{"id":43136,"date":"2024-06-01T22:21:07","date_gmt":"2024-06-01T14:21:07","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43136"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e3%80%8a%e7%82%8e%e6%80%a7%e7%bb%86%e8%83%9e%e5%9b%a0%e5%ad%90%e4%b8%8e%e5%b9%b2%e7%87%a5%e7%bb%bc%e5%90%88%e5%be%81%e9%a3%8e%e9%99%a9%e7%9a%84%e6%bd%9c%e5%9c%a8%e5%85%b3%e8%81%94%ef%bc%9a%e4%b8%80","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43136","title":{"rendered":"\u300a\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u4e0e\u5e72\u71e5\u7efc\u5408\u5f81\u98ce\u9669\u7684\u6f5c\u5728\u5173\u8054\uff1a\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u7684\u89c1\u89e3\u300b"},"content":{"rendered":"\n

<\/p>\n\n\n\n

\u53d1\u8868\u6742\u5fd7\uff1a\u300aAdvances in Rheumatology\u300b<\/p>\n\n\n\n

\u7814\u7a76\u76ee\u7684\uff1a
\u672c\u7814\u7a76\u65e8\u5728\u5229\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u65b9\u6cd5\uff0c\u63a2\u8ba8\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5bf9\u5e72\u71e5\u7efc\u5408\u5f81\uff08SS\uff09\u7684\u56e0\u679c\u5f71\u54cd\uff0c\u5e76\u786e\u5b9aSS\u4e34\u5e8a\u7ba1\u7406\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n\n\n\n

\u7ed3\u679c\uff1a
\u901a\u8fc7\u4e25\u683c\u7684IV\u8d28\u91cf\u63a7\u5236\uff0c91\u79cd\u7ec6\u80de\u56e0\u5b50\u88ab\u7eb3\u5165MR\u5206\u6790\u3002IVW\u5206\u6790\u786e\u5b9a\u4e868\u79cd\u4e0eSS\u5448\u6b63\u76f8\u5173\u7684\u7ec6\u80de\u56e0\u5b50\uff1aAxin-1\u3001T\u7ec6\u80de\u8868\u9762\u7cd6\u86cb\u767dCD5\u3001CUDP1\u3001CXCL10\u3001IL-4\u3001IL-7\u3001MCP-2\u548cTNFRSF9\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u53ef\u80fd\u589e\u52a0SS\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n

\u65b9\u6cd5\uff1a<\/p>\n\n\n\n

    \n
  1. \u7814\u7a76\u8bbe\u8ba1<\/strong>\uff1a\u672c\u7814\u7a76\u9075\u5faaMR\u7684\u4e09\u4e2a\u6838\u5fc3\u5de5\u5177\u53d8\u91cf\uff08IV\uff09\u5047\u8bbe\uff0c\u4f7f\u7528\u516c\u5f00\u53ef\u83b7\u53d6\u7684GWAS\u6c47\u603b\u6570\u636e\u8fdb\u884c\u4e24\u6837\u672cMR\u5206\u6790\u3002<\/li>\n\n\n\n
  2. \u6570\u636e\u6765\u6e90<\/strong>\uff1a\u5faa\u73af\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684GWAS\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u6765\u81eaSCALLOP\u8054\u76df\u7684\u6700\u65b0\u7814\u7a76\uff0cSS\u7684GWAS\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u6765\u81ea\u82f1\u56fd\u751f\u7269\u94f6\u884c\u3002<\/li>\n\n\n\n
  3. IV\u9009\u62e9<\/strong>\uff1a\u9009\u62e9\u4e0e\u5faa\u73af\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u76f8\u5173\u7684\u5148\u524dGWAS\u4e2d\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNP\uff09\u4f5c\u4e3aMR\u8bc4\u4f30\u7684\u5de5\u5177\u53d8\u91cf\uff0c\u9075\u5faa\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u6027\u9608\u503c\uff08p<5\u00d710-6\uff09\u3002<\/li>\n\n\n\n
  4. \u7edf\u8ba1\u5206\u6790<\/strong>\uff1a\u4f7f\u7528\u9006\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09\u3001MR-Egger\u56de\u5f52\u3001MR-Egger\u622a\u8ddd\u3001\u52a0\u6743\u4e2d\u4f4d\u6570\u548c\u52a0\u6743\u6a21\u5f0f\u7b49\u591a\u79cd\u65b9\u6cd5\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002<\/li>\n<\/ol>\n\n\n\n

    \u521b\u65b0\u70b9\uff1a<\/p>\n\n\n\n

      \n
    1. \u9996\u6b21\u5bf9\u5305\u542b\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548cSS\u7684GWAS\u6c47\u603b\u6570\u636e\u8fdb\u884c\u4e24\u6837\u672cMR\u5206\u6790\uff0c\u63ed\u793a\u4e86\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5bf9SS\u7684\u56e0\u679c\u5f71\u54cd\u3002<\/li>\n\n\n\n
    2. \u53d1\u73b0\u4e86\u591a\u79cd\u4e0eSS\u98ce\u9669\u76f8\u5173\u7684\u708e\u6027\u7ec6\u80de\u56e0\u5b50\uff0c\u4e3aSS\u7684\u4e34\u5e8a\u7ba1\u7406\u63d0\u4f9b\u4e86\u65b0\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002<\/li>\n\n\n\n
    3. \u9a8c\u8bc1\u4e86\u4e00\u4e9b\u5148\u524d\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u4e3aSS\u7684\u53d1\u75c5\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002<\/li>\n<\/ol>\n\n\n\n

      \u4e0d\u8db3\uff1a<\/p>\n\n\n\n

        \n
      1. \u7814\u7a76\u4ec5\u7eb3\u5165\u4e86\u6b27\u6d32\u8840\u7edf\u7684\u4e2a\u4f53\uff0c\u9650\u5236\u4e86\u7ed3\u679c\u7684\u666e\u904d\u6027\u3002<\/li>\n\n\n\n
      2. \u7ec6\u80de\u56e0\u5b50\u7684\u6570\u91cf\u6709\u9650\uff0c\u53ef\u80fd\u9057\u6f0f\u4e86\u5176\u4ed6\u91cd\u8981\u7684\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u3002<\/li>\n\n\n\n
      3. \u7814\u7a76\u6ca1\u6709\u533a\u5206\u539f\u53d1\u6027SS\u548c\u7ee7\u53d1\u6027SS\uff0c\u53ef\u80fd\u4f1a\u5f71\u54cd\u7ed3\u679c\u7684\u51c6\u786e\u6027\u3002<\/li>\n\n\n\n
      4. MR\u4f30\u8ba1\u7684\u7cbe\u5ea6\u4e0e\u6837\u672c\u91cf\u6709\u5173\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u6269\u5927\u6837\u672c\u91cf\u8fdb\u884c\u9a8c\u8bc1\u3002<\/li>\n<\/ol>\n\n\n\n

        \u540e\u7eed\u7814\u7a76\uff1a<\/p>\n\n\n\n

          \n
        1. \u8fdb\u4e00\u6b65\u6269\u5927\u7814\u7a76\u6837\u672c\uff0c\u5305\u62ec\u66f4\u591a\u4e0d\u540c\u79cd\u65cf\u7684\u4e2a\u4f53\uff0c\u4ee5\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u7684\u666e\u904d\u6027\u3002<\/li>\n\n\n\n
        2. \u589e\u52a0\u7ec6\u80de\u56e0\u5b50\u7684\u6570\u91cf\uff0c\u8fdb\u884c\u66f4\u5168\u9762\u7684\u5206\u6790\u3002<\/li>\n\n\n\n
        3. \u533a\u5206\u539f\u53d1\u6027SS\u548c\u7ee7\u53d1\u6027SS\uff0c\u63a2\u8ba8\u4e0d\u540c\u7c7b\u578bSS\u4e2d\u7ec6\u80de\u56e0\u5b50\u7684\u4f5c\u7528\u3002<\/li>\n\n\n\n
        4. \u8fdb\u884c\u57fa\u7840\u7814\u7a76\uff0c\u6df1\u5165\u63a2\u8ba8\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5728SS\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528\u3002<\/li>\n\n\n\n
        5. \u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9a8c\u8bc1\u65b0\u53d1\u73b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u5728SS\u8bca\u65ad\u548c\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002<\/li>\n<\/ol>\n\n\n\n

          \u603b\u4e4b\uff0c\u672c\u7814\u7a76\u901a\u8fc7MR\u5206\u6790\u53d1\u73b0\u4e86\u591a\u79cd\u4e0eSS\u98ce\u9669\u76f8\u5173\u7684\u708e\u6027\u7ec6\u80de\u56e0\u5b50\uff0c\u4e3aSS\u7684\u4e34\u5e8a\u7ba1\u7406\u63d0\u4f9b\u4e86\u65b0\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u53d1\u73b0\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u9a8c\u8bc1\u548c\u63a2\u7d22\u5b83\u4eec\u5728SS\u53d1\u75c5\u548c\u8fdb\u5c55\u4e2d\u7684\u7cbe\u786e\u4f5c\u7528\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u6269\u5927\u6837\u672c\u91cf\uff0c\u5305\u62ec\u66f4\u591a\u4e0d\u540c\u79cd\u65cf\u7684\u4e2a\u4f53\uff0c\u8fdb\u884c\u66f4\u5168\u9762\u7684\u5206\u6790\uff0c\u5e76\u6df1\u5165\u63a2\u8ba8\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5728SS\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

          \u5f53\u524d\u6587\u4ef6\u5185\u5bb9\u8fc7\u957f\uff0c\u8c46\u5305\u53ea\u9605\u8bfb\u4e86\u524d 83%\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

          \u53d1\u8868\u6742\u5fd7\uff1a\u300aAdvances in Rheumatology\u300b \u7814\u7a76\u76ee\u7684\uff1a\u672c\u7814\u7a76\u65e8\u5728\u5229\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u65b9 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1,64],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43136"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43136"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43136\/revisions"}],"predecessor-version":[{"id":43137,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43136\/revisions\/43137"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43136"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}