{"id":43582,"date":"2024-06-02T01:17:43","date_gmt":"2024-06-01T17:17:43","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43582"},"modified":"2024-06-06T08:40:26","modified_gmt":"2024-06-06T00:40:26","slug":"962bd3fab6","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43582","title":{"rendered":"\u79c0\u51fa\u5b9e\u529b\uff01\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6c88\u7433\u3001\u5f6d\u667a\u56e2\u961f\uff1a\u80a0\u9053\u83cc\u7fa4\u4e2d\u7684\u591a\u7ec4\u5b66\u5206\u6790\u4e00\u4e3e\u65a9\u83b714+Cell\u5b50\u520a"},"content":{"rendered":"
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1.\u665a\u671fMSI-H\/dMMR\u80c3\u80a0\u764c\u60a3\u8005\u961f\u5217<\/span><\/section>\n

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2.\u5bf9\u514d\u75ab\u7597\u6cd5\u5177\u6709\u539f\u53d1\u6027\u8010\u836f\u6027\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7279\u5f81<\/span><\/section>\n

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3.\u5bf9\u514d\u75ab\u7597\u6cd5\u5177\u6709\u539f\u53d1\u6027\u8010\u836f\u6027\u7684\u7caa\u4fbf\u4ee3\u8c22\u7ec4\u7279\u5f81<\/span><\/section>\n

\u7814\u7a76\u4eba\u5458\u5229\u7528\u6db2\u76f8\u8272\u8c31-\u8d28\u8c31\u6cd5\uff08LC-MS\uff09\u5bf9\u4e0d\u540c\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u7684\u60a3\u8005\u7684\u8840\u6d46\u6837\u672c\u8fdb\u884c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u3002\u7ed3\u679c\u5171\u9274\u5b9a\u51fa143\u79cd\u4ee3\u8c22\u7269\u5728\u5728\u4e24\u7ec4\u60a3\u8005\u95f4\u6709\u5dee\u5f02\uff08\u56fe2C\uff09\u3002\u5176\u4e2d\uff0c\u4e0e\u6cbb\u7597\u53cd\u5e94\u6027\u76f8\u5173\u7684\u4ee3\u8c22\u9014\u5f84\u4e3b\u8981\u6d89\u53ca\u7cbe\u6c28\u9178\u4ee3\u8c22\u548c\u77ed\u94fe\u8102\u80aa\u9178\u4ee3\u8c22\uff08SCFA\uff09\u3002\u7cbe\u6c28\u9178\u4ee3\u8c22\u76f8\u5173\u7684\u4ee3\u8c22\u7269\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u5b58\u5728\u5173\u8054\u3002\u5728\u5bf9\u514d\u75ab\u7597\u6cd5\u5177\u6709\u539f\u53d1\u6027\u8010\u836f\u6027\u7684\u60a3\u8005\u4e2d\uff0c\u4e01\u9178\u3001\u5df1\u9178\u548c\u5f02\u4e01\u9178\u7b49\u77ed\u94fe\u8102\u80aa\u9178\u5bcc\u96c6\uff0c\u800c\u4e19\u9178\u4ee3\u8c22\u901a\u8def\u4e5f\u663e\u793a\u51fa\u663e\u8457\u6027\uff08\u56fe2C\uff09\u3002<\/span><\/o:page><\/p>\n

4.FMT\u5728\u5c0f\u9f20\u4e2d\u7684\u4e34\u5e8a\u76ca\u5904<\/span><\/section>\n

\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5c06\u516d\u540d\u514d\u75ab\u6cbb\u7597\u60a3\u8005\u7684\u7caa\u4fbf\u6837\u672c\u79fb\u690d\u5230\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u9a8c\u8bc1\u80a0\u9053\u83cc\u7fa4\u5728\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\uff08\u56fe3A\uff09\uff08<\/span>PS\uff1a\u5e72\u6e7f\u7ed3\u5408\u662f\u73b0\u5728\u53d1\u6587\u7684\u6700\u4f73\u65b9\u6cd5\uff0c\u5927\u5bb6\u8981\u5b66\u4f1a\u7ed9\u81ea\u5df1\u7684\u8bfe\u9898\u9879\u76ee\u8bbe\u8ba1\u8fd9\u6837\u7684\u5957\u8def\u3002<\/span>\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u63a5\u53d7\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u54cd\u5e94\u60a3\u8005\u7caa\u4fbf\u79fb\u690d\u7684\u5c0f\u9f20\u80bf\u7624\u5927\u5c0f\u663e\u8457\u51cf\u5c0f\uff0c\u5e76\u4e14\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684T\u7ec6\u80de\u4e9a\u7fa4\u6bd4\u4f8b\u589e\u52a0\uff08\u56fe3B-D\uff09\u3002\u7814\u7a76\u4eba\u5458\u63a5\u7740\u5bf9\u5c0f\u9f20\u8840\u6db2\u6837\u672c\u8fdb\u884c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u4ee5\u53ca\u5bf9\u80bf\u7624\u7ec4\u7ec7\u8fdb\u884cRNA-seq\u5206\u6790\u4ee5\u63ed\u793a\u6709\u54cd\u5e94\u7ec4\u548c\u65e0\u54cd\u5e94\u7ec4\u4e4b\u95f4\u7684\u4ee3\u8c22\u548c\u57fa\u56e0\u8868\u8fbe\u5dee\u5f02\u3002\u7ed3\u679c\u5171\u9274\u5b9a\u51fa97\u79cd\u5dee\u5f02\u4ee3\u8c22\uff0c\u5e76\u53d1\u73b0\u7cbe\u6c28\u9178\u4ee3\u8c22\u53ef\u80fd\u5f71\u54cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94\uff0c\u800c\u7cbe\u6c28\u9178\u4ee3\u8c22\u4e0eTreg\u7ec6\u80de\u7684\u5173\u8054\u63d0\u793a\u4e86\u5176\u8c03\u8282\u514d\u75ab\u529f\u80fd\u7684\u6f5c\u5728\u4f5c\u7528\uff08\u56fe3E-G\uff09\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u79c0\u51fa\u5b9e\u529b\uff01\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6c88\u7433\u3001\u5f6d\u667a\u56e2\u961f\uff1a\u80a0\u9053\u83cc\u7fa4\u4e2d\u7684\u591a\u7ec4\u5b66\u5206\u6790\u4e00\u4e3e\u65a9\u83b714+Cell\u5b50\u520a\"<\/span><\/p>\n

\u56fe3 \u7528\u6765\u81eaRs\u7684\u7caa\u4fbf\u8fdb\u884c\u7caa\u4fbf\u5fae\u751f\u7269\u7fa4\u79fb\u690d\uff08FMT\uff09\u540e\uff0c\u5c0f\u9f20\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528\u589e\u5f3a<\/span><\/p>\n

5.\u57fa\u4e8e\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\u5f88\u597d\u5730\u9884\u6d4b\u4e86\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548<\/span><\/section>\n

\u7814\u7a76\u4eba\u5458\u5efa\u7acb\u4e86\u4e00\u4e2a\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u5229\u7528\u80a0\u9053\u83cc\u7fa4\u6570\u636e\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u3002\u8be5\u6a21\u578b\u5728\u8bad\u7ec3\u96c6\u3001\u6d4b\u8bd5\u96c6\u548c\u72ec\u7acb\u9a8c\u8bc1\u96c6\u4e0a\u8868\u73b0\u826f\u597d\uff0c\u9884\u6d4b\u66f2\u7ebf\u4e0b\u9762\u79ef\u5206\u522b\u4e3a0.9\u30010.88\u548c0.79\uff08\u56fe4A\uff09\u3002\u901a\u8fc7\u5206\u6790\u7279\u5f81\u7684\u8d21\u732e\uff0c\u7814\u7a76\u4eba\u5458\u786e\u5b9a<\/span>B. caccae<\/span>\u3001<\/span>V. parvula<\/span>\u3001<\/span>V. atypica<\/span>\u548c<\/span>Clostridiales bacterium<\/span>\u7b49\u80a0\u9053\u83cc\u7fa4\u53ef\u4ee5\u4f5c\u4e3a\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u7279\u5f81\uff08\u56fe4B\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u80a0\u9053\u83cc\u7fa4\u53ef\u80fd\u6210\u4e3a\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u6f5c\u5728\u6307\u6807\uff0c\u5e76\u4e14\u9009\u5b9a\u7684\u5fae\u751f\u7269\u7269\u79cd\u53ef\u80fd\u662f\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span>    <\/span><\/o:page><\/p>\n

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6.\u514d\u75ab\u6cbb\u7597\u83b7\u5f97\u6027\u8010\u836f\u60a3\u8005\u7684\u751f\u7269\u7279\u5f81<\/span><\/section>\n

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\u56fe5 \u4e0eAR\u76f8\u5173\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n

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\u53c2\u8003\u6587\u732edoi\uff1ahttps:\/\/doi.org\/10.1016\/j.xcrm.2023.101355<\/span><\/p>\n


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