{"id":43312,"date":"2024-06-02T01:15:34","date_gmt":"2024-06-01T17:15:34","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43312"},"modified":"2024-06-11T10:32:26","modified_gmt":"2024-06-11T02:32:26","slug":"a2bf155fb4","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43312","title":{"rendered":"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~"},"content":{"rendered":"
\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/p>\n

\u4e0d\u77e5\u4e0d\u89c9\u53c8\u5230\u4e86\u6bd5\u4e1a\u5b63\uff0c\u6bcf\u5e74\u8fd9\u65f6\u5019\u90fd\u4f1a\u6709\u4e00\u7fa4\u5c0f\u4f19\u4f34\u5982\u70ed\u9505\u4e0a\u7684\u8682\u8681\u4e00\u822c\u6349\u6025\uff0c\u4e3a\u4ec0\u4e48\u5462\uff1f\u56e0\u4e3a\u6ca1\u6587\u7ae0\u6bd5\u4e1a\u5457~\u522b\u95ee\u5c0f\u4e91\u600e\u4e48\u77e5\u9053\u7684\uff0c\u6084\u6084\u544a\u8bc9\u4f60\uff0c\u6700\u8fd1\u5c0f\u4e91\u8fd9\u91cc\u5168\u662f\u8fd9\u6837\u7684\u5b9d\u5b9d\u2026\u2026\u4e0d\u8fc7\u80fd\u627e\u5230\u5c0f\u4e91\u5c31\u76f8\u5f53\u4e8e\u4e00\u53ea\u811a\u5df2\u7ecf\u8fc8\u51fa\u4e86\u5b66\u6821\u7684\u5927\u95e8\u54e6~<\/span>\n<\/p>\n

\u4eca\u5929\u5c0f\u4e91\u7ed9\u5927\u5bb6\u5e26\u6765\u4e00\u672c\u6bd5\u4e1a\u795e\u520a\uff0c\u7eaf\u751f\u4fe1\u3001\u6700\u8fd1\u7206\u706b\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4ee5\u53ca\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5e93\u6316\u6398\u901a\u901a\u90fd\u6536\u54e6~\u5b83\u5c31\u662fJournal of Translational Medicine\u3002\u4e0b\u9762\u5c0f\u4e91\u5c31\u5148\u63a5\u5355\u4ecb\u7ecd\u4e00\u4e0b\u8fd9\u4e2a\u6742\u5fd7\u5427<\/span>\uff08<\/span>ps\uff1a\u6709\u6295\u7a3f\u9700\u6c42\u7684\u5b9d\u5b50\u53ef\u4ee5\u901f\u901f\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u54e6<\/span>\uff09<\/span><\/span>\uff1a<\/span><\/span><\/p>\n

\u671f\u520a\u7b80\u4ecb<\/span><\/p>\n

ISSN\uff1a1479-5876<\/span><\/section>\n
\u51fa\u7248\u56fd\u5bb6\uff1a\u82f1\u56fd<\/span><\/section>\n
\u671f\u520a\u5b98\u65b9\u7f51\u7ad9\uff1a<\/span><\/section>\n
<\/span>http:\/\/translational-medicine.biomedcentral.com<\/span><\/section>\n
\u671f\u520a\u6295\u7a3f\u7f51\u5740\uff1a<\/span><\/section>\n

<\/span>https:\/\/www.editorialmanager.com\/jtrm\/<\/span><\/p>\n

\u975e\u9884\u8b66\u671f\u520a<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u8be5\u56fe\u7247\u548c\u6570\u636e\u6765\u6e90\u4e8eLetPub\u7f51\u7ad9<\/span><\/p>\n

\u6839\u636e\u6700\u65b0\u7248\u672c\u7684\u4e2d\u79d1\u9662\u671f\u520a\u5206\u533a\u8be5\u6742\u5fd7\u76ee\u524d\u5927\u7c7b\u5b66\u79d1-\u533b\u5b662\u533a\uff0c\u5c0f\u7c7b\u7814\u7a76\u4e0e\u5b9e\u9a8c2\u533a\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u6839\u636eWOS\u5206\u533a\u5c5e\u4e8e1\u533a\u3002<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u6536\u5f55\u8303\u56f4\u548c\u6587\u7ae0\u7c7b\u578b\uff1a<\/span><\/p>\n

Journal of Translational Medicine<\/span>\u662f\u4e00\u672c\u5f00\u653e\u83b7\u53d6\u671f\u520a\uff0c\u53d1\u8868\u7684\u6587\u7ae0\u91cd\u70b9\u5173\u6ce8\u6765\u81ea\u4eba\u4f53\u5b9e\u9a8c\u7684\u4fe1\u606f\uff0c\u4ee5\u4f18\u5316\u57fa\u7840\u79d1\u5b66\u548c\u4e34\u5e8a\u79d1\u5b66\u4e4b\u95f4\u7684\u4ea4\u6d41\u3002\u8be5\u6742\u5fd7\u6db5\u76d6\u4e86\u8f6c\u5316\u533b\u5b66\u7684\u6240\u6709\u9886\u57df\u3002<\/span><\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1a7.4<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u8be5\u56fe\u7247\u548c\u6570\u636e\u6765\u6e90\u4e8eLetPub\u7f51\u7ad9<\/span><\/p>\n

\u81ea\u5f15\u7387\uff1a<\/span><\/p>\n

\u8be5\u6742\u5fd7\u81ea\u5f15\u7387\u5e38\u5e74\u4fdd\u6301\u57285%\u4ee5\u4e0b\uff0c\u76ee\u524d1.4%\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u8be5\u56fe\u7247\u548c\u6570\u636e\u6765\u6e90\u4e8eLetPub\u7f51\u7ad9<\/span><\/p>\n

\u5e74\u6587\u7ae0\u91cf\uff1a<\/span><\/p>\n

\u8be5\u6742\u5fd7\u7684\u5e74\u6587\u7ae0\u76ee\u524d\u4e3a592\uff0c\u6709\u4e0a\u5347\u8d8b\u52bf\u3002<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u8be5\u56fe\u7247\u548c\u6570\u636e\u6765\u6e90\u4e8eLetPub\u7f51\u7ad9<\/span><\/p>\n

\u5ba1\u7a3f\u5468\u671f\uff1a<\/span><\/p>\n

\u8fd9\u4e2a\u671f\u520a\u5ba1\u7a3f\u5f88\u5feb\uff0c\u6839\u636e\u8fd1\u671f\u6587\u7ae0\u770b\uff0c\u4ece\u6295\u7a3f\u5230\u63a5\u6536\u57fa\u672c\u57281\u4e2a\u6708\u5de6\u53f3\uff0c\u63a5\u6536\u540e\u89c1\u520a\u4e5f\u662f1\u4e2a\u6708\u5185\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u7248\u9762\u8d39\uff1a<\/span><\/p>\n

\u5f00\u653e\u83b7\u53d6\u671f\u520a\uff0c\u7248\u9762\u8d393790\u7f8e\u5143<\/span><\/p>\n

\u7efc\u4e0a\uff0c\u8fd9\u662f\u4e00\u672c\u795e\u520a\u65e0\u7591\u4e86\uff0c\u4e0b\u9762\u5c0f\u4e91\u5c31\u901a\u8fc7\u4e00\u7bc7\u8fd1\u671f\u53d1\u8868\u7684\u6587\u7ae0\u5e26\u5927\u5bb6\u7785\u7785\u8fd9\u672c\u671f\u520a\u4e0a\u6587\u7ae0\u7684\u53ef\u590d\u73b0\u6027\u5427~<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u9898\u76ee\uff1a\u591a\u79cd\u53ef\u6539\u53d8\u5371\u9669\u56e0\u7d20\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5\u4e4b\u95f4\u7684\u9057\u4f20\u5173\u8054\u548c\u56e0\u679c\u5173\u7cfb\uff1a\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u7814\u7a76<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024.5<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u5173\u6ce8\u516c\u4f17\u53f7\uff0c\u540e\u53f0\u53d1\u9001<\/span>\u201c123\u201d<\/span>\u53ef\u4ee5\u76f4\u63a5\u83b7\u53d6\u539f\u6587PDF\uff0c\u6587\u732e\u7f16\u53f7\uff1a240514<\/span><\/section>\n
<\/mp-common-videosnap><\/section>\n
<\/span><\/section>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

\u81ea\u8eab\u514d\u75ab\u6027\u809d\u75c5(AILD)\u7684\u75c5\u56e0\u590d\u6742\uff0c\u6d89\u53ca\u9057\u4f20\u3001\u73af\u5883\u548c\u5176\u4ed6\u5c1a\u672a\u5b8c\u5168\u9610\u660e\u7684\u56e0\u7d20\u3002\u672c\u7814\u7a76\u91c7\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u65b9\u6cd5\u7efc\u5408\u8bc4\u4f30\u4e86\u9057\u4f20\u9884\u6d4b\u7684\u53ef\u6539\u53d8\u5371\u9669\u56e0\u7d20\u4e0eAILD\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u7814\u7a76\u601d\u8def<\/span><\/p>\n

\u4ece\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76(GWAS)\u4e2d\u83b7\u5f97\u4e0e29\u4e2a\u66b4\u9732\u56e0\u7d20\u76f8\u5173\u7684\u9057\u4f20\u53d8\u5f02\u3002\u4f5c\u8005\u8fd8\u4ece\u516c\u5f00\u7684GWAS\u4e2d\u83b7\u5f97\u4e86\u81ea\u8eab\u514d\u75ab\u6027\u809d\u708e(AIH)\u3001\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e(PBC)\u548c\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e(PSC)\u7684\u9057\u4f20\u5173\u8054\u6570\u636e\u3002\u91c7\u7528\u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cf\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u786e\u5b9aAILD\u7684\u6f5c\u5728\u5371\u9669\u56e0\u7d20\u3002<\/span><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n

\u53ef\u6539\u53d8\u7684\u5371\u9669\u56e0\u7d20\u5bf9 AIH \u7684\u56e0\u679c\u5f71\u54cd<\/span><\/p>\n

\u5355\u53d8\u91cfMR\u5206\u6790\u663e\u793a\uff0c\u5728\u751f\u6d3b\u65b9\u5f0f\u90e8\u5206\uff0c\u9057\u4f20\u9884\u6d4b\u7684\u5438\u70df\u8d77\u59cb\uff08OR = 1.637\uff0c95% CI 1.055\u20132.540\uff0cP = 0.028\uff09\u548c\u8f83\u4f4e\u7684\u5496\u5561\u6444\u5165\u91cf\uff08OR = 0.359\uff0c95% CI 0.131\u20130.985\uff0cP = 0.047\uff09\u4e0eAIH\uff08\u81ea\u8eab\u514d\u75ab\u6027\u809d\u708e\uff09\u98ce\u9669\u589e\u52a0\u6709\u5173\u8054\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u53ef\u6539\u53d8\u7684\u5371\u9669\u56e0\u7d20\u5bf9 PBC \u7684\u56e0\u679c\u5f71\u54cd<\/span><\/p>\n

\u5355\u53d8\u91cf\u5206\u6790\u663e\u793a\uff0c\u9057\u4f20\u5b66\u9884\u6d4b\u7684\u5f00\u59cb\u5438\u70df(OR = 1.167, 95%CI 1.005 ~ 1.355, P = 0.043)\u4e0ePBC\u98ce\u9669\u589e\u52a0\u76f8\u5173\u3002\u65e0\u591a\u6548\u6027(MR-Egger\u56de\u5f52\u622a\u8ddd:P = 0.164;MR-PRESSO-Global Test: P = 0.998)\u6216\u5f02\u8d28\u6027(Cochran ‘s Q\u68c0\u9a8c:P = 0.999)\u5728\u5f00\u59cb\u5438\u70df\u4e2d\u88ab\u68c0\u6d4b\u3002<\/span><\/p>\n

\u5728\u76f8\u5173\u75be\u75c5\u677f\u4e2d\uff0c\u9057\u4f20\u9884\u6d4b\u7684\u809d\u5916\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5IBD (OR = 1.212, 95%CI 1.127 ~ 1.303, P = 2.015 \u00d7 10\u22127)\u548cRA (OR = 1.417, 95%CI 1.193 ~ 1.683, P = 7.193 \u00d7 10\u22125)\u4e0ePBC\u98ce\u9669\u589e\u52a0\u663e\u8457\u76f8\u5173\u3002IBD\u548cRA\u5b58\u5728\u5f02\u8d28\u6027(Cochran Q-derived P\u503c< 0.05)\u3002\u6b64\u5916\uff0c\u57fa\u56e0\u9884\u6d4b\u7684SLE\u60a3\u8005\u53d1\u751fPBC\u7684\u98ce\u9669\u589e\u52a0(OR = 1.086, 95%CI 1.017 ~ 1.160, P = 0.014)\u3002\u8840\u6e05\u6307\u6807\u4e2d\uff0c\u8f83\u9ad8\u7684\u7ef4\u751f\u7d20D3 (OR = 0.741, 95%CI 0.560 ~ 0.980, P = 0.036)\u548c\u9499(OR = 0.834, 95%CI 0.699 ~ 0.995, P = 0.044)\u6c34\u5e73\u662fPBC\u7684\u4fdd\u62a4\u56e0\u7d20\uff0c\u4f46\u5b58\u5728\u5f02\u8d28\u6027(Cochran ‘s Q\u68c0\u9a8c:P = 2.140 \u00d7 10\u22123;P = 2.244 \u00d7 10\u22123)\u3002\u4f46\u8840\u6e05\u7ef4\u751f\u7d20D3 (MR-Egger\u56de\u5f52\u622a\u8ddd:P = 0.813)\u548c\u9499(MR-Egger\u56de\u5f52\u622a\u8ddd:P = 0.419)\u6c34\u5e73\u672a\u68c0\u6d4b\u5230\u591a\u6548\u6027\u3002\u800c\u57fa\u56e0\u9884\u6d4bCRP\u5347\u9ad8\u63d0\u793aPBC\u53d1\u75c5\u98ce\u9669\u589e\u52a0(OR = 1.199, 95%CI 1.019 ~ 1.410, P = 0.028)\u3002CRP\u5b58\u5728\u5f02\u8d28\u6027(Cochran ‘s Q\u68c0\u9a8c:P = 4.545 \u00d7 10\u22124)\uff0c\u4f46\u672a\u68c0\u6d4b\u5230\u591a\u6548\u6027(MR-Egger\u56de\u5f52\u622a\u8ddd:P = 0.747)\u3002\u80a5\u80d6\u7279\u5f81\u4e2d\uff0c\u8170\u56f4\u8d8a\u9ad8\uff0cPBC\u53d1\u75c5\u98ce\u9669\u8d8a\u9ad8(OR = 1.272, 95%CI 1.033 ~ 1.567, P = 0.024)\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/p>\n

\u53ef\u6539\u53d8\u7684\u5371\u9669\u56e0\u7d20\u5bf9 PSC \u7684\u56e0\u679c\u5f71\u54cd<\/span><\/p>\n

\u5355\u53d8\u91cfMR\u5206\u6790\u663e\u793a\uff0c\u57fa\u56e0\u9884\u6d4b\u7684\u5f00\u59cb\u5438\u70df(OR = 0.630, 95%CI 0.462-0.860, P = 0.004)\u4e0e\u751f\u6d3b\u65b9\u5f0f\u6bb5PSC\u98ce\u9669\u964d\u4f4e\u76f8\u5173\u3002\u6b64\u5916\uff0c\u9057\u4f20\u9884\u6d4b\u7684IBD (OR = 1.252, 95%CI 1.164 ~ 1.346, P = 1.394 \u00d7 10\u22129)\u548cRA (OR = 1.543, 95%CI 1.279 ~ 1.861, P = 5.728 \u00d7 10\u22126)\u4e0ePSC\u98ce\u9669\u589e\u52a0\u5448\u6b63\u76f8\u5173\u3002\u672a\u68c0\u6d4b\u5230IBD\u7684\u591a\u6548\u6027(MR-Egger\u56de\u5f52\u622a\u8ddd:P = 0.349)\uff0c\u4f46\u68c0\u6d4b\u5230\u5f02\u8d28\u6027(Cochran\u2019s Q\u68c0\u9a8c:P = 8.392 \u00d7 10\u22124)\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u5728\u7cd6\u4ee3\u8c22\u677f\u4e2d\uff0c\u9057\u4f20\u9884\u6d4b\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d(HbA1c) (OR = 0.268, 95%CI 0.141 ~ 0.510, P = 6.172 \u00d7 10\u22125)\u662fPSC\u7684\u4fdd\u62a4\u56e0\u7d20\u3002\u57fa\u56e0\u9884\u6d4b\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005PSC\u7684\u53d1\u75c5\u98ce\u9669\u964d\u4f4e(OR = 0.877, 95%CI 0.780 ~ 0.986, P = 0.028)\u3002\u5728\u80a5\u80d6\u7279\u5f81\u4e2d\uff0cBMI\u8d8a\u9ad8\uff0cPSC\u53d1\u751f\u98ce\u9669\u8d8a\u4f4e(OR = 0.777, 95%CI 0.626 ~ 0.964, P = 0.022)\u3002<\/span><\/p>\n

<\/span>\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/span><\/span><\/p>\n

AIH\u3001PBC \u548c PSC \u7684\u591a\u53d8\u91cf MR \u5206\u6790<\/span><\/p>\n

\u5728\u591a\u53d8\u91cfMR\u5206\u6790\u6a21\u578b\u4e2d\uff0c\u4ec5\u5bf9\u76f8\u4e92\u5173\u8054\u7684\u9057\u4f20\u9884\u6d4b\u7684\u53ef\u6539\u53d8\u5371\u9669\u56e0\u7d20\u8fdb\u884c\u76f8\u4e92\u6821\u6b63\u3002\u80a5\u80d6\u7279\u5f81\u3001\u7cd6\u4ee3\u8c22\u548c\u8102\u4ee3\u8c22\u662f\u9700\u8981\u8c03\u6574\u7684\u5173\u952e\u9057\u4f20\u6027\u53ef\u9884\u6d4b\u53ef\u6539\u53d8\u5371\u9669\u56e0\u7d20\u3002\u4e0e\u5355\u53d8\u91cf\u5206\u6790\u7ed3\u679c\u4e00\u81f4\uff0c\u6821\u6b63\u9057\u4f20\u9884\u6d4b\u7684HDL\/LDL\u3001TG\/LDL\u3001TG\/HDL\u548cTG\/LDL\u540e\uff0c\u9057\u4f20\u9884\u6d4b\u7684TG (OR = 0.884, 95%CI 0.646 ~ 1.210, P = 0.442)\u3001HDL(OR = 0.919, 95%CI 0.685 ~ 1.233, P = 0.575)\u3001LDL (OR = 0.897, 95%CI 0.655 ~ 1.229, P = 0.500)\u548cApoA1 (OR = 0.870, 95%CI 0.656 ~ 1.154, P = 0.334)\u6c34\u5e73\u4e0eAIH\u7684\u53d1\u751f\u98ce\u9669\u65e0\u663e\u8457\u56e0\u679c\u5173\u8054\u3002\u7ecf\u6821\u6b63\u540e\uff0c\u7a7a\u8179\u8840\u7cd6(OR = 1.230, 95%CI 0.593 ~ 2.550, P = 0.577)\u3001\u7a7a\u8179\u80f0\u5c9b\u7d20(OR = 2.101, 95%CI 0.731 ~ 6.036, P = 0.168)\u3001HbA1c\u6c34\u5e73(OR = 0.483, 95%CI 0.186 ~ 1.253, P = 0.135)\u4ee5\u53ca\u9057\u4f20\u9884\u6d4b\u76842\u578b\u7cd6\u5c3f\u75c5(OR = 0.926, 95%CI 0.777 ~ 1.103, P = 0.388)\u4e0eAIH\u7684\u53d1\u751f\u98ce\u9669\u65e0\u5173\u3002\u5728\u591a\u53d8\u91cf\u5206\u6790\u4e2d\uff0c\u80a5\u80d6\u53c2\u6570\u518d\u6b21\u88ab\u8bc1\u5b9e\u72ec\u7acb\u4e8eAIH\u7684\u98ce\u9669\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u4e0eAIH\u7684\u591a\u56e0\u7d20\u5206\u6790\u76f8\u4f3c\uff0c\u591a\u56e0\u7d20\u8c03\u6574\u5e76\u672a\u6539\u53d8\u8102\u4ee3\u8c22\u548c\u7cd6\u4ee3\u8c22\u6307\u6807\u4e0ePBC\u98ce\u9669\u65e0\u5173\u7684\u7ed3\u8bba\u3002\u9ad8\u8170\u56f4(OR = 1.578, 95%CI 0.236 ~ 4.537, P = 0.638)\u5728\u5355\u56e0\u7d20\u5206\u6790\u4e2d\u63d0\u793a\u4e0ePBC\u53d1\u75c5\u98ce\u9669\u589e\u52a0\u76f8\u5173\uff0c\u5728\u591a\u56e0\u7d20\u5206\u6790\u4e2d\u6821\u6b63\u5176\u4ed6\u80a5\u80d6\u7279\u5f81\u540e\uff0c\u5df2\u4e0d\u518d\u63d0\u793a\u4e0ePBC\u53d1\u75c5\u76f8\u5173\u3002<\/span><\/p>\n

\u5728PSC\u7684\u591a\u56e0\u7d20\u5206\u6790\u4e2d\uff0c\u6821\u6b63\u7a7a\u8179\u8840\u7cd6\/\u7a7a\u8179\u80f0\u5c9b\u7d20\/ 2\u578b\u7cd6\u5c3f\u75c5\u540e\uff0cHbA1c (OR = 0.369, 95%CI 0.138 ~ 0.986, P = 0.046)\u4ecd\u53ef\u964d\u4f4ePSC\u7684\u53d1\u75c5\u98ce\u9669\u3002\u4f46\u5728\u591a\u56e0\u7d20\u5206\u6790\u4e2d\uff0c\u6821\u6b63\u5176\u4ed6\u80a5\u80d6\u7279\u5f81\u540e\uff0c\u9ad8BMI (OR = 0.763, 95%CI 0.344 ~ 1.691, P = 0.505)\u4e0ePSC\u7684\u53d1\u751f\u65e0\u5173\u3002<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n

\u672c\u7814\u7a76\u63d0\u4f9b\u4e8629\u4e2a\u9057\u4f20\u9884\u6d4b\u7684\u53ef\u6539\u53d8\u5371\u9669\u56e0\u7d20\u4e0ePSC\u3001PBC\u548cAIH\u98ce\u9669\u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\u7684\u8bc1\u636e\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3aAILD\u7684\u7ba1\u7406\u548c\u9884\u9632\u7b56\u7565\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span>\u8fd8\u5728\u4e3a\u6bd5\u4e1a\u53d1\u6101\u7684\u5b9d\u5b50\uff0c\u4e0d\u59a8\u5c1d\u8bd5\u590d\u73b0\u4e00\u4e0b\uff0c\u6295\u8fd9\u4e2a\u671f\u520a\uff0c\u6ca1\u65f6\u95f4\u6574\u5408\u6216\u8005\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u4e0d\u719f\u6089\u7684\u5c0f\u4f19\u4f34\u4e5f\u53ef\u4ee5\u4ea4\u7ed9\u5c0f\u4e91\uff0c\u4e13\u4e1a\u56e2\u961f\u4e3b\u6253\u8ba9\u60a8\u6ee1\u610f~ <\/span><\/strong><\/p>\n

\n
\n
\n
\n
\n
\n
\"7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~\"<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u70ed\u70b9\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\u5355\u7ec6\u80de\u6d4b\u5e8f<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\u80bf\u7624\u514d\u75ab\u4e0e\u5fae\u73af\u5883<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\u673a\u5668\u5b66\u4e60<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\u5355\u57fa\u56e0\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u751f\u4fe1\u4e91\u670d\u52a1\u5668<\/strong><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/mp-style-type><\/p>\n

\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u4e91\u751f\u4fe1\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff09\uff1a7+\u7eaf\u751f\u4fe1\u53cb\u597dTop\u671f\u520a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u516c\u5171\u6570\u636e\u6316\u6398\u7686\u53ef\u6295\uff01\u9752\u5927\u9644\u9662\u5218\u660e\u519b\u56e2\u961f\uff0c0\u5b9e\u9a8c51\u5929\u8f7b\u677e\u62ff\u4e0b\uff0c\u590d\u73b0\u4e86\u76f4\u63a5\u6bd5\u4e1a~<\/a><\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0d\u77e5\u4e0d\u89c9\u53c8\u5230\u4e86\u6bd5\u4e1a\u5b63\uff0c\u6bcf\u5e74\u8fd9\u65f6\u5019\u90fd\u4f1a\u6709\u4e00\u7fa4\u5c0f\u4f19\u4f34\u5982\u70ed\u9505\u4e0a\u7684\u8682\u8681\u4e00\u822c\u6349\u6025\uff0c\u4e3a\u4ec0\u4e48\u5462\uff1f\u56e0\u4e3a\u6ca1\u6587\u7ae0\u6bd5\u4e1a\u5457~\u522b\u95ee\u5c0f\u4e91\u600e […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43312"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43312"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43312\/revisions"}],"predecessor-version":[{"id":46817,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43312\/revisions\/46817"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43312"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}