{"id":43120,"date":"2024-06-01T22:03:55","date_gmt":"2024-06-01T14:03:55","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43120"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%9a%84%e6%95%b0%e6%8d%ae%e6%9d%a5%e6%ba%90","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43120","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u6570\u636e\u6765\u6e90"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u56e0\u679c\u63a8\u65ad\u5de5\u5177\uff0c\u5df2\u7ecf\u5728\u6d41\u884c\u75c5\u5b66\u548c\u836f\u7269\u5f00\u53d1\u9886\u57df\u5c55\u73b0\u51fa\u4e86\u5de8\u5927\u7684\u6f5c\u529b\u3002\u5176\u57fa\u672c\u539f\u7406\u662f\u5229\u7528\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u901a\u8fc7\u5206\u6790\u8fd9\u4e9b\u53d8\u5f02\u5bf9\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u6765\u63a8\u65ad\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u4e3a\u4e86\u8fdb\u884c\u6709\u6548\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\uff0c\u9ad8\u8d28\u91cf\u548c\u591a\u6837\u5316\u7684\u6570\u636e\u6765\u6e90\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u4ecb\u7ecd\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u4e3b\u8981\u6570\u636e\u6765\u6e90\uff0c\u5e76\u63a2\u8ba8\u6bcf\u79cd\u6570\u636e\u6765\u6e90\u7684\u4f18\u52bf\u548c\u5c40\u9650\u6027\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. GWAS\u7684\u6982\u8ff0<\/h3>\n\n\n\n<p>\u57fa\u56e0\u7ec4\u5bbd\u5173\u8054\u7814\u7a76\uff08Genome-Wide Association Studies, GWAS\uff09\u662f\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u7684\u4e3b\u8981\u6570\u636e\u6765\u6e90\u3002GWAS\u901a\u8fc7\u626b\u63cf\u5168\u57fa\u56e0\u7ec4\u4e2d\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\uff0c\u5bfb\u627e\u4e0e\u7279\u5b9a\u8868\u578b\uff08\u5982\u75be\u75c5\u6216\u751f\u7269\u6807\u5fd7\u7269\uff09\u76f8\u5173\u7684\u9057\u4f20\u53d8\u5f02\u3002\u8fd9\u4e9b\u7814\u7a76\u901a\u5e38\u6d89\u53ca\u5927\u91cf\u7684\u4e2a\u4f53\u6837\u672c\uff0c\u80fd\u591f\u63d0\u4f9b\u4e30\u5bcc\u7684\u9057\u4f20\u53d8\u5f02\u4fe1\u606f\u548c\u8868\u578b\u5173\u8054\u6570\u636e\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. GWAS\u7684\u4f18\u52bf<\/h3>\n\n\n\n<ul>\n<li><strong>\u5927\u89c4\u6a21\u6570\u636e<\/strong>\uff1aGWAS\u901a\u5e38\u5305\u542b\u6570\u5343\u5230\u6570\u767e\u4e07\u4e2a\u4e2a\u4f53\uff0c\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u9057\u4f20\u548c\u8868\u578b\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>\u9ad8\u5206\u8fa8\u7387<\/strong>\uff1a\u901a\u8fc7\u626b\u63cf\u5168\u57fa\u56e0\u7ec4\uff0cGWAS\u80fd\u591f\u8bc6\u522b\u51fa\u4e0e\u7279\u5b9a\u8868\u578b\u663e\u8457\u5173\u8054\u7684SNPs\uff0c\u4e3a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u5de5\u5177\u53d8\u91cf\u3002<\/li>\n\n\n\n<li><strong>\u5e7f\u6cdb\u5e94\u7528<\/strong>\uff1aGWAS\u6570\u636e\u6db5\u76d6\u4e86\u8bb8\u591a\u4e0d\u540c\u7684\u75be\u75c5\u548c\u8868\u578b\uff0c\u4e3a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u63d0\u4f9b\u4e86\u5e7f\u6cdb\u7684\u5e94\u7528\u9886\u57df\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. GWAS\u7684\u5c40\u9650\u6027<\/h3>\n\n\n\n<ul>\n<li><strong>\u4eba\u7fa4\u5f02\u8d28\u6027<\/strong>\uff1a\u4e0d\u540c\u4eba\u7fa4\u7684\u9057\u4f20\u80cc\u666f\u548c\u73af\u5883\u56e0\u7d20\u4e0d\u540c\uff0c\u53ef\u80fd\u5bfc\u81f4GWAS\u7ed3\u679c\u5728\u4e0d\u540c\u4eba\u7fa4\u4e2d\u7684\u9002\u7528\u6027\u6709\u9650\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6548\u6027<\/strong>\uff1a\u4e00\u4e9bSNPs\u53ef\u80fd\u5f71\u54cd\u591a\u4e2a\u8868\u578b\uff0c\u8fdd\u53cd\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u65e0\u591a\u6548\u6027\u5047\u8bbe\uff0c\u589e\u52a0\u4e86\u56e0\u679c\u63a8\u65ad\u7684\u590d\u6742\u6027\u3002<\/li>\n\n\n\n<li><strong>\u5047\u9633\u6027\u7ed3\u679c<\/strong>\uff1a\u7531\u4e8e\u591a\u91cd\u6bd4\u8f83\u95ee\u9898\uff0cGWAS\u53ef\u80fd\u4ea7\u751f\u5047\u9633\u6027\u7ed3\u679c\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u4ee3\u8868\u6027\u6570\u636e\u5e93<\/h3>\n\n\n\n<ul>\n<li><strong>UK Biobank<\/strong>\uff1aUK Biobank\u662f\u76ee\u524d\u4e16\u754c\u4e0a\u6700\u5927\u7684\u751f\u7269\u533b\u5b66\u6570\u636e\u5e93\u4e4b\u4e00\uff0c\u5305\u542b\u4e86\u8d85\u8fc750\u4e07\u540d\u82f1\u56fd\u5c45\u6c11\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u8be6\u7ec6\u7684\u5065\u5eb7\u4fe1\u606f\u3002\u5b83\u4e3aGWAS\u548c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u6570\u636e\u8d44\u6e90\u3002<\/li>\n\n\n\n<li><strong>dbGaP<\/strong>\uff1a\u6570\u636e\u5e93\u4e2d\u7684\u57fa\u56e0\u578b\u548c\u8868\u578b\uff08dbGaP\uff09\u662f\u7f8e\u56fd\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u7ef4\u62a4\u7684\u4e00\u4e2a\u6570\u636e\u5e93\uff0c\u5305\u542b\u4e86\u5927\u91cf\u7684GWAS\u6570\u636e\u548c\u5176\u4ed6\u76f8\u5173\u7814\u7a76\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>GIANT Consortium<\/strong>\uff1aGIANT\uff08Genetic Investigation of Anthropometric Traits\uff09\u8054\u5408\u4f53\u662f\u4e00\u4e2a\u4e13\u95e8\u7814\u7a76\u4eba\u4f53\u8ba1\u91cf\u6027\u72b6\u7684\u56fd\u9645\u5408\u4f5c\u7ec4\u7ec7\uff0c\u63d0\u4f9b\u4e86\u8bb8\u591a\u4e0e\u80a5\u80d6\u3001\u8eab\u9ad8\u7b49\u8868\u578b\u76f8\u5173\u7684GWAS\u6570\u636e\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u751f\u7269\u6837\u672c\u5e93\u548c\u961f\u5217\u7814\u7a76<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u751f\u7269\u6837\u672c\u5e93\u7684\u6982\u8ff0<\/h3>\n\n\n\n<p>\u751f\u7269\u6837\u672c\u5e93\uff08Biobank\uff09\u662f\u6536\u96c6\u548c\u5b58\u50a8\u5927\u91cf\u751f\u7269\u6837\u672c\uff08\u5982\u8840\u6db2\u3001\u5c3f\u6db2\u3001DNA\uff09\u7684\u8bbe\u65bd\uff0c\u8fd9\u4e9b\u6837\u672c\u901a\u5e38\u4f34\u6709\u8be6\u7ec6\u7684\u5065\u5eb7\u548c\u751f\u6d3b\u65b9\u5f0f\u4fe1\u606f\u3002\u751f\u7269\u6837\u672c\u5e93\u4e3aGWAS\u548c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u6570\u636e\u6765\u6e90\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u751f\u7269\u6837\u672c\u5e93\u7684\u4f18\u52bf<\/h3>\n\n\n\n<ul>\n<li><strong>\u8be6\u7ec6\u7684\u8868\u578b\u4fe1\u606f<\/strong>\uff1a\u751f\u7269\u6837\u672c\u5e93\u901a\u5e38\u6536\u96c6\u4e86\u53c2\u4e0e\u8005\u7684\u8be6\u7ec6\u5065\u5eb7\u8bb0\u5f55\u3001\u751f\u6d3b\u65b9\u5f0f\u548c\u73af\u5883\u56e0\u7d20\u4fe1\u606f\uff0c\u4e3a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u8868\u578b\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>\u957f\u671f\u968f\u8bbf<\/strong>\uff1a\u8bb8\u591a\u751f\u7269\u6837\u672c\u5e93\u8fdb\u884c\u957f\u671f\u968f\u8bbf\uff0c\u63d0\u4f9b\u4e86\u7eb5\u5411\u6570\u636e\uff0c\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u7814\u7a76\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\u7684\u52a8\u6001\u5173\u7cfb\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6837\u5316\u7684\u6570\u636e\u7c7b\u578b<\/strong>\uff1a\u751f\u7269\u6837\u672c\u5e93\u4e0d\u4ec5\u5305\u542b\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u8fd8\u5305\u62ec\u8f6c\u5f55\u7ec4\u3001\u4ee3\u8c22\u7ec4\u7b49\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u80fd\u591f\u652f\u6301\u591a\u7ef4\u5ea6\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u751f\u7269\u6837\u672c\u5e93\u7684\u5c40\u9650\u6027<\/h3>\n\n\n\n<ul>\n<li><strong>\u6837\u672c\u91cf\u9650\u5236<\/strong>\uff1a\u76f8\u6bd4\u4e8eGWAS\uff0c\u751f\u7269\u6837\u672c\u5e93\u7684\u6837\u672c\u91cf\u53ef\u80fd\u76f8\u5bf9\u8f83\u5c0f\uff0c\u5c24\u5176\u662f\u5f53\u7814\u7a76\u7279\u5b9a\u4e9a\u7fa4\u4f53\u65f6\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u83b7\u53d6\u7684\u590d\u6742\u6027<\/strong>\uff1a\u751f\u7269\u6837\u672c\u5e93\u7684\u6570\u636e\u901a\u5e38\u9700\u8981\u901a\u8fc7\u4e25\u683c\u7684\u7533\u8bf7\u548c\u5ba1\u6838\u6d41\u7a0b\u624d\u80fd\u83b7\u53d6\uff0c\u589e\u52a0\u4e86\u7814\u7a76\u7684\u590d\u6742\u6027\u548c\u65f6\u95f4\u6210\u672c\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u5f02\u8d28\u6027<\/strong>\uff1a\u4e0d\u540c\u751f\u7269\u6837\u672c\u5e93\u7684\u6570\u636e\u6536\u96c6\u65b9\u6cd5\u548c\u8d28\u91cf\u63a7\u5236\u6807\u51c6\u53ef\u80fd\u4e0d\u540c\uff0c\u5bfc\u81f4\u6570\u636e\u5f02\u8d28\u6027\uff0c\u589e\u52a0\u4e86\u6570\u636e\u6574\u5408\u548c\u5206\u6790\u7684\u96be\u5ea6\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u4ee3\u8868\u6027\u751f\u7269\u6837\u672c\u5e93<\/h3>\n\n\n\n<ul>\n<li><strong>UK Biobank<\/strong>\uff1a\u524d\u6587\u63d0\u5230\u7684UK Biobank\u4e0d\u4ec5\u662fGWAS\u7684\u91cd\u8981\u6570\u636e\u6765\u6e90\uff0c\u4e5f\u662f\u4e00\u4e2a\u7efc\u5408\u6027\u751f\u7269\u6837\u672c\u5e93\uff0c\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u57fa\u56e0\u7ec4\u3001\u8868\u578b\u548c\u591a\u7ec4\u5b66\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>All of Us Research Program<\/strong>\uff1a\u8fd9\u662f\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u53d1\u8d77\u7684\u4e00\u4e2a\u5927\u89c4\u6a21\u751f\u7269\u6837\u672c\u5e93\u9879\u76ee\uff0c\u76ee\u6807\u662f\u6536\u96c6\u6765\u81ea100\u4e07\u540d\u6216\u66f4\u591a\u53c2\u4e0e\u8005\u7684\u57fa\u56e0\u7ec4\u548c\u5065\u5eb7\u6570\u636e\uff0c\u4ee5\u652f\u6301\u5e7f\u6cdb\u7684\u751f\u7269\u533b\u5b66\u7814\u7a76\u3002<\/li>\n\n\n\n<li><strong>China Kadoorie Biobank<\/strong>\uff1a\u4e2d\u56fd\u6162\u6027\u75c5\u524d\u77bb\u6027\u7814\u7a76\uff08China Kadoorie Biobank, CKB\uff09\u662f\u4e00\u4e2a\u5927\u89c4\u6a21\u7684\u751f\u7269\u6837\u672c\u5e93\uff0c\u5305\u542b50\u4e07\u540d\u4e2d\u56fd\u6210\u5e74\u4eba\u7684\u57fa\u56e0\u7ec4\u548c\u5065\u5eb7\u6570\u636e\uff0c\u65e8\u5728\u7814\u7a76\u4e2d\u56fd\u4eba\u7fa4\u7684\u4e3b\u8981\u6162\u6027\u75c5\u98ce\u9669\u56e0\u7d20\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u516c\u5171\u6570\u636e\u5e93\u548c\u8d44\u6e90<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u516c\u5171\u6570\u636e\u5e93\u7684\u6982\u8ff0<\/h3>\n\n\n\n<p>\u516c\u5171\u6570\u636e\u5e93\u662f\u6307\u7531\u653f\u5e9c\u3001\u79d1\u7814\u673a\u6784\u6216\u56fd\u9645\u7ec4\u7ec7\u7ef4\u62a4\u7684\u3001\u514d\u8d39\u5f00\u653e\u8bbf\u95ee\u7684\u57fa\u56e0\u7ec4\u548c\u8868\u578b\u6570\u636e\u8d44\u6e90\u3002\u8fd9\u4e9b\u6570\u636e\u5e93\u901a\u5e38\u6536\u96c6\u548c\u6574\u5408\u4e86\u6765\u81ea\u4e0d\u540c\u7814\u7a76\u7684\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u65b9\u4fbf\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u548c\u5176\u4ed6\u9057\u4f20\u7814\u7a76\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u516c\u5171\u6570\u636e\u5e93\u7684\u4f18\u52bf<\/h3>\n\n\n\n<ul>\n<li><strong>\u514d\u8d39\u5f00\u653e<\/strong>\uff1a\u516c\u5171\u6570\u636e\u5e93\u901a\u5e38\u514d\u8d39\u5f00\u653e\u8bbf\u95ee\uff0c\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u6570\u636e\u8d44\u6e90\uff0c\u964d\u4f4e\u4e86\u7814\u7a76\u6210\u672c\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u6574\u5408<\/strong>\uff1a\u8fd9\u4e9b\u6570\u636e\u5e93\u901a\u5e38\u6574\u5408\u4e86\u6765\u81ea\u4e0d\u540c\u7814\u7a76\u7684\u57fa\u56e0\u7ec4\u548c\u8868\u578b\u6570\u636e\uff0c\u63d0\u4f9b\u4e86\u66f4\u5927\u89c4\u6a21\u548c\u591a\u6837\u5316\u7684\u6570\u636e\u96c6\u3002<\/li>\n\n\n\n<li><strong>\u4fbf\u6377\u6027<\/strong>\uff1a\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u65b9\u4fbf\u5730\u8bbf\u95ee\u548c\u4e0b\u8f7d\u516c\u5171\u6570\u636e\u5e93\u4e2d\u7684\u6570\u636e\uff0c\u652f\u6301\u5feb\u901f\u5f00\u5c55\u7814\u7a76\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u516c\u5171\u6570\u636e\u5e93\u7684\u5c40\u9650\u6027<\/h3>\n\n\n\n<ul>\n<li><strong>\u6570\u636e\u8d28\u91cf\u53c2\u5dee\u4e0d\u9f50<\/strong>\uff1a\u7531\u4e8e\u516c\u5171\u6570\u636e\u5e93\u7684\u6570\u636e\u6765\u81ea\u4e0d\u540c\u7814\u7a76\uff0c\u6570\u636e\u8d28\u91cf\u548c\u6807\u51c6\u53ef\u80fd\u4e0d\u4e00\u81f4\uff0c\u5f71\u54cd\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u66f4\u65b0\u6ede\u540e<\/strong>\uff1a\u4e00\u4e9b\u516c\u5171\u6570\u636e\u5e93\u7684\u6570\u636e\u66f4\u65b0\u9891\u7387\u8f83\u4f4e\uff0c\u53ef\u80fd\u65e0\u6cd5\u63d0\u4f9b\u6700\u65b0\u7684\u7814\u7a76\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>\u9690\u79c1\u548c\u4f26\u7406\u95ee\u9898<\/strong>\uff1a\u5c3d\u7ba1\u516c\u5171\u6570\u636e\u5e93\u901a\u5e38\u5bf9\u6570\u636e\u8fdb\u884c\u4e86\u533f\u540d\u5316\u5904\u7406\uff0c\u4f46\u4ecd\u9700\u6ce8\u610f\u6570\u636e\u9690\u79c1\u548c\u4f26\u7406\u95ee\u9898\uff0c\u786e\u4fdd\u7814\u7a76\u7b26\u5408\u76f8\u5173\u6cd5\u89c4\u548c\u4f26\u7406\u51c6\u5219\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u4ee3\u8868\u6027\u516c\u5171\u6570\u636e\u5e93<\/h3>\n\n\n\n<ul>\n<li><strong>GWAS Catalog<\/strong>\uff1aGWAS Catalog\u662f\u4e00\u4e2a\u7531\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240\uff08EBI\uff09\u548c\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\uff08NHGRI\uff09\u5171\u540c\u7ef4\u62a4\u7684\u6570\u636e\u5e93\uff0c\u6536\u5f55\u4e86\u5927\u91cf\u5df2\u53d1\u8868\u7684GWAS\u7814\u7a76\u7ed3\u679c\u3002<\/li>\n\n\n\n<li><strong>1000 Genomes Project<\/strong>\uff1a\u8fd9\u662f\u4e00\u4e2a\u56fd\u9645\u5408\u4f5c\u9879\u76ee\uff0c\u65e8\u5728\u5efa\u7acb\u4e00\u4e2a\u6db5\u76d6\u5168\u7403\u4e0d\u540c\u4eba\u7fa4\u7684\u57fa\u56e0\u7ec4\u53d8\u5f02\u8d44\u6e90\uff0c\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>Ensembl<\/strong>\uff1aEnsembl\u662f\u4e00\u4e2a\u7531\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u6240\uff08EBI\uff09\u548c\u97e6\u5c14\u79d1\u59c6\u57fa\u91d1\u4f1a\u6851\u683c\u7814\u7a76\u6240\uff08WTSI\uff09\u5171\u540c\u5f00\u53d1\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\uff0c\u63d0\u4f9b\u4e86\u591a\u79cd\u751f\u7269\u7269\u79cd\u7684\u57fa\u56e0\u7ec4\u6ce8\u91ca\u548c\u6570\u636e\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u6982\u8ff0<\/h3>\n\n\n\n<p>\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u662f\u6307\u5728\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7\u5e72\u9884\u8bd5\u9a8c\u83b7\u5f97\u7684\u57fa\u56e0\u7ec4\u548c\u8868\u578b\u6570\u636e\u3002\u8fd9\u4e9b\u6570\u636e\u901a\u5e38\u6765\u6e90\u4e8e\u53c2\u4e0e\u8005\u7684\u57fa\u56e0\u578b\u68c0\u6d4b\u3001\u836f\u7269\u53cd\u5e94\u548c\u5065\u5eb7\u7ed3\u679c\u8bc4\u4f30\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u4f18\u52bf<\/h3>\n\n\n\n<ul>\n<li><strong>\u9ad8\u8d28\u91cf\u6570\u636e<\/strong>\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u901a\u5e38\u7ecf\u8fc7\u4e25\u683c\u7684\u8bbe\u8ba1\u548c\u8d28\u91cf\u63a7\u5236\uff0c\u6570\u636e\u8d28\u91cf\u8f83\u9ad8\u3002<\/li>\n\n\n\n<li><strong>\u5e72\u9884\u4fe1\u606f<\/strong>\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5305\u542b\u4e86\u8be6\u7ec6\u7684\u836f\u7269\u5e72\u9884\u4fe1\u606f\uff0c\u6709\u52a9\u4e8e\u7814\u7a76\u836f\u7269\u9776\u70b9\u548c\u7597\u6548\u3002<\/li>\n\n\n\n<li><strong>\u7eb5\u5411\u6570\u636e<\/strong>\uff1a\u8bb8\u591a\u4e34\u5e8a\u8bd5\u9a8c\u5305\u542b\u968f\u8bbf\u6570\u636e\uff0c\u63d0\u4f9b\u4e86\u957f\u671f\u7684\u5065\u5eb7\u548c\u836f\u7269\u53cd\u5e94\u4fe1\u606f\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u5c40\u9650\u6027<\/h3>\n\n\n\n<ul>\n<li><strong>\u6837\u672c\u91cf\u9650\u5236<\/strong>\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6837\u672c\u91cf\u901a\u5e38\u8f83\u5c0f\uff0c\u53ef\u80fd\u9650\u5236\u4e86\u6570\u636e\u7684\u7edf\u8ba1\u6548\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u83b7\u53d6\u9650\u5236<\/strong>\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u901a\u5e38\u7531\u5236\u836f\u516c\u53f8\u6216\u7814\u7a76\u673a\u6784\u6301\u6709\uff0c\u83b7\u53d6\u6570\u636e\u53ef\u80fd\u9700\u8981\u901a\u8fc7\u4e25\u683c\u7684\u7533\u8bf7\u548c\u5ba1\u6279\u6d41\u7a0b\u3002<\/li>\n\n\n\n<li><strong>\u9009\u62e9\u6027\u504f\u5dee<\/strong>\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u53c2\u4e0e\u8005\u901a\u5e38\u7ecf\u8fc7\u4e25\u683c\u7b5b\u9009\uff0c\u53ef\u80fd\u5bfc\u81f4\u7814\u7a76\u7ed3\u679c\u5728\u4e00\u822c\u4eba\u7fa4\u4e2d\u7684\u9002\u7528\u6027\u53d7\u9650\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u4ee3\u8868\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5e93<\/h3>\n\n\n\n<ul>\n<li><strong>ClinicalTrials.gov<\/strong>\uff1a\u8fd9\u662f\u7f8e\u56fd\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u7ef4\u62a4\u7684\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u548c\u7ed3\u679c\u6570\u636e\u5e93\uff0c\u63d0\u4f9b\u4e86\u5927\u91cf\u5df2\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8be6\u7ec6\u4fe1\u606f\u3002<\/li>\n\n\n\n<li>**European Clinical Trials Database (Eudra<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u56e0\u679c\u63a8\u65ad\u5de5\u5177\uff0c\u5df2\u7ecf\u5728\u6d41\u884c\u75c5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1,64],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43120"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43120"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43120\/revisions"}],"predecessor-version":[{"id":43121,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43120\/revisions\/43121"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43120"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}