{"id":43050,"date":"2024-06-01T19:42:43","date_gmt":"2024-06-01T11:42:43","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43050"},"modified":"2024-06-01T19:42:44","modified_gmt":"2024-06-01T11:42:44","slug":"genetic-support-of-a-causal-relationship-between-iron-status-and-atrial-fibrillation-a-mendelian-randomization-study","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43050","title":{"rendered":"Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote\">\n<p>\u8fd9\u7bc7\u6587\u7ae0\u7684\u6807\u9898\u662f\u300aGenetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study\u300b\uff0c\u4f5c\u8005\u662fTianyi Wang, Jun Cheng\u548cYanggan Wang\u3002\u6587\u7ae0\u53d1\u8868\u5728\u300aGenes &amp; Nutrition\u300b\u4e0a\uff0c\u4e8e2022\u5e74\u3002<\/p>\n<\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u7ed3\u679c\u548c\u65b9\u6cd5\uff1a<\/h3>\n\n\n\n<p><strong>\u80cc\u666f\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u623f\u98a4\uff08Atrial fibrillation, AF\uff09\u662f\u6700\u5e38\u89c1\u7684\u5fc3\u5f8b\u5931\u5e38\u75be\u75c5\uff0c\u4e0e\u4e2d\u98ce\u98ce\u9669\u589e\u52a0\u6709\u5173\u3002<\/li>\n\n\n\n<li>\u5148\u524d\u7684\u52a8\u7269\u548c\u89c2\u5bdf\u6027\u7814\u7a76\u53d1\u73b0\u94c1\u72b6\u6001\uff08iron status\uff09\u4e0e\u623f\u98a4\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\uff0c\u4f46\u94c1\u72b6\u6001\u4e0e\u623f\u98a4\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5c1a\u4e0d\u660e\u786e\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u65b9\u6cd5\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u672c\u7814\u7a76\u4f7f\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian randomization, MR\uff09\u5206\u6790\uff0c\u8fd9\u662f\u4e00\u79cd\u5e7f\u6cdb\u7528\u4e8e\u4f30\u8ba1\u56e0\u679c\u6548\u5e94\u7684\u65b9\u6cd5\uff0c\u4ee5\u63ed\u793a\u7cfb\u7edf\u6027\u94c1\u72b6\u6001\u662f\u5426\u4e0e\u623f\u98a4\u6709\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u4ece\u6d89\u53ca48,972\u540d\u53d7\u8bd5\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08Genetics of Iron Status consortium\uff09\u4e2d\u83b7\u53d6\u4e86\u4e0e\u7cfb\u7edf\u6027\u94c1\u72b6\u6001\u7684\u56db\u4e2a\u751f\u7269\u6807\u5fd7\u7269\u5f3a\u70c8\u76f8\u5173\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\u3002<\/li>\n\n\n\n<li>\u4eceAFGen\uff08Atrial Fibrillation Genetics\uff09\u8054\u76df\u7814\u7a76\u4e2d\u83b7\u53d6\u4e86\u4e0e\u623f\u98a4\u76f8\u5173\u7684\u9057\u4f20\u6c47\u603b\u6570\u636e\uff0c\u5305\u62ec65,446\u4f8b\u623f\u98a4\u75c5\u4f8b\u548c522,744\u540d\u5bf9\u7167\u3002<\/li>\n\n\n\n<li>\u4f7f\u7528\u4e24\u6837\u672cMR\u5206\u6790\u6765\u83b7\u5f97\u56e0\u679c\u4f30\u8ba1\uff0c\u5e76\u901a\u8fc7\u654f\u611f\u6027\u5206\u6790\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u53ef\u4fe1\u5ea6\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7ed3\u679c\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u9057\u4f20\u5de5\u5177\u663e\u793a\u8840\u6e05\u94c1[OR 1.09; 95% CI 1.02\u20131.16; p = 0.01]\u3001\u94c1\u86cb\u767d[OR 1.16; 95% CI 1.02\u20131.33; p = 0.02]\u548c\u8f6c\u94c1\u86cb\u767d\u9971\u548c\u5ea6[OR 1.05; 95% CI 1.01\u20131.11; p = 0.01]\u5bf9\u623f\u98a4\u6709\u6b63\u9762\u5f71\u54cd\u3002<\/li>\n\n\n\n<li>\u9057\u4f20\u5de5\u5177\u663e\u793a\u8f6c\u94c1\u86cb\u767d\u6c34\u5e73[OR 0.90; 95% CI 0.86\u20130.97; p = 0.006]\u4e0e\u623f\u98a4\u5448\u8d1f\u76f8\u5173\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7ed3\u8bba\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u7814\u7a76\u7ed3\u679c\u5f3a\u70c8\u8868\u660e\uff0c\u9057\u4f20\u51b3\u5b9a\u7684\u8f83\u9ad8\u7684\u94c1\u72b6\u6001\u4e0e\u623f\u98a4\u98ce\u9669\u589e\u52a0\u4e4b\u95f4\u5b58\u5728\u56e0\u679c\u8054\u7cfb\u3002<\/li>\n\n\n\n<li>\u8fd9\u4e3a\u623f\u98a4\u7684\u4e34\u5e8a\u9884\u9632\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u7f3a\u70b9\uff1a<\/h3>\n\n\n\n<ul>\n<li>\u6587\u7ae0\u672a\u8be6\u7ec6\u8ba8\u8bba\u94c1\u72b6\u6001\u4e0e\u623f\u98a4\u4e4b\u95f4\u7684\u751f\u7269\u5b66\u673a\u5236\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u4e3b\u8981\u4f9d\u8d56\u4e8e\u73b0\u6709\u7684GWAS\u6570\u636e\u5e93\uff0c\u53ef\u80fd\u5b58\u5728\u4eba\u7fa4\u5206\u5c42\u7684\u504f\u5dee\u3002<\/li>\n\n\n\n<li>\u7531\u4e8e\u6570\u636e\u6765\u6e90\u4e3b\u8981\u662f\u6b27\u6d32\u4eba\u7fa4\uff0c\u7ed3\u679c\u7684\u666e\u9002\u6027\u53ef\u80fd\u53d7\u9650\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u540e\u7eed\u7814\u7a76\u65b9\u5411\uff1a<\/h3>\n\n\n\n<ul>\n<li>\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u94c1\u72b6\u6001\u4e0e\u623f\u98a4\u4e4b\u95f4\u7684\u751f\u7269\u5b66\u673a\u5236\u3002<\/li>\n\n\n\n<li>\u63a2\u7d22\u94c1\u72b6\u6001\u5e72\u9884\u63aa\u65bd\u5bf9\u623f\u98a4\u9884\u9632\u548c\u6cbb\u7597\u6548\u679c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n\n\n\n<li>\u5728\u4e0d\u540c\u79cd\u65cf\u548c\u4eba\u7fa4\u4e2d\u8fdb\u884c\u9a8c\u8bc1\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u7ed3\u679c\u7684\u666e\u9002\u6027\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><\/h3>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u7bc7\u6587\u7ae0\u7684\u6807\u9898\u662f\u300aGenetic support of a causal relationship betwe [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43050"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43050"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43050\/revisions"}],"predecessor-version":[{"id":43051,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43050\/revisions\/43051"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43050"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}