{"id":38047,"date":"2024-04-28T10:52:16","date_gmt":"2024-04-28T02:52:16","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=38047"},"modified":"2024-04-28T10:52:18","modified_gmt":"2024-04-28T02:52:18","slug":"1%e4%b8%aa%e6%9c%88%e6%8e%a5%e6%94%b6%ef%bc%815%e7%a7%8d%e7%bb%86%e8%83%9e%e6%ad%bb%e4%ba%a1%e7%83%ad%e5%ba%94%e6%bf%80m6a%e5%a4%9a%e7%83%ad%e7%82%b9%e8%81%94%e5%90%88%ef%bc%8c%e5%b9%b2%e6%b9%bf","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=38047","title":{"rendered":"1\u4e2a\u6708\u63a5\u6536\uff015\u79cd\u7ec6\u80de\u6b7b\u4ea1+\u70ed\u5e94\u6fc0+m6A\u591a\u70ed\u70b9\u8054\u5408\uff0c\u5e72\u6e7f\u7ed3\u5408\u4e00\u4e3e\u62ff\u4e0b5.7\u5206+\u6587\u7ae0\uff0c\u57fa\u56e0\u96c6\u5df2\u5907\u597d\uff0c\u76f4\u63a5\u62ff\u53bb\u7528\uff01"},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone  wp-image-36510\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=640%2C136\" alt=\"\" width=\"640\" height=\"136\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=300%2C64 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=768%2C163 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?resize=600%2C128 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/1.jpg?w=940 940w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u5c0f\u4e91\u5728PubMed\u7684\u82b1\u56ed\u91cc\u6316\u5440\u6316\u5440\u6316~<\/p>\n<p>\u6316\u5230\u4e86\u597d\u601d\u8def\u5206\u4eab\u7ed9\u5927\u5bb6~<\/p>\n<p>\u5c0f\u4e91\u7248&lt;\u6316\u5440\u6316&gt;\u6539\u7f16\u7684\u600e\u4e48\u6837\uff1f\u8fd9\u76f4\u63a5\u5c31\u662f\u6bcf\u65e5\u5de5\u4f5c\u5199\u7167\u554a <img decoding=\"async\" loading=\"lazy\" width=\"39\" height=\"39\" class=\"wp-image-38048\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-1.png?resize=39%2C39\" data-recalc-dims=\"1\"> \uff0c\u60f3\u770b\u751f\u4fe1\u65b0\u65b9\u5411\u3001\u65b0\u601d\u8def\u7684\u5c0f\u4f19\u4f34\uff0c\u770b\u6211\u7684\u516c\u4f17\u53f7\u51c6\u6ca1\u9519\uff01<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"240\" height=\"240\" class=\"wp-image-38049\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-2.gif?resize=240%2C240\" data-recalc-dims=\"1\"><\/p>\n<p>\u8fd9\u56de\u6316\u5230\u7684\u662f\u4e2a\u591a\u70ed\u70b9\u8054\u5408\u7684\u601d\u8def\uff0c\u521b\u65b0\u6027\u548c\u6570\u636e\u91cf\u9f50\u5907\uff0c\u7edd\u5bf9\u6ee1\u8db3\u9ad8\u8d28\u91cf\u751f\u4fe1\u6587\u7ae0\u7684\u8981\u6c42\uff0c\u521b\u65b0\u6027\u4e3b\u8981\u4f53\u73b0\u5728\u4e24\u70b9\uff1a<\/p>\n<ol>\n<li><strong>\u601d\u8def\u4e0a\u521b\u65b0<\/strong>\uff1a5\u79cd\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f+\u70ed\u5e94\u6fc0+ m6A\u7684\u591a\u70ed\u70b9\u4e32\u8054\uff0c\u9996\u5148\u4ece\u9009\u9898\u4e0a\u5c31\u8d62\u4e86\u666e\u901a\u601d\u8def\u4e00\u5927\u622a<\/li>\n<li><strong>\u9a8c\u8bc1\u5b9e\u9a8c<\/strong>\uff1a\u751f\u4fe1+\u9a8c\u8bc1\u5b9e\u9a8c\uff0c\u8d70\u5e72\u6e7f\u7ed3\u5408\u7684\u8def\u5b50\uff0c\u8fd9\u662f\u751f\u4fe1\u53d1\u5c55\u7684\u5927\u8d8b\u52bf\uff0c\u4e5f\u53ef\u4ee5\u5835\u4f4f\u67d0\u4e9b\u4e0d\u63a5\u53d7\u7eaf\u751f\u4fe1\u671f\u520a\u7684\u5634<\/li>\n<\/ol>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"240\" height=\"240\" class=\"wp-image-38050\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-3.jpeg?resize=240%2C240\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-3.jpeg?w=240 240w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-3.jpeg?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-3.jpeg?resize=100%2C100 100w\" sizes=\"(max-width: 240px) 100vw, 240px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4e24\u6761\u817f\u8d70\u8def\u603b\u6bd4\u4e00\u6761\u817f\u8e66\u7684\u5feb\uff0c\u6240\u4ee5\u8fd9\u7bc7\u6587\u7ae0\u6295\u7a3f1\u4e2a\u6708\u5c31\u63a5\u6536\u4e86\uff0c\u8fd9\u79cd\u9ad8\u8d28\u91cf\u3001\u80fd\u5feb\u901f\u53d1\u6587\u7684\u601d\u8def\u662f\u4e0d\u662f\u8d85\u7ea7\u9002\u5408\u9700\u8981\u6bd5\u4e1a\u53d1\u6587\u7684\u4f60\u6216\u8005\u8bc4\u804c\u79f0\u9700\u8981\u6587\u7ae0\u7684\u4f60\u5462\uff1f\u6587\u4e2d\u9644\u5e265\u79cdRCD\u57fa\u56e0+\u70ed\u5e94\u6fc0\u57fa\u56e0\u96c6\uff0c\u6362\u4e2a\u764c\u79cd\u5c31\u80fd\u590d\u73b0\u5566\uff0c\u5fc3\u52a8\u4e0d\u5982\u884c\u52a8\u54e6\uff01<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-36512 aligncenter\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/3.jpg?resize=298%2C300\" alt=\"\" width=\"298\" height=\"300\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/3.jpg?resize=298%2C300 298w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/3.jpg?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/3.jpg?resize=100%2C100 100w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/3.jpg?w=568 568w\" sizes=\"(max-width: 298px) 100vw, 298px\" data-recalc-dims=\"1\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"236\" class=\"wp-image-38051\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-4.png?resize=640%2C236\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-4.png?w=688 688w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-4.png?resize=300%2C111 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-4.png?resize=600%2C222 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<ul>\n<li>\u9898\u76ee\uff1a\u94dc\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0PDHX\u548c\u70ed\u5e94\u6fc0\u76f8\u5173\u57fa\u56e0HSPD1\u662f\u98df\u7ba1\u764c\u4e2d\u4e0e\u7ec6\u80de\u5e72\u7ec6\u80de\u3001\u5f02\u5e38\u4ee3\u8c22\u548c\u514d\u75ab\u6291\u5236\u76f8\u5173\u7684\u6f5c\u5728\u5173\u952e\u9a71\u52a8\u56e0\u5b50<\/li>\n<li>\u6742\u5fd7\uff1a<em>International Immunopharmacology<\/em><\/li>\n<li>\u5f71\u54cd\u56e0\u5b50\uff1aIF=5.714<\/li>\n<li>\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e743\u6708<\/li>\n<\/ul>\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<p>\u70ed\u5e94\u6fc0\u662f\u98df\u7ba1\u764c(ESCA)\u53d1\u751f\u548c\u53d1\u5c55\u7684\u57fa\u7840\u3002\u70ed\u5e94\u6fc0\u635f\u4f24\u4e0a\u76ae\u7ed3\u6784\uff0c\u5bfc\u81f4\u98df\u7ba1\u7ec6\u80de\u5f02\u5e38\u7684\u201c\u7ec6\u80de\u6b7b\u4ea1-\u4fee\u590d\u201d\u6a21\u5f0f\uff0c\u4ece\u800c\u9a71\u52a8\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8c03\u8282\u6027\u7ec6\u80de\u6b7b\u4ea1(RCD)\u6a21\u5f0f\u7684\u72ec\u7279\u529f\u80fd\u548c\u4e32\u6270\uff0cESCA\u6076\u6027\u80bf\u7624\u4e2d\u7684\u5177\u4f53\u7ec6\u80de\u6b7b\u4ea1\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u6570\u636e\u96c6\/\u961f\u5217<\/strong><\/td>\n<td><strong>\u6570\u636e\u5e93<\/strong><\/td>\n<td><strong>\u6570\u636e\u7c7b\u578b<\/strong><\/td>\n<td><strong>\u6837\u672c\u4fe1\u606f<\/strong><\/td>\n<\/tr>\n<tr>\n<td>TCGA-ESCA<\/td>\n<td>UCSC Xena+ GDC<\/td>\n<td>RNA-seq\u6570\u636e+SNVs\/CNVs\u6570\u636e+\u7532\u57fa\u5316\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>ESCA\u60a3\u8005\u548c\u6b63\u5e38\u5bf9\u7167<\/td>\n<\/tr>\n<tr>\n<td>GSE53625<\/td>\n<td>GEO<\/td>\n<td>RNA \u82af\u7247\u6570\u636e+\u4e34\u5e8a\u4fe1\u606f<\/td>\n<td>119\u4f8bESCC\u60a3\u8005\u80bf\u7624\u548c\u914d\u5bf9\u6b63\u5e38\u7ec4\u7ec7<\/td>\n<\/tr>\n<tr>\n<td>GSE154148\u3001GSE68990\u3001GSE153637<\/td>\n<td>GEO<\/td>\n<td>RNA-seq\u6570\u636e<\/td>\n<td>RBMX\u6572\u9664\u7ec6\u80de<\/td>\n<\/tr>\n<tr>\n<td>RCD\u76f8\u5173\u57fa\u56e0<\/td>\n<td><\/td>\n<td colspan=\"2\">\u5305\u542b\u51cb\u4ea1\u3001\u7ec6\u80de\u7126\u4ea1\u3001\u574f\u6b7b\u6027\u51cb\u4ea1\u3001\u94c1\u6b7b\u4ea1\u548c\u94dc\u6b7b\u4ea1\u5171125\u4e2a\u57fa\u56e0<\/td>\n<\/tr>\n<tr>\n<td>\u70ed\u5e94\u6fc0\u76f8\u5173\u57fa\u56e0<\/td>\n<td><\/td>\n<td colspan=\"2\">25\u4e2a\u57fa\u56e0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u7814\u7a76\u6d41\u7a0b<\/strong><\/p>\n<p>\u9996\u5148\u5229\u7528TCGA-ESCA\u961f\u5217\u6bd4\u8f83\u6b63\u5e38\u98df\u7ba1\u548cESCA\u7ec4\u7ec7\u4e2d\u70ed\u5e94\u6fc0\u548c\u8c03\u8282\u6027\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u57fa\u56e0(HRCDs)\u7684mRNA\u8868\u8fbe\uff0c\u4ee5\u63a2\u7d22\u4e0e\u70ed\u5e94\u6fc0\u548c\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u7684\u5931\u8c03\u6a21\u5f0f\u3002\u5355\u53d8\u91cfcox\u56de\u5f52\u5206\u6790\u7b5b\u9009\u4e0eOS\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\uff0cLasso\u56de\u5f52\u5206\u6790\u6784\u5efa\u57fa\u4e8e6\u4e2aHRCD\u76f8\u5173\u57fa\u56e0\u7684\u98ce\u9669\u6a21\u578b\uff0c\u5e76\u8fdb\u884c\u6a21\u578b\u8bc4\u4f30\u548c\u9a8c\u8bc1\u3002\u901a\u8fc7\u68c0\u6d4b6\u4e2a\u57fa\u56e0\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\uff0c\u786e\u5b9a\u4e86\u4fc3\u8fdbESCA\u8fdb\u5c55\u7684\u5173\u952e\u57fa\u56e0PDHX\u548cHSPD1\uff0c\u7b5b\u9009\u8c03\u8282HSPD1\u6216PDHX\u57fa\u56e0\u8868\u8fbe\u7684RNA\u7532\u57fa\u5316\u4fee\u9970\u57fa\u56e0RBMX\uff0c\u5728RBMX\u6572\u9664\u7ec6\u80de\u6570\u636e\u96c6\u4e2d\u5206\u6790HSPD1\u6216PDHX\u57fa\u56e0\u4e0eRBMX\u7684\u76f8\u5173\u6027\u3002\u5206\u6790PDHX\u548cHSPD1\u4e0e\u514d\u75ab\u6d78\u6da6\u7684\u76f8\u5173\u6027\u4ee5\u53ca\u529f\u80fd\u5bcc\u96c6\u60c5\u51b5\uff0c\u5e76\u5728\u7ec6\u80de\u6837\u672c\u4e2d\u9a8c\u8bc1\u5176\u8868\u8fbe\u548c\u529f\u80fd\u3002<\/p>\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<p><strong>1. ESCA\u4e2d\u70ed\u5e94\u6fc0\u548c\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/strong><\/p>\n<p>\u5728TCGA-ESCA\u961f\u5217\u6bd4\u8f83\u6b63\u5e38\u98df\u7ba1\u548cESCA\u7ec4\u7ec7\u4e2d\u70ed\u5e94\u6fc0\u548c\u8c03\u8282\u6027\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u57fa\u56e0(HRCDs)\u7684mRNA\u8868\u8fbe\uff0c\u4ee5\u63a2\u7d22\u4e0e\u70ed\u5e94\u6fc0\u548c\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u7684\u5931\u8c03\u6a21\u5f0f\uff08\u56fe1A\uff09\u3002\u901a\u8fc7GSVA\u5206\u6790\u70ed\u5e94\u6fc0\u3001\u6cdb\u51cb\u4ea1\u3001\u94dc\u6b7b\u4ea1\u548c\u94c1\u6b7b\u4ea1\u5728\u4e0d\u540c\u7684ESCA\u9636\u6bb5\u7684\u5bcc\u96c6\u5206\u6570\u53d8\u5316\u8d8b\u52bf\uff08\u56fe1E\uff09\uff0c\u53d1\u73b0\u4ece\u7b2c\u4e00\u9636\u6bb5\u5230\u7b2c\u56db\u9636\u6bb5\uff0c\u94dc\u6b7b\u4ea1\u8bc4\u5206\u4fdd\u6301\u5347\u9ad8\uff0c\u8868\u660e\u5728ESCA\u94dc\u4e0b\u5782\u7684\u6f5c\u5728\u4fc3\u80bf\u7624\u4f5c\u7528\u3002<strong>\uff08ps\uff1aGSVA\u5206\u6790\u4e5f\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"305\" height=\"602\" class=\"wp-image-38052\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-5.png?resize=305%2C602\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-5.png?w=305 305w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-5.png?resize=152%2C300 152w\" sizes=\"(max-width: 305px) 100vw, 305px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"536\" height=\"406\" class=\"wp-image-38053\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-6.png?resize=536%2C406\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-6.png?w=536 536w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-6.png?resize=300%2C227 300w\" sizes=\"(max-width: 536px) 100vw, 536px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe1 ESCA\u4e2d\u70ed\u5e94\u6fc0\u548c\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/p>\n<p><strong>2. HRCDs\u76f8\u5173\u98ce\u9669\u6a21\u578b\u7684\u5efa\u7acb\u548c\u8bc4\u4f30<\/strong><\/p>\n<p>\u901a\u8fc7\u5355\u53d8\u91cfcox\u56de\u5f52\u5206\u6790\u7b5b\u9009\u4e0eOS\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\uff08\u56fe2A\uff09\uff0c\u518d\u5229\u7528Lasso\u56de\u5f52\u5206\u6790\u7b5b\u9009\u5f97\u52306\u4e2a\u4e0e\u4e0d\u826f\u9884\u540e\u663e\u8457\u76f8\u5173\u7684HRCD\u57fa\u56e0\uff0c\u5e76\u6784\u5efa\u98ce\u9669\u6a21\u578b\uff08\u56fe2B, C\uff09\u3002\u57fa\u4e8e\u98ce\u9669\u8bc4\u5206\u7684\u6700\u4f73\u4e34\u754c\u503c\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u3001\u4f4e\u8bc4\u5206\u7ec4\uff0c\u8fdb\u884cKM\u751f\u5b58\u5206\u6790\u5e76\u5229\u7528ROC\u66f2\u7ebf\u8bc4\u4f30\u9884\u6d4b\u6027\u80fd\uff08\u56fe2E, F\uff09\uff0c\u5728GSE54625\u9a8c\u8bc1\u96c6\u4e2d\u8fdb\u884c\u6a21\u578b\u9a8c\u8bc1\uff08\u56fe2I, J\uff09\u3002<strong>\uff08ps\uff1a\u5355\u56e0\u7d20\/\u591a\u56e0\u7d20Cox\u56de\u5f52\u3001LASSO\u56de\u5f52\u5206\u6790\u3001KM\u66f2\u7ebf\u3001ROC\u66f2\u7ebf\u7ed8\u5236\u90fd\u53ef\u4ee5\u7528\u5c0f\u4e91\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\u54e6\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html\uff09<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"347\" height=\"475\" class=\"wp-image-38054\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-7.png?resize=347%2C475\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-7.png?w=347 347w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-7.png?resize=219%2C300 219w\" sizes=\"(max-width: 347px) 100vw, 347px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"351\" height=\"226\" class=\"wp-image-38055\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-8.png?resize=351%2C226\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-8.png?w=351 351w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-8.png?resize=300%2C193 300w\" sizes=\"(max-width: 351px) 100vw, 351px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"346\" height=\"235\" class=\"wp-image-38056\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-9.png?resize=346%2C235\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-9.png?w=346 346w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-9.png?resize=300%2C204 300w\" sizes=\"(max-width: 346px) 100vw, 346px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"459\" class=\"wp-image-38057\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-10.png?resize=640%2C459\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-10.png?w=754 754w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-10.png?resize=300%2C215 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-10.png?resize=600%2C431 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe2 \u98ce\u9669\u6a21\u578b\u7684\u5efa\u7acb\u548c\u9a8c\u8bc1<\/p>\n<p><strong>3. \u5173\u952e\u57fa\u56e0\u7b5b\u9009\u53ca\u5176\u4e0e\u5e72\u6027\u3001m6A\u76f8\u5173\u6027\u5206\u6790<\/strong><\/p>\n<p>\u901a\u8fc7\u68c0\u6d4b6\u4e2a\u57fa\u56e0\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\uff0c\u786e\u5b9a\u4e86\u4fc3\u8fdbESCA\u8fdb\u5c55\u7684\u5173\u952e\u57fa\u56e0PDHX\u548cHSPD1\u5177\u6709\u6700\u5f3a\u76f8\u5173\u6027\uff08\u56fe3A\uff09\uff0c\u5728HPA\u6570\u636e\u5e93\u4e2d\u9a8c\u8bc1\u5176\u86cb\u767d\u8868\u8fbe\uff08\u56fe3B\uff09\u3002\u901a\u8fc7Spearma\u0144\u5206\u6790\u5176\u4e0e\u5e72\u7ec6\u80de\u6307\u6570\uff08miRNAs\uff09\u7684\u76f8\u5173\u6027\uff08\u56fe3C\uff0cD\uff09\u3002\u901a\u8fc7\u76f8\u5173\u6027\u5206\u6790\u7b5b\u9009\u53ef\u80fd\u8c03\u8282HSPD1\u6216PDHX\u57fa\u56e0\u8868\u8fbe\u7684RNA\u7532\u57fa\u5316\u4fee\u9970\u57fa\u56e0\uff0c\u53d1\u73b0m6A\u76f8\u5173\u57fa\u56e0RBMX\u4e0eHSPD1\u548cPDHX\u663e\u793a\u51fa\u6700\u5927\u7684\u76f8\u5173\u6027\uff08\u56fe3H\uff09\u3002\u8fdb\u4e00\u6b65\u5206\u6790ESCA\u4e2dRBMX\u7684\u8868\u8fbe\uff08\u56fe3I\uff09\uff0c\u53ca\u5176\u4e0e\u751f\u5b58\u9884\u540e\u7684\u76f8\u5173\u6027\uff08\u56fe3J, K\uff09\u3002\u6700\u540e\u5229\u7528RBMX\u6c89\u9ed8\u7ec6\u80de\u7cfb\u7684\u6570\u636e\u96c6\u5206\u6790\u5bf9\u7167\u548csi-RBMX\u7ec6\u80de\u4e4b\u95f4PDHX\u6216HSPD1\u7684\u8868\u8fbe\u5dee\u5f02\u4ee5\u8bc4\u4f30\u5176\u8c03\u63a7\u5173\u7cfb\uff08\u56fe3L\uff09\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"294\" class=\"wp-image-38058\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-11.png?resize=640%2C294\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-11.png?w=789 789w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-11.png?resize=300%2C138 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-11.png?resize=768%2C352 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-11.png?resize=600%2C275 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"232\" height=\"234\" class=\"wp-image-38059\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-12.png?resize=232%2C234\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-12.png?w=232 232w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-12.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-12.png?resize=100%2C100 100w\" sizes=\"(max-width: 232px) 100vw, 232px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"230\" height=\"221\" class=\"wp-image-38060\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-13.png?resize=230%2C221\" data-recalc-dims=\"1\"> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"398\" class=\"wp-image-38061\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-14.png?resize=640%2C398\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-14.png?w=726 726w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-14.png?resize=300%2C187 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-14.png?resize=600%2C374 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe3 \u5173\u952e\u57fa\u56e0\u7b5b\u9009\u53ca\u5176\u4e0e\u5e72\u6027\u3001m6A\u76f8\u5173\u6027\u5206\u6790<\/p>\n<p><strong>4.<\/strong> <a id=\"post-38047-_Hlk134272864\"><\/a><strong>PDHX\u3001HSPD1\u4e0e\u514d\u75ab\u6d78\u6da6\u7684\u76f8\u5173\u6027\u5206\u6790\u548c\u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/strong><\/p>\n<p>\u5229\u7528quanTIseq\u7b97\u6cd5\u8bc4\u4f30\u4e86TCGA\u961f\u5217\u4e2d\u4e2a\u4f53\u514d\u75ab\u7ec6\u80de\u5206\u6570\uff0c\u5e76\u5206\u6790\u514d\u75ab\u6d78\u6da6\u548c\u57fa\u56e0\u8868\u8fbe\u4e4b\u95f4\u7684Spearman\u76f8\u5173\u6027\uff08\u56fe4A, B\uff09\u3002\u7b5b\u9009HSPD1\u3001PDHX\u9ad8\u8868\u8fbe\u548c\u4f4e\u8868\u8fbe\u60a3\u8005\u95f4\u7684DEGs\uff08\u56fe5A, B\uff09\uff0c\u5e76\u8fdb\u884cKEGG \u548c GSEA\u5206\u6790\uff08\u56fe5 C-F\uff09\uff0c\u53d1\u73b0HSPD1\u6216\u8005PDHX\u4e0e\u5f02\u5e38\u7684\u7ec6\u80de\u4ee3\u8c22\u548c\u529f\u80fd\u6027\u514d\u75ab\u53cd\u5e94\u6709\u5173\u3002 <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"327\" class=\"wp-image-38062\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-15.png?resize=640%2C327\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-15.png?w=897 897w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-15.png?resize=300%2C154 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-15.png?resize=768%2C393 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-15.png?resize=600%2C307 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe4 PDHX\u3001HSPD1\u4e0e\u514d\u75ab\u6d78\u6da6\u7684\u76f8\u5173\u6027\u5206\u6790<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"896\" class=\"wp-image-38063\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-16.png?resize=640%2C896\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-16.png?w=683 683w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-16.png?resize=214%2C300 214w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-16.png?resize=600%2C840 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe5 \u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/p>\n<p><strong>5. <\/strong><a id=\"post-38047-_Hlk134273286\"><\/a><strong>HSPD1\u548cPDHX\u7684\u8868\u8fbe\u548c\u529f\u80fd\u9a8c\u8bc1<\/strong><\/p>\n<p>\u9996\u5148\u5229\u7528qRT-PCR\u6bd4\u8f83\u6b63\u5e38\u98df\u7ba1\u548cESCA\u7ec6\u80de\u7cfb\u4e2dHSPD1\u548cPDHX\u7684\u5dee\u5f02\u8868\u8fbe\uff08\u56fe6A\uff09\u3002\u6c89\u9ed8HSPD1\u548cPDHX\u540e\uff0c\u901a\u8fc7CCK8\u68c0\u6d4b\u7ec6\u80de\u6d3b\u529b\uff08\u56fe6C\uff09\uff0c\u4f24\u53e3\u6108\u5408\u5b9e\u9a8c\u68c0\u6d4b\u7ec6\u80de\u8fc1\u79fb\uff08\u56fe6E\uff09\uff0c\u7ed3\u679c\u663e\u793aHSPD1\u548cPDHX\u6c89\u9ed8\u6291\u5236TE-1\u7ec6\u80de\u7684\u589e\u6b96\u548c\u8fc1\u79fb\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"401\" height=\"241\" class=\"wp-image-38064\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-17.png?resize=401%2C241\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-17.png?w=401 401w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-17.png?resize=300%2C180 300w\" sizes=\"(max-width: 401px) 100vw, 401px\" data-recalc-dims=\"1\" \/> <img decoding=\"async\" loading=\"lazy\" width=\"254\" height=\"275\" class=\"wp-image-38065\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-18.png?resize=254%2C275\" data-recalc-dims=\"1\"> <img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"269\" class=\"wp-image-38066\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-19.png?resize=640%2C269\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-19.png?w=651 651w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-19.png?resize=300%2C126 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/word-image-38047-19.png?resize=600%2C253 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u56fe6 HSPD1\u548cPDHX\u7684\u8868\u8fbe\u548c\u529f\u80fd\u9a8c\u8bc1<\/p>\n<p><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/p>\n<p>\u8fd9\u7bc7\u6587\u7ae0\u4eceRCD+\u70ed\u5e94\u6fc0+m6A\u591a\u70ed\u70b9\u6574\u5408\u5207\u5165\u5206\u6790\uff0c\u521b\u65b0\u6027\u8f83\u9ad8\uff0c\u5185\u5bb9\u6bd4\u8f83\u4e30\u5bcc\uff0c\u6570\u636e\u91cf\u8f83\u5927\uff0c\u5e72\u6e7f\u7ed3\u5408\u5feb\u901f\u4ea7\u51fa\u9ad8\u5206\u6587\u7ae0\u3002\u76ee\u524d\u8fd9\u79cd\u5c06\u591a\u79cd\u7ec6\u80de\u6b7b\u4ea1\u6574\u5408\uff0c\u518d\u4e0e\u5176\u4ed6\u70ed\u70b9\u8054\u5408\u5206\u6790\u7684\u751f\u4fe1\u6587\u7ae0\u8fd8\u4e0d\u591a\uff0c\u4e5f\u5c31\u662f\u8bf4\u8ba9\u4f60\u53bb\u53d1\u6325\u7684\u7a7a\u95f4\u76f8\u5f53\u5927\u54df\uff0c\u5229\u7528\u8fd9\u7bc7\u6587\u7ae0\u641c\u96c6\u5230\u7684\u57fa\u56e0\u96c6\u5408\uff0c\u6362\u4e2a\u764c\u79cd\u80fd\u590d\u73b0\uff0c\u5feb\u884c\u52a8\u8d77\u6765\u5427\uff01<\/p>\n<p><strong>\u5c0f\u4e91\u516c\u4f17\u53f7\u6301\u7eed\u4e3a\u5927\u5bb6\u5e26\u6765\u6700\u65b0\u751f\u4fe1\u601d\u8def\uff0c\u66f4\u591a\u521b\u65b0\u5206\u6790\u601d\u8def\u8bf7\u70b9\u51fb\u94fe\u63a5\uff08https:\/\/mp.weixin.qq.com\/s\/E3dQcP9EAyTc5c5dwgaoLQ\uff09\u3002\u9700\u8981\u590d\u73b0\u6216\u5b9a\u5236\u5206\u6790\u601d\u8def\u7684\u670b\u53cb\u6b22\u8fcecall\u5c0f\u4e91\uff0c\u98ce\u91cc\u96e8\u91cc\u5c0f\u4e91\u516c\u4f17\u53f7\u7b49\u4f60\uff01\u53e6\u5916,\u5bf9\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5411\u611f\u5174\u8da3\u7684\u670b\u53cb\u8fd8\u53ef\u4ee5\u5173\u6ce8\u6211\u4eec\u7684\u751f\u4fe1\u7cfb\u5217\u8bfe\u2014\u2014\u300a\u70ed\u95e8\u53c8\u767e\u642d\u7684\u7ebf\u7c92\u4f53\u4e0e\u7ec6\u80de\u82b1\u5f0f\u6b7b\u4ea1\uff0c\u63ed\u79d8\u6027\u4ef7\u6bd4\u6700\u9ad8\u7684\u5207\u5165\u65b9\u5f0f\uff01\u300b\uff08\u52a0\u4e2a\u7cfb\u5217\u8bfe\u94fe\u63a5\uff0c\u5305\u542b\u591a\u79cd\u7ec6\u80de\u6b7b\u4ea1\u548c\u7ebf\u7c92\u4f53\u751f\u4fe1\u601d\u8def\uff0c\u6709\u610f\u5411\u7684\u5c0f\u4f19\u4f34\u4e5f\u6b22\u8fce\u54a8\u8be2\u5c0f\u4e91\u54e6!<\/strong><\/p>\n<p>1. \u60f3\u53d1\u9ad8\u5206\u53ea\u5206\u6790\u94dc\u6b7b\u4ea1\u8fd8\u4e0d\u591f\uff1f\u7ec6\u80de\u6b7b\u4ea1\u5927\u519b\u6765\u88ad\uff01\u57fa\u4e8e12\u79cd\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u57fa\u56e0\u6784\u5efa\u9884\u540e\u6a21\u578b\uff0c13\u5206+\u751f\u4fe1\u6587\u7ae0\u8f7b\u677e\u6536\u5165\u56ca\u4e2d<\/p>\n<p>2. \u51cb\u4ea1+\u81ea\u566c+\u7126\u4ea1\uff01\u4e09\u91cd\u7ecf\u5178\u70ed\u70b9\u8054\u624b\uff0c\u9884\u540e\u6a21\u578b+\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u5e72\u6e7f\u7ed3\u5408\u6a21\u5f0f\uff0c\u641e\u5b9a8\u5206+\u751f\u4fe1\u6587\u7ae0so easy\uff01\u9644\u5e26\u57fa\u56e0\u96c6\uff0c\u6362\u4e2a\u764c\u79cd\u5373\u590d\u73b0<\/p>\n<p>3. \u201cT\u7ec6\u80de\u589e\u6b96\u201d\u65b9\u5411\u751f\u4fe1\u63a5\u8fde\u53d1\u6587\uff01\u80bf\u7624\u5206\u578b+\u9884\u540e\u5206\u6790\u601d\u8def\uff0c\u518d\u53e0\u52a0\u5355\u7ec6\u80de\u5206\u6790\u548c\u9a8c\u8bc1\u5b9e\u9a8c\u8d85\u5f3abuff\uff0c8\u5206+\u6587\u7ae0\u624b\u5230\u64d2\u6765\uff01<\/p>\n<p>4. \u75c5\u7406\u5206\u6790\u4e0e\u751f\u4fe1\u5f3a\u5f3a\u8054\u624b\uff0c\u5355\u57fa\u56e0\u5206\u6790+\u514d\u75ab\u5206\u6790\u76f4\u8fbe5.7\u5206+\uff0c\u521b\u65b0\u6027\u7edd\u7edd\u5b50\uff0c\u4e0d\u6015\u601d\u8def\u649e\u8f66!\uff01<\/p>\n<p>5. \u8d85\u9ad8\u6027\u4ef7\u6bd4\u7684\u201c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u201d\u6765\u5566\uff01\u516c\u5171\u6570\u636e\u6316\u6398\uff0c\u7b80\u53554\u5f20\u56fe\u641e\u5b9a6\u5206+\uff0c1\u4e2a\u6708\u5c31\u63a5\u6536\uff01\u8d70\u8fc7\u8def\u8fc7\u5343\u4e07\u4e0d\u8981\u9519\u8fc7<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone  wp-image-36585\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/cgi-bin_mmwebwx-bin_webwxgetmsgimg__MsgID4067327085128576594skey@crypt_6e59bc7e_ea4971abc43d31be47b438816c93fae5mmweb_appidwx_webfilehelper.jpg?resize=640%2C279\" alt=\"\" width=\"640\" height=\"279\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/cgi-bin_mmwebwx-bin_webwxgetmsgimg__MsgID4067327085128576594skey@crypt_6e59bc7e_ea4971abc43d31be47b438816c93fae5mmweb_appidwx_webfilehelper.jpg?resize=300%2C131 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/cgi-bin_mmwebwx-bin_webwxgetmsgimg__MsgID4067327085128576594skey@crypt_6e59bc7e_ea4971abc43d31be47b438816c93fae5mmweb_appidwx_webfilehelper.jpg?resize=600%2C263 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/04\/cgi-bin_mmwebwx-bin_webwxgetmsgimg__MsgID4067327085128576594skey@crypt_6e59bc7e_ea4971abc43d31be47b438816c93fae5mmweb_appidwx_webfilehelper.jpg?w=1132 1132w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5c0f\u4e91\u5728PubMed\u7684\u82b1\u56ed\u91cc\u6316\u5440\u6316\u5440\u6316~ \u6316\u5230\u4e86\u597d\u601d\u8def\u5206\u4eab\u7ed9\u5927\u5bb6~ \u5c0f\u4e91\u7248&lt;\u6316\u5440\u6316&gt;\u6539\u7f16\u7684\u600e\u4e48\u6837\uff1f\u8fd9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/38047"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=38047"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/38047\/revisions"}],"predecessor-version":[{"id":38068,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/38047\/revisions\/38068"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=38047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=38047"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=38047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}