{"id":43112,"date":"2024-06-01T21:58:42","date_gmt":"2024-06-01T13:58:42","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43112"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e5%9c%a8%e8%8d%af%e7%89%a9%e5%bc%80%e5%8f%91%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43112","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"\n

<\/h1>\n\n\n\n

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\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u57fa\u672c\u539f\u7406<\/h2>\n\n\n\n

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\u4e09\u4e2a\u4e3b\u8981\u5047\u8bbe<\/h3>\n\n\n\n
    \n
  1. \u5173\u8054\u5047\u8bbe<\/strong>\uff1a\u5de5\u5177\u53d8\u91cf\uff08\u57fa\u56e0\u53d8\u5f02\uff09\u5fc5\u987b\u4e0e\u66b4\u9732\u56e0\u7d20\u663e\u8457\u5173\u8054\u3002<\/li>\n\n\n\n
  2. \u65e0\u6df7\u6742\u5047\u8bbe<\/strong>\uff1a\u5de5\u5177\u53d8\u91cf\u4e0e\u6df7\u6742\u56e0\u7d20\u65e0\u5173\u3002<\/li>\n\n\n\n
  3. \u65e0\u591a\u6548\u6027\u5047\u8bbe<\/strong>\uff1a\u5de5\u5177\u53d8\u91cf\u4ec5\u901a\u8fc7\u66b4\u9732\u56e0\u7d20\u5f71\u54cd\u75be\u75c5\u7ed3\u679c\uff0c\u4e0d\u5b58\u5728\u901a\u8fc7\u5176\u4ed6\u9014\u5f84\u7684\u76f4\u63a5\u5f71\u54cd\u3002<\/li>\n<\/ol>\n\n\n\n

    \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5e94\u7528<\/h2>\n\n\n\n

    1. \u8bc6\u522b\u6f5c\u5728\u836f\u7269\u9776\u70b9<\/h3>\n\n\n\n

    \u8bc6\u522b\u6709\u6548\u7684\u836f\u7269\u9776\u70b9\u662f\u836f\u7269\u5f00\u53d1\u7684\u7b2c\u4e00\u6b65\u3002\u4f20\u7edf\u7684\u9776\u70b9\u53d1\u73b0\u65b9\u6cd5\u4f9d\u8d56\u4e8e\u89c2\u5bdf\u6027\u7814\u7a76\uff0c\u5bb9\u6613\u53d7\u5230\u6df7\u6742\u56e0\u7d20\u548c\u9006\u56e0\u679c\u5173\u7cfb\u7684\u5f71\u54cd\u3002\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u901a\u8fc7\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u80fd\u591f\u66f4\u51c6\u786e\u5730\u8bc4\u4f30\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4ece\u800c\u5e2e\u52a9\u8bc6\u522b\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\u3002<\/p>\n\n\n\n

    \u4f8b\u5982\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5df2\u7ecf\u901a\u8fc7MR\u7814\u7a76\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u8fd9\u4e3a\u4ed6\u6c40\u7c7b\u836f\u7269\uff08\u5982\u963f\u6258\u4f10\u4ed6\u6c40\uff09\u4f5c\u4e3a\u964d\u8102\u6cbb\u7597\u7684\u6709\u6548\u6027\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u9057\u4f20\u5b66\u8bc1\u636e\u3002<\/p>\n\n\n\n

    2. \u9a8c\u8bc1\u836f\u7269\u9776\u70b9\u7684\u6709\u6548\u6027<\/h3>\n\n\n\n

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    3. \u9884\u6d4b\u836f\u7269\u7684\u526f\u4f5c\u7528<\/h3>\n\n\n\n

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    4. \u4f18\u5316\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1<\/h3>\n\n\n\n

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    5. \u91cd\u65b0\u5b9a\u4f4d\u5df2\u6709\u836f\u7269<\/h3>\n\n\n\n

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    \u4f8b\u5982\uff0cSGLT2\u6291\u5236\u5242\u6700\u521d\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff0c\u4f46MR\u7814\u7a76\u53d1\u73b0\u5176\u9776\u70b9\u57fa\u56e0\u53d8\u5f02\u4e0e\u964d\u4f4e\u5fc3\u8870\u98ce\u9669\u76f8\u5173\uff0c\u8fd9\u4e3aSGLT2\u6291\u5236\u5242\u5728\u5fc3\u8870\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u9057\u4f20\u5b66\u652f\u6301\u3002<\/p>\n\n\n\n

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    \u6848\u4f8b\u4e00\uff1aIL6R\u57fa\u56e0\u4e0e\u708e\u75c7\u6027\u75be\u75c5<\/h3>\n\n\n\n

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    \u6848\u4f8b\u4e8c\uff1aANGPTL3\u57fa\u56e0\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5<\/h3>\n\n\n\n

    ANGPTL3\u57fa\u56e0\u53d8\u5f02\u901a\u8fc7MR\u7814\u7a76\u88ab\u53d1\u73b0\u4e0e\u964d\u4f4e\u7684\u8840\u8102\u6c34\u5e73\u548c\u51cf\u5c11\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\u76f8\u5173\u3002\u57fa\u4e8e\u8fd9\u4e00\u53d1\u73b0\uff0cANGPTL3\u6291\u5236\u5242\uff08\u5982evinacumab\uff09\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u5e76\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u964d\u8102\u548c\u5fc3\u8840\u7ba1\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n\n\n\n

    \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u4f18\u52bf<\/h2>\n\n\n\n

    1. \u63a7\u5236\u6df7\u6742\u56e0\u7d20<\/h3>\n\n\n\n

    MR\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u5929\u7136\u5730\u63a7\u5236\u4e86\u6df7\u6742\u56e0\u7d20\u7684\u5f71\u54cd\u3002\u8fd9\u4e00\u7279\u70b9\u4f7f\u5f97MR\u80fd\u591f\u63d0\u4f9b\u6bd4\u4f20\u7edf\u89c2\u5bdf\u6027\u7814\u7a76\u66f4\u53ef\u9760\u7684\u56e0\u679c\u63a8\u65ad\uff0c\u4ece\u800c\u63d0\u9ad8\u836f\u7269\u9776\u70b9\u8bc6\u522b\u548c\u9a8c\u8bc1\u7684\u51c6\u786e\u6027\u3002<\/p>\n\n\n\n

    2. \u63d0\u524d\u9884\u6d4b\u836f\u7269\u6548\u5e94<\/h3>\n\n\n\n

    \u901a\u8fc7MR\u5206\u6790\uff0c\u53ef\u4ee5\u5728\u65e9\u671f\u9884\u6d4b\u836f\u7269\u5e72\u9884\u5bf9\u75be\u75c5\u7684\u6f5c\u5728\u5f71\u54cd\u548c\u526f\u4f5c\u7528\u3002\u8fd9\u6709\u52a9\u4e8e\u4f18\u5316\u836f\u7269\u5f00\u53d1\u7b56\u7565\uff0c\u51cf\u5c11\u4e34\u5e8a\u8bd5\u9a8c\u5931\u8d25\u7684\u98ce\u9669\uff0c\u8282\u7ea6\u65f6\u95f4\u548c\u6210\u672c\u3002<\/p>\n\n\n\n

    3. \u63d0\u4f9b\u9057\u4f20\u5b66\u8bc1\u636e<\/h3>\n\n\n\n

    MR\u63d0\u4f9b\u4e86\u57fa\u4e8e\u9057\u4f20\u5b66\u7684\u56e0\u679c\u63a8\u65ad\uff0c\u4e3a\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u79d1\u5b66\u4f9d\u636e\u3002\u8fd9\u4e00\u4f18\u52bf\u5728\u8bc6\u522b\u548c\u9a8c\u8bc1\u65b0\u836f\u9776\u70b9\u3001\u9884\u6d4b\u836f\u7269\u526f\u4f5c\u7528\u548c\u4f18\u5316\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u65b9\u9762\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n\n\n\n

    \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5c40\u9650\u6027\u53ca\u6539\u8fdb\u65b9\u5411<\/h2>\n\n\n\n

    \u5c3d\u7ba1\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u5177\u6709\u8bf8\u591a\u4f18\u52bf\uff0c\u4f46\u5176\u5e94\u7528\u4e5f\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\u3002<\/p>\n\n\n\n

    1. \u5de5\u5177\u53d8\u91cf\u9009\u62e9\u7684\u6311\u6218<\/h3>\n\n\n\n

    \u627e\u5230\u5408\u9002\u7684\u5de5\u5177\u53d8\u91cf\u662fMR\u7814\u7a76\u7684\u5173\u952e\uff0c\u4f46\u5e76\u975e\u6240\u6709\u66b4\u9732\u56e0\u7d20\u90fd\u80fd\u627e\u5230\u5f3a\u6709\u529b\u7684\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u53ef\u4ee5\u901a\u8fc7\u6574\u5408\u66f4\u591a\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u7684\u57fa\u56e0\u7ec4\u5bbd\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6765\u53d1\u73b0\u65b0\u7684\u5de5\u5177\u53d8\u91cf\u3002<\/p>\n\n\n\n

    2. \u591a\u6548\u6027\u95ee\u9898<\/h3>\n\n\n\n

    \u591a\u6548\u6027\u662fMR\u7814\u7a76\u4e2d\u7684\u4e00\u5927\u6311\u6218\uff0c\u56e0\u4e3a\u8bb8\u591a\u57fa\u56e0\u53d8\u5f02\u53ef\u80fd\u5f71\u54cd\u591a\u4e2a\u8868\u578b\uff0c\u4ece\u800c\u8fdd\u53cd\u65e0\u591a\u6548\u6027\u5047\u8bbe\u3002\u6539\u8fdb\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u591a\u57fa\u56e0\u8bc4\u5206\u3001MR-Egger\u56de\u5f52\u548c\u52a0\u6743\u4e2d\u503c\u6cd5\u7b49\u6280\u672f\u6765\u68c0\u6d4b\u548c\u8c03\u6574\u591a\u6548\u6027\u5f71\u54cd\u3002<\/p>\n\n\n\n

    3. \u6837\u672c\u91cf\u548c\u6570\u636e\u5f02\u8d28\u6027<\/h3>\n\n\n\n

    MR\u5206\u6790\u9700\u8981\u5927\u6837\u672c\u91cf\u6765\u786e\u4fdd\u8db3\u591f\u7684\u7edf\u8ba1\u6548\u80fd\uff0c\u4f46\u5927\u6837\u672c\u91cf\u7684\u83b7\u53d6\u53ef\u80fd\u9762\u4e34\u8d44\u6e90\u548c\u6280\u672f\u9650\u5236\u3002\u6b64\u5916\uff0c\u4e0d\u540c\u6570\u636e\u96c6\u4e4b\u95f4\u7684\u5f02\u8d28\u6027\u4e5f\u53ef\u80fd\u5f71\u54cd\u7ed3\u679c\u7684\u51c6\u786e\u6027\u3002\u901a\u8fc7\u5efa\u7acb\u56fd\u9645\u5408\u4f5c\u548c\u5171\u4eab\u6570\u636e\u5e93\uff0c\u53ef\u4ee5\u589e\u52a0\u6837\u672c\u91cf\u548c\u63d0\u9ad8\u6570\u636e\u8d28\u91cf\u3002<\/p>\n\n\n\n

    \u7ed3\u8bba<\/h2>\n\n\n\n

    \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u5927\u7684\u56e0\u679c\u63a8\u65ad\u5de5\u5177\uff0c\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u901a\u8fc7\u8bc6\u522b\u548c\u9a8c\u8bc1\u836f\u7269\u9776\u70b9\u3001\u9884\u6d4b\u836f\u7269\u6548\u5e94\u548c\u526f\u4f5c\u7528\u3001\u4f18\u5316\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4ee5\u53ca\u836f\u7269\u91cd\u65b0\u5b9a\u4f4d\uff0cMR\u4e3a\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u548c\u65b9\u6cd5\u3002\u5c3d\u7ba1\u9762\u4e34\u4e00\u4e9b\u6311\u6218\uff0c\u5982\u5de5\u5177\u53d8\u91cf\u9009\u62e9\u3001\u591a\u6548\u6027\u548c\u6837\u672c\u91cf\u95ee\u9898\uff0cMR\u7684\u4e0d\u65ad\u53d1\u5c55\u548c\u65b9\u6cd5\u6539\u8fdb\u5c06\u4e3a\u836f\u7269\u5f00\u53d1\u5e26\u6765\u66f4\u591a\u7684\u673a\u9047\u548c\u521b\u65b0\u3002\u968f\u7740\u57fa\u56e0\u7ec4\u5b66\u548c\u751f\u7269\u4fe1\u606f\u5b66\u7684\u8fdb\u6b65\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5728\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5e94\u7528\u524d\u666f\u5c06\u66f4\u52a0\u5e7f\u9614\uff0c\u6700\u7ec8\u6709\u52a9\u4e8e\u5f00\u53d1\u51fa\u66f4\u6709\u6548\u548c\u5b89\u5168\u7684\u65b0\u836f\uff0c\u6539\u5584\u60a3\u8005\u7684\u5065\u5eb7\u548c\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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