{"id":43138,"date":"2024-06-01T22:21:37","date_gmt":"2024-06-01T14:21:37","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43138"},"modified":"2024-06-01T22:48:57","modified_gmt":"2024-06-01T14:48:57","slug":"%e6%8e%a2%e7%b4%a2%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%a0%94%e7%a9%b6%e7%9a%84%e5%88%a9%e5%99%a8%ef%bc%9amr-base%e5%b9%b3%e5%8f%b0%e8%af%a6%e8%a7%a3","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43138","title":{"rendered":"\u63a2\u7d22\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u7684\u5229\u5668\uff1aMR-Base\u5e73\u53f0\u8be6\u89e3"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><\/h1>\n\n\n\n<p>\u5728\u5f53\u4eca\u533b\u5b66\u548c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u4e2d\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u56e0\u5176\u80fd\u591f\u5229\u7528\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u63a8\u65ad\u66b4\u9732\u4e0e\u75be\u75c5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u6b63\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\u3002MR-Base\u4f5c\u4e3a\u8fd9\u4e00\u9886\u57df\u7684\u9886\u5148\u5de5\u5177\uff0c\u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f3a\u5927\u4e14\u6613\u4e8e\u4f7f\u7528\u7684\u5e73\u53f0\uff0c\u6781\u5927\u5730\u7b80\u5316\u4e86MR\u7814\u7a76\u7684\u8fc7\u7a0b\u3002\u672c\u6587\u5c06\u6df1\u5165\u63a2\u8ba8MR-Base\u7684\u529f\u80fd\u3001\u4f7f\u7528\u65b9\u6cd5\u4ee5\u53ca\u5728\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4ec0\u4e48\u662fMR-Base\uff1f<\/h2>\n\n\n\n<p>MR-Base\u662f\u4e00\u4e2a\u5f00\u653e\u8bbf\u95ee\u7684\u8d44\u6e90\u5e93\u548c\u5206\u6790\u5e73\u53f0\uff0c\u4e13\u4e3a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7814\u7a76\u8bbe\u8ba1\u3002\u5b83\u96c6\u6210\u4e86\u5927\u91cf\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08Genome-Wide Association Studies, GWAS\uff09\u6570\u636e\uff0c\u5e76\u63d0\u4f9b\u4e00\u7cfb\u5217\u5de5\u5177\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u56e0\u679c\u63a8\u65ad\u548c\u6570\u636e\u5206\u6790\u3002MR-Base\u7684\u76ee\u7684\u662f\u7b80\u5316MR\u7814\u7a76\u6d41\u7a0b\uff0c\u4f7f\u5f97\u65e0\u8bba\u662f\u521d\u5b66\u8005\u8fd8\u662f\u8d44\u6df1\u7814\u7a76\u4eba\u5458\u90fd\u80fd\u8f7b\u677e\u5f00\u5c55\u9ad8\u8d28\u91cf\u7684MR\u7814\u7a76\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">MR-Base\u7684\u4e3b\u8981\u529f\u80fd<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u6570\u636e\u6574\u5408<\/h3>\n\n\n\n<p>MR-Base\u96c6\u6210\u4e86\u8d85\u8fc710,000\u4e2aGWAS\u7814\u7a76\u7684\u6570\u636e\uff0c\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\u3002\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u8f7b\u677e\u83b7\u53d6\u8fd9\u4e9b\u6570\u636e\uff0c\u8fdb\u884c\u5404\u79cd\u5f62\u5f0f\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u5728\u7ebf\u5206\u6790<\/h3>\n\n\n\n<p>MR-Base\u63d0\u4f9b\u4e86\u5f3a\u5927\u7684\u5728\u7ebf\u5206\u6790\u5de5\u5177\u3002\u7528\u6237\u53ef\u4ee5\u4e0a\u4f20\u81ea\u5df1\u7684\u6570\u636e\uff0c\u6216\u8005\u4f7f\u7528\u5df2\u6709\u7684\u516c\u5171\u6570\u636e\u8fdb\u884c\u5206\u6790\u3002\u8be5\u5e73\u53f0\u652f\u6301\u591a\u79cdMR\u5206\u6790\u65b9\u6cd5\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul>\n<li><strong>\u9006\u65b9\u5dee\u52a0\u6743\u6cd5\uff08Inverse Variance Weighted, IVW\uff09\uff1a<\/strong> \u8fd9\u662f\u6700\u5e38\u7528\u7684MR\u5206\u6790\u65b9\u6cd5\uff0c\u901a\u8fc7\u52a0\u6743\u5e73\u5747\u6765\u4f30\u8ba1\u66b4\u9732\u4e0e\u7ed3\u679c\u4e4b\u95f4\u7684\u56e0\u679c\u6548\u5e94\u3002<\/li>\n\n\n\n<li><strong>MR-Egger\u56de\u5f52\uff1a<\/strong> \u7528\u4e8e\u68c0\u6d4b\u548c\u6821\u6b63\u57fa\u56e0\u591a\u6548\u6027\u3002<\/li>\n\n\n\n<li><strong>\u52a0\u6743\u4e2d\u4f4d\u6570\u6cd5\uff1a<\/strong> \u63d0\u4f9b\u4e86\u4e00\u79cd\u9c81\u68d2\u7684\u56e0\u679c\u6548\u5e94\u4f30\u8ba1\u65b9\u6cd5\uff0c\u7279\u522b\u9002\u7528\u4e8e\u5b58\u5728\u5f02\u5e38\u503c\u7684\u60c5\u51b5\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">3. \u7ed3\u679c\u53ef\u89c6\u5316<\/h3>\n\n\n\n<p>MR-Base\u5185\u7f6e\u4e86\u4e30\u5bcc\u7684\u53ef\u89c6\u5316\u5de5\u5177\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u76f4\u89c2\u5730\u5c55\u793a\u5206\u6790\u7ed3\u679c\u3002\u8fd9\u4e9b\u5de5\u5177\u5305\u62ec\u6563\u70b9\u56fe\u3001\u68ee\u6797\u56fe\u548c\u6f0f\u6597\u56fe\u7b49\uff0c\u80fd\u591f\u6709\u6548\u5730\u5448\u73b0\u6570\u636e\u7684\u5206\u5e03\u548c\u7edf\u8ba1\u7ed3\u679c\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">4. \u6570\u636e\u5171\u4eab\u4e0e\u534f\u4f5c<\/h3>\n\n\n\n<p>MR-Base\u652f\u6301\u7814\u7a76\u4eba\u5458\u4e4b\u95f4\u7684\u6570\u636e\u5171\u4eab\u4e0e\u534f\u4f5c\u3002\u7528\u6237\u53ef\u4ee5\u5c06\u81ea\u5df1\u7684\u7814\u7a76\u7ed3\u679c\u4e0a\u4f20\u5230\u5e73\u53f0\uff0c\u4e0e\u5168\u7403\u7684MR\u7814\u7a76\u793e\u533a\u5171\u4eab\uff0c\u4ece\u800c\u4fc3\u8fdb\u79d1\u5b66\u7814\u7a76\u7684\u5f00\u653e\u4e0e\u900f\u660e\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5982\u4f55\u4f7f\u7528MR-Base\uff1f<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6b65\u9aa4\u4e00\uff1a\u6ce8\u518c\u548c\u767b\u5f55<\/h3>\n\n\n\n<p>\u9996\u5148\uff0c\u7528\u6237\u9700\u8981\u5728MR-Base\u5e73\u53f0\u4e0a\u6ce8\u518c\u4e00\u4e2a\u8d26\u53f7\uff0c\u5e76\u767b\u5f55\u7cfb\u7edf\u3002\u6ce8\u518c\u8fc7\u7a0b\u7b80\u5355\u5feb\u6377\uff0c\u53ea\u9700\u63d0\u4f9b\u57fa\u672c\u7684\u4e2a\u4eba\u4fe1\u606f\u548c\u7814\u7a76\u673a\u6784\u4fe1\u606f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6b65\u9aa4\u4e8c\uff1a\u6570\u636e\u5bfc\u5165<\/h3>\n\n\n\n<p>\u767b\u5f55\u540e\uff0c\u7528\u6237\u53ef\u4ee5\u9009\u62e9\u5bfc\u5165\u81ea\u5df1\u7684GWAS\u6570\u636e\uff0c\u6216\u8005\u4eceMR-Base\u63d0\u4f9b\u7684\u516c\u5171\u6570\u636e\u96c6\u4e2d\u9009\u62e9\u611f\u5174\u8da3\u7684\u6570\u636e\u3002MR-Base\u652f\u6301\u591a\u79cd\u6570\u636e\u683c\u5f0f\uff0c\u5e76\u63d0\u4f9b\u8be6\u7ec6\u7684\u5bfc\u5165\u6307\u5357\uff0c\u786e\u4fdd\u6570\u636e\u4e0a\u4f20\u8fc7\u7a0b\u987a\u5229\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6b65\u9aa4\u4e09\uff1a\u9009\u62e9\u5206\u6790\u65b9\u6cd5<\/h3>\n\n\n\n<p>\u5bfc\u5165\u6570\u636e\u540e\uff0c\u7528\u6237\u53ef\u4ee5\u6839\u636e\u7814\u7a76\u9700\u6c42\u9009\u62e9\u5408\u9002\u7684MR\u5206\u6790\u65b9\u6cd5\u3002MR-Base\u63d0\u4f9b\u4e86\u591a\u79cd\u5206\u6790\u9009\u9879\uff0c\u5e76\u9644\u6709\u8be6\u7ec6\u7684\u4f7f\u7528\u8bf4\u660e\u548c\u53c2\u6570\u8bbe\u7f6e\u6307\u5357\uff0c\u5e2e\u52a9\u7528\u6237\u9009\u62e9\u6700\u4f73\u7684\u5206\u6790\u8def\u5f84\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6b65\u9aa4\u56db\uff1a\u8fd0\u884c\u5206\u6790<\/h3>\n\n\n\n<p>\u8bbe\u7f6e\u597d\u5206\u6790\u53c2\u6570\u540e\uff0c\u7528\u6237\u53ef\u4ee5\u70b9\u51fb\u8fd0\u884c\u6309\u94ae\uff0cMR-Base\u5c06\u81ea\u52a8\u8fdb\u884c\u6570\u636e\u5904\u7406\u548c\u5206\u6790\u3002\u6574\u4e2a\u8fc7\u7a0b\u65e0\u9700\u7528\u6237\u624b\u52a8\u5e72\u9884\uff0c\u7cfb\u7edf\u4f1a\u5728\u540e\u53f0\u81ea\u52a8\u5b8c\u6210\u6240\u6709\u8ba1\u7b97\u4efb\u52a1\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6b65\u9aa4\u4e94\uff1a\u67e5\u770b\u548c\u5bfc\u51fa\u7ed3\u679c<\/h3>\n\n\n\n<p>\u5206\u6790\u5b8c\u6210\u540e\uff0c\u7528\u6237\u53ef\u4ee5\u5728\u5e73\u53f0\u4e0a\u67e5\u770b\u8be6\u7ec6\u7684\u7ed3\u679c\u62a5\u544a\u3002MR-Base\u63d0\u4f9b\u591a\u79cd\u7ed3\u679c\u5c55\u793a\u5f62\u5f0f\uff0c\u5305\u62ec\u56fe\u8868\u548c\u8868\u683c\uff0c\u7528\u6237\u53ef\u4ee5\u6839\u636e\u9700\u8981\u8fdb\u884c\u67e5\u770b\u548c\u5bfc\u51fa\u3002\u6b64\u5916\uff0c\u7528\u6237\u8fd8\u53ef\u4ee5\u5c06\u7ed3\u679c\u4fdd\u5b58\u5230\u81ea\u5df1\u7684\u8d26\u53f7\u4e2d\uff0c\u65b9\u4fbf\u65e5\u540e\u67e5\u9605\u548c\u5206\u4eab\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">MR-Base\u7684\u4f18\u52bf<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u6613\u7528\u6027<\/h3>\n\n\n\n<p>MR-Base\u7684\u7528\u6237\u754c\u9762\u8bbe\u8ba1\u7b80\u6d01\u76f4\u89c2\uff0c\u5373\u4f7f\u662f\u6ca1\u6709\u7f16\u7a0b\u80cc\u666f\u7684\u7814\u7a76\u4eba\u5458\u4e5f\u80fd\u8f7b\u677e\u4e0a\u624b\u3002\u8be6\u7ec6\u7684\u64cd\u4f5c\u6307\u5357\u548c\u5728\u7ebf\u5e2e\u52a9\u6587\u6863\u8fdb\u4e00\u6b65\u964d\u4f4e\u4e86\u4f7f\u7528\u95e8\u69db\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u6570\u636e\u5168\u9762<\/h3>\n\n\n\n<p>MR-Base\u96c6\u6210\u4e86\u6d77\u91cf\u7684GWAS\u6570\u636e\uff0c\u6db5\u76d6\u4e86\u4f17\u591a\u66b4\u9732\u56e0\u7d20\u548c\u75be\u75c5\u7ed3\u679c\uff0c\u6781\u5927\u5730\u62d3\u5c55\u4e86\u7814\u7a76\u4eba\u5458\u7684\u9009\u62e9\u8303\u56f4\u3002\u901a\u8fc7MR-Base\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5feb\u901f\u627e\u5230\u6240\u9700\u7684\u6570\u636e\uff0c\u5f00\u5c55\u5404\u7c7bMR\u5206\u6790\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3. 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\u793e\u533a\u548c\u534f\u4f5c<\/h3>\n\n\n\n<p>MR-Base\u9f13\u52b1\u6570\u636e\u5171\u4eab\u548c\u534f\u4f5c\uff0c\u7528\u6237\u53ef\u4ee5\u5c06\u81ea\u5df1\u7684\u7814\u7a76\u6210\u679c\u4e0a\u4f20\u5230\u5e73\u53f0\uff0c\u4e0e\u5168\u7403\u7684MR\u7814\u7a76\u793e\u7fa4\u5171\u4eab\u3002\u8fd9\u79cd\u5f00\u653e\u548c\u534f\u4f5c\u7684\u7814\u7a76\u6a21\u5f0f\uff0c\u6709\u52a9\u4e8e\u63a8\u52a8\u79d1\u5b66\u7814\u7a76\u7684\u8fdb\u6b65\u3002<\/p>\n\n\n\n<h2 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