a3\u8005\u6216\u5065\u5eb7\u5bf9\u7167\u7ec4\u4e2d\u7279\u5b9a\u7269\u79cd\u4e0e\u4f53\u91cd\u6307\u6570\u4e4b\u95f4\u7684\u5173\u7cfb<\/p>\n

            \n
          1. \u4e0d\u540cBMI\u7ec4\u4e2dCRC\u7684\u7caa\u4fbf\u4ee3\u8c22\u7ec4\u5b66\u53d8\u5316<\/li>\n<\/ol>\n

            \u9274\u4e8e\u80a0\u9053\u83cc\u7fa4\u4e0e\u5bbf\u4e3b-\u5fae\u751f\u7269\u5171\u4ee3\u8c22\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u7caa\u4fbf\u6837\u672c\u7684\u975e\u9776\u5411\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\uff0c\u4ee5\u7814\u7a76\u4e0d\u540cBMI\u7ec4\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4e0e\u5065\u5eb7\u5bf9\u7167\u8005\u4e4b\u95f4\u7caa\u4fbf\u4ee3\u8c22\u7269\u7684\u5dee\u5f02\u3002<\/p>\n

            \u901a\u8fc7\u6b63\u4ea4\u504f\u6700\u5c0f\u4e8c\u4e58\u5224\u522b\u5206\u6790\u6a21\u578b\uff0c\u89c2\u5bdf\u5230CRC\u60a3\u8005\u7684\u4ee3\u8c22\u7ec4\u6210\u5728\u4e0d\u540cBMI\u7ec4\u4e2d\u4e0e\u76f8\u5e94\u7684\u5065\u5eb7\u5bf9\u7167\u7ec4\u6709\u663e\u8457\u5dee\u5f02\uff08\u56fe3A\uff09\u3002\u7136\u540e\uff0c\u5206\u522b\u5bf9N-CRC\u3001Ov-CRC\u548cOb-CRC\u8fdb\u884c\u4e86\u5dee\u5f02\u4ee3\u8c22\u7269\u7684\u7814\u7a76\uff08\u56fe3B\u548c\u56feS2A\uff1b\u8868S4\uff09\u3002\u5927\u591a\u6570\u5dee\u5f02\u4ee3\u8c22\u7269\u5728\u80a5\u80d6\u7ec4\u548c\u975e\u80a5\u80d6\u7ec4\u4e4b\u95f4\u662f\u660e\u663e\u4e0d\u540c\u7684\uff08\u56feS2B\uff09\u3002\u5728Ob-CRC\u4e2d\uff0c\u7814\u7a76\u89c2\u5bdf\u5230\u4e0e\u8102\u80aa\u9178\u4ee3\u8c22\u5bc6\u5207\u76f8\u5173\u7684\u4ee3\u8c22\u7269\u7684\u663e\u8457\u53d8\u5316\uff0c\u5176\u4e2d\u5305\u62ec\u5bcc\u96c6\u7684\u8d56\u6c28\u9178\u78f7\u8102\u9170\u7518\u6cb9\u916f\uff08LysoPG\uff0914:1\u548c\u8017\u7aed\u7684\u78f7\u8102\u9187\u80c6\u78b1\uff08plasmenyl-PCs\uff0929:0\u3002\u76f8\u6bd4\u4e8eOb-CTRL\uff0cOb-CRC\u4e2d\u7684\u78f7\u8102\u9187\u80c6\u78b1\u8fdb\u4e00\u6b65\u51cf\u5c11\uff0c\u8fd9\u63d0\u793a\u6c27\u5316\u5e94\u6fc0\u53ef\u80fd\u662f\u80a5\u80d6\u4eba\u7fa4\u4e2dCRC\u53d1\u751f\u7684\u91cd\u8981\u673a\u5236\u3002<\/p>\n

            \u6709\u8da3\u7684\u662f\uff0c\u7ed3\u679c\u663e\u793a\u80c6\u56fa\u9187\u4e0eBMI\u5728CRC\u548c\u5bf9\u7167\u7ec4\u4e2d\u5747\u5448\u8d1f\u76f8\u5173\uff08\u56feS2C\uff09\uff0c\u4f46\u4ec5\u5728N-CRC\u548cOv-CRC\u4e0e\u76f8\u5e94\u7684\u5065\u5eb7\u5bf9\u7167\u7ec4\u4e2d\u53d1\u751f\u4e86\u53d8\u5316\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u68c0\u9a8c\u4e86\u5728\u4e0d\u540cBMI\u7ec4\u7684CRC\u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u8005\u4e2d\u53d8\u5316\u7684\u9009\u62e9\u6027\u5dee\u5f02\u7269\u79cd\u4e0e\u5dee\u5f02\u4ee3\u8c22\u7269\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08\u56fe3C\uff09\u3002\u4f8b\u5982\uff0cF. prausnitzii\u5728Ob-CTRL\u4e2d\u4e0e\u80c6\u56fa\u9187\u5448\u8d1f\u76f8\u5173\uff0c\u63d0\u793aF. prausnitzii\u53ef\u80fd\u53c2\u4e0e\u80c6\u6c41\u9178\u4ee3\u8c22\u3002\u672c\u6587\u8fd8\u9a8c\u8bc1\u4e86F. prausnitzii\u5728\u4f53\u5916\u4ee3\u8c22\u80c6\u56fa\u9187\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u6709\u673a\u5316\u5408\u7269\u5728Ob-CRC\u548c\u975e\u80a5\u80d6CRC\u4e2d\u7684\u72ec\u7279\u4f5c\u7528\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u5e76\u53ef\u80fd\u53c2\u4e0eCRC\u4e2d\u72ec\u7279\u7684\u4ee3\u8c22\u7269-\u5fae\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

            \"Figure<\/p>\n

            \u56fe 3 \u4e0d\u540c\u4f53\u91cd\u6307\u6570\u7ec4\u7684 CRC \u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u7ec4\u7684\u4ee3\u8c22\u7ec4\u5b66\u7279\u5f81<\/p>\n

              \n
            1. \u4e0d\u540cBMI\u7ec4\u4e2dCRC\u7684\u5fae\u751f\u7269\u57fa\u56e0\u7684\u53d8\u5316<\/li>\n<\/ol>\n

              \u672c\u7814\u7a76\u901a\u8fc7\u5bf9KO\u6570\u636e\u5e93\u4e2d\u7684\u5fae\u751f\u7269\u57fa\u56e0\u8fdb\u884c\u6ce8\u91ca\uff0c\u5e76\u7ed8\u5236\u4e86\u4e00\u4e2a\u70ed\u56fe\uff08\u56fe4A\u548c\u56feS3\uff09\uff0c\u5c55\u793a\u4e86Ob-CRC\u548c\u975e\u80a5\u80d6CRC\u4e2d\u76f8\u5173\u901a\u8def\u4e2d\u7684KO\u57fa\u56e0\u7684\u5dee\u5f02\u8868\u8fbe\u60c5\u51b5\uff08\u8868S6\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0cOb-CRC\u6d89\u53ca\u5230\u7532\u70f7\u4ee3\u8c22\u3001\u7518\u6cb9\u78f7\u8102\u4ee3\u8c22\u548c\u8102\u591a\u7cd6\uff08LPS\uff09\u751f\u7269\u5408\u6210\u7b49\u901a\u8def\u53d1\u751f\u4e86\u663e\u8457\u6539\u53d8\u3002\u8fd9\u4e9b\u4ee3\u8c22\u901a\u8def\u5728Ob-CRC\u7684\u80cc\u666f\u4e0b\u5c24\u4e3a\u91cd\u8981\uff0c\u53ef\u80fd\u5bfc\u81f4\u8102\u8d28\u5e73\u8861\u7684\u7d0a\u4e71\uff0c\u8fd9\u4e00\u89c2\u70b9\u5f97\u5230\u4e86\u5bf9\u7caa\u4fbf\u4ee3\u8c22\u7269\u7684\u89c2\u5bdf\u7684\u8bc1\u5b9e\u3002<\/p>\n

              \u672c\u6587\u8fd8\u8fdb\u884c\u4e86KO\u57fa\u56e0\u4e0e\u5fae\u751f\u7269\u79cd\u7fa4\u4e4b\u95f4\u76f8\u5173\u6027\u7684\u6574\u5408\u5206\u6790\uff08\u56fe4B\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u67d0\u4e9b\u5fae\u751f\u7269\u79cd\u7fa4\u4e0eKO\u57fa\u56e0\u7684\u4e30\u5ea6\u53d8\u5316\u5bc6\u5207\u76f8\u5173\u3002\u4f8b\u5982\uff0cP. stomatis\u4e0etorZ\u5448\u6b63\u76f8\u5173\uff0c\u6697\u793a\u5176\u53ef\u80fd\u53c2\u4e0e\u4e86TMAO\u4ee3\u8c22\u3002\u76f8\u53cd\uff0c\u4e00\u4e9b\u76ca\u751f\u83cc\u5982F. prausnitzii\u548cR. inulinivorans\u4e0e\u5927\u91cf\u7f3a\u5931\u7684KO\u57fa\u56e0\u5448\u6b63\u76f8\u5173\uff0c\u8868\u660e\u8fd9\u4e9b\u76ca\u751f\u83cc\u5728CRC\u4e2d\u7684\u7f3a\u5931\u53ef\u80fd\u662f\u5bfc\u81f4\u4ee3\u8c22\u5931\u8861\u7684\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

              \u672c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cOb-CRC\u8868\u73b0\u51fa\u72ec\u7279\u7684\u5fae\u751f\u7269\u9176\u53cd\u5e94\u548c\u4ee3\u8c22\u8fc7\u7a0b\uff0c\u53d7\u5230\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u7684\u663e\u8457\u53d8\u5316\u7684\u9a71\u52a8\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u4e86\u89e3Ob-CRC\u4e2d\u80a0\u9053\u83cc\u7fa4\u4e0e\u4ee3\u8c22\u52a8\u6001\u4e4b\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u89c1\u89e3\u3002<\/strong><\/p>\n

              <\/p>\n

              \u56fe 4 KO \u57fa\u56e0\u4e2d\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u529f\u80fd\u6539\u53d8<\/p>\n

                \n
              1. \u5fae\u751f\u7269\u548c\u4ee3\u8c22\u6807\u5fd7\u7269\u4e4b\u95f4\u7684\u5173\u8054<\/li>\n<\/ol>\n

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                \u603b\u7684\u6765\u8bf4\uff0c\u6570\u636e\u8868\u660e\u5fae\u751f\u7269KO\u57fa\u56e0\u548c\u4ee3\u8c22\u7269\u7684\u53d8\u5316\u4e0eCRC\u7caa\u4fbf\u4e2d\u5fae\u751f\u7269\u7684\u53d8\u5316\u76f8\u5173\uff0c\u8fd9\u53ef\u80fd\u90e8\u5206\u89e3\u91ca\u4e86\u80a5\u80d6\u4eba\u7fa4CRC\u7279\u5f02\u6027\u53d1\u75c5\u673a\u5236\u3002<\/strong><\/p>\n

                <\/p>\n

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                  \n
                1. \u4e0d\u540cBMI\u7ec4\u7684CRC\u7684\u968f\u673a\u68ee\u6797\u8bca\u65ad\u6a21\u578b<\/li>\n<\/ol>\n

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                  <\/strong><\/p>\n

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