{"id":43331,"date":"2024-06-02T01:15:44","date_gmt":"2024-06-01T17:15:44","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43331"},"modified":"2024-06-11T10:32:49","modified_gmt":"2024-06-11T02:32:49","slug":"db85fefb4a","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43331","title":{"rendered":"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~"},"content":{"rendered":"
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\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/p>\n

\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF\uff09\u76f8\u4fe1\u5927\u5bb6\u90fd\u4e0d\u964c\u751f\uff0c\u5728\u764c\u75c7\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c<\/span>\u901a\u8fc7\u8c03\u63a7CAFs\u6216\u514b\u670d\u5176\u5c4f\u969c\u4f5c\u7528\u6291\u5236\u80bf\u7624\u4e5f\u662f\u80bf\u7624\u6cbb\u7597\u7684\u65b0\u624b\u6bb5<\/span>\u3002\u76ee\u524d\u4e5f\u6709\u5f88\u591a\u76f8\u5173\u6587\u7ae0\u53d1\u8868\u3002<\/span><\/p>\n

\u73af\u72b6RNA\uff08circRNA\uff09\u81ea1976\u5e74\u88ab\u53d1\u73b0\uff0c\u7ecf\u8fc730\u591a\u5e74\u7684\u6c89\u5bc2\u540e\uff0c\u57282013\u5e74\u4e00\u9e23\u60ca\u4eba\uff0c\u5e76\u5728\u968f\u540e\u51e0\u5e74\u65f6\u95f4\u91cc\u8fc5\u901f\u6210\u4e3a\u65b0\u4e00\u4ee3\u660e\u661f\u5206\u5b50\u3002<\/span>\u8fd1\u5e74\u6765\uff0c\u73af\u72b6RNA\u76f8\u5173\u7814\u7a76\u7206\u70b8\u5f0f\u589e\u957f<\/span>\u3002<\/span><\/p>\n

\u90a3\u4e48\uff0c\u8fd9\u4e24\u5927\u70ed\u70b9\u7ed3\u5408\u4f1a\u8fbe\u5230\u4ec0\u4e48\u6837\u7684\u6548\u679c\u5462\uff1f\u7b54\u6848\u662f37+\u6587\u7ae0\u6536\u5165\u56ca\u4e2d\uff01\uff01\uff01<\/span><\/p>\n

\u4eca\u5929\u5206\u4eab\u7684\u8fd9\u7bc7\u6587\u732e\u5c31\u662f\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u7b2c\u56db\u533b\u9662\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u6559\u6388\u56e2\u961f\u8fd1\u671f\u5728<\/span>Molecular Cancer<\/span>\u6742\u5fd7\u53d1\u8868\u7684\u9898\u4e3a\u201ccircNOX4 activates an infammatory fbroblast niche to promote tumor growth and metastasis in NSCLC via FAP\/IL-6 axis\u201d\u4e0eCAF\u548c\u73af\u72b6RNA\u8fd9\u4e24\u5927\u70ed\u70b9\u76f8\u5173\u7684\u6587\u7ae0\u3002<\/span><\/span>\u8be5\u7814\u7a76\u7d27\u63e1circRNA\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e24\u5927\u70ed\u70b9\uff0c\u91c7\u7528\u591a\u79cd\u5b9e\u9a8c\u624b\u6bb5\uff08\u751f\u7269\u4fe1\u606f\u5b66\u3001\u514d\u75ab\u7ec4\u5316\u3001circRNA\u5fae\u9635\u5217\u5206\u6790\u3001\u8367\u5149\u539f\u4f4d\u6742\u4ea4\u53caRNA\u514d\u75ab\u6c89\u6dc0\u7b49\uff09\u5e76\u7ed3\u5408\u4f53\u5185\u5916\u6a21\u578b\uff0c<\/span>\u5168\u9762\u8bc4\u4f30\u4e86circNOX4\u7684\u529f\u80fd\u548c\u673a\u5236\u3002<\/span><\/span>PS\uff1a\u6070\u597d\uff0c\u5c0f\u4e91\u4e0d\u624d\uff0c\u4e5f\u5c31\u4f1a\u4e00\u4e9b\u4ec0\u4e48\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u5566\uff0c\u601d\u8def\u8bbe\u8ba1\u5566\u7b49\u7b49\uff0c\u7ecf\u6211\u624b\u7684SCI\u6ca1\u6709\u51e0\u4e07\u4e5f\u6709\u51e0\u5343\uff0c\u54c8\u54c8\uff0c\u5141\u8bb8\u6211\u51e1\u5c14\u8d5b\u4e00\u4e0b~\u5750\u7b49\u5404\u4f4d\u5149\u4e34\uff01<\/span><\/o:page><\/p>\n

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\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/p>\n

\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/span><\/p>\n

\u9898\u76ee\uff1acircNOX4\u901a\u8fc7FAP\/IL-6\u8f74\u6fc0\u6d3b\u708e\u6027\u6210\u7ea4\u7ef4\u7ec6\u80de\u9f9b\uff0c\u4fc3\u8fdbNSCLC\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb<\/span><\/p>\n

\u6742\u5fd7\uff1aMolecular Cancer<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=37.3<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e743\u6708<\/span><\/p>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\uff0c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u4e14\u5df2\u6709\u7814\u7a76\u8868\u660e\u4fc3\u8fdb\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u764c\u75c7\u8f6c\u79fb\u53d1\u5c55\u3002\u7531\u4e8eCAFs\u7684\u5f02\u8d28\u6027\u548c\u53ef\u5851\u6027\uff0c\u64cd\u63a7\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6fc0\u6d3b\u8868\u578b\u662f\u764c\u75c7\u6cbb\u7597\u7684\u4e00\u4e2a\u6709\u524d\u666f\u7684\u7b56\u7565\u3002\u7136\u800c\uff0c\u9a71\u52a8\u8f6c\u79fb\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u6fc0\u6d3b\u548c\u8868\u578b\u8f6c\u6362\u7684\u6f5c\u5728\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002<\/span><\/p>\n

\u672c\u7814\u7a76\u7814\u7a76\u63a2\u8ba8\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u6fc0\u6d3b\u86cb\u767d\uff08FAP\uff09\u9633\u6027CAFs\u7684\u4e34\u5e8a\u610f\u4e49\uff0c\u5e76\u7b5b\u9009\u4e86CAF\u7279\u5f02\u6027\u73af\u72b6RNA\uff08circRNAs\uff09\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684CAF\u7279\u5f02\u6027circRNA\uff0ccircNOX4\uff0c\u5b83\u901a\u8fc7miR-329-5p\/FAP\/IL-6\u8f74\u4fc3\u8fdb\u4e86NSCLC\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n

\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/span><\/p>\n

\u7814\u7a76\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n

1.FAP\u5728NSCLC TME\u4e2d\u7684\u8868\u8fbe\u53ca\u5176\u4e34\u5e8a\u610f\u4e49<\/span><\/p>\n

\u4e00\u65b9\u9762\u6536\u96c6NSCLC\u60a3\u8005\u7684\u80bf\u7624\u6837\u672c\uff0c\u5229\u7528<\/span>\u514d\u75ab\u7ec4\u5316\u67d3\u8272<\/span>\uff08<\/span>IHC<\/span>\uff09\u5bf9FAP\u7684\u8868\u8fbe\u8fdb\u884c\u8bc4\u4f30\uff0c\u53d1\u73b0FAP\u5728\u80bf\u7624\u95f4\u8d28\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u4e0e\u80bf\u7624\u7684\u4fb5\u88ad\u6027\u548c\u591a\u53d1\u8fdc\u7aef\u8f6c\u79fb\u5448\u6b63\u76f8\u5173\uff1b\u53e6\u4e00\u65b9\u9762\u5728TCGA\u6570\u636e\u5e93\u4e2d\uff0c\u5229\u7528<\/span><\/span>\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790<\/span>\u9a8c\u8bc1\u4e86FAP\u5728\u80ba\u817a\u764c\uff08LUAD\uff09\u548c\u80ba\u9cde\u764c\uff08LUSC\uff09\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u6b63\u5e38\u80ba\u7ec4\u7ec7\u663e\u8457\u4e0a\u8c03\u3002<\/span><\/span>\uff08PS\uff1a\u60f3\u901a\u8fc7\u751f\u7269\u4fe1\u606f\u5b66\u6316\u6398\u516c\u5171\u6570\u636e\u5e93\u6765\u5b8c\u6210KPI\u7684\u670b\u53cb\uff0c\u6216\u8005\u624b\u5934\u6709\u8d44\u6e90\u4f46\u6ca1\u65f6\u95f4\u6574\u5408\u7684\u670b\u53cb\uff0c\u7edf\u7edf\u770b\u8fc7\u6765\uff0c\u5c0f\u4e91\u5c31\u662f\u90a3\u4e2a\u5929\u9009\u56e2\u961f\uff01\u6211\u8fd9\u8fb9\u968f\u65f6\u5f85\u547d\uff0c\u4e07\u4e8b\u4ff1\u5907\uff0c\u5c31\u5dee\u4f60\u5566\uff01\uff09<\/span><\/p>\n

\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/p>\n

2.circNOX4\u5728CAF\u4e2d\u8868\u8fbe\u4e0a\u8c03\uff0c\u4e0eNSCLC\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u76f8\u5173<\/span><\/p>\n

\u5bf9CFAs\u548cNFs\uff08\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\uff09\u8fdb\u884c<\/span>circRNA\u5fae\u9635\u5217\u7b5b\u9009<\/span>\uff0c\u5e76\u5229\u7528<\/span>ceRNA\u7f51\u7edc<\/span>\u3001<\/span>\u51dd\u80f6\u7535\u6cf3<\/span>\u548c<\/span>Sanger\u6d4b\u5e8f<\/span>\u6280\u672f\u6700\u7ec8\u5f97\u5230circNOX4\u662f\u5728CAFs\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u7684circRNA\uff1b\u901a\u8fc7<\/span>qRT-PCR<\/span>\u548c<\/span>\u8367\u5149\u539f\u4f4d\u6742\u4ea4<\/span>\uff08FISH\uff09\u53d1\u73b0circNOX4\u5728CAFs\u4e2d\u8868\u8fbe\u663e\u8457\u4e0a\u8c03\uff0c\u4e14\u5728\u7624\u5185\u95f4\u8d28\u4e2d\u8868\u8fbe\u3002<\/span>\u5355\u56e0\u7d20\u548c\u591a\u56e0\u7d20Cox\u56de\u5f52<\/span>\u6a21\u578b\u663e\u793a\uff0c\u9ad8\u8868\u8fbe\u7684circNOX4\u4e0eNSCLC\u60a3\u8005\u7684\u8fdc\u5904\u8f6c\u79fb\u548c\u4e0d\u826f\u9884\u540e\u76f8\u5173\u8054\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0ccircNOX4\u4e0e\u8f6c\u79fb\u8fdb\u5c55\u76f8\u5173\uff0c\u53ef\u80fd\u662fNSCLC\u60a3\u8005\u7684\u9884\u540e\u6807\u5fd7\u7269\u3002<\/span> <\/span><\/o:page><\/p>\n

\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/span><\/p>\n

3.circNOX4\u8bf1\u5bfc\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u5e76\u4fc3\u8fdbNSCLC\u4f53\u5916\u8fc1\u79fb\u548c\u4fb5\u88ad<\/span><\/p>\n

\u91c7\u7528<\/span>\u57fa\u56e0\u6572\u9664\u548c\u8fc7\u8868\u8fbe<\/span>\u6280\u672f\uff0c\u89c2\u5bdfcircNOX4\u6572\u4f4e\u6216\u8fc7\u8868\u8fbe\u5bf9\u7ec6\u80de\u884c\u4e3a\u7684\u5f71\u54cd\u3002\u901a\u8fc7<\/span>CCK-8<\/span>\u3001<\/span>\u80f6\u539f\u6536\u7f29\u5b9e\u9a8c<\/span>\u3001\u5212\u75d5\u6108\u5408\u5b9e\u9a8c\u53ca<\/span>transwell\u5171\u57f9\u517b\u7cfb\u7edf<\/span>\uff0c\u53d1\u73b0circNOX4\u7684\u8fc7\u8868\u8fbe\u589e\u5f3a\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6536\u7f29\u80fd\u529b\uff0c\u8fc7\u8868\u8fbecircNOX4\u589e\u52a0\u4e86\u764c\u7ec6\u80de\u7684\u8fc1\u79fb\u80fd\u529b\uff0c\u4fc3\u8fdb\u4e86A549\u548cPC9\u7ec6\u80de\u7684\u4fb5\u88ad\u3002<\/span><\/span><\/p>\n

\"IF=37.3!\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u8d75\u65b0\u660e\u3001\u5218\u4e3d\u534e\u56e2\u961f\u51ed\u4e00\u5df1\u4e4b\u529b\u6380\u8d77\u201c\u6210\u7ea4\u7ef4\u7ec6\u80de\u201d\u5185\u5377\uff01\u73af\u72b6RNA\u52a9\u529b\u7684\u5929\u82b1\u677f\u601d\u8def\uff0c\u5185\u5bb9\u592a\u4e30\u5bcc\u5566~\"<\/span><\/p>\n

4.circNOX4\u7684\u6572\u4f4e\u53ef\u51cf\u8f7bCAF\u4ecb\u5bfc\u7684NSCLC\u4f53\u5185\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb<\/span><\/p>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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