{"id":43358,"date":"2024-06-02T01:16:01","date_gmt":"2024-06-01T17:16:01","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43358"},"modified":"2024-06-11T10:33:15","modified_gmt":"2024-06-11T02:33:15","slug":"ce4f010065","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43358","title":{"rendered":"\u540c\u6d4e\u5927\u5b66\u533b\u5b66\u9662\u5f20\u6625\u6797\u6559\u6388\u5e26\u9886\u56e2\u961f\u53c8\u5377\u8d77\u6765\u4e86\uff0110\u79cd\u673a\u5668\u5b66\u4e60101\u79cd\u7ec4\u5408+AI\u884d\u751f\u6280\u672f\uff0c\u5b9e\u529b\u62ff\u4e0b1\u533a10.6\u9ad8\u5206\uff01"},"content":{"rendered":"
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\"\u540c\u6d4e\u5927\u5b66\u533b\u5b66\u9662\u5f20\u6625\u6797\u6559\u6388\u5e26\u9886\u56e2\u961f\u53c8\u5377\u8d77\u6765\u4e86\uff0110\u79cd\u673a\u5668\u5b66\u4e60101\u79cd\u7ec4\u5408+AI\u884d\u751f\u6280\u672f\uff0c\u5b9e\u529b\u62ff\u4e0b1\u533a10.6\u9ad8\u5206\uff01\"<\/p>\n

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1\u3001\u5927\u6837\u672c\u6570\u636e\u589e\u52a0\u6587\u7ae0\u53ef\u9760\u6027\uff1a<\/span><\/strong>\u672c\u7bc7\u5c0610\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7ec4\u5408\u6210101\u79cd\u7ec4\u5408\uff0c\u4ece\u4e2d\u5efa\u7acb\u4e86\u57fa\u4e8e254\u4e2a\u6837\u672c\u8f6c\u5f55\u7ec4\u8c31\u9884\u6d4b\u603b\u751f\u5b58\u7684\u6700\u4f73\u6a21\u578b\u3002<\/span><\/p>\n

2\u3001\u591a\u56e0\u7d20\u7ed3\u5408\u7a81\u663e\u6587\u7ae0\u521b\u65b0\u6027\uff1a<\/span><\/strong>\u672c\u6587\u5c06AIDPI\u4e0e\u4e34\u5e8a\u56e0\u7d20\u5408\u5e76\uff0c\u6a21\u578b\u751f\u6210\u7684\u4eba\u5de5\u667a\u80fd\u884d\u751f\u9884\u540e\u6307\u6570(AIDPI)\u662f\u4e00\u79cd\u72ec\u7acb\u7684\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4f18\u4e8e\u4e34\u5e8a\u75c5\u7406\u56e0\u7d20\u548c\u5148\u524d\u53d1\u8868\u7684\u7279\u5f81\u3002\u5c06AIDPI\u4e0e\u4e34\u5e8a\u56e0\u7d20\u5408\u5e76\u53ef\u63d0\u9ad8\u9884\u6d4b\u51c6\u786e\u6027\u3002<\/span><\/p>\n

3\u3001\u5e72\u6e7f\u7ed3\u5408\u9a8c\u8bc1\u7ed3\u8bba\u51c6\u786e\u6027\uff1a<\/span><\/strong>\u672c\u6587\u5b9e\u9a8c\u7ed3\u679c\u9ad8AIDPI\u7ec4\u7684\u60a3\u8005\u8868\u73b0\u51fa\u5316\u7597\u8010\u836f\u6027\uff0c\u540c\u65f6MYC\u548cSQLE\u8fc7\u8868\u8fbe\uff0cmTORC1\u4fe1\u53f7\u901a\u8def\u589e\u52a0\uff0cPI3K-Akt\u4fe1\u53f7\u901a\u8def\u4e2d\u65ad\uff0c\u514d\u75ab\u6d78\u6da6\u51cf\u5c11\uff0c\u6709\u6548\u8bc1\u5b9e\u4e86\u672c\u6587\u5b9e\u9a8c\u7ed3\u8bba\uff0c\u8868\u660eAIDPI\u662f\u8bc6\u522bOSA\u60a3\u8005\u7684\u4e00\u4e2a\u53ef\u9760\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n

\u60f3\u53d1\u9ad8\u5206\u6587\u7ae0\u7684\u5c0f\u4f19\u4f34\u4eec\uff0c\u8d76\u7d27\u7801\u4f4f\u8fd9\u4e9b\u601d\u8def\u884c\u52a8\u8d77\u6765\u5427~<\/span>(ps\uff1a\u5c0f\u4e91\u8fd9\u91cc\u6709\u65b0\u9c9c\u51fa\u7089\u7684\u751f\u4fe1\u70ed\u70b9\uff0c\u8fd8\u6709\u597d\u7528\u7684\u670d\u52a1\u5668\u4f9b\u4f60\u4f7f\u7528\uff0c\u6b22\u8fce\u6765call\u54e6)  <\/span><\/strong><\/p>\n

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\"\u540c\u6d4e\u5927\u5b66\u533b\u5b66\u9662\u5f20\u6625\u6797\u6559\u6388\u5e26\u9886\u56e2\u961f\u53c8\u5377\u8d77\u6765\u4e86\uff0110\u79cd\u673a\u5668\u5b66\u4e60101\u79cd\u7ec4\u5408+AI\u884d\u751f\u6280\u672f\uff0c\u5b9e\u529b\u62ff\u4e0b1\u533a10.6\u9ad8\u5206\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

  <\/span><\/p>\n

\"\u540c\u6d4e\u5927\u5b66\u533b\u5b66\u9662\u5f20\u6625\u6797\u6559\u6388\u5e26\u9886\u56e2\u961f\u53c8\u5377\u8d77\u6765\u4e86\uff0110\u79cd\u673a\u5668\u5b66\u4e60101\u79cd\u7ec4\u5408+AI\u884d\u751f\u6280\u672f\uff0c\u5b9e\u529b\u62ff\u4e0b1\u533a10.6\u9ad8\u5206\uff01\"<\/p>\n

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\u6742\u5fd7\uff1aClin. Transl. Med.<\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50\uff1aIF=10.6<\/span><\/section>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e741\u6708<\/span><\/p>\n

\u5173\u6ce8\u516c\u4f17\u53f7\uff0c\u540e\u53f0\u53d1\u9001<\/span>\u201c123\u201d<\/span>\u53ef\u4ee5\u76f4\u63a5\u83b7\u53d6\u539f\u6587PDF\uff0c\u6587\u732e\u7f16\u53f7\uff1a240515<\/span><\/section>\n
<\/mp-common-videosnap><\/section>\n
<\/span><\/section>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

\u9aa8\u8089\u7624\uff08OSA\uff09\u662f\u4e00\u4e2a\u4e34\u5e8a\u6311\u6218\uff0c\u51765\u5e74\u751f\u5b58\u7387\u8f83\u4f4e\u3002\u76ee\u524d\uff0c\u7531\u4e8e\u7f3a\u4e4f\u5148\u8fdb\u7684\u5206\u5c42\u6a21\u578b\uff0c\u4f7f\u4e2a\u6027\u5316\u6cbb\u7597\u53d8\u5f97\u56f0\u96be\u3002\u672c\u7814\u7a76\u65e8\u5728\u5bfb\u627e\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5bf9\u9ad8\u5371OSA\u60a3\u8005\u8fdb\u884c\u5206\u5c42\u5e76\u6307\u5bfc\u6cbb\u7597\u3002<\/span><\/p>\n

\u6570\u636e\u6765\u6e90<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u7c7b\u578b<\/span><\/p>\n<\/td>\n

\n

\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE21257<\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

n=53<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE33382 <\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

n=82<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE16091<\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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n=34<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE14827<\/span><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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n=27<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE87437<\/span><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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n=21<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE42352<\/span>        <\/span><\/o:page><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

3\u4e2a\u6210\u9aa8\u7ec6\u80de[OBs]\uff0c12\u4e2a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de[MSCs]\u548c19\u4e2aOSA\u7ec6\u80de\u7cfb<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE16089<\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

\u6297MTX\u7684Saos2\u53ca\u5176\u4eb2\u672c\u7ec6\u80de\u7cfb\uff0c\u5206\u522b\u67093\u4e2a\u91cd\u590d<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE9967<\/span><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

\u6765\u81ea18\u4f8b\u60a3\u8005\u7684OSA\u6837\u672c\u548c\u914d\u5bf9\u7684\u6b63\u5e38\u9aa8\u7ec4\u7ec7\u7684RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE238110<\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

186\u4f8b\u521d\u7ea7\u72acOSA\u6837\u672c\u7684RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

CCLE-23Q2<\/span><\/p>\n<\/td>\n

\n

CCLE<\/span><\/p>\n<\/td>\n

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\u7ec6\u80de\u7cfb\u591a\u7ec4\u5b66<\/span><\/p>\n<\/td>\n

\n

\u6279\u91cfRNAseq\u3001\u57fa\u56e0\u6c34\u5e73\u62f7\u8d1d\u6570\u6570\u636e\u548c\u6a21\u578b\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PRJNA681896<\/span><\/p>\n<\/td>\n

\n

Sra<\/span><\/p>\n<\/td>\n

\n

scRNA-seq<\/span><\/p>\n<\/td>\n

\n

6\u4e2aOSA\u6d3b\u68c0\u6837\u672c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u7684\u539f\u59cb\u6570\u636e<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PRJNA698672<\/span><\/p>\n<\/td>\n

\n

Sra<\/span><\/p>\n<\/td>\n

\n

scRNA-seq<\/span><\/p>\n<\/td>\n

\n

\u5305\u62ec\u6765\u81ea4\u540d\u60a3\u8005\u7684OSA\u7ec4\u7ec7\u548c\u914d\u5bf9\u7684\u90bb\u8fd1\u6b63\u5e38\u7ec4\u7ec7<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7814\u7a76\u601d\u8def<\/span><\/p>\n

\u672c\u658710\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7ec4\u5408\u6210101\u79cd\u7ec4\u5408\uff0c\u4ece\u4e2d\u5efa\u7acb\u4e86\u57fa\u4e8e254\u4e2a\u6837\u672c\u8f6c\u5f55\u7ec4\u8c31\u9884\u6d4b\u603b\u751f\u5b58\u7684\u6700\u4f73\u6a21\u578b\u3002\u8bc4\u4f30\u4e86\u8f6c\u5f55\u7ec4\u3001\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u666f\u89c2\u7684\u6539\u53d8\uff0c\u4ee5\u9610\u660e\u5bfc\u81f4\u9884\u540e\u4e0d\u826f\u7684\u673a\u5236\u3002scRNA-seq\u63ed\u793a\u4e86OSA\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u7684\u57fa\u56e0\u4f5c\u4e3a\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u901a\u8fc7\u6c89\u9ed8SQLE\u901a\u8fc7\u964d\u4f4e\u80c6\u56fa\u9187\u548c\u6291\u5236FAK\/PI3K\/Akt\/mTOR\u901a\u8def\u6765\u963b\u788dOSA\uff0c\u6700\u540eSQLE\u6291\u5236\u5242\u5728\u4f53\u5185\u6291\u5236OSA\u8fdb\u5c55\uff0c\u63d0\u9ad8\u5316\u7597\u6548\u679c\u3002<\/span><\/o:page><\/section>\n

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1\u3001AIDPI\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1<\/span><\/p>\n

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3\u3001\u786e\u5b9a\u9ad8AIDPI\u60a3\u8005\u7684\u6cbb\u7597\u9776\u70b9<\/span><\/p>\n

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