{"id":43080,"date":"2024-06-01T21:28:13","date_gmt":"2024-06-01T13:28:13","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43080"},"modified":"2024-06-01T21:28:15","modified_gmt":"2024-06-01T13:28:15","slug":"cd8nkt-%e7%bb%86%e8%83%9e%e4%b8%8e-nk-%e7%bb%86%e8%83%9e%e4%b8%8a%e7%9a%84-cd16%e2%88%92cd56-%e4%b8%8e%e8%82%9d%e7%bb%86%e8%83%9e%e7%99%8c%e7%9a%84%e5%9b%a0%e6%9e%9c%e5%85%b3%e7%b3%bb%ef%bc%9a","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43080","title":{"rendered":"CD8+NKT \u7ec6\u80de\u4e0e NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u4e0e\u809d\u7ec6\u80de\u764c\u7684\u56e0\u679c\u5173\u7cfb\uff1a\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p><strong>\u53d1\u8868\u6742\u5fd7<\/strong>\uff1aInfectious Agents and Cancer<\/p>\n\n\n\n<p><strong>\u901a\u8baf\u4f5c\u8005\u5355\u4f4d<\/strong>\uff1a\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u821f\u5c71\u533b\u9662\u611f\u67d3\u79d1<\/p>\n\n\n\n<p><strong>\u7814\u7a76\u76ee\u7684<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u662f\u5168\u7403\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u8f83\u9ad8\u7684\u539f\u53d1\u6027\u809d\u810f\u6076\u6027\u80bf\u7624\u3002<\/li>\n\n\n\n<li>\u6700\u8fd1\uff0c\u6709\u5927\u91cf\u8bc1\u636e\u8868\u660e NK \u7ec6\u80de\u76f8\u5173\u514d\u75ab\u7279\u5f81\u4e0e HCC \u7684\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u4f46\u5b83\u4eec\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5c1a\u672a\u5f97\u5230\u8bc1\u5b9e\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u663e\u793a\uff0cNK \u7ec6\u80de\u76f8\u5173\u514d\u75ab\u7279\u5f81\u4e0e HCC \u4e4b\u95f4\u5b58\u5728\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n<li>\u91cd\u8981\u7684\u662f\uff0cCD8+NKT \u7ec6\u80de\u5bf9 HCC \u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff08OR=0.9996\uff1b95%CI\uff0c0.9993\u20130.9999\uff1bP=0.0489\uff09\u3002<\/li>\n\n\n\n<li>NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u5bf9 HCC \u4e5f\u6709\u7c7b\u4f3c\u7684\u4fdd\u62a4\u4f5c\u7528\uff08OR=0.9997\uff1b95%CI\uff0c0.9996\u20130.9999\uff1bP=0.0117\uff09\u3002<\/li>\n\n\n\n<li>Egger \u622a\u8ddd\u663e\u793a\u6ca1\u6709\u591a\u6548\u6027\u548c\u6df7\u6742\u56e0\u7d20\u3002<\/li>\n\n\n\n<li>\u6b64\u5916\uff0cCochran \u7684 Q \u68c0\u9a8c\u6ca1\u6709\u53d1\u73b0\u652f\u6301\u5f02\u8d28\u6027\u5b58\u5728\u7684\u8db3\u591f\u8bc1\u636e\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4e3b\u8981\u65b9\u6cd5<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u672c\u7814\u7a76\u8fdb\u884c\u4e86\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u7814\u7a76\uff0c\u4ee5\u63a2\u8ba8 NK \u7ec6\u80de\u76f8\u5173\u514d\u75ab\u7279\u5f81\u4e0e HCC \u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n<li>\u4ece\u6700\u8fd1\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u4e2d\u63d0\u53d6\u4e86\u6b27\u6d32\u8840\u7edf\u4e2a\u4f53\u7684 NK \u7ec6\u80de\u76f8\u5173\u514d\u75ab\u7279\u5f81\u7684\u9057\u4f20\u53d8\u5f02\u3002<\/li>\n\n\n\n<li>HCC \u6570\u636e\u6765\u81ea\u82f1\u56fd\u751f\u7269\u94f6\u884c\u8054\u76df\u7684 GWAS \u6c47\u603b\u8ba1\u6570\u6570\u636e\uff0c\u5305\u62ec 372,184 \u540d\u5973\u6027\u548c\u7537\u6027\u53d7\u8bd5\u8005\uff0c\u5176\u4e2d 168 \u4f8b\u75c5\u4f8b\u548c 372,016 \u4f8b\u5bf9\u7167\uff0c\u5747\u4e3a\u6b27\u6d32\u8840\u7edf\u3002<\/li>\n\n\n\n<li>\u654f\u611f\u6027\u5206\u6790\u4e3b\u8981\u7528\u4e8e\u5f02\u8d28\u6027\u548c\u591a\u6548\u6027\u6d4b\u8bd5\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u521b\u65b0\u70b9<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u9996\u6b21\u4f7f\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u65b9\u6cd5\uff0c\u63a2\u8ba8\u4e86 CD8+NKT \u7ec6\u80de\u4e0e NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u4e0e HCC \u7684\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n<li>\u53d1\u73b0 CD8+NKT \u7ec6\u80de\u548c NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u5bf9 HCC \u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u4e3a HCC \u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u9776\u70b9\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7f3a\u70b9<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u672c\u7814\u7a76\u4ec5\u4f7f\u7528\u4e86\u6b27\u6d32\u8840\u7edf\u4e2a\u4f53\u7684\u6570\u636e\uff0c\u53ef\u80fd\u5b58\u5728\u79cd\u65cf\u5c40\u9650\u6027\u3002<\/li>\n\n\n\n<li>\u672c\u7814\u7a76\u672a\u8003\u8651\u5176\u4ed6\u6f5c\u5728\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u996e\u98df\u4e60\u60ef\u3001\u751f\u6d3b\u65b9\u5f0f\u7b49\u3002<\/li>\n\n\n\n<li>\u672c\u7814\u7a76\u672a\u8fdb\u884c\u529f\u80fd\u5b9e\u9a8c\uff0c\u65e0\u6cd5\u786e\u5b9a CD8+NKT \u7ec6\u80de\u548c NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u5bf9 HCC \u7684\u5177\u4f53\u4f5c\u7528\u673a\u5236\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u540e\u7eed\u7814\u7a76<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u8fdb\u4e00\u6b65\u6269\u5927\u7814\u7a76\u4eba\u7fa4\uff0c\u5305\u62ec\u4e0d\u540c\u79cd\u65cf\u548c\u5730\u533a\u7684\u4e2a\u4f53\uff0c\u4ee5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u7684\u666e\u904d\u6027\u3002<\/li>\n\n\n\n<li>\u8003\u8651\u7eb3\u5165\u5176\u4ed6\u6f5c\u5728\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u5982\u996e\u98df\u4e60\u60ef\u3001\u751f\u6d3b\u65b9\u5f0f\u7b49\uff0c\u4ee5\u66f4\u5168\u9762\u5730\u4e86\u89e3 HCC \u7684\u53d1\u75c5\u673a\u5236\u3002<\/li>\n\n\n\n<li>\u8fdb\u884c\u529f\u80fd\u5b9e\u9a8c\uff0c\u786e\u5b9a CD8+NKT \u7ec6\u80de\u548c NK \u7ec6\u80de\u4e0a\u7684 CD16\u2212CD56 \u5bf9 HCC \u7684\u5177\u4f53\u4f5c\u7528\u673a\u5236\uff0c\u4e3a HCC \u7684\u6cbb\u7597\u63d0\u4f9b\u66f4\u6709\u529b\u7684\u8bc1\u636e\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5b9a\u5236\u5316\u5206\u6790<\/strong>\uff1a<\/p>\n\n\n\n<ul>\n<li>\u4e91\u751f\u4fe1\u63d0\u4f9b\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\uff0c\u5e2e\u52a9\u60a8\u6df1\u5165\u4e86\u89e3\u57fa\u56e0\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n<li>\u6211\u4eec\u7684\u4e13\u4e1a\u56e2\u961f\u53ef\u4ee5\u6839\u636e\u60a8\u7684\u7814\u7a76\u9700\u6c42\uff0c\u8bbe\u8ba1\u548c\u5b9e\u65bd\u4e2a\u6027\u5316\u7684\u5206\u6790\u65b9\u6848\uff0c\u4e3a\u60a8\u63d0\u4f9b\u51c6\u786e\u3001\u53ef\u9760\u7684\u7ed3\u679c\u3002<\/li>\n\n\n\n<li>\u9664\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\uff0c\u6211\u4eec\u8fd8\u63d0\u4f9b\u751f\u7269\u4fe1\u606f\u5b66\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u7b49\u591a\u4e2a\u9886\u57df\u3002<\/li>\n\n\n\n<li>\u6211\u4eec\u53ef\u4ee5\u5e2e\u52a9\u60a8\u5904\u7406\u548c\u5206\u6790\u5927\u89c4\u6a21\u7684\u751f\u7269\u6570\u636e\uff0c\u6316\u6398\u5176\u4e2d\u7684\u5173\u952e\u4fe1\u606f\uff0c\u4e3a\u60a8\u7684\u7814\u7a76\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5982\u679c\u60a8\u5bf9\u6211\u4eec\u7684\u5b9a\u5236\u5316\u5206\u6790\u670d\u52a1\u611f\u5174\u8da3\uff0c\u8bf7\u968f\u65f6\u8054\u7cfb\u6211\u4eec\uff0c\u6211\u4eec\u5c06\u7aed\u8bda\u4e3a\u60a8\u670d\u52a1\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u53d1\u8868\u6742\u5fd7\uff1aInfectious Agents and Cancer \u901a\u8baf\u4f5c\u8005\u5355\u4f4d\uff1a\u6e29\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u821f\u5c71\u533b\u9662\u611f\u67d3 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43080"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43080"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43080\/revisions"}],"predecessor-version":[{"id":43081,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43080\/revisions\/43081"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43080"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}