{"id":43449,"date":"2024-06-02T01:16:43","date_gmt":"2024-06-01T17:16:43","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43449"},"modified":"2024-06-11T11:41:07","modified_gmt":"2024-06-11T03:41:07","slug":"f56a3cdf28","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43449","title":{"rendered":"\u539f\u6765\u6211\u548cNature Communications\u5c31\u5dee\u4e2a\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff01\u6b66\u6c49\u5927\u5b66\u7f2a\u5c0f\u5e73\/\u7530\u5251\u6ce2\u56e2\u961f\u8054\u5408\u673a\u5668\u5b66\u4e60\u62ff\u4e0b16+\uff01"},"content":{"rendered":"
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\"\u539f\u6765\u6211\u548cNature<\/p>\n

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1.<\/span>\u672c\u7814\u7a76\u901a\u8fc7\u5bf9CMR\u56fe\u50cf\u8fdb\u884c\u4eba\u5de5\u667a\u80fd\u9ad8\u901a\u91cf\u8bc6\u522b\uff0c\u80fd\u591f\u5feb\u901f\u800c\u51c6\u786e\u5730\u5b9a\u91cf<\/span>\u5de6\u5fc3\u5ba4\u5ba4\u58c1\u533a\u57df\u539a\u5ea6<\/span>\uff0c\u4e14\u76f8\u6bd4\u76ee\u524d\u5e38\u7528\u7684\u56fe\u50cf\u8bc6\u522b\u7b97\u6cd5\uff0c\u5728\u8bc6\u522b\u901f\u5ea6\u548c\u51c6\u786e\u6027\u65b9\u9762\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u4f18\u52bf\u3002<\/span><\/span><\/section>\n
2.<\/span>\u901a\u8fc7\u6574\u5408MR\u548c\u89c2\u5bdf\u6027\u6570\u636e\uff0c\u63a2\u8ba8\u4e86\u5de6\u5fc3\u5ba4\u5ba4\u58c1\u533a\u57df\u539a\u5ea6\u4e0e\u591a\u79cd\u5fc3\u8840\u7ba1\u75be\u75c5\u4e4b\u95f4\u7684\u5173\u8054\u3002\u5e76\u7b5b\u9009\u5f71\u54cd\u5de6\u5fc3\u5ba4\u5ba4\u58c1\u533a\u57df\u539a\u5ea6\u8868\u578b\u53d8\u5f02\u7684\u57fa\u56e0\uff0c\u5206\u6790\u6f5c\u5728\u529f\u80fd\u3002<\/span><\/span><\/section>\n
3.<\/span>\u6570\u636e\u6765\u6e90\u4e8e\u516c\u5f00\u53ef\u7528\u7684\u6570\u636e\u96c6\u548c\u6570\u636e\u5e93\uff0c\u65b9\u4fbf\u79d1\u7814\u4eba\u5458\u8fdb\u884c\u5b66\u4e60\u548c\u590d\u73b0\u3002<\/span><\/span>\uff08PS\uff1a\u672c\u6587\u7684\u751f\u4fe1\u5206\u6790\u90e8\u5206\u7684\u6570\u636e\u90fd\u6765\u6e90\u4e8e\u516c\u5f00\u6570\u636e\u5e93\u548c\u7f51\u7ad9\uff0c\u5bb9\u6613\u590d\u73b0\uff0c\u611f\u5174\u8da3\u7684\u5b9d\u5b50\u76f4\u63a5\u626b\u7801\u627e\u6211\u5662\uff01\uff09<\/span><\/strong><\/section>\n
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\"\u539f\u6765\u6211\u548cNature<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

   <\/span><\/strong><\/o:page><\/section>\n
\"\u539f\u6765\u6211\u548cNature<\/span><\/section>\n

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\u6742\u5fd7\uff1aNature Communications<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=16.6<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7411\u6708<\/span><\/section>\n

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\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
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\u6b64\u5916\uff0c\u7eb3\u5165\u4e86\u6765\u81eaUKB\u6570\u636e\u96c6\u4e2d2006\u5e74\u81f32010\u5e74\u7684500\u5e45\u4e2d\u8154\u56fe\u50cf\u8fdb\u884c\u72ec\u7acb\u8bc4\u4f30\u3002\u6392\u9664\u6807\u51c6\u4e3a\uff1a\uff081\uff09\u6392\u9664\u5f71\u50cf\u5b66\u4e0d\u826f\u3001\u9057\u4f20\u6570\u636e\u4fe1\u606f\u7f3a\u5931\u3001\u65e2\u5f80\u5fc3\u808c\u6897\u6b7b\u3001\u5fc3\u529b\u8870\u7aed\u8bca\u65ad\u4ee5\u53ca\u4f53\u91cd\u6307\u6570(BMI) < 16\u6216> 40 kg\/m2\u7684\u53c2\u4e0e\u8005\uff1b\uff082\uff09\u6392\u9664\u6ca1\u6709\u57fa\u56e0\u578b\u6570\u636e\u7684\u4e2a\u4f53\uff1b\uff083\uff09\u6392\u9664\u7f3a\u5931\u5438\u70df\u548c\u996e\u9152\u4fe1\u606f\u7684\u53c2\u4e0e\u8005\uff1b\uff084\uff09\u6392\u9664\u5728\u5165\u7ec4UKB\u4e4b\u524d\u60a3\u6709\u76f8\u5e94\u75be\u75c5\u7684\u4e2a\u4f53\u3002\u6700\u7ec8\u6837\u672c\u91cf\u4e3a439,981\u4eba\u3002<\/span>        <\/span> <\/span> <\/o:p><\/section>\n
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1. \u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60\u5bf9\u5de6\u5fc3\u5ba4\u8fdb\u884c\u5206\u5272<\/span><\/section>\n
\u6240\u5efa\u7acb\u7684\u6d4b\u91cf\u539a\u5ea6\u7684SMM\u7a0b\u5e8f\u5982\u56fe1\u6240\u793a\u3002\u4e3a\u4e86\u5728\u5206\u5272\u4efb\u52a1\u4e2d\u5b9e\u73b0\u6700\u5148\u8fdb\u7684\u6027\u80fd\uff0c\u4f7f\u7528\u7531\u4e00\u4f4d\u4e34\u5e8a\u4e13\u5bb6\u6ce8\u91ca\u7684\u81ea\u52a8\u5fc3\u810f\u8bca\u65ad\u6311\u6218(ACDC)\u6570\u636e\u96c6\u6765\u8bad\u7ec3\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u5728382\u5f20\u6d4b\u8bd5\u56fe\u50cf\u4e2d\uff0c\u670980\u5f20\u56fe\u50cf\u5c5e\u4e8e\u4e24\u4e2a\u4e2d\u8154\u5207\u7247\u3002\u7531\u4e8e\u540e\u7eed\u5206\u6790\u4ec5\u4f7f\u7528\u4e2d\u8154\u5207\u7247\u91cf\u5316\u7ed3\u679c\uff0c\u56e0\u6b64\u6211\u4eec\u5bf9\u6bcf\u4e2a\u75c5\u4f8b\u7684\u4e24\u4e2a\u4e2d\u8154\u5207\u7247\u8fdb\u884c\u8bc4\u4f30\uff0c\u4ee5\u786e\u4fdd\u6bd4\u8f83\u7684\u4e00\u81f4\u6027\u3002\u6b64\u5916\uff0c\u7531\u4e8eGWAS\u662f\u5728UKB\u6570\u636e\u96c6\u4e0a\u6267\u884c\u7684\uff0c\u7eb3\u5165\u4e86\u6765\u81eaUKB\u6570\u636e\u96c6\u7684500\u5e45\u4e2d\u8154\u56fe\u50cf\u8fdb\u884c\u72ec\u7acb\u8bc4\u4f30\u3002\u4ece1420\u5f20ACDC\u56fe\u50cf\u4e2d\u8bad\u7ec3\u51fa\u57fa\u4e8eDeep Layer Aggregation\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b16,17\u4f5c\u4e3a\u7f51\u7edc\u67b6\u6784\u3002\u4ece\u8fd9\u4e9b\u6570\u636e\u4e2d\u8bad\u7ec3\u51fa\u57fa\u4e8e\u6df1\u5c42\u805a\u5408\uff08Deep Layer Aggregation\uff0cDLA\uff09\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u4f5c\u4e3a\u7f51\u7edc\u67b6\u6784\u3002\u7ecf\u8fc7\u8bad\u7ec3\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u968f\u540e\u88ab\u7528\u4e8e\u8f93\u51fa\u8d85\u8fc745,000\u4eba\u7684UKB\u6210\u50cf\u5b50\u7814\u7a76\u4e2d\u7684LV\u5206\u5272\u7ed3\u679c\u3002<\/span><\/section>\n
\"\u539f\u6765\u6211\u548cNature<\/section>\n
\u56fe1 \u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u5de6\u5fc3\u5ba4\u58c1\u539a\u5ea6\u6d4b\u91cf <\/span>   <\/span><\/o:page><\/section>\n
2. \u5de6\u5fc3\u5ba4\u533a\u57df\u58c1\u539a\u5ea6\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76<\/span><\/section>\n
\u4e3a\u4e86\u4e86\u89e3\u5fc3\u808c\u58c1\u539a\u53d8\u5f02\u7684\u5171\u540c\u9057\u4f20\u57fa\u7840\uff0c\u5bf9\u6bcf\u4e2a\u961f\u5217\u4e2d\u768412\u4e2aLVRWT\u6027\u72b6\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217GWAS\u3002\u5171\u9274\u5b9a\u51fa72\u4e2a\u4e0e12\u4e2aLVRWT\u6027\u72b6\u76f8\u5173\u7684\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u53d8\u5f02\uff08P<5\u00d710\u22128<\/sup>\uff09\uff0c\u5305\u62ec\u6536\u7f29\u672b\u671fIS\u768416\u4e2a\u53d8\u5f02\u3001I\u76842\u4e2a\u53d8\u5f02\u3001IL\u76847\u4e2a\u53d8\u5f02\u3001AL\u768410\u4e2a\u53d8\u5f02\u3001a\u76843\u4e2a\u53d8\u5f02\u548cAS\u76847\u4e2a\u53d8\u5f02\uff1b\u5728\u8212\u5f20\u672b\u671f\uff0cIS\u67095\u4e2a\u53d8\u5f02\uff0cI\u67093\u4e2a\u53d8\u5f02\uff0cIL\u67093\u4e2a\u53d8\u5f02\uff0cAL\u67094\u4e2a\u53d8\u5f02\uff0cA\u67093\u4e2a\u53d8\u5f02\uff0cAS\u67099\u4e2a\u53d8\u5f02\uff08\u56fe2\uff09\u3002<\/span><\/section>\n
\"\u539f\u6765\u6211\u548cNature    <\/span><\/o:page><\/section>\n
\u56fe2  12 \u79cd LVRWT \u8868\u578b\u7684\u5168\u57fa\u56e0\u7ec4\u5b66\u7ed3\u679c<\/span><\/section>\n
3. 12 \u4e2a LVRWT \u6027\u72b6\u98ce\u9669\u53d8\u5f02\u7684\u529f\u80fd\u8868\u5f81<\/span><\/section>\n
LVRWT GWAS\u57fa\u56e0\u5ea7\u5171\u5305\u542b6345\u4e2a\u8fde\u9501\u4e0d\u5e73\u8861\u5019\u9009\u53d8\u5f02\uff08LD, r2 >.6\uff09\u548c62\u4e2a\u5148\u5bfc\u53d8\u5f02\u3002\u4e3a\u4e86\u8868\u5f8112\u4e2aLVRWT\u6027\u72b6\u7684\u98ce\u9669\u53d8\u5f02\u7279\u5f81\uff0c\u6211\u4eec\u9996\u5148\u901a\u8fc7SnpEff19\u751f\u6210\u4e86\u63a7\u5236\u53d8\u5f02\u96c6\uff0c\u5e76\u529f\u80fd\u6027\u5730\u5b9a\u4e49\u4e86\u53d8\u5f02\u7684\u57fa\u56e0\u7ec4\u4f4d\u7f6e\u5206\u5e03\u3002\u4e0e\u5bf9\u7167\u53d8\u5f02\u4f53\u76f8\u6bd4\uff0c\u6211\u4eec\u53d1\u73b0\u98ce\u9669\u53d8\u5f02\u4f53\u5728\u5185\u542b\u5b50\u533a\u3001\u57fa\u56e0\u4e0a\u4e0b\u6e38\u533a\u548c\u57fa\u56e0\u95f4\u533a\u663e\u8457\u5bcc\u96c6\uff08\u56fe3a, b\uff09\u3002\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u98ce\u9669\u53d8\u5f02\u4f53\u662f\u5426\u5728\u9057\u4f20\u8c03\u63a7\u5143\u4ef6\u4e2d\u5bcc\u96c6\uff0c\u89c2\u5bdf\u5230\uff0c\u5728\u542f\u52a8\u5b50[H3K4\u4e09\u7532\u57fa\u5316\u6807\u8bb0(H3K4me3)]\u3001\u589e\u5f3a\u5b50[H3K4\u5355\u7532\u57fa\u5316\u6807\u8bb0(H3K4me1)\u3001H3K27\u4e59\u9170\u5316\u6807\u8bb0(H3K27ac)\u548cH3K36\u4e09\u7532\u57fa\u5316\u6807\u8bb0(H3K36me3)]\u548c\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u4f4d\u70b9(TFBSs)\u7684\u7ec4\u86cb\u767d\u6807\u8bb0\u4e2d\uff0c12\u4e2aLVRWT\u6027\u72b6\u7684\u98ce\u9669\u53d8\u5f02\u663e\u8457\u5bcc\u96c6\u3002\u800c\u6291\u5236\u8f6c\u5f55[H3K9\u4e09\u7532\u57fa\u5316\u6807\u8bb0(H3K9me3)]\u7684\u663e\u8457\u7f3a\u5931\uff08\u56fe3c\uff09\u300212\u4e2aLVRWT\u7684\u98ce\u9669\u53d8\u5f02\u5728CVD\u7684GWASs\u4f4d\u70b9\u4e2d\u663e\u8457\u5bcc\u96c6\uff08\u56fe3d\uff09\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u98ce\u9669\u53d8\u5f02\u53ef\u80fd\u901a\u8fc7\u6fc0\u6d3b\u67d3\u8272\u8d28\u72b6\u6001\u6765\u8c03\u8282\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u75c5\u7387\u589e\u52a0\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"\u539f\u6765\u6211\u548cNature<\/section>\n
\u56fe3  12 \u4e2a LVRWT \u6027\u72b6\u7684\u98ce\u9669\u53d8\u5f02\u7684\u529f\u80fd\u8868\u5f81<\/span><\/section>\n
4. \u5de6\u5fc3\u5ba4\u533a\u57df\u58c1\u539a\u76f8\u5173\u6613\u611f\u57fa\u56e0\u7684\u9274\u5b9a\u548c\u529f\u80fd\u6ce8\u91ca<\/span><\/section>\n
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\"\u539f\u6765\u6211\u548cNature<\/section>\n
\u56fe4 \u4e0e LVRWT \u76f8\u5173\u7684\u6613\u611f\u57fa\u56e0\u7684\u901a\u8def\u5bcc\u96c6\u548c\u7ec4\u7ec7\u5bcc\u96c6<\/span><\/section>\n
5.\u5de6\u5fc3\u5ba4\u533a\u57df\u58c1\u539a\u5ea6\u7684\u9057\u4f20\u6027\u548c\u9057\u4f20\u76f8\u5173\u6027<\/span><\/section>\n
\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7\u65b9\u5dee\u6210\u5206\u5206\u6790\u4f30\u8ba1\u53ef\u5f52\u56e0\u4e8e\u57fa\u56e0\u578b\u7684 LVRWT \u8868\u578b\u53d8\u5f02\u7684\u6bd4\u4f8b\u3002\u6536\u7f29\u672b\u671f\u9694\u5185 LVRWT \u7684\u5168\u57fa\u56e0\u7ec4\u53d8\u5f02\u9057\u4f20\u529b\u4f30\u8ba1\u503c\u6700\u9ad8\uff08ED-IS\uff0c\u4e3a 28%\uff09\uff0c\u5176\u6b21\u662f\u8212\u5f20\u672b\u671f\u9694\u4e0b LVRWT\uff08ED-IS\uff0c25%\uff09\uff0c\u800c\u8212\u5f20\u672b\u671f\u524d\u5916\u4fa7 LVRWT \u7684\u9057\u4f20\u529b\u8f83\u4f4e\uff0c\u9057\u4f20\u7387\u4e3a 17%\uff08\u56fe5a\uff09\u3002\u89c2\u5bdf\u5230 LVRWT \u6027\u72b6\u4e4b\u95f4\u7684\u663e\u8457\u9057\u4f20\u76f8\u5173\u6027\uff0c\u8303\u56f4\u4ece\u9ad8\u5230\u4f4e\uff08\u56fe5a\uff09\u3002\u8fd9\u53cd\u5e94\u4e86\u5728\u76f8\u540c\u5fc3\u810f\u5468\u671f\u9636\u6bb5\u7684\u533a\u57df\u4e4b\u95f4\u53d1\u73b0\u4e86\u5f88\u5f3a\u7684\u6b63\u76f8\u5173\u9057\u4f20\uff0c\u800c\u5728\u4e0d\u540c\u5fc3\u810f\u5468\u671f\u9636\u6bb5\u7684\u533a\u57df\u4e4b\u95f4\u53d1\u73b0\u4e86\u4e2d\u5ea6\u76f8\u5173\uff0c\u8fd9\u53ef\u80fd\u53cd\u6620\u4e86\u9057\u4f20\u6548\u5e94\u5bf9\u5fc3\u810f\u58c1\u53d1\u80b2\u7684\u5f71\u54cd\u3002<\/span>    <\/span><\/o:page><\/section>\n
\u7531\u4e8e LVRWT \u548c LV \u8154\u5ba4\u7684\u76f8\u4e92\u4f9d\u8d56\u6027\u4ee5\u53ca\u58c1\u539a\u91cd\u5851\u7684\u91cd\u8981\u6027\uff0c\u9996\u5148\u4f7f\u7528 LVRWT \u6c47\u603b\u7edf\u8ba1\u6570\u636e\u548c\u6700\u8fd1\u53d1\u8868\u7684 LV GWAS \u7684\u6c47\u603b\u6570\u636e\uff0c\u901a\u8fc7\u8fde\u9501\u4e0d\u5e73\u8861\u8bc4\u5206\u56de\u5f52 \uff08LDSC\uff09 \u5206\u6790\u6765\u91cf\u5316\u5b83\u4eec\u7684\u9057\u4f20\u76f8\u5173\u6027\u5f3a\u5ea6\u3002LVRWT\u6027\u72b6\u4e0e\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08LVEF\uff09\u548c\u6bcf\u640f\u8f93\u51fa\u91cf\uff08SV\uff09\u7b49\u5de6\u5fc3\u5ba4\u5bb9\u79ef\u548c\u529f\u80fd\u6027\u72b6\u5177\u6709\u9ad8\u5ea6\u6b63\u5411\u7684\u9057\u4f20\u76f8\u5173\u6027\uff0c\u8868\u660e\u5b83\u4eec\u6709\u5f3a\u70c8\u7684\u751f\u7406\u8054\u7cfb\uff08\u56fe5b\uff09\u3002\u6b64\u5916\uff0c\u8fd8\u7814\u7a76\u4e86 12 \u4e2a LVRWT \u6027\u72b6\u4e0e\u53ef\u80fd\u4ecb\u5bfc CVD \u8fdb\u5c55\u7684\u5fc3\u810f\u6d4b\u91cf\u503c\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\uff0cLVRWT\u6027\u72b6\u4e0e\u5fc3\u7387\u3001\u8212\u5f20\u538b\u548c\u6536\u7f29\u538b\u7b49\u6027\u72b6\u9ad8\u5ea6\u6b63\u76f8\u5173\uff08\u56fe5b\uff09\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4e86\u7814\u7a76LVRWT\u6027\u72b6\u9057\u4f20\u5b66\u4f5c\u4e3a\u7406\u89e3\u5fc3\u810f\u91cd\u5851\u9a71\u52a8\u56e0\u7d20\u7684\u8865\u5145\u9014\u5f84\u7684\u7406\u7531\u3002<\/span><\/section>\n
\u4e3a\u4e86\u68c0\u9a8cLVRWT\u6027\u72b6\u548cCVDs\u4e4b\u95f4\u7684\u5171\u540c\u9057\u4f20\u6548\u5e94\uff0c\u5bf911\u4e2a\u9009\u5b9a\u7684CVDs\u6027\u72b6\u7684GWAS\u6c47\u603b\u7edf\u8ba1\u8fdb\u884c\u4e86\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790\u3002\u6b63\u5982\u9884\u671f\u7684\u90a3\u6837\uff0c\u89c2\u5bdf\u5230 12 \u4e2a LVRWT \u6027\u72b6\u4e0e CVDs\uff08\u5982 HCM\u3001\u9ad8\u8840\u538b\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u3001\u6162\u6027\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u548c\u7f3a\u8840\u6027\u5352\u4e2d\uff09\u5448\u7edf\u8ba1\u5b66\u6b63\u9057\u4f20\u76f8\u5173\u6027\u3002\u4e0e\u5176\u4ed6LVRWT\u6027\u72b6\u76f8\u6bd4\uff0c\u8212\u5f20\u672b\u671f\u524dLVRWT\u4e0eHCM\u7684\u9057\u4f20\u76f8\u5173\u6027\u6700\u9ad8\uff0c\u5bf9\u4e8e\u9694\u4e0bLVRWT\uff0c\u89c2\u5bdf\u5230\u4e0e\u6536\u7f29\u671f\u548c\u8212\u5f20\u671f\u7ec8\u672bHCM\u7684\u9057\u4f20\u6b63\u76f8\u5173\u3002\u6b64\u5916\uff0c\u4e0e\u5176\u4ed6\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u6bd4\uff0cHCM \u4f5c\u4e3a\u75be\u75c5\u4e0e LVRWT \u7684\u9057\u4f20\u76f8\u5173\u6027\u4f30\u8ba1\u503c\u6700\u9ad8\uff08\u56fe5c\uff09\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u5173\u4e8eLVRWT\u6027\u72b6\u4e0eCVDs\u4e4b\u95f4\u9057\u4f20\u76f8\u5173\u6027\u7684\u53d1\u73b0\u4e3a\u9057\u4f20\u91cd\u53e0\u63d0\u4f9b\u4e86\u5b9a\u91cf\u652f\u6301\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"\u539f\u6765\u6211\u548cNature<\/span><\/section>\n
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