{"id":43597,"date":"2024-06-02T01:17:50","date_gmt":"2024-06-01T17:17:50","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43597"},"modified":"2024-06-06T08:39:07","modified_gmt":"2024-06-06T00:39:07","slug":"f3c6169682","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43597","title":{"rendered":"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01"},"content":{"rendered":"
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\u6742\u5fd7\uff1aJournal of Translational Medicine<\/span><\/section>\n
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\u6570\u636e\u6765\u6e90<\/span><\/section>\n\n\n\n\n\n\n
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\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/section>\n<\/td>\n
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GSE132257<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n
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10\u4e2aCRC\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n
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GSE39582<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n
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GSE17536<\/span><\/section>\n<\/td>\n
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GEO<\/span><\/section>\n<\/td>\n
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RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n
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\u7814\u7a76\u601d\u8def<\/span><\/p>\n

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\u56fe1 \u603b\u4f53\u4e73\u9178\u5316\u6c34\u5e73\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u4e0a\u8c03\uff0c\u5e76\u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173<\/span><\/p>\n

2.\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9a\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0\uff08LRGs\uff09<\/span><\/strong><\/span><\/p>\n

\u5bf9\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u4e86\u6df1\u5165\u5206\u6790\uff0c\u5c06\u6240\u6709\u7ec6\u80de\u805a\u4e3a22\u4e2a\u4e0d\u540c\u7684\u7ec4\uff0c\u5982\u56fe2A\u6240\u793a\u300211\u4e2a\u7279\u5b9a\u7ec6\u80de\u7c07\u7684\u5206\u5e03\u5982\u56fe2B\u6240\u793a\u3002\u6839\u636e\u4e2d\u4f4dAUC<\/span>\u8bc4\u5206\uff0c\u5bf9\u6240\u6709\u7ec6\u80de\u8fdb\u884cLRGs\u7684AUC\u8bc4\u5206\uff0c\u5e76\u5c06\u5176\u5206\u4e3a\u9ad8\u4e73\u5316AUC\u7ec4\u548c\u4f4e\u4e73\u5316AUC\u7ec4\uff08\u56fe2C\uff09\u3002\u5177\u6709\u5927\u91cf\u4e73\u9178\u76f8\u5173\u57fa\u56e0\uff08LRGs\uff09\u7684\u7ec6\u80de\u4e3b\u8981\u662f\u7ea2\u8272\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5982NK\u7ec6\u80de\u3001T\u7ec6\u80de\u548cB\u7ec6\u80de\uff08\u56fe2D\uff09\u3002\u968f\u540e\uff0c\u5728\u9ad8\u4e73\u9178\u5316\u7ec4\u548c\u4f4e\u4e73\u9178\u5316\u7ec4\u4e4b\u95f4\u9274\u5b9a\u4e86879\u4e2a\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\uff08DEGs\uff09\u3002\u6b64\u5916\uff0c\u76f8\u5173\u5206\u6790\u663e\u793a\u4e86\u4e0e\u4e73\u5316\u6d3b\u6027\u6700\u5bc6\u5207\u76f8\u5173\u7684\u524d100\u4e2a\u9ad8\u5ea6\u4e73\u5316\u76f8\u5173\u7684\u57fa\u56e0\uff08CORGs\uff09\uff08\u56fe2E\uff09\u3002\u901a\u8fc7\u57fa\u56e0\u96c6\u53d8\u5f02\u5206\u6790\uff08GSVA\uff09\u3001\u57fa\u56e0\u672c\u4f53\uff08GO\uff09\u5206\u6790\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86LRGs\u76f8\u5173\u7684\u5206\u5b50\u7279\u5f81\u3002\u4e73\u9178\u5316\u5728\u201cMYC\u201d\u3001\u201cPI3K-AKT-mTOR\u201d\u3001\u201c\u7f3a\u6c27\u201d\u7b49\u4fc3\u80bf\u7624\u901a\u8def\u4e2d\u53d1\u6325\u4e86\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5e76\u4e0e\u514d\u75ab\u76f8\u5173\u901a\u8def\u5982\u201cINTERFERON_GAMMA_RESPONSE\u201d\u3001\u201cIL2_STAT5_SIGNALING\u201d\u548c\u201cTGF_BETA_SIGNALING\u201d\u76f8\u5173\uff08\u56fe2F-H\uff09\u3002<\/span><\/section>\n

\"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01\"<\/span><\/p>\n

\u56fe2 \u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9aCRC\u4e2d\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0(LRGs)<\/span><\/section>\n

3.\u65b0\u578b\u7684LRG\u6807\u5fd7\u7269\u63ed\u793a\u4e86\u5bf9\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u7684\u9884\u6d4b\u80fd\u529b<\/span><\/strong><\/span><\/p>\n

\u5206\u6790TCGA\u961f\u5217\u6765\u63d0\u53d6LRG\u9884\u540e\u7279\u5f81\u3002\u9996\u5148\uff0c\u901a\u8fc7\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u786e\u5b9a\u4e8667\u4e2a\u4e0eCRC\u76f8\u5173\u7684\u5019\u9009\u57fa\u56e0\uff0c\u5982\u70ed\u56fe\uff08\u56fe3A\uff09\u6240\u793a\u3002\u7136\u540e\u91c7\u7528Lasso\u5206\u6790\uff0c\u9274\u5b9a\u4e8623\u4e2a\u57fa\u56e0\uff08\u56fe3B\uff09\u3002\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u6210\u4e00\u4e2aLRG\u8bc4\u5206\u7684\u9884\u6d4b\u6a21\u578b\uff08LRGS\uff09\uff08\u56fe3C\uff09\u3002\u6700\u521d\u768411\u4e2a\u57fa\u56e0\u4e0e\u9ad8\u98ce\u9669\u76f8\u5173\uff0c\u800c\u968f\u540e\u768412\u4e2a\u57fa\u56e0\u4e0e\u4f4e\u98ce\u9669\u76f8\u5173\u3002\u8be5\u7efc\u5408\u6a21\u578b\u6574\u5408\u4e86\u8fd9\u4e9b\u4e2a\u4f53\u57fa\u56e0\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u4ee5\u4f5c\u4e3a\u8bc4\u4f30CRC\u9884\u540e\u7684\u53c2\u8003\u5de5\u5177\u3002<\/span><\/o:page><\/section>\n
\u6839\u636e\u4e2d\u4f4d\u98ce\u9669\u8bc4\u5206\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u3001\u4f4e\u98ce\u9669\u7ec4\uff0c\u8bc4\u4f30LRG\u7279\u5f81\u7684\u9884\u540e\u4ef7\u503c\u3002Kaplan-Meier\u751f\u5b58\u671f\u5206\u6790\u663e\u793a\uff0c\u4e24\u7ec4\u6765\u81eaGSE39582\u548cGSE17536\u7684CRC\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c\u6b64\u5916\uff0cROC\u5206\u6790\u663e\u793a1-\u30012-\u30013-\u30014-\u548c5\u5e74\u5bf9TCGA\u8bad\u7ec3\u96c6\u3001GSE39582\u6d4b\u8bd5\u96c6\u548cGSE17536\u6d4b\u8bd5\u96c6\u5177\u6709\u8f83\u5f3a\u7684\u9884\u6d4b\u80fd\u529b\uff08\u56fe3D-F\uff09\u3002<\/span>   <\/span><\/section>\n

\"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01\"<\/span><\/p>\n

\u56fe3 \u65b0\u578bLRG\u7279\u5f81\u63ed\u793a\u4e86\u5bf9\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u7684\u5f3a\u5927\u9884\u6d4b\u80fd\u529b<\/span><\/section>\n
4.LRGS\u4e2d\u5173\u952e\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u7684\u9a8c\u8bc1<\/strong><\/span><\/section>\n
scRNA-seq\u6570\u636e\u5206\u6790\u663e\u793a\uff0cHSPB1\u3001ACTG1\u3001SFPQ\u3001RBM3\u3001LY6E\u3001AP2M1\u3001RAB5C\u3001MED10\u3001RBM17\u3001METTL9\u3001LGALS4\u4e3b\u8981\u5728\u4e0a\u76ae\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u800cLEPROTL1\u3001TERF2IP\u5728T\u548cNK\u7ec6\u80de\u3001ARL4C\u3001ARPC1B\u3001SLC2A3\u3001H2AFY\u3001LITAF\u5728\u5355\u6838\u7ec6\u80de\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe\u7a81\u51fa\uff08\u56fe4A\uff09\u3002\u6b64\u5916\uff0cNR1H2\u3001PTTG1\u5728\u6240\u6709\u7ec6\u80de\u7c07\u4e2d\u5747\u68c0\u6d4b\u6c34\u5e73\u8f83\u4f4e\u3002KEGG\u5bcc\u96c6\u5206\u6790\u4e5f\u8868\u660e\uff0cLRGs\u4e0e\u541e\u566c\u5c0f\u4f53\u3001\u6297\u539f\u52a0\u5de5\u548c\u5448\u9012\u7b49\u6709\u5173\uff08\u56fe4B\uff09\u3002\u968f\u540e\uff0c\u5927\u91cfRNA\u8f6c\u5f55\u7ec4\u8fdb\u4e00\u6b65\u5206\u6790\u663e\u793a\uff0cLEPROTL1\u3001SLC2A3\u3001LY6E\u3001ARL4C\u3001AP2M1\u3001RAB5C\u3001LITAF\u4e0e\u514d\u75ab\u8bc4\u5206\u5448\u6b63\u76f8\u5173\uff0c\u800cLLC2A3\u3001LY6E\u6574\u4f53\u4e0e\u514d\u75ab\u7ec6\u80de\u81a8\u80c0\u5448\u8d1f\u76f8\u5173\uff0c LITAF\u3001ARL4C\u3001SLC2A3\u548cLEPROTL1\u4e0e\u51e0\u4e4e\u6240\u6709\u514d\u75ab\u7ec6\u80de\u663e\u8457\u76f8\u5173\u3002\u5bf9\u4e0d\u540c\u7ec6\u80de\u7cfb\u4e2d\u7279\u5f81\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u4e86\u5168\u9762\u7684\u8bc4\u4f30\u3002\u4e0e\u6b63\u5e38\u7ec6\u80de\u7cfb\u76f8\u6bd4\uff0cCRC\u7ec6\u80de\u7cfb\u4e2dRBM17\u3001TERF2IP\u3001AP2M1\u3001NR1H2\u3001MED10\u3001HSPA1B\u3001ARL4C\u3001LY6E\u3001ARPC1B\u3001HSPB1\u7684RNA\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08\u56fe4C\uff09\u3002\u6b64\u5916\uff0c\u4e3a\u4e86\u52a0\u5f3a\u8fd9\u4e9b\u57fa\u56e0\u8868\u8fbe\u6539\u53d8\u5728CRC\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u5b83\u4eec\u5728\u4e34\u5e8a\u7ec4\u7ec7\u4e2d\u7684\u6c34\u5e73\uff08\u56fe4D\uff09\u3002\u6b64\u5916\uff0c\u7814\u7a76\u6269\u5c55\u5230\u6838\u5fc3\u98ce\u9669\u57fa\u56e0\u7684\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\uff0c\u5305\u62ecAP2M1\u3001LY6E\u3001ARL4C\u3001ARPC1B\u548cTERF2IP\uff0c\u4e0eRNA\u6c34\u5e73\u4e00\u81f4(\u56fe4E-I)\u3002<\/span><\/section>\n

\"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01\"<\/span><\/p>\n

\u56fe4 \u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9aCRC\u4e2d\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0(LRGs)<\/span><\/section>\n
5.\u4e0eLRG\u6807\u5fd7\u7269\u76f8\u5173\u7684\u751f\u7269\u5b66\u673a\u5236\u7684\u9884\u6d4b<\/strong><\/span><\/section>\n
\u6df1\u5165\u7814\u7a76\u4e86LRGS\u6a21\u578b\u5728TCGA\u961f\u5217\u4e2d\u7684\u57fa\u56e0\u7ec4\u5f02\u8d28\u6027\u3002\u6211\u4eec\u5bf9LRG\u7a81\u53d8\u57fa\u56e0\u7684\u7a81\u53d8\u666f\u89c2\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u4e0e\u9891\u7e41\u7a81\u53d8\u7684\u57fa\u56e0\u5982APC\u3001TP53\u3001TTN\u548cKRAS\u8fdb\u884c\u4e86\u76f8\u5173\u6027\u5206\u6790\uff08\u56fe5A, B\uff09\uff0c\u7ed3\u679c\u663e\u793aLRGs\u4e0d\u643a\u5e26\u5b9e\u8d28\u6027\u7684\u7a81\u53d8\u8d1f\u62c5\uff0c\u4f46\u4e0e\u201cRTK-RAS\u201d\u3001\u201cWNT\u201d\u3001\u201cHippo\u201d\u3001\u201cPI3K\u201d\u3001\u201cMYC\u201d\u548c\u514d\u75ab\u76f8\u5173\u901a\u8def\u5982\u201cTGF-\u03b2\u201d\u7b49\u4fc3\u80bf\u7624\u901a\u8def\u5bc6\u5207\u76f8\u5173\uff08\u56fe5C\uff09\u3002\u968f\u540e\uff0c\u8fdb\u884c\u4e86\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff0c\u9ad8\u5371\u7ec4\u5728\u8840\u7ba1\u751f\u6210\u201d\u3001\u201c\u9876\u7aef\u8fde\u63a5\u201d\u3001\u201c\u51dd\u56fa\u201d\u548c\u201c\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\u201d\u4e2d\u5bcc\u96c6\uff08\u56fe5D\uff09\u3002\u4f4e\u98ce\u9669\u7ec4\u5728\u201cE2F\u9776\u70b9\u201d\u3001\u201cMYC\u9776\u70b9\u201d\u3001\u201c\u6c27\u5316\u78f7\u9178\u5316\u201d\u3001\u201cG2M\u68c0\u67e5\u70b9\u201d\u548c\u201cMTORC1\u4fe1\u53f7\u901a\u8def\u201d\u4e2d\u8868\u73b0\u51fa\u5bcc\u96c6\uff08\u56fe5E\uff09\u3002\u6839\u636e\u98ce\u9669\u8bc4\u5206\uff0cGSVA\u5206\u6790\u663e\u793a122\u6761\u901a\u8def\u5b58\u5728\u53cc\u5411\u8868\u8fbe\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9ad8\u5371\u7ec4\u4e0e\u201cnotch\u4fe1\u53f7\u901a\u8def\u201d\u3001\u201cWNT\u4fe1\u53f7\u901a\u8def\u201d\u3001\u201cECM\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u201d\u3001\u201c\u5c40\u7076\u7c98\u9644\u201d\u548c\u201c\u919a\u8102\u4ee3\u8c22\u201d\u7b49\u901a\u8def\u5448\u6b63\u76f8\u5173\uff0c\u5747\u6709\u52a9\u4e8e\u80bf\u7624\u751f\u957f\uff08\u56fe5F\uff09\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5bf9\u6807\u5fd7\u901a\u8def\u6d3b\u52a8\u4e0eLRG\u98ce\u9669\u8bc4\u5206\u8fdb\u884c\u4e86\u76f8\u5173\u6027\u5206\u6790\uff0c\u63ed\u793a\u4e86\u9ad8\u5371\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\u4e4b\u95f4\u7684\u4e0d\u540c\u7279\u5f81\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u9ad8\u98ce\u9669\u4e0e\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\u3001\u8840\u7ba1\u751f\u6210\u3001\u7f3a\u6c27\u3001notch\u4fe1\u53f7\u4ee5\u53ca\u5728IL2-STAT5\u4fe1\u53f7\u3001TGF\u03b2\u4fe1\u53f7\u3001IL6 Jak stat\u4fe1\u53f7\u3001IFN\u03b3\u4fe1\u53f7\u7b49\u514d\u75ab\u4fe1\u53f7\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff08\u56fe5G\uff09\u3002<\/span><\/section>\n

\"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01\"<\/span><\/p>\n

\u56fe5 \u9884\u6d4b\u4e0eLRGs\u98ce\u9669\u76f8\u5173\u7684\u751f\u7269\u5b66\u673a\u5236<\/span><\/section>\n
6.LRG\u8bc4\u5206\u91cd\u5851\u4e86\u514d\u75ab\u7ec6\u80de\u7684\u81a8\u80c0\u666f\u89c2<\/strong><\/span><\/section>\n

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