{"id":43384,"date":"2024-06-02T01:16:16","date_gmt":"2024-06-01T17:16:16","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43384"},"modified":"2024-06-11T11:43:06","modified_gmt":"2024-06-11T03:43:06","slug":"1124333dfa","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43384","title":{"rendered":"Advanced Science\uff01\u673a\u5668\u5b66\u4e60\u4e0d\u6127\u662f\u6700\u5f3a\u8f85\u52a9\uff0c\u5de8\u566c\u7ec6\u80de+\u5355\u7ec6\u80de\u6d4b\u5e8f\u62ff\u634f\u5f97\u6b7b\u6b7b\u7684\uff01\u601d\u8def\u544a\u6025\u5c31\u770b\u6d59\u5927\u8d75\u9e4f\u56e2\u961f\u8fd9\u7bc7\u6587\u7ae0\uff01"},"content":{"rendered":"
\n
\"Advanced<\/section>\n
\u4eca\u5929\u8981\u7ed9\u5c0f\u4f19\u4f34\u4eec\u5e26\u6765\u70b9\u4e0d\u4e00\u6837\u7684\u77e5\u8bc6\uff01\u6cdb\u764c\u7814\u7a76\u662f\u4e00\u79cd\u7efc\u5408\u6027\u7684\u79d1\u7814\u65b9\u6cd5\uff0c\u6d89\u53ca\u5bf9\u591a\u79cd\u7c7b\u578b\u764c\u75c7\u7684\u5171\u540c\u7279\u5f81\u548c\u5dee\u5f02\u6027\u8fdb\u884c\u7cfb\u7edf\u6027\u5206\u6790\u3002\u6211\u4eec\u90fd\u77e5\u9053\uff0c\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u800c\u6cdb\u764c\u7814\u7a76\u5219\u53ef\u901a\u8fc7\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u548c\u5355\u7ec6\u80de\u5206\u6790\u7b49\u6280\u672f\uff0c\u63ed\u793a\u5de8\u566c\u7ec6\u80de\u5728\u4e0d\u540c\u764c\u75c7\u4e2d\u7684\u591a\u6837\u6027\u548c\u590d\u6742\u6027\u3002<\/span>\u8fd9\u79cd\u521b\u65b0\u6027\u7684\u7ed3\u5408\u6210\u4e3a\u8fd1\u5e74\u6765\u79d1\u5b66\u5bb6\u4eec\u63a2\u7a76\u80bf\u7624\u5fae\u73af\u5883\u7684\u91cd\u8981\u51fa\u53d1\u70b9\uff0c\u9ad8\u5206\u6587\u7ae0\u5c42\u51fa\u4e0d\u7a77\uff01<\/span><\/section>\n
\u4eca\u5929\u8981\u5411\u5927\u5bb6\u5206\u4eab\u8fd9\u7bc7\u53d1\u8868\u5728\u300aAdvanced Science\u300b\uff08IF-15.1\uff09\u7684\u6587\u7ae0\uff0c\u4fbf\u5229\u7528\u673a\u5668\u5b66\u4e60\u8054\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u89c1\u89e3\uff0c\u6784\u5efa\u4e86\u80fd\u4e00\u79cd\u9884\u6d4b\u6cdb\u764c\u60a3\u8005ICI\u6cbb\u7597\u7684M.Sig\u6a21\u578b\uff01\u73b0\u5728\u8ddf\u7740\u5c0f\u4e91\u4e00\u8d77\u8d70\u8fd1\u8fd9\u7bc7\u9ad8\u5f71\u54cd\u6587\u7ae0\uff0c\u770b\u770b\u5b83\u7a76\u7adf\u6709\u600e\u6837\u7684\u9b45\u529b\u5427~<\/span><\/section>\n
1\u3001\u672c\u7814\u7a76\u805a\u7126\u4e8e<\/span>\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u54cd\u5e94\u9884\u6d4b<\/span>\uff0c\u901a\u8fc7\u63a2\u7d22<\/span><\/span>APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span>\uff0c\u4e3a\u7406\u89e3ICI\u6cbb\u7597\u53cd\u5e94\u7684\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u89c6\u89d2\u3002<\/span><\/section>\n
2\u3001\u672c\u7814\u7a76\u7ed3\u5408<\/span>\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5<\/span>\uff0c\u5728\u7ec6\u80de\u5c42\u9762\u4e0a\u89e3\u6790\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u7efc\u5408\u5206\u6790\u5927\u91cf\u6570\u636e\uff0c\u7814\u7a76\u8005\u4eec\u6784\u5efa\u4e86M.Sig\u6a21\u578b\uff0c\u5e76\u5229\u7528\u771f\u5b9e\u4e16\u754c\u7684\u514d\u75ab\u6cbb\u7597\u6570\u636e\u8fdb\u884c\u4e86\u6709\u6548\u7684\u9a8c\u8bc1\uff0c\u5c55\u793a\u4e86\u5176\u65b9\u6cd5\u7684\u4e25\u8c28\u6027\u548c\u521b\u65b0\u6027\u3002<\/span>\uff08ps\uff1a<\/span><\/span><\/strong><\/span>\u60f3\u8ba9\u4f60\u7684\u7814\u7a76\u8bfe\u9898\u7cbe\u51c6\u547d\u4e2d\uff0c\u8bba\u6587\u53d1\u8868\u5982\u63a2\u56ca\u53d6\u7269\uff1f\u522b\u6025\uff0c\u5c0f\u4e91\u6765\u5e2e\u5fd9\uff01\u5404\u79cd\u751f\u4fe1\u5206\u6790\u4e00\u7f51\u6253\u5c3d\uff0c\u800c\u4e14\u8fd8\u6709\u7269\u7f8e\u4ef7\u5ec9\u7684\u673a\u5668\u5b66\u4e60\u8bfe\u7a0b\u4e3a\u4f60\u52a9\u653b\uff01<\/span>\uff09<\/span><\/span><\/span><\/span><\/o:page><\/section>\n
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\"Advanced<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/section>\n
\"Advanced<\/span><\/section>\n

\u9898\u76ee\uff1a\u6cdb\u764c\u75c7\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u5206\u8fa8\u56fe\u8c31\u5206\u6790\u63ed\u793a APOE+ \u5de8\u566c\u7ec6\u80de\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/span><\/span><\/p>\n

\u6742\u5fd7\uff1aAdvanced Science<\/span><\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=15.1<\/span><\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e744\u6708<\/span><\/span><\/section>\n
\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u5df2\u7ecf\u6210\u4e3a\u591a\u79cd\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u7684\u4e3b\u6d41\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80c3\u80a0\u764c\u7b49\u3002\u7136\u800c\uff0c\u5c3d\u7ba1ICIs\u5728\u6cbb\u7597\u67d0\u4e9b\u764c\u75c7\u65b9\u9762\u663e\u793a\u51fa\u4e86\u663e\u8457\u7684\u7597\u6548\uff0c\u4f46\u4e34\u5e8a\u5e94\u7528\u4e2d\u4ecd\u5b58\u5728\u4e00\u4e9b\u9650\u5236\uff0c\u5982\u6709\u9650\u7684\u54cd\u5e94\u7387\u548c\u4e00\u4e9b\u526f\u4f5c\u7528\u3002\u8fd9\u4e9b\u9650\u5236\u4fc3\u4f7f\u7814\u7a76\u8005\u5f00\u53d1\u751f\u7269\u6807\u5fd7\u7269\u6765\u9884\u6d4b\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\uff0c\u5e76\u4f18\u5316\u6cbb\u7597\u65b9\u6848\u4ee5\u514b\u670d\u514d\u75ab\u62b5\u6297<\/span>\u3002\u4f20\u7edf\u7684\u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\u4e3b\u8981\u5173\u6ce8\u80bf\u7624\u7ec4\u7ec7\u7684\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\uff08WES\uff09\u6216RNA\u6d4b\u5e8f\uff08RNA-seq\uff09\uff0c\u4f46\u8fd9\u4e9b\u65b9\u6cd5\u4ec5\u53cd\u6620\u4e86\u80bf\u7624\u7684\u5e73\u5747\u9057\u4f20\u7279\u5f81\uff0c\u5982\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u7684\u8868\u8fbe\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u548c\u80bf\u7624\u7a81\u53d8\u8d1f\u62c5\uff08TMB\uff09\u3002\u6700\u8fd1\uff0c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u6280\u672f\u7684\u53d1\u5c55\u4e3a\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u63d0\u4f9b\u4e86\u591a\u79cd\u6280\u672f\uff0c\u6709\u52a9\u4e8e\u8bc6\u522b\u66f4\u654f\u611f\u7684\u6807\u8bb0\u7269\u3002<\/span><\/section>\n
\u7814\u7a76\u601d\u8def<\/span><\/o:page><\/section>\n
\"Advanced<\/span><\/section>\n
\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n
1\u3001\u4e00\u4e2a\u57fa\u4e8e\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7684M.Sig\u6a21\u578b\u80fd\u591f\u6709\u6548\u9884\u6d4b\u6cdb\u764c\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u7684\u53cd\u5e94\u548c\u9884\u540e<\/span><\/section>\n
\u901a\u8fc7\u6574\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f(scRNA-seq)\u548c\u6279\u91cfRNA\u6d4b\u5e8f\u6570\u636e\uff0c\u7814\u7a76\u8005\u6784\u5efa\u4e86\u4e00\u4e2a\u9884\u6d4b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\u6cbb\u7597\u53cd\u5e94\u7684M.Sig\u6a21\u578b\u3002\u968f\u540e\uff0c\u4ed6\u4eec\u5229\u7528\u4e86\u516b\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5bf9\u6a21\u578b\u8fdb\u884c\u8bad\u7ec3\u548c\u4f18\u5316\uff0c\u5e76\u901a\u8fc7\u4ea4\u53c9\u9a8c\u8bc1(CV)\u6765\u7cbe\u7ec6\u5316\u6a21\u578b\u53c2\u6570\u3002\u5728\u8bad\u7ec3\u96c6\u4e2d\uff0c<\/span>\u652f\u6301\u5411\u91cf\u673a(SVM)\u6a21\u578b\u5c55\u73b0\u4e86\u6700\u9ad8\u7684\u533a\u57df\u4e0b\u66f2\u7ebf(<\/span>AUC<\/span>)\u503c\uff0c\u8fbe\u5230\u4e860.72\uff0c\u88ab\u9009\u4e3a\u6700\u7ec8\u6a21\u578b<\/span><\/span>\u3002\u5728\u9a8c\u8bc1\u96c6\u4e2d\uff0c<\/span>\u8be5\u6a21\u578b\u7684AUC\u503c\u4fdd\u6301\u57280.74\uff0c\u663e\u793a\u4e86\u6a21\u578b\u7684\u7a33\u5b9a\u6027\u548c\u6709\u6548\u6027<\/span>\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u8fd8\u901a\u8fc7\u7279\u5f81\u6392\u540d\u8ba1\u7b97\u4e86AUC\u503c\uff0c\u5e76\u5b9a\u4e49\u4e86\u5305\u542b35\u4e2a\u7279\u5f81\u7684M.Sig\u6a21\u578b\u3002<\/span>\u8be5\u6a21\u578b\u5728\u8bad\u7ec3\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e2d\u7684AUC\u503c\u4e0e\u4e4b\u524d\u76f8\u6bd4\u53d8\u5316\u4e0d\u5927\uff0c\u8868\u660e\u6a21\u578b\u5177\u6709\u8f83\u597d\u7684\u6cdb\u5316\u80fd\u529b<\/span>\u3002\u901a\u8fc7\u6bd4\u8f83M.Sig\u6a21\u578b\u4e0e\u5176\u4ed613\u4e2a\u5df2\u77e5\u7684\u514d\u75ab\u76f8\u5173\u7b7e\u540d\uff0c\u7814\u7a76\u8005\u53d1\u73b0M.Sig\u6a21\u578b\u5728\u8bad\u7ec3\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e2d\u7684AUC\u503c\u5747\u9ad8\u4e8e\u5176\u4ed6\u6a21\u578b\uff0c\u8bc1\u5b9e\u4e86M.Sig\u6a21\u578b\u5728\u9884\u6d4bICI\u6cbb\u7597\u53cd\u5e94\u65b9\u9762\u7684\u4f18\u8d8a\u6027\u3002<\/span><\/span><\/span><\/section>\n
\"Advanced<\/span><\/span><\/section>\n
\u56fe1 \u6a21\u578b\u6784\u5efa\u7684\u5de5\u4f5c\u6d41\u7a0b\u3001\u4e0d\u540c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7684AUC\u503c\u6bd4\u8f83<\/span><\/section>\n
2\u3001\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u4e2d\uff0c\u975e\u54cd\u5e94\u8005\u4e2dAPOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u6bd4\u54cd\u5e94\u8005\u9ad8<\/span><\/section>\n
\u901a\u8fc7\u4f7f\u7528t-\u5206\u5e03\u968f\u673a\u90bb\u57df\u5d4c\u5165\uff08tSNE\uff09\u6280\u672f\u5bf9\u5de8\u566c\u7ec6\u80de\u8fdb\u884c\u964d\u7ef4\u5904\u7406\uff0c\u7814\u7a76\u8005\u80fd\u591f\u5c06\u5de8\u566c\u7ec6\u80de\u7ec6\u5206\u4e3a\u4e0d\u540c\u7684\u4e9a\u7fa4\uff0c\u5e76\u53d1\u73b0\u5728ICI\u6cbb\u7597\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u4e2d\uff0c<\/span>\u975e\u54cd\u5e94\u8005\u4f53\u5185APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u54cd\u5e94\u8005<\/span>\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u591a\u8def\u514d\u75ab\u7ec4\u5316\uff08multiplex immunohistochemistry, mIHC\uff09\u5206\u6790\uff0c\u7814\u7a76\u8005\u8fdb\u4e00\u6b65\u786e\u8ba4\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\u7ec6\u80de\uff08Tex\uff09\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u79cd\u4f5c\u7528\u53ef\u80fd\u901a\u8fc7\u514d\u75ab\u6291\u5236\u673a\u5236\u5f71\u54cdICI\u6cbb\u7597\u7684\u6548\u679c\u3002\u7814\u7a76\u8005\u8fd8\u89c2\u5bdf\u5230\uff0c<\/span>\u5728\u54cd\u5e94\u8005\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u8ddd\u79bb\u8f83\u975e\u54cd\u5e94\u8005\u66f4\u957f\uff0c\u800c\u5728\u975e\u54cd\u5e94\u8005\u4e2d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u66f4\u4e3a\u7d27\u5bc6<\/span>\u3002<\/span><\/span><\/span><\/section>\n
\"Advanced<\/span><\/section>\n
\u56fe2 \u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u5de8\u566c\u7ec6\u80de\u4e9a\u7fa4\u7684 M.Sig.Score \u4e0d\u540c<\/span><\/span><\/section>\n
3\u3001APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\uff08Tex\uff09\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528    <\/span><\/o:page><\/section>\n
\u901a\u8fc7\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u4e2d\u8fdb\u884c\u7ec6\u80de\u95f4\u901a\u4fe1\uff08Cell-Cell Interaction, CCI\uff09\u5206\u6790\uff0c\u7814\u7a76\u8005\u53d1\u73b0<\/span>APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ T\u7ec6\u80de\u4e4b\u95f4\u5b58\u5728\u5927\u91cf\u7684\u7ec6\u80de\u95f4\u901a\u4fe1\uff0c\u5c24\u5176\u662f\u5728\u975e\u54cd\u5e94\u8005\u4e2d\uff0cCD8+ T\u7ec6\u80de\u663e\u793a\u51fa\u589e\u52a0\u7684\u5165\u7ad9\u901a\u4fe1\u5f3a\u5ea6\uff0c\u800cAPOE+\u5de8\u566c\u7ec6\u80de\u5219\u663e\u793a\u51fa\u589e\u52a0\u7684\u51fa\u7ad9\u901a\u4fe1\u5f3a\u5ea6<\/span>\u3002\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u63ed\u793a\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u7279\u5b9a\u901a\u4fe1\u6a21\u5f0f\uff0c\u5176\u4e2dAPOE+\u5de8\u566c\u7ec6\u80de\u4e0a\u7684MIF\uff08CD74+CXCR4\uff09\u53d7\u4f53\u7684\u901a\u4fe1\u4f5c\u7528\u5c24\u4e3a\u663e\u8457\uff0c\u53ef\u80fd\u901a\u8fc7\u514d\u75ab\u6291\u5236\u4f5c\u7528\u5f71\u54cdICI\u7684\u7597\u6548\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u5229\u7528\u6765\u81ea\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08TCGA\uff09\u548c\u57fa\u56e0\u8868\u8fbe\u7efc\u5408\u6570\u636e\u5e93\uff08GEO\uff09\u7684TNBC\u8f6c\u5f55\u6570\u636e\uff0c\u8ba1\u7b97\u4e86\u76f8\u5e94\u7684Exhausted.score\u548cAPOE.score\uff0c\u5e76\u53d1\u73b0\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c<\/span>APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u662f\u5bfc\u81f4TNBC\u60a3\u8005ICI\u6cbb\u7597\u5931\u8d25\u7684\u5173\u952e\u56e0\u7d20\u4e4b\u4e00<\/span>\u3002<\/span><\/span><\/span><\/section>\n
\"Advanced<\/span><\/span><\/section>\n
\u56fe3 APOE+\u5de8\u566c\u7ec6\u80de\u4e0e CD8+ Tex \u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd TNBC \u7684 ICI \u53cd\u5e94<\/span><\/section>\n
4\u3001APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\uff08Tex\uff09\u7ec6\u80de\u4e4b\u95f4\u7684\u7a7a\u95f4\u8ddd\u79bb\u5bf9ICI\u6cbb\u7597\u53cd\u5e94\u7684\u5f71\u54cd<\/span><\/section>\n
\u7814\u7a76\u8005\u9009\u53d6\u4e86\u63a5\u53d7ICI\u6cbb\u7597\u7684\u54cd\u5e94\u8005\u548c\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u6837\u672c\uff0c\u901a\u8fc7mIHC\u6280\u672f\u89c2\u5bdf\u5230\u5728\u54cd\u5e94\u8005\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u8ddd\u79bb\u8f83\u957f\uff0c\u800c\u5728\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7684\u8ddd\u79bb\u8f83\u77ed\u3002\u901a\u8fc7\u7a7a\u95f4\u5206\u6790\uff0c\u7814\u7a76\u8005\u6d4b\u91cf\u4e86CD8+ Tex\u7ec6\u80de\u548cCD8+\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u5230APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6700\u8fd1\u8ddd\u79bb\uff0c\u53d1\u73b0<\/span>\u5728\u54cd\u5e94\u8005\u4e2d\u5927\u591a\u6570CD8+ Tex\u7ec6\u80de\u4f4d\u4e8eAPOE+\u5de8\u566c\u7ec6\u80de200\u5fae\u7c73\u4ee5\u5916\uff0c\u800c\u5728\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cCD8+ Tex\u7ec6\u80de\u6570\u91cf\u66f4\u591a\u4e14\u66f4\u63a5\u8fd1APOE+\u5de8\u566c\u7ec6\u80de<\/span>\u3002\u76f8\u53cd\uff0cCD8+\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u4e0eAPOE+\u5de8\u566c\u7ec6\u80de\u7684\u8ddd\u79bb\u5728\u54cd\u5e94\u8005\u4e2d\u8f83\u77ed\u3002<\/span><\/span><\/o:page><\/section>\n
5\u3001APOE\u6291\u5236\u5242\u4e0eICI\u6cbb\u7597\u7684\u8054\u5408\u4f7f\u7528\u663e\u793a\u51fa\u6700\u4f73\u7684\u6cbb\u7597\u6548\u679c<\/span><\/section>\n
\u901a\u8fc7\u5efa\u7acb4T1\u8377\u7624\u5c0f\u9f20\u6a21\u578b\uff0c\u7814\u7a76\u8005\u5c06\u5c0f\u9f20\u968f\u673a\u5206\u4e3a\u56db\u7ec4\uff1a\u5bf9\u7167\u7ec4\uff08G1\uff09\u3001APOE\u6291\u5236\u5242\uff08COG 133 TFA\uff09\u6cbb\u7597\u7ec4\uff08G2\uff09\u3001\u6297PD-1\u6cbb\u7597\u7ec4\uff08G3\uff09\u4ee5\u53caAPOE\u6291\u5236\u5242\u548c\u6297PD-1\u8054\u5408\u6cbb\u7597\u7ec4\uff08G4\uff09\u3002\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u4ece\u7b2c8\u5929\u5f00\u59cb\uff0c\u901a\u8fc7\u4f53\u5185\u6210\u50cf\u6280\u672f\u89c2\u5bdf\u5404\u7ec4\u5c0f\u9f20\u80bf\u7624\u5927\u5c0f\u7684\u53d8\u5316\u3002\u7ed3\u679c\u663e\u793a\uff0c<\/span>\u8054\u5408\u6cbb\u7597\u7ec4\uff08G4\uff09\u5728\u80bf\u7624\u6291\u5236\u6548\u679c\u4e0a\u8868\u73b0\u6700\u4f73\uff0c\u4e0e\u80bf\u7624\u57fa\u7ebf\u76f8\u6bd4\uff0c\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u5dee\u5f02<\/span>\u3002\u6b64\u5916\uff0c\u901a\u8fc7Hematoxylin-eosin\uff08H&E\uff09\u67d3\u8272\u3001ki67\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u67d3\u8272\u548c\u591a\u91cd\u514d\u75ab\u7ec4\u5316\uff08mIHC\uff09\u67d3\u8272\u5bf9\u5c0f\u9f20\u80bf\u7624\u6807\u672c\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u5206\u6790\u3002H&E\u67d3\u8272\u786e\u8ba4\u4e86\u80bf\u7624\u7ec4\u7ec7\u7684\u5b58\u5728\uff0c\u800cki67\u9633\u6027\u7387\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u6700\u4f4e\uff0c\u8868\u660e\u8be5\u7ec4\u7684\u80bf\u7624\u589e\u6b96\u6f5c\u529b\u53d7\u5230\u6291\u5236\u3002mIHC\u67d3\u8272\u7ed3\u679c\u8868\u660e\uff0c<\/span>\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u8ddd\u79bb\u4e0d\u8d85\u8fc7100\u5fae\u7c73\u7684\u7ec6\u80de\u6570\u91cf\u663e\u8457\u4f4e\u4e8e\u5176\u4ed6\u7ec4\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86APOE\u6291\u5236\u5242\u80fd\u591f\u901a\u8fc7\u5e72\u6270APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u589e\u5f3aICI\u6cbb\u7597\u7684\u6548\u679c<\/span>\u3002<\/span><\/span><\/span><\/section>\n
\"Advanced<\/span><\/span><\/section>\n
\u56fe4 adapalene\u5bf9PCa\u7ec6\u80de\u4e2dRA\u4fe1\u53f7\u548c\u4ee3\u8c22\u9014\u5f84\u7684\u5f71\u54cd<\/span><\/section>\n
6\u3001\u9a8c\u8bc1M.Sig\u6a21\u578b\u7684\u6cdb\u764c\u9002\u7528\u6027<\/span><\/section>\n
\u5728\u9a8c\u8bc1M.Sig\u6a21\u578b\u7684\u6cdb\u764c\u9002\u7528\u6027\u65b9<\/span>\u9762\uff0c\u7814\u7a76\u8005\u91c7\u7528\u4e86\u771f\u5b9e\u4e16\u754c\u7684\u514d\u75ab\u6cbb\u7597\u6570\u636e\u8fdb\u884c\u5206\u6790\u3002\u4ed6\u4eec\u5229\u7528\u4e86\u6765\u81ea\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u6570\u636e\u96c6\uff0c\u901a\u8fc7\u5355\u6837\u672c\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\uff08ssGSEA\uff09\u7b97\u6cd5\u6765\u8bc4\u4f30\u6bcf\u4e2a\u57fa\u56e0\u5728M.Sig\u6a21\u578b\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u636e\u6b64\u8ba1\u7b97\u4e86M.Sig\u5f97\u5206\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5141\u8bb8\u7814\u7a76\u8005\u4eec\u8bc4\u4f30\u4e2a\u4f53\u60a3\u8005\u5bf9ICI\u6cbb\u7597\u7684\u53ef\u80fd\u53cd\u5e94\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c<\/span>M.Sig\u6a21\u578b\u5728\u591a\u4e2a\u764c\u75c7\u961f\u5217\u4e2d\u5c55\u73b0\u51fa\u4e86\u8f83\u9ad8\u7684\u51c6\u786e\u6027\uff0c\u80fd\u591f\u6709\u6548\u9884\u6d4b\u60a3\u8005\u5bf9ICI\u6cbb\u7597\u7684\u53cd\u5e94<\/span>\u3002<\/span><\/span><\/span><\/section>\n
\"Advanced<\/span><\/span><\/section>\n
\u56fe5 \u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u4e2d\u514d\u75ab\u7ec6\u80de\u666f\u89c2\u7684UMAP\u56fe<\/span><\/o:page><\/section>\n
\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n
\u672c\u7814\u7a76\u901a\u8fc7\u6574\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f(scRNA-seq)\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684M.Sig\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u80fd\u591f\u6709\u6548\u9884\u6d4b\u6cdb\u764c\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\u6cbb\u7597\u7684\u53cd\u5e94\u548c\u9884\u540e\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u4e2d\uff0c\u975e\u54cd\u5e94\u8005\u4f53\u5185APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u54cd\u5e94\u8005\uff0c\u4e14APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT(Tex)\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ca\u7a7a\u95f4\u8ddd\u79bb\u4e0eICI\u6cbb\u7597\u53cd\u5e94\u5bc6\u5207\u76f8\u5173\u3002\u6b64\u5916\uff0cAPOE\u6291\u5236\u5242\u4e0eICI\u7684\u8054\u5408\u4f7f\u7528\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6700\u4f73\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u4e3a\u63d0\u9ad8ICI\u6cbb\u7597\u6548\u679c\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/span>\u5bf9\u673a\u5668\u5b66\u4e60\u611f\u5174\u8da3\u7684\u5b9d\u5b50\u4e00\u5b9a\u4e0d\u8981\u9519\u8fc7\u6211\u4eec\u7684\u81ea\u5b66\u8bfe\u7a0b\u54e6~<\/span><\/section>\n
<\/mp-common-product><\/section>\n
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\"Advanced<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

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\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70ed\u70b9\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u7ec6\u80de\u6d4b\u5e8f<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u4e0e\u5fae\u73af\u5883<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u673a\u5668\u5b66\u4e60<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u57fa\u56e0\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u751f\u4fe1\u4e91\u670d\u52a1\u5668<\/strong><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/span><\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u4e91\u751f\u4fe1\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff09\uff1aAdvanced Science\uff01\u673a\u5668\u5b66\u4e60\u4e0d\u6127\u662f\u6700\u5f3a\u8f85\u52a9\uff0c\u5de8\u566c\u7ec6\u80de+\u5355\u7ec6\u80de\u6d4b\u5e8f\u62ff\u634f\u5f97\u6b7b\u6b7b\u7684\uff01\u601d\u8def\u544a\u6025\u5c31\u770b\u6d59\u5927\u8d75\u9e4f\u56e2\u961f\u8fd9\u7bc7\u6587\u7ae0\uff01<\/a><\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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