{"id":43134,"date":"2024-06-01T22:20:11","date_gmt":"2024-06-01T14:20:11","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43134"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%a0%94%e7%a9%b6%e5%b7%a5%e5%85%b7%e5%85%a8%e8%a7%a3%e6%9e%90","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43134","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u5de5\u5177\u5168\u89e3\u6790"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization\uff0cMR\uff09\u662f\u4e00\u79cd\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u63a2\u8ba8\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\u7684\u65b9\u6cd5\u3002\u968f\u7740MR\u7814\u7a76\u7684\u666e\u53ca\uff0c\u5404\u79cd\u8ba1\u7b97\u5de5\u5177\u548c\u8f6f\u4ef6\u5e73\u53f0\u7684\u5f00\u53d1\u6781\u5927\u5730\u63a8\u52a8\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u8fdb\u6b65\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u4ecb\u7ecd\u51e0\u79cd\u4e3b\u8981\u7684MR\u7814\u7a76\u5de5\u5177\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u66f4\u597d\u5730\u5f00\u5c55MR\u7814\u7a76\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. MR-Base<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n\n\n<p>MR-Base\u662f\u4e00\u4e2a\u5f00\u653e\u8bbf\u95ee\u7684\u8d44\u6e90\u5e93\u548c\u5206\u6790\u5e73\u53f0\uff0c\u4e13\u95e8\u7528\u4e8e\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u3002\u5b83\u96c6\u6210\u4e86\u591a\u79cd\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\uff0c\u63d0\u4f9b\u4e86\u4e00\u7cfb\u5217\u5206\u6790\u5de5\u5177\uff0c\u65b9\u4fbf\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u56e0\u679c\u63a8\u65ad\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u529f\u80fd<\/h3>\n\n\n\n<ul>\n<li><strong>\u6570\u636e\u6574\u5408\uff1a<\/strong> MR-Base\u96c6\u6210\u4e86\u8d85\u8fc710,000\u4e2aGWAS\u7814\u7a76\u7684\u6570\u636e\uff0c\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\u3002<\/li>\n\n\n\n<li><strong>\u5728\u7ebf\u5206\u6790\uff1a<\/strong> \u63d0\u4f9b\u4e86\u5728\u7ebf\u5206\u6790\u5de5\u5177\uff0c\u7528\u6237\u53ef\u4ee5\u4e0a\u4f20\u81ea\u5df1\u7684\u6570\u636e\u6216\u4f7f\u7528\u5df2\u6709\u6570\u636e\u8fdb\u884cMR\u5206\u6790\u3002<\/li>\n\n\n\n<li><strong>\u591a\u79cd\u5206\u6790\u65b9\u6cd5\uff1a<\/strong> \u652f\u6301\u591a\u79cdMR\u5206\u6790\u65b9\u6cd5\uff0c\u5982IVW\uff08Inverse Variance Weighted\uff09\u3001MR-Egger\u3001\u52a0\u6743\u4e2d\u4f4d\u6570\u6cd5\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u679c\u53ef\u89c6\u5316\uff1a<\/strong> \u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u53ef\u89c6\u5316\u5de5\u5177\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u76f4\u89c2\u5730\u5c55\u793a\u5206\u6790\u7ed3\u679c\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f7f\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>MR-Base\u9002\u7528\u4e8e\u5404\u79cd\u89c4\u6a21\u7684MR\u7814\u7a76\uff0c\u4ece\u521d\u5b66\u8005\u5230\u8d44\u6df1\u7814\u7a76\u4eba\u5458\u90fd\u53ef\u4ee5\u4ece\u4e2d\u53d7\u76ca\u3002\u901a\u8fc7MR-Base\uff0c\u7528\u6237\u53ef\u4ee5\u65b9\u4fbf\u5730\u9a8c\u8bc1\u5047\u8bbe\u3001\u53d1\u73b0\u65b0\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5e76\u4e0e\u5168\u7403\u7684MR\u7814\u7a76\u793e\u7fa4\u5171\u4eab\u7ed3\u679c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. TwoSampleMR<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n\n\n<p>TwoSampleMR\u662f\u4e00\u4e2a\u57fa\u4e8eR\u8bed\u8a00\u7684\u5305\uff0c\u8bbe\u8ba1\u7528\u4e8e\u6267\u884c\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u3002\u5b83\u4e0eMR-Base\u7d27\u5bc6\u96c6\u6210\uff0c\u4f7f\u7528\u6237\u80fd\u591f\u8f7b\u677e\u8bbf\u95ee\u548c\u5206\u6790\u5927\u89c4\u6a21\u7684GWAS\u6570\u636e\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u529f\u80fd<\/h3>\n\n\n\n<ul>\n<li><strong>\u6570\u636e\u83b7\u53d6\uff1a<\/strong> \u63d0\u4f9b\u7b80\u5355\u7684\u63a5\u53e3\u4eceMR-Base\u83b7\u53d6GWAS\u6458\u8981\u7edf\u8ba1\u6570\u636e\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u5904\u7406\uff1a<\/strong> \u5305\u542b\u6570\u636e\u6e05\u6d17\u548c\u51c6\u5907\u5de5\u5177\uff0c\u786e\u4fdd\u6570\u636e\u7684\u4e00\u81f4\u6027\u548c\u51c6\u786e\u6027\u3002<\/li>\n\n\n\n<li><strong>MR\u5206\u6790\uff1a<\/strong> \u652f\u6301\u591a\u79cdMR\u5206\u6790\u65b9\u6cd5\uff0c\u5305\u62ecIVW\u3001MR-Egger\u3001\u52a0\u6743\u4e2d\u4f4d\u6570\u6cd5\u548c\u52a0\u6743\u6a21\u5f0f\u6cd5\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u654f\u611f\u6027\u5206\u6790\uff1a<\/strong> \u63d0\u4f9b\u591a\u79cd\u654f\u611f\u6027\u5206\u6790\u5de5\u5177\uff0c\u4ee5\u68c0\u6d4b\u548c\u6821\u6b63\u591a\u6548\u6027\u53ca\u5176\u4ed6\u6f5c\u5728\u504f\u501a\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f7f\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>TwoSampleMR\u9002\u5408\u9700\u8981\u7075\u6d3b\u6027\u548c\u53ef\u91cd\u590d\u6027\u7684\u7814\u7a76\u4eba\u5458\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u4e60\u60ef\u4f7f\u7528R\u8fdb\u884c\u6570\u636e\u5206\u6790\u7684\u79d1\u7814\u4eba\u5458\u3002\u901a\u8fc7TwoSampleMR\uff0c\u7528\u6237\u53ef\u4ee5\u5feb\u901f\u5b9e\u73b0\u590d\u6742\u7684MR\u5206\u6790\uff0c\u5e76\u751f\u6210\u9ad8\u8d28\u91cf\u7684\u56fe\u8868\u548c\u62a5\u544a\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. GSMR\uff08Generalized Summary-data-based Mendelian Randomization\uff09<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n\n\n<p>GSMR\u662f\u4e00\u79cd\u57fa\u4e8e\u5e7f\u4e49\u6458\u8981\u6570\u636e\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u65b9\u6cd5\uff0c\u4e13\u4e3a\u5904\u7406\u548c\u6821\u6b63\u591a\u6548\u6027\u95ee\u9898\u8bbe\u8ba1\u3002\u5b83\u5229\u7528\u5e7f\u4e49\u7ebf\u6027\u6df7\u5408\u6a21\u578b\uff08GLMM\uff09\u6765\u8fdb\u884cMR\u5206\u6790\uff0c\u63d0\u9ad8\u4e86\u7ed3\u679c\u7684\u51c6\u786e\u6027\u548c\u53ef\u9760\u6027\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u529f\u80fd<\/h3>\n\n\n\n<ul>\n<li><strong>\u591a\u6548\u6027\u6821\u6b63\uff1a<\/strong> \u6709\u6548\u68c0\u6d4b\u548c\u6821\u6b63\u57fa\u56e0\u591a\u6548\u6027\u95ee\u9898\uff0c\u51cf\u5c11\u56e0\u591a\u6548\u6027\u5f15\u5165\u7684\u504f\u501a\u3002<\/li>\n\n\n\n<li><strong>\u5e7f\u4e49\u7ebf\u6027\u6a21\u578b\uff1a<\/strong> \u91c7\u7528GLMM\uff0c\u63d0\u9ad8\u4e86\u5bf9\u590d\u6742\u6570\u636e\u7ed3\u6784\u7684\u5904\u7406\u80fd\u529b\u3002<\/li>\n\n\n\n<li><strong>\u5927\u89c4\u6a21\u6570\u636e\u5206\u6790\uff1a<\/strong> \u80fd\u5904\u7406\u5927\u89c4\u6a21\u7684GWAS\u6570\u636e\uff0c\u9002\u5408\u9ad8\u7ef4\u6570\u636e\u5206\u6790\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f7f\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>GSMR\u7279\u522b\u9002\u7528\u4e8e\u5904\u7406\u5b58\u5728\u591a\u6548\u6027\u95ee\u9898\u7684\u5927\u89c4\u6a21MR\u7814\u7a76\u3002\u901a\u8fc7GSMR\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u66f4\u51c6\u786e\u5730\u8bc4\u4f30\u66b4\u9732\u56e0\u7d20\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. LD Hub<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n\n\n<p>LD Hub\u662f\u4e00\u4e2a\u7efc\u5408\u7684\u5728\u7ebf\u5de5\u5177\uff0c\u63d0\u4f9b\u4e86\u5927\u91cf\u4e0e\u8fde\u9501\u4e0d\u5e73\u8861\uff08LD\uff09\u76f8\u5173\u7684\u6570\u636e\u548c\u8d44\u6e90\u3002\u5b83\u5141\u8bb8\u7528\u6237\u8fdb\u884c\u8de8\u8868\u578b\u7684\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790\uff0c\u5e76\u6574\u5408\u4e86\u591a\u79cdGWAS\u6570\u636e\uff0c\u652f\u6301\u591a\u79cdMR\u5206\u6790\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u529f\u80fd<\/h3>\n\n\n\n<ul>\n<li><strong>\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790\uff1a<\/strong> \u63d0\u4f9b\u8de8\u8868\u578b\u7684\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790\u5de5\u5177\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u7406\u89e3\u4e0d\u540c\u8868\u578b\u4e4b\u95f4\u7684\u9057\u4f20\u5173\u7cfb\u3002<\/li>\n\n\n\n<li><strong>\u6570\u636e\u6574\u5408\uff1a<\/strong> \u96c6\u6210\u4e86\u591a\u79cdGWAS\u6570\u636e\uff0c\u652f\u6301\u5e7f\u6cdb\u7684\u8868\u578b\u548c\u57fa\u56e0\u6570\u636e\u5206\u6790\u3002<\/li>\n\n\n\n<li><strong>\u5728\u7ebf\u5de5\u5177\uff1a<\/strong> \u63d0\u4f9b\u65b9\u4fbf\u7684\u5728\u7ebf\u754c\u9762\uff0c\u7528\u6237\u65e0\u9700\u4e0b\u8f7d\u4efb\u4f55\u8f6f\u4ef6\u5373\u53ef\u8fdb\u884c\u5206\u6790\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f7f\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>LD Hub\u9002\u5408\u9700\u8981\u5206\u6790\u9057\u4f20\u76f8\u5173\u6027\u548c\u8fdb\u884c\u591a\u8868\u578bMR\u5206\u6790\u7684\u7814\u7a76\u4eba\u5458\u3002\u901a\u8fc7LD Hub\uff0c\u7528\u6237\u53ef\u4ee5\u8f7b\u677e\u8fdb\u884c\u5927\u89c4\u6a21\u7684\u9057\u4f20\u76f8\u5173\u6027\u7814\u7a76\uff0c\u5e76\u63a2\u7d22\u4e0d\u540c\u8868\u578b\u4e4b\u95f4\u7684\u590d\u6742\u5173\u7cfb\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. PLINK<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n\n\n<p>PLINK\u662f\u4e00\u4e2a\u5e7f\u6cdb\u4f7f\u7528\u7684\u9057\u4f20\u6570\u636e\u5206\u6790\u5de5\u5177\uff0c\u9002\u7528\u4e8e\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u3002\u5c3d\u7ba1PLINK\u4e0d\u662f\u4e13\u95e8\u4e3aMR\u8bbe\u8ba1\u7684\uff0c\u4f46\u5176\u5f3a\u5927\u7684\u57fa\u56e0\u6570\u636e\u5904\u7406\u80fd\u529b\u4f7f\u5176\u6210\u4e3aMR\u7814\u7a76\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u5de5\u5177\u4e4b\u4e00\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e3b\u8981\u529f\u80fd<\/h3>\n\n\n\n<ul>\n<li><strong>\u6570\u636e\u7ba1\u7406\uff1a<\/strong> \u652f\u6301\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u6570\u636e\u7684\u7ba1\u7406\u548c\u5904\u7406\uff0c\u5305\u62ec\u8d28\u91cf\u63a7\u5236\u3001\u57fa\u56e0\u578b\u6570\u636e\u683c\u5f0f\u8f6c\u6362\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u5173\u8054\u5206\u6790\uff1a<\/strong> \u63d0\u4f9b\u591a\u79cd\u5173\u8054\u5206\u6790\u5de5\u5177\uff0c\u9002\u7528\u4e8eGWAS\u7814\u7a76\u3002<\/li>\n\n\n\n<li><strong>\u591a\u6001\u6027\u5206\u6790\uff1a<\/strong> \u652f\u6301\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNP\uff09\u5206\u6790\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u6f5c\u5728\u7684\u9057\u4f20\u6807\u8bb0\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4f7f\u7528\u6848\u4f8b<\/h3>\n\n\n\n<p>PLINK\u9002\u5408\u9700\u8981\u5904\u7406\u548c\u5206\u6790\u5927\u89c4\u6a21\u57fa\u56e0\u6570\u636e\u7684\u7814\u7a76\u4eba\u5458\u3002\u901a\u8fc7PLINK\uff0c\u7528\u6237\u53ef\u4ee5\u8fdb\u884c\u6570\u636e\u9884\u5904\u7406\u548c\u57fa\u672c\u5206\u6790\uff0c\u4e3aMR\u7814\u7a76\u63d0\u4f9b\u9ad8\u8d28\u91cf\u7684\u6570\u636e\u652f\u6301\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7ed3\u8bba<\/h2>\n\n\n\n<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u4f9d\u8d56\u4e8e\u9ad8\u8d28\u91cf\u7684\u6570\u636e\u548c\u5f3a\u5927\u7684\u5206\u6790\u5de5\u5177\u3002MR-Base\u3001TwoSampleMR\u3001GSMR\u3001LD Hub\u548cPLINK\u7b49\u5de5\u5177\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u5168\u9762\u7684\u652f\u6301\uff0c\u5e2e\u52a9\u4ed6\u4eec\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u3001\u73af\u5883\u548c\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u901a\u8fc7\u5408\u7406\u9009\u62e9\u548c\u4f7f\u7528\u8fd9\u4e9b\u5de5\u5177\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5f00\u5c55\u66f4\u9ad8\u8d28\u91cf\u7684MR\u7814\u7a76\uff0c\u63a8\u52a8\u9057\u4f20\u6d41\u884c\u75c5\u5b66\u9886\u57df\u7684\u53d1\u5c55\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization\uff0cMR\uff09\u662f\u4e00\u79cd\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u63a2\u8ba8\u66b4\u9732\u56e0 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1,64],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43134"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43134"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43134\/revisions"}],"predecessor-version":[{"id":43135,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43134\/revisions\/43135"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43134"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}