{"id":43132,"date":"2024-06-01T22:16:19","date_gmt":"2024-06-01T14:16:19","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43132"},"modified":"2024-06-01T22:16:21","modified_gmt":"2024-06-01T14:16:21","slug":"%e8%a7%a3%e8%af%bb%e3%80%8ahereditas%e3%80%8b%e6%9d%82%e5%bf%97%e6%96%87%e7%ab%a0%ef%bc%9a%e5%9f%ba%e5%9b%a0%e5%a4%9a%e6%80%81%e6%80%a7%e4%b8%8e%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab%e6%80%a7%e7%96%be","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43132","title":{"rendered":"\u89e3\u8bfb\u300aHereditas\u300b\u6742\u5fd7\u6587\u7ae0\uff1a\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u5173\u8054\u7814\u7a76"},"content":{"rendered":"\n

<\/h1>\n\n\n\n

\u53d1\u8868\u6742\u5fd7<\/h2>\n\n\n\n

\u672c\u6587\u53d1\u8868\u5728\u300aHereditas\u300b\u6742\u5fd7\u4e0a\uff0c\u8fd9\u662f\u4e00\u4e2a\u81f4\u529b\u4e8e\u9057\u4f20\u5b66\u7814\u7a76\u7684\u56fd\u9645\u5b66\u672f\u671f\u520a\u3002\u8be5\u671f\u520a\u4ee5\u5176\u4e25\u683c\u7684\u5ba1\u7a3f\u6d41\u7a0b\u548c\u9ad8\u8d28\u91cf\u7684\u7814\u7a76\u5185\u5bb9\u800c\u8457\u79f0\uff0c\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u9057\u4f20\u5b66\u9886\u57df\uff0c\u5305\u62ec\u57fa\u56e0\u591a\u6001\u6027\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u5206\u5b50\u9057\u4f20\u5b66\u7b49\u3002<\/p>\n\n\n\n

\u7814\u7a76\u76ee\u7684<\/h2>\n\n\n\n

\u672c\u6587\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u63a2\u8ba8\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u7814\u7a76\u65e8\u5728\uff1a<\/p>\n\n\n\n

    \n
  1. \u9610\u660e\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u4e2d\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/li>\n\n\n\n
  2. \u5206\u6790\u8fd9\u4e9b\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u75be\u75c5\u53d1\u75c5\u98ce\u9669\u548c\u4e34\u5e8a\u7279\u5f81\u4e4b\u95f4\u7684\u5173\u8054\u3002<\/li>\n\n\n\n
  3. \u63a2\u8ba8\u57fa\u56e0-\u73af\u5883\u4ea4\u4e92\u4f5c\u7528\u5728\u75be\u75c5\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528\u3002<\/li>\n<\/ol>\n\n\n\n

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    \u7814\u7a76\u65b9\u6cd5<\/h2>\n\n\n\n

    1. \u7814\u7a76\u8bbe\u8ba1<\/h3>\n\n\n\n

    \u8be5\u7814\u7a76\u91c7\u7528\u4e86\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u8bbe\u8ba1\uff0c\u9009\u53d6\u4e86\u4e00\u5b9a\u6570\u91cf\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u548c\u5065\u5eb7\u5bf9\u7167\u8005\u3002\u901a\u8fc7\u57fa\u56e0\u7ec4\u5206\u6790\u6280\u672f\uff0c\u68c0\u6d4b\u5e76\u6bd4\u8f83\u4e86\u4e24\u7ec4\u4eba\u7fa4\u4e2d\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/p>\n\n\n\n

    2. \u53c2\u4e0e\u8005<\/h3>\n\n\n\n

    \u7814\u7a76\u5171\u62db\u52df\u4e86500\u540d\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u548c500\u540d\u5065\u5eb7\u5bf9\u7167\u8005\u3002\u6240\u6709\u53c2\u4e0e\u8005\u5747\u901a\u8fc7\u8be6\u7ec6\u7684\u4e34\u5e8a\u68c0\u67e5\u548c\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u786e\u8ba4\u75be\u75c5\u72b6\u6001\u3002\u60a3\u8005\u7ec4\u5305\u62ec\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5982\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u548c\u591a\u53d1\u6027\u786c\u5316\uff08MS\uff09\u3002<\/p>\n\n\n\n

    3. \u57fa\u56e0\u68c0\u6d4b<\/h3>\n\n\n\n

    \u5229\u7528\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86\u53c2\u4e0e\u8005\u8840\u6db2\u6837\u672c\u4e2d\u7684\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u3002\u4e3b\u8981\u5173\u6ce8\u7684\u57fa\u56e0\u5305\u62ec\uff1a<\/p>\n\n\n\n

      \n
    • HLA\u57fa\u56e0\uff08\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\uff09<\/li>\n\n\n\n
    • CTLA4\u57fa\u56e0\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff09<\/li>\n\n\n\n
    • PTPN22\u57fa\u56e0\uff08\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176N22\uff09<\/li>\n<\/ul>\n\n\n\n

      4. \u6570\u636e\u5206\u6790<\/h3>\n\n\n\n

      \u901a\u8fc7\u7edf\u8ba1\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u6bd4\u8f83\u4e86\u60a3\u8005\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e2d\u57fa\u56e0\u591a\u6001\u6027\u7684\u9891\u7387\uff0c\u5e76\u8bc4\u4f30\u4e86\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u75be\u75c5\u53d1\u75c5\u98ce\u9669\u4e4b\u95f4\u7684\u5173\u8054\u3002\u6b64\u5916\uff0c\u8fd8\u5206\u6790\u4e86\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u60a3\u8005\u4e34\u5e8a\u7279\u5f81\uff08\u5982\u75be\u75c5\u6d3b\u52a8\u6027\u3001\u4e25\u91cd\u7a0b\u5ea6\u7b49\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n\n\n\n

      \u7814\u7a76\u7ed3\u679c<\/h2>\n\n\n\n

      1. \u57fa\u56e0\u591a\u6001\u6027\u5206\u5e03<\/h3>\n\n\n\n

      \u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u60a3\u8005\u7ec4\u4e2dHLA\u3001CTLA4\u548cPTPN22\u57fa\u56e0\u7684\u591a\u6001\u6027\u9891\u7387\u663e\u8457\u9ad8\u4e8e\u5065\u5eb7\u5bf9\u7167\u7ec4\u3002\u4f8b\u5982\uff0cHLA-DRB1*15\u57fa\u56e0\u578b\u5728SLE\u60a3\u8005\u4e2d\u7684\u9891\u7387\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u800cCTLA4\u548cPTPN22\u57fa\u56e0\u7684\u7279\u5b9a\u591a\u6001\u6027\u4e5f\u5728RA\u548cMS\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u9891\u7387\u3002<\/p>\n\n\n\n

      2. \u57fa\u56e0\u591a\u6001\u6027\u4e0e\u75be\u75c5\u98ce\u9669<\/h3>\n\n\n\n

      \u901a\u8fc7\u5173\u8054\u5206\u6790\uff0c\u7814\u7a76\u53d1\u73b0\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u75c5\u98ce\u9669\u663e\u8457\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u643a\u5e26HLA-DRB1*15\u57fa\u56e0\u578b\u7684\u4e2a\u4f53\u60a3SLE\u7684\u98ce\u9669\u662f\u672a\u643a\u5e26\u8005\u76842.5\u500d\uff1b\u540c\u6837\uff0c\u643a\u5e26CTLA4\u57fa\u56e0\u591a\u6001\u6027\u7684\u4e2a\u4f53\u60a3RA\u7684\u98ce\u9669\u4e5f\u663e\u8457\u589e\u52a0\u3002<\/p>\n\n\n\n

      3. \u57fa\u56e0\u591a\u6001\u6027\u4e0e\u4e34\u5e8a\u7279\u5f81<\/h3>\n\n\n\n

      \u8fdb\u4e00\u6b65\u5206\u6790\u663e\u793a\uff0c\u7279\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u4e0d\u4ec5\u4e0e\u75be\u75c5\u53d1\u75c5\u98ce\u9669\u76f8\u5173\uff0c\u8fd8\u4e0e\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\u5bc6\u5207\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u643a\u5e26PTPN22\u57fa\u56e0\u591a\u6001\u6027\u7684RA\u60a3\u8005\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u75be\u75c5\u6d3b\u52a8\u6027\u548c\u4e25\u91cd\u7a0b\u5ea6\u3002\u8fd9\u8868\u660e\u57fa\u56e0\u591a\u6001\u6027\u53ef\u80fd\u5f71\u54cd\u75be\u75c5\u7684\u4e34\u5e8a\u8868\u73b0\u548c\u8fdb\u5c55\u3002<\/p>\n\n\n\n

      \u521b\u65b0\u70b9<\/h2>\n\n\n\n

      \u672c\u7814\u7a76\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u9057\u4f20\u5b66\u7814\u7a76\u65b9\u9762\u5177\u6709\u4ee5\u4e0b\u521b\u65b0\u70b9\uff1a<\/p>\n\n\n\n

        \n
      1. \u591a\u57fa\u56e0\u7efc\u5408\u5206\u6790\uff1a<\/strong> \u672c\u7814\u7a76\u4e0d\u4ec5\u5173\u6ce8\u5355\u4e00\u57fa\u56e0\u7684\u591a\u6001\u6027\uff0c\u8fd8\u7efc\u5408\u5206\u6790\u4e86\u591a\u4e2a\u76f8\u5173\u57fa\u56e0\u7684\u591a\u6001\u6027\uff0c\u63d0\u4f9b\u4e86\u66f4\u5168\u9762\u7684\u9057\u4f20\u5b66\u89c6\u89d2\u3002<\/li>\n\n\n\n
      2. \u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\uff1a<\/strong> \u91c7\u7528\u5148\u8fdb\u7684\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\uff0c\u786e\u4fdd\u4e86\u6570\u636e\u7684\u51c6\u786e\u6027\u548c\u5168\u9762\u6027\uff0c\u63d0\u9ad8\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002<\/li>\n\n\n\n
      3. \u5e7f\u6cdb\u7684\u75be\u75c5\u8986\u76d6\uff1a<\/strong> \u7814\u7a76\u6db5\u76d6\u4e86\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff08\u5982SLE\u3001RA\u548cMS\uff09\uff0c\u589e\u5f3a\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u666e\u904d\u6027\u548c\u5e94\u7528\u4ef7\u503c\u3002<\/li>\n<\/ol>\n\n\n\n

        \u4e0d\u8db3\u4e4b\u5904<\/h2>\n\n\n\n

        \u5c3d\u7ba1\u672c\u7814\u7a76\u5728\u57fa\u56e0\u591a\u6001\u6027\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u4e0d\u8db3\u4e4b\u5904\uff1a<\/p>\n\n\n\n

          \n
        1. \u6837\u672c\u91cf\u9650\u5236\uff1a<\/strong> \u5c3d\u7ba1500\u540d\u60a3\u8005\u548c500\u540d\u5bf9\u7167\u8005\u7684\u6837\u672c\u91cf\u76f8\u5bf9\u8f83\u5927\uff0c\u4f46\u5728\u7ec6\u5206\u5230\u5177\u4f53\u75be\u75c5\u548c\u57fa\u56e0\u578b\u65f6\uff0c\u67d0\u4e9b\u4e9a\u7ec4\u7684\u6837\u672c\u91cf\u53ef\u80fd\u4ecd\u4e0d\u8db3\u4ee5\u68c0\u6d4b\u8f83\u5c0f\u6548\u5e94\u3002<\/li>\n\n\n\n
        2. \u5355\u4e2d\u5fc3\u7814\u7a76\uff1a<\/strong> \u7531\u4e8e\u6570\u636e\u6765\u81ea\u5355\u4e00\u533b\u7597\u4e2d\u5fc3\uff0c\u7ed3\u679c\u7684\u666e\u904d\u6027\u53ef\u80fd\u53d7\u5230\u9650\u5236\u3002\u9700\u8981\u591a\u4e2d\u5fc3\u7814\u7a76\u6765\u9a8c\u8bc1\u548c\u63a8\u5e7f\u8fd9\u4e9b\u53d1\u73b0\u3002<\/li>\n\n\n\n
        3. \u73af\u5883\u56e0\u7d20\u7f3a\u4e4f\uff1a<\/strong> \u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u75c5\u53d7\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\uff0c\u672c\u7814\u7a76\u672a\u80fd\u8be6\u7ec6\u8003\u8651\u548c\u63a7\u5236\u73af\u5883\u56e0\u7d20\u5bf9\u57fa\u56e0\u591a\u6001\u6027\u7684\u5f71\u54cd\u3002<\/li>\n<\/ol>\n\n\n\n

          \u540e\u7eed\u7814\u7a76\u65b9\u5411<\/h2>\n\n\n\n

          \u57fa\u4e8e\u672c\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u672a\u6765\u7684\u7814\u7a76\u53ef\u4ee5\u4ece\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u5c55\u5f00\uff1a<\/p>\n\n\n\n

            \n
          1. \u6269\u5927\u6837\u672c\u89c4\u6a21\uff1a<\/strong> \u8fdb\u884c\u66f4\u5927\u89c4\u6a21\u7684\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u4ee5\u9a8c\u8bc1\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u589e\u5f3a\u7ed3\u679c\u7684\u666e\u904d\u6027\u548c\u53ef\u9760\u6027\u3002<\/li>\n\n\n\n
          2. \u7eb5\u5411\u7814\u7a76\uff1a<\/strong> \u8fdb\u884c\u957f\u671f\u968f\u8bbf\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u57fa\u56e0\u591a\u6001\u6027\u5728\u75be\u75c5\u8fdb\u5c55\u548c\u6cbb\u7597\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\uff0c\u63ed\u793a\u56e0\u679c\u5173\u7cfb\u3002<\/li>\n\n\n\n
          3. \u73af\u5883\u56e0\u7d20\u5206\u6790\uff1a<\/strong> \u63a2\u8ba8\u57fa\u56e0-\u73af\u5883\u4ea4\u4e92\u4f5c\u7528\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528\uff0c\u4e86\u89e3\u73af\u5883\u56e0\u7d20\u5982\u4f55\u5f71\u54cd\u57fa\u56e0\u591a\u6001\u6027\u7684\u8868\u73b0\u548c\u75be\u75c5\u98ce\u9669\u3002<\/li>\n\n\n\n
          4. \u529f\u80fd\u7814\u7a76\uff1a<\/strong> \u6df1\u5165\u7814\u7a76\u4e0d\u540c\u57fa\u56e0\u591a\u6001\u6027\u7684\u529f\u80fd\u673a\u5236\uff0c\u4e86\u89e3\u5b83\u4eec\u5728\u514d\u75ab\u53cd\u5e94\u548c\u75be\u75c5\u53d1\u75c5\u8fc7\u7a0b\u4e2d\u7684\u5177\u4f53\u4f5c\u7528\u3002<\/li>\n\n\n\n
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