{"id":43106,"date":"2024-06-01T21:54:49","date_gmt":"2024-06-01T13:54:49","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43106"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%9a%84%e7%a0%94%e7%a9%b6%e6%96%b9%e6%b3%95%e5%92%8c%e6%ad%a5%e9%aa%a4","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43106","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u7814\u7a76\u65b9\u6cd5\u548c\u6b65\u9aa4"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u662f\u4e00\u79cd\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u7814\u7a76\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u7ed3\u679c\u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\u7684\u65b9\u6cd5\u3002\u5b83\u7ed3\u5408\u4e86\u9057\u4f20\u5b66\u548c\u6d41\u884c\u75c5\u5b66\u7684\u4f18\u52bf\uff0c\u80fd\u591f\u6709\u6548\u63a7\u5236\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\u3002\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u5c06\u8be6\u7ec6\u9610\u8ff0\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u7814\u7a76\u65b9\u6cd5\u548c\u6b65\u9aa4\uff0c\u5305\u62ec\u7814\u7a76\u8bbe\u8ba1\u3001\u6570\u636e\u6536\u96c6\u3001\u5de5\u5177\u53d8\u91cf\u9009\u62e9\u3001\u6570\u636e\u5206\u6790\u548c\u7ed3\u679c\u89e3\u91ca\u7b49\u65b9\u9762\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u7814\u7a76\u8bbe\u8ba1<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1.1 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class=\"wp-block-heading\">3.2 \u5355\u4e00\u5de5\u5177\u53d8\u91cf\u4e0e\u591a\u5de5\u5177\u53d8\u91cf<\/h3>\n\n\n\n<p>\u7814\u7a76\u8005\u53ef\u4ee5\u9009\u62e9\u5355\u4e00\u7684\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u6216\u9009\u62e9\u591a\u4e2a\u57fa\u56e0\u53d8\u5f02\u5e76\u8fdb\u884c\u5408\u5e76\u5206\u6790\uff08\u591a\u57fa\u56e0\u8bc4\u5206\uff09\u3002\u591a\u5de5\u5177\u53d8\u91cf\u6cd5\u53ef\u4ee5\u589e\u5f3a\u5de5\u5177\u53d8\u91cf\u7684\u5173\u8054\u6027\uff0c\u5e76\u63d0\u9ad8\u7814\u7a76\u7684\u7edf\u8ba1\u6548\u80fd\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u6570\u636e\u5206\u6790<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">4.1 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class=\"wp-block-heading\">4.2 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class=\"wp-block-heading\">4.3 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class=\"wp-block-heading\">5. \u7ed3\u679c\u89e3\u91ca<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">5.1 \u7edf\u8ba1\u663e\u8457\u6027<\/h3>\n\n\n\n<p>\u7814\u7a76\u8005\u9700\u8981\u62a5\u544a\u56e0\u679c\u6548\u5e94\u4f30\u8ba1\u7684\u7edf\u8ba1\u663e\u8457\u6027\u3002\u5e38\u7528\u7684\u7edf\u8ba1\u663e\u8457\u6027\u68c0\u9a8c\u5305\u62ecp\u503c\u548c\u7f6e\u4fe1\u533a\u95f4\u3002\u5982\u679c\u7ed3\u679c\u5177\u6709\u7edf\u8ba1\u663e\u8457\u6027\uff0c\u8bf4\u660e\u66b4\u9732\u56e0\u7d20\u5bf9\u75be\u75c5\u7ed3\u679c\u5177\u6709\u663e\u8457\u7684\u56e0\u679c\u5f71\u54cd\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">5.2 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class=\"wp-block-heading\">6. \u6848\u4f8b\u5206\u6790<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">6.1 \u7814\u7a76\u80cc\u666f<\/h3>\n\n\n\n<p>\u5047\u8bbe\u6211\u4eec\u8fdb\u884c\u4e00\u9879MR\u7814\u7a76\uff0c\u65e8\u5728\u63a2\u8ba8\u8840\u6e05\u5c3f\u9178\u6c34\u5e73\uff08\u66b4\u9732\u56e0\u7d20\uff09\u4e0e\u51a0\u5fc3\u75c5\uff08\u75be\u75c5\u7ed3\u679c\uff09\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u5df2\u6709\u89c2\u5bdf\u6027\u7814\u7a76\u8868\u660e\u9ad8\u5c3f\u9178\u6c34\u5e73\u4e0e\u51a0\u5fc3\u75c5\u98ce\u9669\u589e\u52a0\u76f8\u5173\uff0c\u4f46\u56e0\u679c\u5173\u7cfb\u5c1a\u4e0d\u660e\u786e\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6.2 \u6570\u636e\u6536\u96c6<\/h3>\n\n\n\n<p>\u6211\u4eec\u5229\u7528\u6765\u81ea\u5927\u578b\u751f\u7269\u94f6\u884c\uff08\u5982UK Biobank\uff09\u7684\u6570\u636e\uff0c\u5305\u542b\u53c2\u4e0e\u8005\u7684\u57fa\u56e0\u6570\u636e\u548c\u8868\u578b\u6570\u636e\u3002\u901a\u8fc7GWAS\u8bc6\u522b\u4e0e\u5c3f\u9178\u6c34\u5e73\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\u53d8\u5f02\uff08\u5982SLC2A9\u57fa\u56e0\u53d8\u5f02\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6.3 \u5de5\u5177\u53d8\u91cf\u9009\u62e9<\/h3>\n\n\n\n<p>\u9009\u62e9\u591a\u4e2a\u4e0e\u5c3f\u9178\u6c34\u5e73\u76f8\u5173\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u786e\u4fdd\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5f02\u6ee1\u8db3\u5173\u8054\u5047\u8bbe\u3001\u65e0\u6df7\u6742\u5047\u8bbe\u548c\u65e0\u591a\u6548\u6027\u5047\u8bbe\u3002\u91c7\u7528\u591a\u57fa\u56e0\u8bc4\u5206\u65b9\u6cd5\uff0c\u5c06\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5f02\u5408\u5e76\u4e3a\u4e00\u4e2a\u5de5\u5177\u53d8\u91cf\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6.4 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