**\u53d1\u8868\u6742\u5fd7**\uff1aHuman Genomics
**\u901a\u8baf\u4f5c\u8005\u5355\u4f4d**\uff1a\u5f90\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5bbf\u8fc1\u533b\u9662
**\u7814\u7a76\u76ee\u7684**\uff1a
– \u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u7ecf\u5e38\u89c2\u5bdf\u5230 COVID-19 \u60a3\u8005\u51fa\u73b0\u6076\u5fc3\u3001\u5455\u5410\u7b49\u6d88\u5316\u75c7\u72b6\u3002\u7136\u800c\uff0cCOVID-19 \u4e0e\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5c1a\u4e0d\u6e05\u695a\u3002
– \u672c\u7814\u7a76\u65e8\u5728\u5229\u7528\u4e24\u6837\u672c\u3001\u591a\u53d8\u91cf\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u65b9\u6cd5\uff0c\u63a2\u8ba8 COVID-19 \u4e0e\u5e38\u89c1\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5e76\u63a2\u7d22\u6f5c\u5728\u7684\u4e2d\u4ecb\u56e0\u7d20\u5bf9\u8fd9\u79cd\u5173\u7cfb\u7684\u5f71\u54cd\u3002
**\u4e3b\u8981\u7ed3\u679c**\uff1a
– MR \u5206\u6790\u663e\u793a\uff0cSARS-CoV-2 \u611f\u67d3\uff08OR=1.09\uff0c95%CI 1.01-1.18\uff0cP=0.03\uff09\u3001\u4e25\u91cd COVID-19\uff08OR=1.02\uff0c95%CI 1.00-1.04\uff0cP=0.02\uff09\u548c COVID-19 \u4f4f\u9662\uff08OR=1.04\uff0c95%CI 1.01-1.06\uff0cP=0.01\uff09\u4e0e\u80c3\u98df\u7ba1\u53cd\u6d41\u75c5\uff08GERD\uff09\u5b58\u5728\u56e0\u679c\u5173\u8054\uff0c\u5e76\u53ef\u80fd\u589e\u52a0\u5176\u53d1\u75c5\u98ce\u9669\u3002
– \u4e2d\u4ecb\u5206\u6790\u8868\u660e\uff0c\u4f53\u91cd\u6307\u6570\uff08BMI\uff09\u662f SARS-CoV-2 \u611f\u67d3\u4e0e GERD \u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\u7684\u4e3b\u8981\u4e2d\u4ecb\u53d8\u91cf\uff0cBMI \u4ecb\u5bfc\u4e86 36%\uff0895%CI 20-53%\uff09\u7684\u6548\u5e94\u3002
**\u4e3b\u8981\u65b9\u6cd5**\uff1a
– \u672c\u7814\u7a76\u4ece\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u7684\u6c47\u603b\u6570\u636e\u4e2d\u63d0\u53d6\u4e0e COVID-19 \u4e25\u91cd\u7a0b\u5ea6\u76f8\u5173\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNP\uff09\u3002\u5e38\u89c1\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u4e3b\u8981\u6765\u81ea\u82f1\u56fd\u751f\u7269\u94f6\u884c\uff08UK Biobank\uff09\u7814\u7a76\u548c FinnGen \u7814\u7a76\u3002
– \u7136\u540e\uff0c\u4f7f\u7528\u9006\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09\u3001\u5b5f\u5fb7\u5c14\u968f\u673a\u5316-Egger \u56de\u5f52\uff08MR Egger\uff09\u3001\u52a0\u6743\u4e2d\u4f4d\u6570\u4f30\u8ba1\u3001\u52a0\u6743\u6a21\u5f0f\u548c\u7b80\u5355\u6a21\u5f0f\u65b9\u6cd5\u8fdb\u884c\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u3002IVW \u4f5c\u4e3a\u4e3b\u8981\u5206\u6790\u65b9\u6cd5\uff0c\u591a\u53d8\u91cf\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u7528\u4e8e\u63a2\u7d22\u4f53\u91cd\u6307\u6570\uff08BMI\uff09\u548c 2 \u578b\u7cd6\u5c3f\u75c5\u7684\u4e2d\u4ecb\u6548\u5e94\u3002
**\u521b\u65b0\u70b9**\uff1a
– \u9996\u6b21\u5229\u7528\u4e24\u6837\u672c\u3001\u591a\u53d8\u91cf\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u65b9\u6cd5\uff0c\u63a2\u8ba8\u4e86 COVID-19 \u4e0e\u5e38\u89c1\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5e76\u63a2\u7d22\u4e86\u6f5c\u5728\u7684\u4e2d\u4ecb\u56e0\u7d20\u5bf9\u8fd9\u79cd\u5173\u7cfb\u7684\u5f71\u54cd\u3002
– \u53d1\u73b0\u4e86 SARS-CoV-2 \u611f\u67d3\u4e0e GERD \u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5e76\u786e\u5b9a BMI \u662f\u5176\u4e2d\u7684\u4e3b\u8981\u4e2d\u4ecb\u53d8\u91cf\u3002
**\u7f3a\u70b9**\uff1a
– \u7814\u7a76\u4ec5\u7eb3\u5165\u4e86\u6b27\u6d32\u8840\u7edf\u7684\u4e2a\u4f53\uff0c\u53ef\u80fd\u5b58\u5728\u79cd\u65cf\u5c40\u9650\u6027\u3002
– \u7814\u7a76\u672a\u8003\u8651\u5176\u4ed6\u6f5c\u5728\u7684\u4e2d\u4ecb\u56e0\u7d20\uff0c\u5982\u996e\u98df\u4e60\u60ef\u3001\u751f\u6d3b\u65b9\u5f0f\u7b49\u3002
– \u7814\u7a76\u7ed3\u679c\u9700\u8981\u5728\u66f4\u5927\u89c4\u6a21\u7684\u4eba\u7fa4\u4e2d\u8fdb\u884c\u9a8c\u8bc1\u3002
**\u540e\u7eed\u7814\u7a76**\uff1a
– \u8fdb\u4e00\u6b65\u6269\u5927\u7814\u7a76\u4eba\u7fa4\uff0c\u5305\u62ec\u4e0d\u540c\u79cd\u65cf\u548c\u5730\u533a\u7684\u4e2a\u4f53\uff0c\u4ee5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u7684\u666e\u904d\u6027\u3002
– \u8003\u8651\u7eb3\u5165\u66f4\u591a\u7684\u6f5c\u5728\u4e2d\u4ecb\u56e0\u7d20\uff0c\u5982\u996e\u98df\u4e60\u60ef\u3001\u751f\u6d3b\u65b9\u5f0f\u7b49\uff0c\u4ee5\u66f4\u5168\u9762\u5730\u4e86\u89e3 COVID-19 \u4e0e\u6d88\u5316\u7cfb\u7edf\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002
– \u5f00\u5c55\u673a\u5236\u7814\u7a76\uff0c\u63a2\u8ba8 SARS-CoV-2 \u611f\u67d3\u5bfc\u81f4 GERD \u7684\u5177\u4f53\u673a\u5236\uff0c\u4e3a\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u7406\u8bba\u4f9d\u636e\u3002
**\u5b9a\u5236\u5316\u5206\u6790**\uff1a
– \u4e91\u751f\u4fe1\u63d0\u4f9b\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\uff0c\u5e2e\u52a9\u60a8\u6df1\u5165\u4e86\u89e3\u57fa\u56e0\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002
– \u6211\u4eec\u7684\u4e13\u4e1a\u56e2\u961f\u53ef\u4ee5\u6839\u636e\u60a8\u7684\u7814\u7a76\u9700\u6c42\uff0c\u8bbe\u8ba1\u548c\u5b9e\u65bd\u4e2a\u6027\u5316\u7684\u5206\u6790\u65b9\u6848\uff0c\u4e3a\u60a8\u63d0\u4f9b\u51c6\u786e\u3001\u53ef\u9760\u7684\u7ed3\u679c\u3002
– \u9664\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\uff0c\u6211\u4eec\u8fd8\u63d0\u4f9b\u751f\u7269\u4fe1\u606f\u5b66\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u7b49\u591a\u4e2a\u9886\u57df\u3002
– \u6211\u4eec\u53ef\u4ee5\u5e2e\u52a9\u60a8\u5904\u7406\u548c\u5206\u6790\u5927\u89c4\u6a21\u7684\u751f\u7269\u6570\u636e\uff0c\u6316\u6398\u5176\u4e2d\u7684\u5173\u952e\u4fe1\u606f\uff0c\u4e3a\u60a8\u7684\u7814\u7a76\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002
\u5982\u679c\u60a8\u5bf9\u6211\u4eec\u7684\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\u611f\u5174\u8da3\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u4eec\uff0c\u6211\u4eec\u5c06\u7aed\u8bda\u4e3a\u60a8\u670d\u52a1\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"
**\u53d1\u8868\u6742\u5fd7**\uff1aHuman Genomics **\u901a\u8baf\u4f5c\u8005\u5355\u4f4d**\uff1a\u5f90\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5bbf\u8fc1\u533b\u9662 **\u7814\u7a76\u76ee\u7684* […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43038"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43038"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43038\/revisions"}],"predecessor-version":[{"id":43075,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43038\/revisions\/43075"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43038"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}