{"id":43420,"date":"2024-06-02T01:16:32","date_gmt":"2024-06-01T17:16:32","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43420"},"modified":"2024-06-11T11:41:31","modified_gmt":"2024-06-11T03:41:31","slug":"b5363cdfff","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43420","title":{"rendered":"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01"},"content":{"rendered":"
\n
<\/mp-common-profile><\/section>\n
\u5927\u5bb6\u597d\uff0c\u5e08\u54e5\u4eca\u5929\u7ed9\u5927\u5bb6\u5e26\u6765\u7684\u8fd9\u7bc7\u6587\u7ae0\uff0c\u5206\u503c\u4e0d\u662f\u6700\u9ad8\uff0c\u4f46\u662f\u975e\u5e38\u5438\u775b\uff0c\u81ea\u5e26\u5149\u73af\uff0c\u6bd5\u7adf\u63a2\u8ba8\u7684\u53ef\u662f\u582a\u79f0\u201c\u795e\u836f\u201d\u7684\u5c0f\u6a97\u78b1\uff08<\/span>BBR<\/span>\uff09\u3002\u5c0f\u6a97\u78b1\u88ab\u8bc1\u660e\u5177\u6709\u591a\u79cd\u836f\u7406\u4f5c\u7528\uff0c\u5305\u62ec\u6297\u83cc\u3001\u6297\u708e\u3001\u964d\u8840\u7cd6\u3001\u964d\u8840\u8102\u3001\u6297\u52a8\u8109\u786c\u5316\u3001\u6297<\/span>AD<\/span>\u548c\u6297\u6c27\u5316\u7b49\uff0c\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u5e7f\uff0c\u7814\u7a76\u610f\u4e49\u5927\u3002<\/span><\/span><\/section>\n
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<\/mp-common-profile><\/section>\n
\"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01\"<\/span>    <\/span><\/o:page><\/section>\n
l<\/span>\u9898\u76ee\uff1a\u7b5b\u9009\u5e76\u9274\u5b9a\u5c0f\u6a97\u78b1\u6297\u708e\u7684\u5173\u952e\u9776\u6807EIF2AK2<\/span><\/span><\/section>\n
l<\/span>\u671f\u520a\uff1aActa Pharm Sin B<\/span><\/span><\/section>\n
l<\/span>IF=14.5<\/span><\/span><\/section>\n
l<\/span>\u89c1\u520a\uff1a2023<\/span>.5<\/span><\/span><\/section>\n
\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
\u5c0f\u6a97\u78b1\u88ab\u8bc1\u660e\u5177\u6709\u591a\u79cd\u836f\u7406\u4f5c\u7528\uff0c\u7279\u522b\u662f\u6297\u83cc\u3001\u6297\u708e\u65b9\u9762\u7b49\uff0c\u4f46\u662f\u5bf9\u5176\u5177\u4f53\u7684\u9776\u70b9\u57fa\u56e0\u9274\u5b9a\u4ecd\u9700\u8fdb\u4e00\u6b65\u7684\u63a2\u8ba8\u3002\u672c\u6587\u4f5c\u8005\u8ba1\u5212\u5229\u7528ABPP\u6280\u672f\uff0c\u7b5b\u9009\u5e76\u9274\u5b9aBBR\u7684\u5173\u952e\u6297\u708e\u57fa\u56e0\u3002<\/span><\/section>\n
\u7814\u7a76\u601d\u8def<\/span><\/section>\n
1\uff0c<\/span>\u901a\u8fc7\u7ec6\u80de\u5b66\u5b9e\u9a8c\uff0c\u7b5b\u9009\u51fa\u6700\u6709\u6548\u7684<\/span>BBR<\/span>\u5149\u4eb2\u548c\u63a2\u9488\uff0c\u7528\u4e8e\u540e\u7eed\u9776\u70b9\u7b5b\u9009\uff1b<\/span><\/span><\/section>\n
2\uff0c<\/span>\u5229\u7528\u4e0a\u8ff0\u63a2\u9488\uff0c\u901a\u8fc7ABPP\u6280\u672f\uff0c\u6316\u6398<\/span>BBR<\/span>\u7684\u6f5c\u5728\u9776\u70b9\u57fa\u56e0\uff0c\u5e76\u8fdb\u884c\u9a8c\u8bc1\uff1b<\/span><\/span><\/section>\n
3\uff0c<\/span>\u901a\u8fc7\u5206\u5b50\u5bf9\u63a5\u548c\u5355\u70b9\u7a81\u53d8\u6280\u672f\uff0c\u786e\u8ba4<\/span>BBR<\/span>\u4e0e\u9776\u70b9\u57fa\u56e0<\/span>EIF2AK2<\/span>\u7684\u7ed3\u5408\u57df\uff1b<\/span><\/span><\/section>\n
4\uff0c\u4f53\u5185\/\u4f53\u5916\u5b9e\u9a8c\u63a2\u7a76EIF2AK2\u6297\u708e\u7684\u5177\u4f53\u9014\u5f84\uff1b<\/span><\/section>\n
\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n
1. BBR\u5149\u4eb2\u548c\u63a2\u9488<\/span>\u7b5b\u9009<\/span><\/span><\/section>\n
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\"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01\"<\/span><\/p>\n

\u56fe1 BBR\u5149\u4eb2\u548c\u63a2\u9488\u7b5b\u9009<\/span><\/section>\n
2. BBR\u76ee\u6807\u8bc6\u522b<\/span>\u53ca\u914d\u5bf9\u9a8c\u8bc1<\/span><\/span><\/section>\n
\u752811b\u63a2\u9488\u4e0eTHP-1\u7ec6\u80de\u5904\u7406\uff0c\u5c06\u6807\u8bb0\u7684\u86cb\u767d\u8d28\u7ec4\u4e0eCy3\u8fde\u63a5\u540e\uff0c\u901a\u8fc7SDS-PAGE\u7535\u6cf3\u5206\u79bb\u3001LC-MS\/MS\u5206\u6790\uff0c\u83b7\u5f9744\u4e2aBBR\u7684\u6f5c\u5728\u9776\u6807\uff08\u56fe2B-C\uff09\uff0c\u5e76\u901a\u8fc7WB\u5b9e\u9a8c\u8fdb\u884c4\u4e2a\u9776\u6807\u7684\u9a8c\u8bc1\uff08\u56fe2D\uff09\u3002\u901a\u8fc7CETSA\u5b9e\u9a8c\uff0c\u68c0\u6d4b\u786e\u8ba4BBR\u4e0e\u56db\u79cd\u9776\u6807\u7684\u914d\u5bf9(\u56fe3A)\u3002\u901a\u8fc7\u91cd\u7ec4\u86cb\u767dSPR\u5206\u6790\u4ee5\u53ca\u5206\u5b50\u5bf9\u63a5\u5206\u6790\uff0c\u518d\u6b21\u786e\u8ba4BBR\u4e0e\u9776\u6807\u4e4b\u95f4\u7684\u4f5c\u7528(\u56fe3B-G)\u3002<\/span><\/o:page><\/section>\n

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\u56fe2 \u76ee\u6807\u86cb\u767d\u5206\u6790<\/span><\/section>\n

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\u56fe3 BBR\u4e0e\u9776\u6807\u7684\u914d\u5bf9\u5206\u6790<\/span><\/o:page><\/section>\n
3. BBR\u4e0eEIF2AK2\u7684\u7ed3\u5408<\/span><\/section>\n
\u514d\u75ab\u5171\u6c89\u6dc0\uff08IP\uff09\u786e\u8ba4<\/span>BBR<\/span>\u53ef\u964d\u4f4e<\/span>EIF2AK2\u7684\u4e8c\u805a\u5316<\/span>\u53ca\u5e95\u7269\u78f7\u9178\u5316<\/span>\uff08\u56fe4A,B\uff09<\/span><\/span><\/section>\n

\"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01\"<\/span><\/p>\n

\u56fe4 BBR\u4e0eEIF2AK2\u7684\u7ed3\u5408<\/span><\/section>\n
4. EIF2AK2\u7684\u529f\u80fd\u7814\u7a76<\/span><\/section>\n
\u5bf9\u4e8eEIF2AK2\u7684\u5206\u5b50\u4f5c\u7528\uff0c\u4f5c\u8005\u901a\u8fc7\u6bd4\u8f83\u53d1\u73b0\uff0cBBR\u53ef\u4ee5\u6291\u5236NLRP3\u7684\u8868\u8fbe\uff0c\u800cC16\u867d\u7136\u53ef\u4ee5\u6291\u5236EIF2AK2\uff0c\u5374\u5bf9NLRP3\u65e0\u5f71\u54cd\uff0c\u7531\u6b64\u8868\u660e\uff0c<\/span>BBR<\/span>\u7684\u9776\u70b9\u662f<\/span>EIF2AK2<\/span>\uff08\u56fe5D-E)\u3002\u540c\u6837\u7684\u7ed3\u8bba\u4e5f\u51fa\u73b0\u5728\u5bf9\u8111\u7ec4\u7ec7\u7684\u68c0\u6d4b\uff0cBBR\u53ef\u8c03\u8282EIF2AK2\u6765\u6291\u5236\u8111\u708e\u75c7\uff08\u56fe5F-G\uff09\u3002<\/span><\/span><\/o:page><\/section>\n

\"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01\"<\/span><\/p>\n

\u56fe5 EIF2AK2\u7684\u529f\u80fd\u7814\u7a76<\/span><\/section>\n
6. EIF2AK2\u57fa\u56e0<\/span>\u7684\u4f53\u5185\u529f\u80fd\u9a8c\u8bc1<\/span><\/span><\/section>\n
\u4f5c\u8005\u5bf9<\/span>EIF2AK2<\/span>\u6572\u9664\u9f20\u65bd\u52a0<\/span>BBR<\/span>\u540e\uff0c\u53d1\u73b0<\/span>BBR<\/span>\u964d\u4f4e\u708e\u75c7\u56e0\u5b50\u7684\u8868\u578b\u88ab\u51cf\u5f31\uff08\u56fe6A-F\uff09\uff1b\u800c\u809d\u810f\u7684\u75c5\u7406\u67d3\u8272\u4e5f\u53d1\u73b0\uff0c\u57fa\u56e0\u6572\u9664\u9f20\u5bf9<\/span>BBR<\/span>\u7684\u964d\u4f4e\u809d\u810f\u708e\u75c7\u53d8\u5f97\u4e0d\u591f\u660e\u663e\uff08\u56fe6G\uff09\u3002<\/span><\/span><\/o:page><\/section>\n

\"IF14.5\uff01\u4e2d\u533b\u201c\u795e\u836f\u201d\u5c0f\u6a97\u78b1\u7684\u6297\u708e\u9776\u6807\u786e\u5b9a\uff1a\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u6c6a\u71d5\u7fd4\u56e2\u961f\uff0cABPP\u6280\u672f\u5999\u7528\uff0c\u4e00\u62db\u63a5\u4e00\u62db\u7684\u7cbe\u5f69\uff01\"<\/span><\/p>\n

\u56fe6 BBR\u7684\u9776\u70b9\u662fEIF2AK2\u7684\u4f53\u5185\u5b9e\u9a8c<\/span><\/section>\n
\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n
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