{"id":38018,"date":"2024-04-28T10:44:38","date_gmt":"2024-04-28T02:44:38","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=38018"},"modified":"2024-04-28T10:44:40","modified_gmt":"2024-04-28T02:44:40","slug":"%e6%b3%b0%e8%a3%a4%e8%be%a3%ef%bc%812030%e4%b8%aa%e7%ba%bf%e7%b2%92%e4%bd%93%e7%9b%b8%e5%85%b3%e5%9f%ba%e5%9b%a0%e5%ae%8c%e6%95%b4%e5%a5%89%e4%b8%8a%ef%bc%8c%e4%b8%8d%e7%94%a8%e6%8b%85%e5%bf%83","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=38018","title":{"rendered":"\u6cf0\u88e4\u8fa3\uff012030\u4e2a\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u5b8c\u6574\u5949\u4e0a\uff0c\u4e0d\u7528\u62c5\u5fc3\u7b5b\u4e0d\u5230\u5dee\u5f02\u57fa\u56e0\u4e86\uff0c\u5c06\u7ebf\u7c92\u4f53\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u3001\u514d\u75ab\u6d78\u6da6\u642d\u914d\uff0c\u8f7b\u677e\u62ff\u4e0b8\u5206+\uff01"},"content":{"rendered":"

\"\"<\/h2>\n

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<\/p>\n

\u5bf9\u4e8e\u5c1a\u6709\u8fdf\u7591\u7684\u4eba\uff0c\u5176\u6700\u5927\u7684\u62c5\u5fc3\u70b9\u5fc5\u7136\u662f—\u6211\u7814\u7a76\u7684\u65b9\u5411\u662f\u5426\u548c\u7ebf\u7c92\u4f53\u6709\u5173\uff1f\u6216\u8005\u8bf4\uff0c\u6211\u8fd9\u4e2a\u65b9\u5411\u80fd\u5426\u6316\u6398\u5230\u4e0e\u7ebf\u7c92\u4f53\u76f8\u5173\u7684\u663e\u8457\u5dee\u5f02\u57fa\u56e0\u4e86\uff1f<\/p>\n

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    \n
  1. \u7406\u8bba\u5c42\u9762: <\/strong>\u7ebf\u7c92\u4f53\u662f\u7ec6\u80de\u4e2d\u751f\u4ea7\u80fd\u91cf\u7684\u4e3b\u8981\u573a\u6240\uff0c\u53c2\u4e0e\u591a\u79cd\u7ec6\u80de\u751f\u547d\u6d3b\u52a8\uff0c\u7ebf\u7c92\u4f53\u7a33\u6001\u5bf9\u7ef4\u6301\u6b63\u5e38\u7684\u7ec6\u80de\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002\u7edd\u5927\u90e8\u5206\u75be\u75c5\u7684\u53d1\u75c5\u548c\u6cbb\u7597\u8fc7\u7a0b\u5747\u6d89\u53ca\u5230\u7ec6\u80de\u529f\u80fd\u7684\u53d8\u5316\uff0c\u56e0\u6b64\uff0c\u4e0e\u7ebf\u7c92\u4f53\u76f4\u63a5\u6216\u8005\u95f4\u63a5\u76f8\u5173\u7684\u7814\u7a76\u6570\u91cf\u81ea\u7136\u5f88\u591a\u3002<\/li>\n
  2. \u6280\u672f\u5c42\u9762\uff1a<\/strong>\u7ebf\u7c92\u4f53\u529f\u80fd\u590d\u6742\uff0c\u6d89\u53ca\u57fa\u56e0\u6570\u91cf\u5de8\u5927\uff0c\u80fd\u83b7\u5f97\u663e\u8457\u5dee\u5f02\u57fa\u56e0\u6982\u7387\u9ad8\u3002<\/li>\n<\/ol>\n

    \u5c0f\u4e91\u4eca\u5929\u627e\u52301\u7bc78\u5206+\u5206\u6790\u7ebf\u7c92\u4f53\u57fa\u56e0\u4e0e\u80c3\u764c\u7684\u6587\u7ae0\uff0c\u8be5\u6587\u7ae0\u5e76\u672a\u5c06\u7ebf\u7c92\u4f53\u57fa\u56e0\u4e0e\u7ec6\u80de\u6b7b\u4ea1\u8fdb\u884c\u5173\u8054\uff0c\u800c\u662f\u4ece\u80bf\u7624\u5fae\u73af\u5883\u3001\u514d\u75ab\u6d78\u6da6\u7b49\u89d2\u5ea6\u6765\u8ba8\u8bba\u7ebf\u7c92\u4f53\u57fa\u56e0\u7684\u529f\u80fd\uff1b\u540c\u65f6\uff0c\u8be5\u6587\u7ae0\u5217\u4e3e\u51fa\u4e862030\u4e2a\u7ebf\u7c92\u4f53\u57fa\u56e0\uff0c\u53ef\u8c13\u662f\u6700\u4e30\u5bcc\u7684\u7248\u672c\uff0c\u4e3a\u5927\u5bb6\u7684\u5206\u6790\u63d0\u4f9b\u4e86\u53c2\u8003\uff08\u6709\u9700\u8981\u57fa\u56e0\u96c6\u7684\u7c89\u4e1d\uff0c\u53ef\u4ee5\u5173\u6ce8\u516c\u4f17\u53f7\u56de\u590d\u83b7\u53d6<\/strong>\uff09\u3002\u4e0b\u9762\uff0c\u6211\u4eec\u4e00\u8d77\u770b\u770b\u8fd9\u7bc7\u6587\u7ae0\u5427\uff08\u5982\u679c\u6ca1\u6709\u5206\u6790\u601d\u8def\u6216\u8005\u6587\u732e\u590d\u73b0\u6709\u56f0\u96be\uff0c\u53ef\u4ee5\u627e\u5c0f\u4e91\uff0c\u8d85\u591a\u521b\u65b0\u6027\u9ad8\u7684\u5206\u6790\u601d\u8def\u548c\u5206\u6790\u670d\u52a1\u4f9b\u4f60\u9009\u62e9\uff01\uff09<\/strong>\u3002<\/p>\n

    \"\"<\/p>\n

    <\/p>\n

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    \u6742\u5fd7\uff1aJournal of translational medicine<\/p>\n

    \u5f71\u54cd\u56e0\u5b50\uff1a8.44<\/p>\n

    \u53d1\u8868\u65f6\u95f4\uff1a2023\u5e743\u6708<\/p>\n

    \"\u56fe\u7247\"\u6570\u636e\u4fe1\u606f<\/strong> \"\u56fe\u7247\"<\/p>\n\n\n\n\n\n\n
    \u6570\u636e\u96c6\/\u961f\u5217<\/strong><\/td>\n\u6570\u636e\u5e93<\/strong><\/td>\n\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n\u6837\u672c\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n
    TCGA-STAD<\/td>\nTCGA<\/td>\nRNA-seq\u548c\u4e34\u5e8a\u4fe1\u606f<\/td>\n317 \u4f8b\u80c3\u817a\u764c\u548c29\u4e2a\u5065\u5eb7\u5bf9\u7167<\/td>\n<\/tr>\n
    GSE15459<\/td>\nGEO<\/td>\n\u82af\u7247\u6570\u636e\u548c\u4e34\u5e8a\u4fe1\u606f<\/td>\n182 \u4f8b\u80c3\u817a\u764c\u60a3\u8005<\/td>\n<\/tr>\n
    GSE66229<\/td>\nGEO<\/td>\n\u82af\u7247\u6570\u636e\u548c\u4e34\u5e8a\u4fe1\u606f<\/td>\n150\u5bf9\u80c3\u817a\u764c\u548c\u764c\u65c1\u7ec4\u7ec7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \"\u56fe\u7247\"\u7814\u7a76\u601d\u8def<\/strong> \"\u56fe\u7247\"<\/p>\n

    \u57fa\u4e8eTCGA\u548cGEO\u6570\u636e\u5e93\u4e2d\u7684STAD\u8868\u8fbe\u8c31\u53ca\u82af\u7247\u6570\u636e\uff0c\u5229\u7528\u201climma\u201d\u5305\u83b7\u5f97\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0(DEGs)\uff1b\u5c06DEGs\u4e0e\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u53d6\u4ea4\u96c6\uff0c\u83b7\u5f972031\u4e2a\u5dee\u5f02\u8868\u8fbe\u7684\u7ebf\u7c92\u4f53\u57fa\u56e0\uff1b\u901a\u8fc7\u5355\u53d8\u91cfCox\u56de\u5f52\u3001Lasso\u56de\u5f52\u5206\u6790\u548c\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u7b5b\u9009\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\uff0c\u6784\u5efa\u65b0\u7684\u9884\u540e\u76f8\u5173\u57fa\u56e0\u96c6\uff0c\u5229\u7528\u57fa\u56e0\u96c6\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u98ce\u9669\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\uff1b\u5bf9\u9ad8\/\u4f4e\u98ce\u9669\u7ec4\u60a3\u8005\u7684\u5dee\u5f02\u57fa\u56e0\u8fdb\u884cGO\u3001KEGG\u548cGSEA\u5bcc\u96c6\u5206\u6790\uff1b\u57fa\u4e8e\u201cESTIMATE\u201d\u5305\u8ba1\u7b97\u9ad8\/\u4f4e\u98ce\u9669\u7ec4\u60a3\u8005\u7684\u80bf\u7624\u5fae\u73af\u5883\u5206\u6570\u548c\u514d\u75ab\u8bc4\u5206\uff1b\u4f7f\u7528R\u5305\u7684CIBERSORT\u7b97\u6cd5\u8ba1\u7b97\u9ad8\/\u4f4e\u98ce\u9669\u7ec4\u60a3\u8005\u4e2d22\u79cd\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de(TIIC)\u7684\u4e30\u5ea6\uff1b\u4f7f\u7528R\u5305\u201cpRRophetic\u201d\u8ba1\u7b97\u60a3\u8005\u5bf9138\u79cd\u5316\u7597\/\u9776\u5411\u7597\u6cd5\u836f\u7269\u53cd\u5e94\u7684\u80fd\u529b\uff1b\u6700\u540e\u5229\u7528qPCR\u6cd5\u68c0\u6d4b4\u79cd\u7ebf\u7c92\u4f53\u76f8\u5173\u7279\u5f81\u57fa\u56e0\u5728\u4e34\u5e8a\u60a3\u8005\u548c\u7ec6\u80de\u7cfb\u4e2d\u7684\u8868\u8fbe\uff08\u56fe1\uff09\u3002<\/p>\n

    <\/p>\n

    \u56fe1\uff0c\u672c\u7814\u7a76\u7684\u5206\u6790\u6d41\u7a0b\u56fe<\/p>\n

    \"\u56fe\u7247\"\u4e3b\u8981\u7ed3\u679c<\/strong> \"\u56fe\u7247\"<\/p>\n

      \n
    1. STAD\u4e2d\u4e0e\u7ebf\u7c92\u4f53\u76f8\u5173\u7684DEGs\u7684\u9274\u5b9a\u548c\u98ce\u9669\u6a21\u578b\u6784\u5efa<\/strong><\/li>\n<\/ol>\n

      \u5bf9\u4e0a\u8ff03\u4e2a\u6570\u636e\u96c6\u8fdb\u884cDEG\uff08\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff09\u5206\u6790\uff0c\u5171\u83b7\u5f972145\u4e2a\u53ef\u7f16\u7801\u7684DEGs\uff08\u56fe2A\uff09\uff1b\u8fdb\u4e00\u6b65\u5c06GSEA\u4e2d\u7b5b\u9009\u51fa\u7684\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u548c\u4e0a\u8ff0DEGs\u8fdb\u884c\u4e86\u8054\u5408\u5206\u6790\uff0c\u5171\u7b5b\u9009\u51faSTAD\u4e2d\u7684183\u4e2a\u5019\u9009\u7ebf\u7c92\u4f53\u76f8\u5173DEGs\uff08\u56fe2B\uff09\uff1b\u901a\u8fc7\u5355\u56e0\u7d20Cox\u56de\u5f52\u5206\u6790\u7b5b\u9009\u51fa19\u4e2a\u57fa\u56e0\u4f5c\u4e3aSTAD\u60a3\u8005\u9884\u540e\u7684\u6f5c\u5728\u5371\u9669\u56e0\u7d20\uff08\u56fe2C\uff09\u3002\u5229\u7528LASSO\u56de\u5f52\u5206\u6790\u3001\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u6700\u7ec8\u786e\u8ba4\u51fa4\u4e2a\u5907\u9009\u57fa\u56e0\uff08\u56fe2D\uff0cE\uff09\u3002\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u5206\u522b\u5728\u80bf\u7624\u6837\u672c\u4e2d\u89c2\u5bdf\u5230\u8f83\u9ad8\u7684NOX4\u548cFKBP10\u8868\u8fbe\u4ee5\u53ca\u8f83\u4f4e\u7684ALDH3A2\u548cMAOA\u8868\u8fbe\uff08\u56fe2F\uff09\u3002\uff08ps\uff1a\u5dee\u5f02\u57fa\u56e0\u5206\u6790\u548c\u706b\u5c71\u56fe\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/a><\/strong>\u3002<\/a><\/p>\n

      <\/p>\n

      <\/p>\n

      \u56fe2.STAD\u4e2d\u4e0e\u7ebf\u7c92\u4f53\u76f8\u5173\u7684DEGs\u7684\u9274\u5b9a\u548c\u98ce\u9669\u6a21\u578b\u6784\u5efa<\/p>\n

      \u5229\u7528\u60a3\u8005\u76844\u4e2a\u7ebf\u7c92\u4f53\u76f8\u5173DEGs\u57fa\u56e0\u96c6\u7684\u4e2d\u4f4d\u98ce\u9669\u8bc4\u5206\uff0c\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u98ce\u9669\u548c\u4f4e\u98ce\u9669\u4e9a\u7ec4\u3002K-M\u66f2\u7ebf\u663e\u793a\u9ad8\u5371\u7ec4\u60a3\u8005\u7684OS\u8f83\u5dee\uff08P\u2009=0.0009\uff0c\u56fe3A\uff09\u3002ROC\u66f2\u7ebf\u8bc1\u660e\u4e86\u9884\u540e\u98ce\u9669\u6a21\u578b\u7684\u51c6\u786e\u6027\uff08\u56fe3B\uff09\u3002\u98ce\u9669\u8bc4\u5206\u4e0e\u751f\u5b58\u65f6\u95f4\u3001\u751f\u5b58\u72b6\u6001\u548c\u98ce\u9669\u7b49\u7ea7\u4e4b\u95f4\u7684\u5173\u7cfb\u8bc1\u660e\u4e86\u98ce\u9669\u6a21\u578b\u7684\u9884\u540e\u4f5c\u7528\uff08\u56fe3C\uff09\u3002GSE66229\u548cGSE15459\u6570\u636e\u96c6\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u9884\u540e\u98ce\u9669\u6a21\u578b\u7684\u7a33\u5065\u6027\uff08\u56fe3D\uff09\u3002\u5728GSE66229\u6570\u636e\u96c6\u4e2d\uff0c1\u5e74\u30013\u5e74\u548c5\u5e74\u751f\u5b58\u7387\u7684ROC\u66f2\u7ebf\u7684AUC\u503c\u5206\u522b\u4e3a0.620\u30010.625\u548c0.601\uff08\u56fe3E\uff09\u3002<\/p>\n

      <\/p>\n

      <\/p>\n

      \u56fe3.\u4e0e\u7ebf\u7c92\u4f53\u76f8\u5173\u7684DEGs\u98ce\u9669\u6a21\u578b\u6784\u5efa\u548c\u9a8c\u8bc1<\/p>\n

        \n
      1. \u9ad8\u5371\u548c\u4f4e\u5371\u4eba\u7fa4DEGs\u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/strong><\/li>\n<\/ol>\n

        \u5bf9\u9ad8\u98ce\u9669\u548c\u4f4e\u98ce\u9669\u60a3\u8005\u7ec4\u7684298\u4e2aDEG\u8fdb\u884c\u4e86GO\u5206\u6790\uff0c\u53d1\u73b0\u5dee\u5f02\u57fa\u56e0\u4e3b\u8981\u5bcc\u96c6\u5728\u542b\u80f6\u539f\u86cb\u767d\u7684ECM\uff08\u7ec6\u80de\u5916\u57fa\u8d28\uff09\u548c\u80f6\u539f\u86cb\u767d\u4e09\u805a\u4f53\u4e2d\uff08\u56fe4A)\u3002KEGG\u5206\u6790\u5f97\u5230\u7684\u524d10\u6761\u901a\u8def\u4f9d\u6b21\u4e3a\uff1a\u86cb\u767d\u8d28\u6d88\u5316\u5438\u6536\u3001\u764c\u86cb\u767d\u591a\u7cd6\u3001\u7c98\u7740\u6591\u3001\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u611f\u67d3\u3001PI3K-Akt\u4fe1\u53f7\u901a\u8def\u3001ECM-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u7ec6\u80de\u7c98\u9644\u5206\u5b50\u3001\u8f74\u7a81\u5bfc\u5411\u3001cAMP\u4fe1\u53f7\u901a\u8def\u3001\u8840\u7ba1\u5e73\u6ed1\u808c\u6536\u7f29\uff08\u56fe4B\uff09\u3002GSEA\u7ed3\u679c\u8868\u660e\uff0c\u98ce\u9669\u8bc4\u5206\u4e0e\u9ad8\u98ce\u9669\u7ec4\u7684ECM\u7cd6\u86cb\u767d\u3001\u6838\u5fc3\u57fa\u8d28\u4f53\u3001ECM\u7ec4\u7ec7\u663e\u7740\u76f8\u5173\uff08\u56fe4C\uff09\u3002<\/p>\n

        <\/p>\n

        <\/p>\n

        \u56fe4.\u9ad8\u5371\u548c\u4f4e\u5371\u4eba\u7fa4DEGs\u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/p>\n

          \n
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          \u5bf9\u9ad8\u98ce\u9669\u548c\u4f4e\u98ce\u9669\u60a3\u8005\u7ec4\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u9ad8\u5371\u7ec4\u5e7c\u7a1aB\u7ec6\u80de\u3001\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u3001M0\u5de8\u566c\u7ec6\u80de\u548cM2\u5de8\u566c\u7ec6\u80de\u542b\u91cf\u663e\u7740\u5347\u9ad8\uff08\u56fe5A\uff09\u3002ESTIMATE\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4f4e\u5371\u7ec4\u60a3\u8005\u76f8\u6bd4\uff0c\u9ad8\u5371\u7ec4\u60a3\u8005\u7684\u514d\u75ab\u8bc4\u5206\u66f4\u9ad8\uff0c\u80bf\u7624\u7eaf\u5ea6\u663e\u8457\u964d\u4f4e\uff08P=0.370\uff09\uff08\u56fe5C\u3001D)\u3002\u7531\u6b64\uff0c\u4f5c\u8005\u63a8\u6d4b\u6fc0\u6d3b\u7684CD8+T\u7ec6\u80de\u7279\u5f81\u4e0e\u57fa\u8d28\u4f53\u548cCAF\u7279\u5f81\u5448\u8d1f\u76f8\u5173\uff0c\u63d0\u793a\u80bf\u7624\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u53ef\u80fd\u5bfc\u81f4\u9ad8\u5371\u7ec4STAD\u60a3\u8005\u9884\u540e\u8f83\u5dee\u3002\u5206\u6790\u53d1\u73b0\uff0c43\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u5728\u9ad8\u98ce\u9669\u7ec4\u4e2d\u53d7\u5230\u663e\u7740\u8c03\u8282\uff08\u56fe5E\uff09\u3002<\/p>\n

          <\/p>\n

          <\/p>\n

          \u56fe5\u7ebf\u7c92\u4f53\u76f8\u5173\u98ce\u9669\u8bc4\u5206\u4e0e STAD \u4e2d\u7684\u514d\u75ab\u7279\u5f81\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173<\/p>\n

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          <\/p>\n

          <\/p>\n

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            \n
          1. \u4e0d\u540c\u98ce\u9669\u8bc4\u5206STAD\u60a3\u8005\u5bf9\u6cbb\u7597\u6548\u679c\u7684\u9884\u6d4b<\/strong><\/li>\n<\/ol>\n

            \u4f5c\u8005\u9884\u6d4b\u4e86138\u79cd\u836f\u7269\uff08\u5305\u62ec\u5316\u7597\u3001\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\uff09\u5bf9\u4e0d\u540c\u98ce\u9669\u8bc4\u5206\u7ec4STAD\u60a3\u8005\u7684\u6548\u529b\uff0c\u53d1\u73b0\u9ad8\u98ce\u9669\u7ec4\u60a3\u8005\u53ef\u80fd\u5bf9\u96f7\u5e15\u9709\u7d20\u3001PD-0325901\u3001\u8fbe\u6c99\u66ff\u5c3c\u7b49\u66f4\u654f\u611f\uff0c\u800c\u4f4e\u98ce\u9669\u7ec4\u60a3\u8005\u53ef\u80fd\u5bf9AZD7762\u3001CEP-701\u3001\u7532\u6c28\u8776\u5464\u7b49\u66f4\u654f\u611f\uff0c\u53ef\u4e3a\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u53ef\u9760\u53c2\u8003\uff08\u56fe7\uff09\u3002 <\/p>\n

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              \n
            1. \u5bf9STAD\u4e2d\u7ebf\u7c92\u4f53\u76f8\u5173hub\u57fa\u56e0\u7684\u5b9e\u9a8c\u9a8c\u8bc1<\/strong><\/li>\n<\/ol>\n

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              <\/p>\n

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              \"\u56fe\u7247\"\u603b\u7ed3<\/strong> \"\u56fe\u7247\"<\/p>\n

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              \uff08https:\/\/mp.weixin.qq.com\/s\/YGCWkrgAJXt-IxiC_s-2IQ\uff09<\/p>\n

              Nature\u91cd\u78c5\u7efc\u8ff0\u52a0\u6301\uff0c\u7ebf\u7c92\u4f53\u65b9\u5411\u751f\u4fe1\u4f9d\u7136\u575a\u633a\uff0c8\u5206+\u6587\u7ae0\u4e00\u4e3e\u62ff\u4e0b\uff0c\u59a5\u59a5\u7684\u53d1\u6587\u548c\u7533\u8bfe\u9898\u5229\u5668\uff01<\/p>\n

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