{"id":43100,"date":"2024-06-01T21:50:39","date_gmt":"2024-06-01T13:50:39","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43100"},"modified":"2024-06-01T21:50:41","modified_gmt":"2024-06-01T13:50:41","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e6%bc%ab%e8%b0%88","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43100","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u6f2b\u8c08"},"content":{"rendered":"\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u57fa\u672c\u539f\u7406<\/h1>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u662f\u73b0\u4ee3\u9057\u4f20\u6d41\u884c\u75c5\u5b66\u4e2d\u7684\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u65b9\u6cd5\uff0c\u5229\u7528\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u7814\u7a76\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u7ed3\u679c\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u4e0e\u4f20\u7edf\u7684\u89c2\u5bdf\u6027\u7814\u7a76\u4e0d\u540c\uff0cMR\u5229\u7528\u4e86\u9057\u4f20\u53d8\u5f02\u5728\u4e2a\u4f53\u95f4\u968f\u673a\u5206\u914d\u7684\u7279\u70b9\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5728\u514b\u670d\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\u65b9\u9762\u5177\u6709\u72ec\u7279\u7684\u4f18\u52bf\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u89e3\u91ca\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u57fa\u7840\u7406\u8bba\u3001\u5176\u5229\u7528\u7684\u81ea\u7136\u968f\u673a\u5316\u8fc7\u7a0b\uff0c\u4ee5\u53ca\u4e0e\u4f20\u7edf\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u7684\u5bf9\u6bd4\uff0c\u5e76\u4ecb\u7ecdMR\u7684\u4e09\u4e2a\u4e3b\u8981\u5047\u8bbe\uff1a\u5173\u8054\u5047\u8bbe\u3001\u65e0\u6df7\u6742\u5047\u8bbe\u3001\u65e0\u591a\u6548\u6027\u5047\u8bbe\u3002<\/p>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u57fa\u7840\u7406\u8bba<\/h2>\n\n\n\n

\u81ea\u7136\u968f\u673a\u5316\u8fc7\u7a0b<\/h3>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u57fa\u7840\u7406\u8bba\u6e90\u81ea\u5b5f\u5fb7\u5c14\u9057\u4f20\u5b9a\u5f8b\u3002\u5b5f\u5fb7\u5c14\u5b9a\u5f8b\u63cf\u8ff0\u4e86\u9057\u4f20\u53d8\u5f02\u5728\u7236\u6bcd\u548c\u5b50\u4ee3\u4e4b\u95f4\u7684\u968f\u673a\u5206\u914d\uff0c\u8fd9\u79cd\u968f\u673a\u5206\u914d\u7c7b\u4f3c\u4e8e\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\u7684\u968f\u673a\u5316\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u4e00\u4e2a\u7279\u5b9a\u7684\u57fa\u56e0\u53d8\u5f02\u5728\u7236\u6bcd\u4f20\u9012\u7ed9\u5b50\u4ee3\u7684\u8fc7\u7a0b\u4e2d\u662f\u968f\u673a\u7684\uff0c\u8fd9\u610f\u5473\u7740\u5728\u5927\u578b\u7fa4\u4f53\u4e2d\uff0c\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5f02\u5728\u4e0d\u540c\u4e2a\u4f53\u95f4\u7684\u5206\u5e03\u662f\u968f\u673a\u7684\uff0c\u4e0d\u53d7\u73af\u5883\u548c\u884c\u4e3a\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

\u8fd9\u79cd\u81ea\u7136\u968f\u673a\u5316\u8fc7\u7a0b\u5141\u8bb8\u7814\u7a76\u8005\u5c06\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u7814\u7a76\u66b4\u9732\u56e0\u7d20\uff08\u5982\u8840\u8102\u6c34\u5e73\u3001\u4f53\u91cd\u6307\u6570\u7b49\uff09\u4e0e\u75be\u75c5\u7ed3\u679c\uff08\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u7b49\uff09\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u56e0\u4e3a\u8fd9\u4e9b\u9057\u4f20\u53d8\u5f02\u5728\u4e2a\u4f53\u95f4\u662f\u968f\u673a\u5206\u5e03\u7684\uff0c\u6240\u4ee5\u53ef\u4ee5\u8ba4\u4e3a\u5b83\u4eec\u4e0e\u6df7\u6742\u56e0\u7d20\uff08\u5982\u751f\u6d3b\u65b9\u5f0f\u3001\u73af\u5883\u56e0\u7d20\uff09\u65e0\u5173\uff0c\u4ece\u800c\u80fd\u591f\u8f83\u597d\u5730\u63a7\u5236\u6df7\u6742\u504f\u501a\u3002<\/p>\n\n\n\n

\u4e0e\u4f20\u7edf\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u7684\u5bf9\u6bd4<\/h3>\n\n\n\n

\u5728\u4f20\u7edf\u7684\u89c2\u5bdf\u6027\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u901a\u5e38\u4f7f\u7528\u56de\u5f52\u5206\u6790\u6765\u63a2\u8ba8\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u7ed3\u679c\u4e4b\u95f4\u7684\u5173\u8054\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5e38\u5e38\u53d7\u5230\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\u7684\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u4e00\u4e2a\u89c2\u5bdf\u6027\u7814\u7a76\u53ef\u80fd\u53d1\u73b0\u9ad8\u8840\u8102\u6c34\u5e73\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\uff0c\u4f46\u65e0\u6cd5\u786e\u5b9a\u9ad8\u8840\u8102\u6c34\u5e73\u662f\u5426\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u539f\u56e0\uff0c\u8fd8\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u5bfc\u81f4\u4e86\u9ad8\u8840\u8102\u6c34\u5e73\uff0c\u6216\u662f\u4e24\u8005\u90fd\u53d7\u5230\u67d0\u4e9b\u6df7\u6742\u56e0\u7d20\uff08\u5982\u4e0d\u5065\u5eb7\u7684\u996e\u98df\u4e60\u60ef\uff09\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5229\u7528\u4e86\u57fa\u56e0\u53d8\u5f02\u7684\u968f\u673a\u5206\u914d\u7279\u6027\uff0c\u80fd\u591f\u6709\u6548\u63a7\u5236\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\uff0c\u4ece\u800c\u66f4\u53ef\u9760\u5730\u63a8\u65ad\u56e0\u679c\u5173\u7cfb\u3002\u901a\u8fc7\u5c06\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0cMR\u80fd\u591f\u63d0\u4f9b\u7c7b\u4f3c\u4e8e\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u56e0\u679c\u63a8\u65ad\u80fd\u529b\u3002<\/p>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u4e09\u4e2a\u4e3b\u8981\u5047\u8bbe<\/h2>\n\n\n\n

\u8981\u6210\u529f\u5e94\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u65b9\u6cd5\uff0c\u5fc5\u987b\u6ee1\u8db3\u4ee5\u4e0b\u4e09\u4e2a\u5173\u952e\u5047\u8bbe\uff1a<\/p>\n\n\n\n

1. \u5173\u8054\u5047\u8bbe\uff08Relevance Assumption\uff09<\/h3>\n\n\n\n

\u5173\u8054\u5047\u8bbe\u8981\u6c42\u6240\u9009\u62e9\u7684\u57fa\u56e0\u53d8\u5f02\uff08\u5de5\u5177\u53d8\u91cf\uff09\u5fc5\u987b\u4e0e\u7814\u7a76\u7684\u66b4\u9732\u56e0\u7d20\u663e\u8457\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u5982\u679c\u7814\u7a76\u7684\u662f\u8840\u8102\u6c34\u5e73\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u5f71\u54cd\uff0c\u90a3\u4e48\u6240\u9009\u62e9\u7684\u57fa\u56e0\u53d8\u5f02\u5fc5\u987b\u663e\u8457\u5f71\u54cd\u8840\u8102\u6c34\u5e73\u3002\u8fd9\u4e2a\u5047\u8bbe\u786e\u4fdd\u5de5\u5177\u53d8\u91cf\u786e\u5b9e\u80fd\u591f\u53cd\u6620\u66b4\u9732\u56e0\u7d20\u7684\u53d8\u5316\uff0c\u4ece\u800c\u5728\u56e0\u679c\u63a8\u65ad\u4e2d\u8d77\u4f5c\u7528\u3002<\/p>\n\n\n\n

2. \u65e0\u6df7\u6742\u5047\u8bbe\uff08Independence Assumption\uff09<\/h3>\n\n\n\n

\u65e0\u6df7\u6742\u5047\u8bbe\u8981\u6c42\u5de5\u5177\u53d8\u91cf\u4e0e\u6df7\u6742\u56e0\u7d20\u65e0\u5173\u3002\u56e0\u4e3a\u57fa\u56e0\u53d8\u5f02\u662f\u968f\u673a\u5206\u914d\u7684\uff0c\u6240\u4ee5\u5728\u7406\u8bba\u4e0a\uff0c\u5b83\u4eec\u4e0d\u5e94\u8be5\u4e0e\u4efb\u4f55\u6df7\u6742\u56e0\u7d20\uff08\u5982\u793e\u4f1a\u7ecf\u6d4e\u5730\u4f4d\u3001\u996e\u98df\u4e60\u60ef\u7b49\uff09\u76f8\u5173\u8054\u3002\u8fd9\u4e00\u5047\u8bbe\u786e\u4fdd\u4e86\u5de5\u5177\u53d8\u91cf\u4ec5\u901a\u8fc7\u66b4\u9732\u56e0\u7d20\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\uff0c\u800c\u4e0d\u53d7\u5176\u4ed6\u6df7\u6742\u56e0\u7d20\u7684\u5e72\u6270\uff0c\u4ece\u800c\u4f7f\u5f97\u56e0\u679c\u63a8\u65ad\u66f4\u4e3a\u53ef\u9760\u3002<\/p>\n\n\n\n

3. \u65e0\u591a\u6548\u6027\u5047\u8bbe\uff08Exclusion Restriction Assumption\uff09<\/h3>\n\n\n\n

\u65e0\u591a\u6548\u6027\u5047\u8bbe\u8981\u6c42\u5de5\u5177\u53d8\u91cf\u53ea\u901a\u8fc7\u7814\u7a76\u7684\u66b4\u9732\u56e0\u7d20\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\uff0c\u800c\u4e0d\u76f4\u63a5\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\u6216\u901a\u8fc7\u5176\u4ed6\u9014\u5f84\u95f4\u63a5\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u57fa\u56e0\u53d8\u5f02\u4e0d\u5e94\u6709\u5176\u4ed6\u9014\u5f84\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\uff0c\u9664\u4e86\u901a\u8fc7\u66b4\u9732\u56e0\u7d20\u8fd9\u4e00\u9014\u5f84\u3002\u4f8b\u5982\uff0c\u5982\u679c\u67d0\u4e2a\u57fa\u56e0\u53d8\u5f02\u4e0d\u4ec5\u5f71\u54cd\u8840\u8102\u6c34\u5e73\uff0c\u8fd8\u76f4\u63a5\u5f71\u54cd\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\uff0c\u90a3\u4e48\u8fd9\u4e2a\u57fa\u56e0\u53d8\u5f02\u5c31\u4e0d\u9002\u5408\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u56e0\u4e3a\u5b83\u8fdd\u53cd\u4e86\u65e0\u591a\u6548\u6027\u5047\u8bbe\u3002<\/p>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5e94\u7528\u4e0e\u5b9e\u4f8b<\/h2>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u73b0\u4ee3\u533b\u5b66\u7814\u7a76\u4e2d\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u5c24\u5176\u662f\u5728\u786e\u5b9a\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u548c\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u75be\u75c5\u98ce\u9669\u7684\u56e0\u679c\u4f5c\u7528\u65b9\u9762\u3002\u4f8b\u5982\uff1a<\/p>\n\n\n\n

1. \u7814\u7a76\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08HDL-C\uff09\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u5f71\u54cd<\/h3>\n\n\n\n

\u4f20\u7edf\u89c2\u5bdf\u6027\u7814\u7a76\u8868\u660e\uff0c\u9ad8\u6c34\u5e73\u7684HDL-C\uff08\u4fd7\u79f0\u201c\u597d\u80c6\u56fa\u9187\u201d\uff09\u4e0e\u8f83\u4f4e\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u76f8\u5173\u3002\u7136\u800c\uff0cMR\u7814\u7a76\u5229\u7528\u5f71\u54cdHDL-C\u6c34\u5e73\u7684\u57fa\u56e0\u53d8\u5f02\uff08\u5982CETP\u57fa\u56e0\u53d8\u5f02\uff09\u53d1\u73b0\uff0c\u5c3d\u7ba1HDL-C\u6c34\u5e73\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u76f8\u5173\uff0c\u4f46\u8fd9\u79cd\u5173\u8054\u53ef\u80fd\u5e76\u4e0d\u5177\u6709\u56e0\u679c\u6027\u3002\u8fd9\u4e00\u53d1\u73b0\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9884\u9632\u548c\u6cbb\u7597\u7b56\u7565\u4ea7\u751f\u4e86\u91cd\u8981\u5f71\u54cd\uff0c\u63d0\u793a\u5355\u7eaf\u63d0\u9ad8HDL-C\u6c34\u5e73\u53ef\u80fd\u5e76\u4e0d\u80fd\u6709\u6548\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u3002<\/p>\n\n\n\n

2. \u63a2\u8ba8BMI\u5bf9\u7cd6\u5c3f\u75c5\u7684\u56e0\u679c\u5173\u7cfb<\/h3>\n\n\n\n

\u901a\u8fc7\u5229\u7528\u4e0eBMI\u76f8\u5173\u7684\u57fa\u56e0\u53d8\u5f02\uff08\u5982FTO\u57fa\u56e0\u53d8\u5f02\uff09\uff0cMR\u7814\u7a76\u80fd\u591f\u66f4\u51c6\u786e\u5730\u8bc4\u4f30BMI\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8f83\u9ad8\u7684BMI\u786e\u5b9e\u662f2\u578b\u7cd6\u5c3f\u75c5\u7684\u56e0\u679c\u98ce\u9669\u56e0\u7d20\uff0c\u8fd9\u652f\u6301\u4e86\u516c\u5171\u536b\u751f\u9886\u57df\u51cf\u80a5\u548c\u63a7\u5236\u4f53\u91cd\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n

\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u4f18\u52bf\u4e0e\u5c40\u9650\u6027<\/h2>\n\n\n\n

\u4f18\u52bf<\/h3>\n\n\n\n
    \n
  1. \u6709\u6548\u63a7\u5236\u6df7\u6742\u56e0\u7d20<\/strong>\uff1a\u7531\u4e8e\u57fa\u56e0\u53d8\u5f02\u5728\u4e2a\u4f53\u95f4\u7684\u968f\u673a\u5206\u914d\u7279\u6027\uff0cMR\u80fd\u591f\u6709\u6548\u63a7\u5236\u8bb8\u591a\u6df7\u6742\u56e0\u7d20\uff0c\u4f7f\u56e0\u679c\u63a8\u65ad\u66f4\u52a0\u53ef\u9760\u3002<\/li>\n\n\n\n
  2. \u907f\u514d\u9006\u56e0\u679c\u5173\u7cfb<\/strong>\uff1aMR\u80fd\u591f\u533a\u5206\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\u4e4b\u95f4\u7684\u56e0\u679c\u65b9\u5411\uff0c\u907f\u514d\u9006\u56e0\u679c\u5173\u7cfb\u7684\u5f71\u54cd\u3002<\/li>\n\n\n\n
  3. \u63d0\u4f9b\u65b0\u7684\u751f\u7269\u5b66\u89c1\u89e3<\/strong>\uff1aMR\u80fd\u591f\u63ed\u793a\u4f20\u7edf\u89c2\u5bdf\u6027\u7814\u7a76\u65e0\u6cd5\u53d1\u73b0\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u63d0\u4f9b\u65b0\u7684\u751f\u7269\u5b66\u89c1\u89e3\u548c\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/li>\n<\/ol>\n\n\n\n

    \u5c40\u9650\u6027<\/h3>\n\n\n\n
      \n
    1. \u5de5\u5177\u53d8\u91cf\u9009\u62e9\u56f0\u96be<\/strong>\uff1a\u9009\u62e9\u5408\u9002\u7684\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u662fMR\u7814\u7a76\u7684\u5173\u952e\uff0c\u4f46\u5e76\u4e0d\u603b\u662f\u5bb9\u6613\u627e\u5230\u5408\u9002\u7684\u5de5\u5177\u53d8\u91cf\u3002<\/li>\n\n\n\n
    2. \u591a\u6548\u6027\u95ee\u9898<\/strong>\uff1a\u5373\u4f7f\u6ee1\u8db3\u65e0\u591a\u6548\u6027\u5047\u8bbe\uff0c\u57fa\u56e0\u53d8\u5f02\u53ef\u80fd\u4ecd\u4f1a\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\uff0c\u5bfc\u81f4\u6df7\u6742\u6548\u5e94\u3002<\/li>\n\n\n\n
    3. \u6837\u672c\u91cf\u8981\u6c42\u9ad8<\/strong>\uff1a\u7531\u4e8e\u57fa\u56e0\u53d8\u5f02\u5bf9\u66b4\u9732\u56e0\u7d20\u7684\u5f71\u54cd\u901a\u5e38\u8f83\u5c0f\uff0cMR\u7814\u7a76\u901a\u5e38\u9700\u8981\u8f83\u5927\u7684\u6837\u672c\u91cf\u4ee5\u786e\u4fdd\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002<\/li>\n<\/ol>\n\n\n\n

      \u7ed3\u8bba<\/h2>\n\n\n\n

      \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u662f\u4e00\u79cd\u5f3a\u5927\u7684\u5de5\u5177\uff0c\u4e3a\u7406\u89e3\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u7ed3\u679c\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u63d0\u4f9b\u4e86\u72ec\u7279\u7684\u89c6\u89d2\u3002\u901a\u8fc7\u5229\u7528\u81ea\u7136\u754c\u4e2d\u57fa\u56e0\u53d8\u5f02\u7684\u968f\u673a\u5206\u914d\u7279\u6027\uff0cMR\u80fd\u591f\u6709\u6548\u63a7\u5236\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\uff0c\u63d0\u4f9b\u6bd4\u4f20\u7edf\u89c2\u5bdf\u6027\u7814\u7a76\u66f4\u53ef\u9760\u7684\u56e0\u679c\u63a8\u65ad\u3002\u7136\u800c\uff0c\u6210\u529f\u5e94\u7528MR\u65b9\u6cd5\u9700\u8981\u6ee1\u8db3\u4e25\u683c\u7684\u5047\u8bbe\uff0c\u5e76\u9700\u8981\u7cbe\u5fc3\u9009\u62e9\u5408\u9002\u7684\u5de5\u5177\u53d8\u91cf\u3002\u5c3d\u7ba1\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u73b0\u4ee3\u533b\u5b66\u7814\u7a76\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\uff0c\u80fd\u591f\u63ed\u793a\u65b0\u7684\u751f\u7269\u5b66\u673a\u5236\u548c\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u4e3a\u516c\u5171\u536b\u751f\u548c\u4e34\u5e8a\u5b9e\u8df5\u63d0\u4f9b\u91cd\u8981\u7684\u6307\u5bfc\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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