{"id":43531,"date":"2024-06-02T01:17:21","date_gmt":"2024-06-01T17:17:21","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43531"},"modified":"2024-06-06T08:41:31","modified_gmt":"2024-06-06T00:41:31","slug":"fef9244cac","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43531","title":{"rendered":"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01"},"content":{"rendered":"
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\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/a><\/section>\n
\u5404\u4f4d\u5c0f\u4f19\u4f34\u4eec\u5927\u5bb6\u597d\uff0c\u6211\u662f\u4e13\u6ce8\u4e8e\u751f\u4fe1\u5206\u6790\u7814\u7a76\u4e0e\u5b9e\u8df5\u7684\u5c0f\u4e91\u5440~\u4e13\u4e3a\u5927\u5bb6\u63d0\u4f9b\u72ec\u7279\u800c\u524d\u6cbf\u7684\u7814\u7a76\u9009\u9898\u3001\u5206\u6790\u601d\u8def\uff0c\u8fd9\u4e0d\uff0c\u4eca\u5929\u5c31\u7ed9\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u805a\u7126\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\u7684\u521b\u65b0\u529b\u6ee1\u6ee1\u7684\u6587\u7ae0\uff01<\/span><\/section>\n
\u7533\u535a\u518d\u6b21\u96be\u4e0a\u5929\u9645\uff01\u51e0\u5e74\u524d\u672c\u4eba\u7533\u535a\u8fd8\u7b97\u987a\u5229\uff0c\u53ef\u4eca\u5e74\u5c0f\u5e08\u59b9\u624b\u63e13\u7bc7SCI\u8fd8\u662f\u6ca1\u7ade\u4e89\u8fc7\u53e6\u5916\u51e0\u4f4d\u5927\u795e\uff0c\u53ef\u89c1\u8bf8\u4f4d\u51b2\u535a\u7684\u540c\u5b66\u771f\u662f\u201c\u6709bear\u6765\u201d\u5440~~~<\/span><\/section>\n
\u770b\u7740\u5e08\u59b9\u96be\u8fc7\uff0c\u9a6c\u4e0a\u62ff\u51fa\u4e86\u524d\u9635\u5b50\u5bfc\u5e08\u63a8\u8350\u7684\u6587\u732e\uff0c<\/span>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u3001\u673a\u5668\u5b66\u4e60\u3001\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u4e09\u7ba1\u9f50\u4e0b\uff0c\u5728\u8fc7\u654f\u6027\u75be\u75c5\u54ee\u5598AA\u548c\u6d41\u884c\u6027\u75be\u75c5COVID-19\u4e4b\u95f4\u5efa\u7acb\u8054\u7cfb\uff0c\u627e\u51fa\u8c03\u8282AA\u653b\u51fb\u548c\u9632\u5fa1COVID-19\u611f\u67d3\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u7684\u514d\u75ab\u7ec6\u80decDC2s<\/span>\u3002\u5176\u4e2d\u91cd\u8981\u7684\u51e0\u6b65\u662f\u8fd9\u6837\u64cd\u4f5c\u7684\uff1a<\/span><\/span><\/section>\n
1.<\/span>\u501f\u52a9<\/span>GWAS\u6570\u636e\u96c6\u548c\u53cc\u5411\u53cc\u6837\u672cMR\u5206\u6790\uff0c\u9009\u5b9a\u8840\u6db2\u53c2\u6570\u4f5c\u4e3a\u5371\u9669\u56e0\u7d20\uff0c\u7814\u7a76\u8fc7\u654f\u6027\u75be\u75c5\u4e0eCOVID-19\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb<\/span>\uff0c\u8bc1\u660e\u767d\u7ec6\u80de\u8ba1\u6570\u4f5c\u4e3aAA\u548cCOVID-19\u8054\u7cfb\u7684\u5173\u952e\u3002<\/span><\/span><\/section>\n
2.<\/span>\u4f7f\u7528<\/span>bulk\u8f6c\u5f55\u7ec4\u6570\u636e\u96c6\u8fdb\u884c\u673a\u5668\u5b66\u4e60\uff0c\u7b5b\u9009AA\u548cCOVID-19\u4e2d\u5171\u4eab\u7684\u6b67\u89c6\u6027\u514d\u75ab\u7ec6\u80de<\/span>\u3002<\/span><\/span><\/section>\n
3.<\/span>\u5bf9scRNA-seq\u6570\u636e\u8fdb\u884c\u80fd\u91cf\u4ee3\u8c22\u3001\u7ec6\u80de\u95f4\u901a\u8baf\u3001\u7ec6\u80de\u5e72\u6027\u548c\u5206\u5316\u4ee5\u53ca\u5206\u5b50\u5bf9\u63a5\u5206\u6790\uff0c\u7814\u7a76\u4e86cDC2s\u7684\u6570\u91cf\u3001\u6d3b\u6027\u3001\u7ec6\u80de\u95f4\u901a\u8baf\u548c\u5206\u5316<\/span>\uff0c\u5e76\u5229\u7528<\/span>\u5206\u5b50\u5bf9\u63a5\u5206\u6790\u63ed\u793a\u4e86cDC2s\u7684\u6297\u539f\u5448\u9012<\/span>\u8fc7\u7a0b\u3002<\/span>    <\/span><\/span><\/section>\n
\u6709\u8fd9\u6837\u7684\u53cc\u75be\u75c5\u7814\u7a76\u8303\u6587\uff0c\u8fd8\u4e0d\u5b66\u8d77\u6765\uff0c\u4f60\u7684SCI\u53d1\u8868\u9a6c\u4e0a\u4e0d\u5c31\u63d0\u4e0a\u65e5\u7a0b\u54af\uff01<\/span><\/strong>\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u548c\u673a\u5668\u5b66\u4e60\u611f\u5174\u8da3\u4f46\u6280\u672f\u53d7\u9650\u7684\uff0c\u6216\u662f\u5bf9\u751f\u4fe1\u5206\u6790\u65b9\u5411\u8ff7\u832b\u7684\u5b9d\u5b50\u4eec\uff0c\u5feb\u6765\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u626b\u9664\u969c\u788d\u5427\uff01<\/span><\/section>\n
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\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n

\u9898\u76ee\uff1a\u4f20\u7edf\u6811\u7a81\u72b6\u7ec6\u80de2\u5c06\u8fc7\u654f\u6027\u54ee\u5598\u4e0eCOVID-19\u7684\u9057\u4f20\u56e0\u679c\u5173\u7cfb\u8054\u7cfb\u8d77\u6765:\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u548c\u8f6c\u5f55\u7ec4\u5b66\u7814\u7a76<\/span><\/p>\n

\u671f\u520a\uff1aJournal of Big Data<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=8.1<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/p>\n

\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
\u6700\u8fd1\u7684\u8bc1\u636e\u8868\u660e\u8fc7\u654f\u6027\u54ee\u5598(AA)\u53ef\u964d\u4f4e2019\u51a0\u72b6\u75c5\u6bd2\u75c5(COVID-19)\u7684\u98ce\u9669\u3002\u4eba\u80ba\u7ec4\u7ec7\u4e2d\u7684DC\u4e9a\u578b\u4e4b\u4e00\u5e38\u89c4DC2 (cDC2)\uff0c\u5728AA\u80ba\u4e2d\u6570\u91cf\u660e\u663e\u4e0a\u8c03\u3002SARS-CoV-2\u611f\u67d3\u540e\uff0ccDC2s\u88ab\u6fc0\u6d3b\u5e76\u5728\u60a3\u8005\u80ba\u90e8\u79ef\u805a\u3002\u514d\u75ab\u7ec6\u80de\u5728\u8c03\u8282AA\u653b\u51fb\u548c\u9632\u5fa1COVID-19\u611f\u67d3\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u4f5c\u4e3a\u6700\u6709\u6548\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u8fde\u63a5\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u3002\u7136\u800c\uff0c\u539f\u56e0\u5c1a\u4e0d\u6e05\u695a\u3002<\/span><\/section>\n
\u6570\u636e\u6765\u6e90<\/span><\/o:page><\/section>\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/section>\n<\/td>\n
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\u6570\u636e\u5e93<\/span><\/section>\n<\/td>\n
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\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n
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\u8be6\u7ec6\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n
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–<\/span><\/section>\n<\/td>\n
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COVID-19 hg<\/span><\/section>\n<\/td>\n
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–<\/span><\/section>\n<\/td>\n
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COVID-19\u60a3\u8005\u654f\u611f\u6027\u3001\u4f4f\u9662\u6cbb\u7597\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n
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–<\/span><\/section>\n<\/td>\n
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FinnGen<\/span><\/section>\n<\/td>\n
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–<\/span><\/section>\n<\/td>\n
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AA\u60a3\u8005\u7684\u4fe1\u606f\uff0c\u5305\u62ec\u836f\u7269\u8fc7\u654f\u63a5\u89e6\u6027\u76ae\u708e\u3001\u54ee\u5598\u53f2\u3001\u9f3b\u708e\u53f2\u7b49<\/span><\/section>\n<\/td>\n<\/tr>\n
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–<\/span><\/section>\n<\/td>\n
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GWAS\u76ee\u5f55<\/span><\/section>\n<\/td>\n
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–<\/span><\/section>\n<\/td>\n
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\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\u548c\u767d\u7ec6\u80de\u8ba1\u6570<\/span><\/section>\n<\/td>\n<\/tr>\n
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–<\/span><\/section>\n<\/td>\n
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IEU Open GWAS Project<\/span><\/section>\n<\/td>\n
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–<\/span><\/section>\n<\/td>\n
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\u7ea2\u7ec6\u80de\u8ba1\u6570\u3001\u8840\u7ea2\u86cb\u767d\u6d53\u5ea6\u3001\u5e73\u5747\u8840\u5c0f\u677f\u4f53\u79ef\u7b49<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE69683<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq<\/span><\/section>\n<\/td>\n
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AA\u60a3\u8005\u8840\u6db2\u6837\u54c1\u8f6c\u5f55\u7ec4\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE171110<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq<\/span><\/section>\n<\/td>\n
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COVID-19\u60a3\u8005\u8840\u6db2\u6837\u54c1\u8f6c\u5f55\u7ec4\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE196822<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq<\/span><\/section>\n<\/td>\n
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COVID-19\u60a3\u8005\u8840\u6db2\u6837\u54c1\u8f6c\u5f55\u7ec4\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE193816<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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scRNA-seq<\/span><\/section>\n<\/td>\n
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AA\u60a3\u8005\u6c14\u9053\u7c98\u819c\u7ec4\u7ec7\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE145926<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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scRNA-seq<\/span><\/section>\n<\/td>\n
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COVID-19\u60a3\u8005\u6c14\u9053\u7c98\u819c\u7ec4\u7ec7\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
          <\/o:p><\/span><\/section>\n
\u7814\u7a76\u601d\u8def<\/span><\/section>\n
\u4f5c\u8005\u4f7f\u752818\u4e2aGWAS\u6570\u636e\u96c6\uff0c\u91c7\u7528\u53cc\u5411\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5206\u6790\uff0c\u5e76\u5c06\u8840\u6db2\u53c2\u6570\u4f5c\u4e3a\u5371\u9669\u56e0\u7d20\uff0c\u7814\u7a76\u8fc7\u654f\u6027\u75be\u75c5\u4e0eCOVID-19\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u8fdb\u4e00\u6b65\u4f7f\u75283\u4e2a\u5927\u91cf\u8f6c\u5f55\u7ec4\u6570\u636e\u96c6\u8fdb\u884c\u673a\u5668\u5b66\u4e60\uff0c\u7b5b\u9009AA\u548cCOVID-19\u4e2d\u5171\u4eab\u7684\u6b67\u89c6\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u5e76\u9274\u5b9a\u51facDC2s\u3002\u5bf92\u4e2a\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u8fdb\u884c\u4e86\u80fd\u91cf\u4ee3\u8c22\u3001\u7ec6\u80de\u95f4\u901a\u8baf\u3001\u7ec6\u80de\u5e72\u6027\u548c\u5206\u5316\u4ee5\u53ca\u5206\u5b50\u5bf9\u63a5\u5206\u6790\uff0c\u7814\u7a76\u4e86cDC2s\u7684\u6570\u91cf\u3001\u6d3b\u6027\u3001\u7ec6\u80de\u95f4\u901a\u8baf\u548c\u5206\u5316\uff0c\u5e76\u5229\u7528\u5206\u5b50\u5bf9\u63a5\u5206\u6790\u63ed\u793a\u4e86cDC2s\u7684\u6297\u539f\u5448\u9012\u8fc7\u7a0b\u3002<\/span><\/o:page><\/section>\n

\n<\/span><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n
\u56fe1  \u8bbe\u8ba1\u6d41\u7a0b<\/span><\/section>\n
<\/o:p><\/span><\/section>\n
\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n
1.  AA\u4e0eCOVID – 19\u5448\u8d1f\u76f8\u5173<\/span><\/section>\n
\u4f5c\u8005\u7b5b\u9009\u4e0d\u540c\u8fc7\u654f\u8868\u578b\u548cCOVID-19\u4f4f\u9662\u7387\u7684\u5de5\u5177\u53d8\u91cfSNP\u3002\u5728\u8fc7\u654f\u8868\u578b\u4e2d\uff0cIVW\u5206\u6790\u663e\u793aAA\u964d\u4f4e\u4e86COVID-19\u4f4f\u9662\u98ce\u9669\u3002\u5176\u4ed63\u79cdMR\u65b9\u6cd5\u7684\u7ed3\u679c\u65b9\u5411\u4e00\u81f4(\u56fe2A\u3001B)\uff0c\u4e5f\u672a\u80fd\u89c2\u5bdf\u5230\u5176\u4ed6\u8fc7\u654f\u8868\u578b\u4e0eCOVID-19\u98ce\u9669\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb(\u56fe2A)\u3002\u4f5c\u8005\u8fdb\u884c\u591a\u79cd\u7c7b\u578b\u7684\u654f\u611f\u6027\u5206\u6790\u9a8c\u8bc1\u4e0a\u8ff0\u7ed3\u679c\u7684\u7a33\u5065\u6027\u548c\u53ef\u9760\u6027\u3002MR-Egger\u622a\u8ddd\u68c0\u9a8c\u663e\u793a\u4e0d\u5b58\u5728\u6c34\u5e73\u591a\u6548\u6027\uff0c\u7136\u800c\u5728Cochran\u2019s Q\u68c0\u9a8c\u4e2d\uff0c\u4e00\u4e9b\u8fc7\u654f\u548cCOVID-19\u8868\u578b\u4e4b\u95f4\u5b58\u5728\u5f02\u8d28\u6027(\u56fe2C)\u3002\u7531\u4e8e\u91c7\u7528\u968f\u673a\u6548\u5e94IVW\u65b9\u6cd5\uff0cMR\u4f30\u8ba1\u503c\u5e76\u672a\u5931\u6548\u3002<\/span><\/o:page><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n
\u56fe2  AA\u4e0eCOVID-19\u4f4f\u9662\u5448\u8d1f\u76f8\u5173<\/span><\/section>\n
<\/o:p><\/span><\/section>\n
2.  \u767d\u7ec6\u80de\u8ba1\u6570\u5728AA\u548cCOVID – 19\u4e4b\u95f4\u67b6\u8d77\u4e86\u6865\u6881<\/span><\/section>\n
\u4f5c\u8005\u901a\u8fc7MR\u5206\u6790\u8bc4\u4f30AA\u5bf9COVID-19\u76f8\u5173\u8840\u6db2\u53d8\u91cf\u7684\u5f71\u54cd\u3002AA\u4e0e\u767d\u7ec6\u80de\u8ba1\u6570\u5448\u6b63\u76f8\u5173\uff0c\u4e0e\u5176\u4ed6\u4e09\u79cdMR\u65b9\u6cd5\u83b7\u5f97\u7684\u7ed3\u679c\u65b9\u5411\u4e00\u81f4(\u56fe3)\uff0c\u800cAA\u4e0e\u5176\u4ed6\u8840\u6db2\u53d8\u91cf\u4e4b\u95f4\u6ca1\u6709\u663e\u8457\u5173\u8054(\u56fe3)\u3002\u6b64\u5916\uff0c\u654f\u611f\u6027\u5206\u6790\u6ca1\u6709\u663e\u793a\u4efb\u4f55\u591a\u6027\u72b6\u7684\u8bc1\u636e\uff0c\u4f46\u53cd\u6620\u4e86\u5f02\u8d28\u6027\u7684\u5b58\u5728\u3002\u5728\u968f\u673a\u6548\u5e94IVW\u65b9\u6cd5\u4e0b\u88ab\u63a5\u53d7(\u56fe3)\u3002\u7559\u4e00\u6cd5\u5206\u6790\u8fdb\u4e00\u6b65\u6392\u9664\u4e86\u5355\u4e2aSNP\u5bf9MR\u4f30\u8ba1\u503c\u7684\u663e\u8457\u5f71\u54cd\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n
\u56fe3  \u767d\u7ec6\u80de\u8ba1\u6570\u5728AA\u548cCOVID-19\u4e4b\u95f4\u67b6\u8d77\u4e86\u6865\u6881<\/span><\/section>\n
3.  DC\u662fAA\u548cCOVID – 19\u4e2d\u6700\u5177\u9274\u522b\u6027\u7684\u767d\u7ec6\u80de<\/span><\/section>\n
\u4f5c\u8005\u75284\u79cd\u72ec\u7acb\u7684\u7b97\u6cd5\u6765\u8bc6\u522b\u6865\u63a5AA\u548c\u65b0\u51a0\u80ba\u708e\u7684\u7279\u5b9a\u7c7b\u578b\u7684\u767d\u7ec6\u80de\u3002\u4e0e\u5065\u5eb7\u53d7\u8bd5\u8005\u76f8\u6bd4\uff0cAA\/COVID-19\u60a3\u8005\u8840\u6db2\u4e2d\u7684\u7c92\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\u6c34\u5e73\u660e\u663e\u8f83\u9ad8\uff0cB\u7ec6\u80de\u548cT\u7ec6\u80de\u6c34\u5e73\u8f83\u4f4e(\u56fe4A)\u3002AA\u60a3\u8005\u8840\u6db2\u4e2dDC\u8868\u8fbe\u4e0a\u8c03\uff0cCOVID-19\u60a3\u8005\u8840\u6db2\u4e2dDC\u8868\u8fbe\u4e0b\u8c03(\u56fe4A)\u3002\u968f\u540e\uff0c\u5206\u522b\u5e94\u7528Boruta\u3001Random Forest\u548cSVM RFE\u4e09\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff0c\u8bc6\u522bAA\/COVID-19\u60a3\u8005\u4e0e\u5065\u5eb7\u53d7\u8bd5\u8005\u4e4b\u95f4\u6700\u5177\u533a\u522b\u6027\u768416\u4e2a\u514d\u75ab\u7ec6\u80de(\u56fe4B)\u3002\u901a\u8fc7\u4ea4\u53c9\u786e\u5b9aDC\u4e3a\u76ee\u6807\u7ec6\u80de(\u56fe4C)\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n
\u56fe4  \u6811\u7a81\u72b6\u7ec6\u80de(DC)\u662fAA\u548cCOVID-19\u4e2d\u6700\u5177\u533a\u522b\u6027\u7684\u514d\u75ab\u7ec6\u80de<\/span><\/section>\n
4.  cDC2\u5728AA\u52a0\u91cd\u4e2d\u4e0a\u8c03\/\u6fc0\u6d3b\uff0c\u5728\u91cd\u75c7COVID – 19\u4e2d\u4e0b\u8c03\/\u6fc0\u6d3b<\/span><\/section>\n
\u4f5c\u8005\u5bf9AA\u548cCOVID-19\u961f\u5217\u7684\u6c14\u9053\u9ecf\u819c\u8fdb\u884c\u4e86scRNA-seq\u5206\u6790,\u63ed\u793a\u4e24\u8005\u5728\u7ec6\u80de\u4e9a\u578b\u6c34\u5e73\u4e0a\u7684\u76f8\u5173\u6027\u3002\u9996\u5148\u5bf9\u6570\u636e\u96c6\u6574\u5408\u5e76\u6821\u6b63\u6279\u6b21\u6548\u5e94\uff0c\u6ce8\u91ca\u4e868\u79cd\u7c7b\u578b\u7684\u7ec6\u80de\uff08\u56fe5A\uff09\u3002\u6709Ag\u4fb5\u67d3\u7684AA\u7684DC\u7ec6\u80de\u6bd4\u4f8b\u6700\u9ad8\u3002\u800c\u5bf9\u4e8eCOVID-19\u4e25\u91cd\u611f\u67d3\u7684\u60a3\u8005\u8868\u73b0\u51fa\u8f83\u4f4e\u7684DC\u7ec6\u80de\u6bd4\u4f8b(\u56fe5B)\u3002\u968f\u540e\u4f5c\u8005\u5c06DC\u5206\u4e3a5\u4e2a\u7ec6\u80de\u4e9a\u578b(\u56fe5C)\uff0c\u5e76\u786e\u8ba4\u4e86\u5b83\u4eec\u7684\u7ec6\u80de\u6807\u8bb0\u7269(\u56fe5D)\u3002\u5728AA\u4e2d\u6709Ag\u6fc0\u53d1\u7684AA\u8868\u73b0\u51fa\u6700\u9ad8\u6bd4\u4f8b\u7684cDC2\uff0c\u5728COVID-19\u4e25\u91cd\u611f\u67d3\u60a3\u8005\u8868\u73b0\u51fa\u663e\u8457\u8f83\u4f4e\u6bd4\u4f8b\u7684cDC\uff08\u56fe5E\uff09\u3002\u7efc\u4e0acDC2s\u6c34\u5e73\u5728AA\u52a0\u91cd\u671f\u4e0a\u8c03\uff0c\u5728COVID-19\u91cd\u75c7\u671f\u4e0b\u8c03\u3002<\/span>    <\/span><\/o:page><\/section>\n
\u4f5c\u8005\u53d1\u73b0AAs\u5bf9Ag\u7684\u80fd\u91cf\u4ee3\u8c22\u6c34\u5e73\u5347\u9ad8\uff0c\u4e14\u4e0eACs\u76f8\u6bd4\uff0cAAs\u7684\u80fd\u91cf\u4ee3\u8c22\u6c34\u5e73\u66f4\u9ad8\uff0c\u4e25\u91cd\u7684COVID-19\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u80fd\u91cf\u4ee3\u8c22\u6c34\u5e73(\u56fe5F)\u3002\u7814\u7a76\u53d1\u73b0cDC2s\u5177\u6709\u5411T\u7ec6\u80de\u5448\u9012\u6297\u539f\u7684\u80fd\u529b\u3002\u5728\u6297\u539f\u66b4\u9732\u7684\u60c5\u51b5\u4e0b\uff0cAA\u7684cDC2\u5411T\u7ec6\u80de\u53d1\u9001\u7684\u4fe1\u53f7\u66f4\u591a\uff1b\u6765\u81eaCOVID-19\u60a3\u8005\u7684cDC2s\u503e\u5411\u4e8e\u589e\u52a0\u5411T\u7ec6\u80de\u7684\u4fe1\u53f7\u4f20\u9012(\u56fe5G, H)\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u5728AA\u548cCOVID-19\u6076\u5316\u72b6\u6001\u4e2d\u5b58\u5728\u66f4\u591a\u6d3b\u5316\u7684cDC2s\u3002<\/span><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/o:page><\/section>\n
\u56fe5  \u5e38\u89c4\u6811\u7a81\u72b62\u7ec6\u80de(cDC2s)\u5728AA\u52a0\u91cd\u65f6\u589e\u52a0\/\u6fc0\u6d3b\uff0c\u5728\u91cd\u75c7COVID-19\u65f6\u4e0b\u8c03\/\u6fc0\u6d3b<\/span><\/section>\n
5.  EXOC4\u3001ZBTB46\u3001TLR1\u548cTNFSF4\u53d8\u5f02\u4fc3\u8fdbcDC2\u5206\u5316\uff0ccDC2\u4ecb\u5bfcAA\u4e2dSARS\u2011CoV\u20112\u6297\u539f\u5448\u9012<\/span><\/section>\n
\u4f5c\u8005\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e86\u5171\u4eab\u7684\u9057\u4f20\u673a\u5236\u3002\u5728AA\u768436\u4e2a\u53d8\u91cfSNP\u4e2d\uff0c16\u4e2aSNP\u8868\u73b0\u51fa\u8f6c\u5f55\u8c03\u63a7\u533a\u53d8\u5f02\u7684\u529f\u80fd\u540e\u679c\uff0c13\u4e2aSNP\u5bf9\u5e94\u57fa\u56e0\u5728DCs\u4e2d\u9ad8\u8868\u8fbe(\u56fe6A)\u3002\u5143\u666f\u89c2\u5bcc\u96c6\u5206\u6790\u663e\u793a\uff0c\u8fd913\u4e2a\u57fa\u56e0\u96c6\u4e2d\u4e8eAA(\u513f\u7ae5\u54ee\u5598)\u3001\u75c5\u6bd2(\u5bf9\u75c5\u6bd2\u7684\u53cd\u5e94)\u548c\u514d\u75ab\u7ec6\u80de(\u767d\u7ec6\u80de\u6d3b\u5316\u7684\u8d1f\u8c03\u63a7)(\u56fe6B)\u3002<\/span><\/section>\n
\u7814\u7a76\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u5206\u5316\u548c\u6297\u539f\u5448\u9012\u3002CytoTRACE\u5206\u6790\u9884\u6d4b\uff0c\u6765\u81eaAA  Ag\u7684\u524dDC\u6709\u66f4\u9ad8\u7684\u53d1\u80b2\u6f5c\u529b\uff1b\u6765\u81eaCOVID-19\u60a3\u8005\u7684\u524dDC\u5206\u5316\u80fd\u529b\u8f83\u4f4e(\u56fe6C, D)\u3002\u5355\u7247\u5206\u6790\u7ed8\u5236\u4e86AAs\u548cACs\u4ecePre-DC\u5230cDC1\/cDC2\u7684\u5206\u5316\u8f68\u8ff9(\u56fe6E)\uff0c\u5176\u4e2dZBTB46\u548cEXOC4\u4e0eAAs\u4e2d\u5206\u5316\u7684\u76f8\u5173\u6027\u66f4\u9ad8(\u56fe6F)\uff0c\u968f\u5206\u5316\u8fc7\u7a0bZBTB46\u5728AAs\u548cACs\u4e2d\u5747\u4e0a\u8c03\uff0cEXOC4\u5728AAs\u4e2d\u4e0b\u8c03\uff0c\u800c\u5728ACs\u4e2d\u4e0a\u8c03(\u56fe6G)\u3002\u86cb\u767d\u5bf9\u63a5\u5206\u6790\u663e\u793a\u4e86cDC2s\u4ecb\u5bfc\u7684\u6297\u539f\u5448\u9012\u8fc7\u7a0b\uff0c\u663e\u793a\u76f8\u4e92\u4f5c\u7528\u529b\u548c\u8ddd\u79bb(\u56fe6H\u3001I)\u3002\u5f53\u6297\u539f\u66b4\u9732\u65f6\uff0cTLR1\u548cTNFSF4\u5728AAs\u4e2d\u7684\u8868\u8fbe\u5747\u9ad8\u4e8eACs(\u56fe6J)\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"\u7814\u7a76\u53cc\u75be\u75c5\u5f53\u7136\u8981buff\u53e0\u6ee1\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316+\u673a\u5668\u5b66\u4e60\uff0c\u4e24\u5927\u7537\u795e\u9707\u573a\uff01\u4e2d\u5357\u5927\u5b66\u5f20\u674e\u6d0b\u6559\u6388\u56e2\u961f8\u5206\u65b0\u4f5c\u901f\u5b66\uff01\"<\/span><\/section>\n
\u56fe6  EXOC4\u3001ZBTB46\u3001TLR1\u548cTNFSF4\u53d8\u5f02\u4fc3\u8fdbcDC2\u5206\u5316\uff0ccDC2\u4ecb\u5bfcAA\u4e2dSARS-CoV-2\u6297\u539f\u5448\u9012<\/span><\/section>\n
<\/o:p><\/span><\/section>\n
\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n
\u6570\u636e\u4e0d\u591a\uff0c\u96be\u5ea6\u9002\u4e2d\uff0c\u518d\u9002\u5408\u4e0d\u8fc7\u5c0f\u5e08\u59b9\u8fd9\u6837\u521a\u5165\u95e8\u7684\u751f\u4fe1\u79d1\u7814er\u5566\uff01<\/span>\u770b\u6765\u660e\u5e74\u548c\u5c0f\u5e08\u59b9\u80fd\u518d\u7eed\u524d\u7f18\u5566\uff01<\/span>\u60f3\u5c1d\u8bd5\u6587\u4e2d\u51fa\u73b0\u7684\u5206\u6790\u5de5\u5177\u6216\u5176\u4ed6\u7ebf\u4e0a\u8d44\u6e90\uff1f\u53cc\u75be\u75c5\u5206\u6790\u8fd8\u6709\u4ec0\u4e48\u65b9\u5411\u80fd\u6ee1\u8db3\u4f60\u7684\u6587\u7ae0\u9700\u6c42\uff1f\u8fd9\u4e9b\u7591\u60d1\u7edf\u7edf\u4ea4\u7ed9\u5c0f\u4e91\u5e2e\u4f60\u89e3\u51b3\u5427\uff01<\/span><\/span><\/strong><\/o:page><\/section>\n
\u5982\u679c\u4f60\u8fd8\u82e6\u607c\u4e8e\u751f\u4fe1\u5206\u6790\u6ca1\u6709\u601d\u8def\uff0c\u6216\u8005\u5acc\u5206\u6790\u65b9\u6cd5\u592a\u8fc7\u7b80\u5355\u3001\u592a\u8fc7\u8001\u5957\uff0c\u60f3\u8981\u521b\u65b0\u601d\u8def\u7684\uff0c\u6216\u8005\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u3001\u591a\u7ec4\u5b66\u8054\u5408\u5206\u6790\u7b49\u65b9\u5411\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u5feb\u6765\u8054\u7cfb\u5c0f\u4e91\u5427\uff01<\/span><\/section>\n
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