{"id":43039,"date":"2024-06-01T19:12:57","date_gmt":"2024-06-01T11:12:57","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43039"},"modified":"2024-06-01T19:12:59","modified_gmt":"2024-06-01T11:12:59","slug":"mr-ggi%ef%bc%9a%e4%bd%bf%e7%94%a8%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e5%87%86%e7%a1%ae%e6%8e%a8%e6%96%ad%e5%9f%ba%e5%9b%a0-%e5%9f%ba%e5%9b%a0%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43039","title":{"rendered":"MR-GGI\uff1a\u4f7f\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u51c6\u786e\u63a8\u65ad\u57fa\u56e0-\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<ul>\n<li>\u8fd9\u7bc7\u6587\u7ae0\u7684\u6807\u9898\u662f\u201cMR-GGI: accurate inference of gene\u2013gene interactions using Mendelian randomization\u201d\uff0c\u4f5c\u8005\u662fWonseok Oh, Junghyun Jung\u548cJong Wha J. Joo\u3002\u6587\u7ae0\u53d1\u8868\u5728\u300aBMC Bioinformatics\u300b\u4e0a\uff0c\u4e8e2024\u5e74\u3002<\/li>\n\n\n\n<li><strong>\u6458\u8981\u548c\u80cc\u666f\uff1a<\/strong><\/li>\n\n\n\n<li>\u6587\u7ae0\u8ba8\u8bba\u4e86\u57fa\u56e0\u4e4b\u95f4\u7684\u8c03\u63a7\u8fc7\u7a0b\u4ee5\u53ca\u5982\u4f55\u901a\u8fc7\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff08GRN\uff09\u5206\u6790\u6765\u7406\u89e3\u8fd9\u4e9b\u8fc7\u7a0b\u3002<\/li>\n\n\n\n<li>\u4f20\u7edf\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u5206\u6790\u9700\u8981\u51c6\u786e\u5730\u8bc6\u522b\u57fa\u56e0\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u672a\u77e5\u7684\u6df7\u6742\u56e0\u7d20\u53ef\u80fd\u4f1a\u5f71\u54cd\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\uff0c\u4f7f\u5f97\u89e3\u91ca\u53d8\u5f97\u590d\u6742\u3002<\/li>\n\n\n\n<li>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian randomization, MR\uff09\u662f\u9057\u4f20\u5b66\u4e2d\u7528\u4e8e\u56e0\u679c\u63a8\u65ad\u7684\u4e00\u79cd\u6709\u4ef7\u503c\u5de5\u5177\uff0c\u5b83\u901a\u8fc7\u4f7f\u7528\u5de5\u5177\u53d8\u91cf\u6765\u4f30\u8ba1\u56e0\u679c\u5173\u7cfb\uff0c\u4ece\u800c\u89e3\u51b3\u6df7\u6742\u6548\u5e94\u95ee\u9898\u3002<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong><\/li>\n\n\n\n<li>\u672c\u6587\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u7edf\u8ba1\u65b9\u6cd5\uff0c\u79f0\u4e3aMR-GGI\uff08MR-based method for inferring Gene\u2013Gene Interaction\uff09\uff0c\u7528\u4e8e\u5229\u7528\u95e8\u5fb7\u5c14\u968f\u673a\u5316\u51c6\u786e\u63a8\u65ad\u57fa\u56e0-\u57fa\u56e0\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/li>\n\n\n\n<li>MR-GGI\u5c06\u4e00\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u66b4\u9732\u56e0\u7d20\uff0c\u53e6\u4e00\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u7ed3\u679c\uff0c\u4f7f\u7528\u56e0\u679c\u987a\u5f0f\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08cis-SNPs\uff09\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u5728\u9006\u65b9\u5dee\u52a0\u6743MR\u6a21\u578b\u4e2d\u8fdb\u884c\u5e94\u7528\u3002<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong><\/li>\n\n\n\n<li>\u901a\u8fc7\u6a21\u62df\u5b9e\u9a8c\uff0c\u4f5c\u8005\u5c55\u793a\u4e86MR-GGI\u5728\u5b58\u5728\u6df7\u6742\u6548\u5e94\u7684\u60c5\u51b5\u4e0b\u63a7\u5236I\u578b\u9519\u8bef\uff08false positives\uff09\u548c\u4fdd\u6301\u7edf\u8ba1\u529f\u6548\u7684\u80fd\u529b\u3002<\/li>\n\n\n\n<li>\u5728DREAM5\u6570\u636e\u96c6\u4e0a\uff0c\u4e0e\u5176\u4ed6\u7528\u4e8e\u751f\u7269\u7f51\u7edc\u63a8\u65ad\u7684\u65b9\u6cd5\u76f8\u6bd4\uff0cMR-GGI\u5c55\u793a\u4e86\u66f4\u9ad8\u7684F1\u5206\u6570\uff0c\u8868\u660e\u5176\u5728\u51c6\u786e\u63a8\u65ad\u57fa\u56e0-\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u65b9\u9762\u7684\u4f18\u52bf\u3002<\/li>\n\n\n\n<li>\u5e94\u7528\u5230\u9175\u6bcd\u57fa\u56e0\u7ec4\u6570\u636e\u4e2d\uff0cMR-GGI\u6210\u529f\u5730\u8bc6\u522b\u4e86\u516d\u4e2a\u529f\u80fd\u7c07\uff0c\u5e76\u901a\u8fc7\u57fa\u56e0\u672c\u4f53\uff08Gene Ontology\uff09\u5206\u6790\u786e\u8ba4\u6bcf\u4e2a\u7c07\u6267\u884c\u4e0d\u540c\u7684\u529f\u80fd\u89d2\u8272\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u8bba\uff1a<\/strong><\/li>\n\n\n\n<li>\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cMR-GGI\u80fd\u591f\u5728\u771f\u5b9e\u751f\u7269\u73af\u5883\u4e2d\u51c6\u786e\u63a8\u65ad\u57fa\u56e0-\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\uff0c\u5c3d\u7ba1\u5b58\u5728\u6df7\u6742\u6548\u5e94\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43039"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43039"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43039\/revisions"}],"predecessor-version":[{"id":43040,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43039\/revisions\/43040"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43039"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}