{"id":43732,"date":"2024-06-02T01:18:42","date_gmt":"2024-06-01T17:18:42","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43732"},"modified":"2024-06-06T08:38:15","modified_gmt":"2024-06-06T00:38:15","slug":"5aa4369be3","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43732","title":{"rendered":"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01"},"content":{"rendered":"
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\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/section>\n
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1.\u8be5\u7814\u7a76\u57fa\u4e8e\u5bf9\u5927\u4f17\u516c\u5f00\u7684\u7f8e\u56fd\u56fd\u5bb6\u5065\u5eb7\u4e0e\u8425\u517b\u8c03\u67e5(<\/span>NHANES<\/span>)\u6570\u636e\u5e93\uff0c\u5bf9\u5176<\/span>2003<\/span>~<\/span>2018<\/span>\u5e74\u7684\u6570\u636e\u8fdb\u884c\u4e86\u7b5b\u9009\uff0c\u6700\u7ec8\u5171\u7eb3\u5165<\/span>1602<\/span>\u540d\u53d7\u8bd5\u8005\u3002<\/span><\/span><\/span><\/section>\n
2.\u8be5\u7814\u7a76\u662f\u57fa\u4e8e<\/span>\u751f\u5b58<\/span>\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u907f\u514d\u4e86\u673a\u5668\u5b66\u4e60\u6a21\u578b\u76f4\u63a5\u7528\u4e8e\u6570\u636e\u53ef\u80fd\u4f1a\u9020\u6210\u626d\u66f2\u98ce\u9669\u9884\u6d4b\uff0c\u7efc\u5408\u8003\u8651\u4e86<\/span>\u751f\u5b58\u65f6\u95f4<\/span>\u548c<\/span>\u751f\u5b58\u6982\u7387<\/span>\uff0c\u51c6\u786e\u8bc6\u522b\u4e0e\u6b7b\u4ea1\u76f8\u5173\u7684\u73af\u5883\u5316\u5b66\u7269\u8d28\u3002\u5176\u6b21\uff0c\u5728<\/span>\u5173\u8054\u5206\u6790<\/span>\u4e2d\u53ea\u5305\u62ec\u4e86<\/span>\u5355\u4e00<\/span>\u7684\u73af\u5883\u5316\u5b66\u7269\u8d28\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e86\u504f\u5dee\u3002<\/span><\/span><\/section>\n
3.\u4e3a\u4fdd\u8bc1\u6a21\u578b\u53ef\u4fe1\u5ea6\uff0c\u91c7\u7528<\/span>\u4ea4\u53c9\u9a8c\u8bc1\u65b9\u6cd5<\/span>\u5145\u5206\u5229\u7528\u6570\u636e\uff0c<\/span>SMOTE<\/span>\u51cf\u8f7b\u6a21\u578b\u6027\u80fd\u65b9\u9762\u7684\u5f71\u54cd\u3002\u8bbe\u7f6e<\/span>\u5bf9\u7167<\/span>\u68c0\u9a8c\u6f5c\u5728\u6df7\u6742\u56e0\u7d20\uff0c<\/span>\u654f\u611f\u5ea6\u5206\u6790<\/span>\u6765\u8bc4\u4f30\u7a33\u5065\u6027\u3002<\/span>\u5bf9\u673a\u5668\u5b66\u4e60\u611f\u5174\u8da3\u5e76\u4e14<\/span>\u60f3\u8981\u53d1\u8868\u9ad8\u5206SCI\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u501f\u9274\u4e00\u4e0b\u672c\u6587\u7684\u7814\u7a76\u601d\u8def\u54e6~<\/span><\/span>ps\uff1a\u673a\u5668\u5b66\u4e60\u518d\u8054\u5408\u764c\u75c7\u7814\u7a76\u65e0\u7591\u662f\u53d1\u6587\u5229\u5668\uff0c\u4f46\u5e38\u89c4\u5957\u8def\u60f3\u8981\u53d1\u4e2a\u597d\u6587\u7ae0\u53ef\u8c13\u75f4\u4eba\u8bf4\u68a6\uff0c\u90a3\u5bf9\u673a\u5668\u5b66\u4e60\u611f\u5174\u8da3\u4f46\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\u54e6\uff01\u8fd9\u91cc\u6709\u9ad8\u5206\u6613\u590d\u73b0\u7684\u521b\u65b0\u601d\u8def\uff0c\u5c0f\u4f19\u4f34\u4eec\u8d76\u7d27\u6765\u516c\u4f17\u53f7\u540e\u53f0\u627e\u6211\u5662\uff01<\/span><\/section>\n
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\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
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\u6742\u5fd7\uff1aEcotoxicology and Environmental Safety<\/span><\/section>\n
\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e741\u6708<\/span><\/section>\n
\u5173\u6ce8\u516c\u4f17\u53f7\uff0c\u540e\u53f0\u53d1\u9001<\/span>\u201c123\u201d<\/span>\u53ef\u4ee5\u76f4\u63a5\u83b7\u53d6\u539f\u6587PDF\uff0c\u6587\u732e\u7f16\u53f7\uff1a240524<\/span><\/section>\n
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\u6570\u636e\u6765\u6e90<\/span><\/section>\n
\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u548c\u9884\u9632\u4e2d\u5fc3(CDC)\u521b\u7acb\u7684\u5168\u56fd\u5065\u5eb7\u4e0e\u8425\u517b\u8c03\u67e5(NHANES)\u6570\u636e\u5e93(http:\/\/www.cdc.gov\/nchs\/nhanes.htm)\uff0c\u8be5\u6570\u636e\u5e93\u6bcf\u4e24\u5e74\u5bf9\u5177\u6709\u5168\u56fd\u4ee3\u8868\u6027\u7684\u7f8e\u56fd\u5c45\u6c11\u6837\u672c\u8fdb\u884c\u8bbf\u8c08\u3001\u5b9e\u9a8c\u5ba4\u6d4b\u8bd5\u548c\u4f53\u683c\u68c0\u67e5\uff0c\u8be5\u7814\u7a76\u5229\u7528\u4e86\u5176<\/span>2003\u5e74\u81f32018\u5e74\u7684\u6570\u636e\uff0c\u521d\u59cb\u517180312 \u4eba\u3002\u672c\u7814\u7a76\u5305\u62ec\u4e86\u540c\u65f6\u6d4b\u91cf\u8840\u6e05\/\u5c3f\u6db2\u4e2d\u91d1\u5c5e\u3001\u9ad8\u6c2f\u9178\u76d0\u3001\u90bb\u82ef\u4e8c\u7532\u9178\u76d0\u3001\u915a\u7c7b\u3001\u6740\u866b\u5242\u3001\u591a\u6c1f\u70f7\u57fa\u5316\u5b66\u54c1 (PFC)\u3001\u591a\u73af\u82b3\u70c3 (PAH) \u548c\u6325\u53d1\u6027\u6709\u673a\u5316\u5408\u7269 (VOC) \u7684\u4e2a\u4f53(\u6392\u9664\u6837\u54c1\uff1aN = 78447)\u3002\u5176\u6b21\uff0c\u8fdb\u4e00\u6b65\u6392\u9664\u4e86\u5e74\u9f84\u5c0f\u4e8e18\u5c81(N = 254)\uff0c\u6b7b\u4e8e\u4f24\u5bb3(N = 9)\u7684\u4eba\u3002\u6700\u540e\uff0c1602\u540d\u53d7\u8bd5\u8005\u88ab\u7eb3\u5165\u7814\u7a76\u3002(\u622a\u81f32019\u5e7412\u670831\u65e5)\u4ece\u56fd\u5bb6\u536b\u751f\u4fdd\u5065\u670d\u52a1\u4e2d\u5fc3(https:\/\/www.cdc.gov\/nchs\/data-li nkage\/mortality.htm)\u83b7\u5f97\u7684\u6570\u636e\u786e\u5b9a\u6b7b\u4ea1\u7387\u3002<\/span><\/span><\/section>\n
\u7814\u7a76\u601d\u8def<\/span><\/section>\n
\u5229\u7528\u7f8e\u56fd\u56fd\u5bb6\u5065\u5eb7\u4e0e\u8425\u517b\u8c03\u67e5(NHANES)\u6570\u636e\u5e93\uff0c\u91c7\u7528Coxnet\u8fdb\u884c\u7279\u5f81\u9009\u62e9,\u9009\u62e9\u4e86\u524d20\u540d\u7684\u73af\u5883\u5316\u5b66\u54c1\uff0c\u5229\u7528Python 3.11.2 \u4e2d\u7684 Scikit-survival 0.20.0\u57fa\u4e8e\u5e94\u7528\u53ef\u89e3\u91ca\u751f\u5b58\u673a\u5668\u5b66\u4e60\u65b9\u6cd5(CoxPH\u3001Coxnet\u3001RSF\u3001GBS\u548cEST)\u5efa\u7acb\u751f\u5b58\u9884\u6d4b\u6a21\u578b, \u4ee5\u63a2\u8ba8\u8840\u6e05\/\u5c3f\u6db2\u4e2d\u5177\u6709\u4ee3\u8868\u6027\u76848\u7c7b\u73af\u5883\u5316\u5b66\u7269\u8d28\u4e2d\u768443\u79cd(\u6392\u9664\u68c0\u6d4b\u4e0b\u9650(LLOD)\u4f4e\u4e8e70%\u7684\u73af\u5883\u5316\u5b66\u54c1)\u548c 18 \u4e2a\u4e34\u5e8a\u53d8\u91cf\u4e0e\u5168\u56e0\u6b7b\u4ea1\u7387\u3001\u7279\u5b9a\u539f\u56e0\u6b7b\u4ea1\u7387\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u6240\u6709\u7279\u5f81\u7684\u7f3a\u5931\u7387\u5747\u4f4e\u4e8e10%\u3002\u6839\u636eICD-10\u5206\u7c7b\u7cfb\u7edf\u5b9a\u4e49\u6b7b\u56e0\uff0c\u5e76\u5c06\u5176\u5206\u4e3a\u4e09\u7c7b\uff1a\u5168\u56e0\u6b7b\u4ea1\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1(I00-I09\u3001I11\u3001I13\u3001I20-I51)\u548c\u764c\u75c7\u6b7b\u4ea1(C00-C97)\u3002\u91c7\u7528STATA SE 15.1\uff0cR 4.0.5\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002RCS\u548cSHAP\u504f\u76f8\u5173\u56fe\u5206\u6790\u5404\u79cd\u73af\u5883\u5316\u5b66\u7269\u8d28\u4e0e\u6b7b\u4ea1\u7387\u7684\u5173\u7cfb\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
\u56fe1\u6a21\u578b\u63a8\u5bfc\u548c\u9a8c\u8bc1\u7684\u6d41\u7a0b\u56fe<\/span><\/section>\n
\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n
1.<\/span>\u57fa\u7ebf\u7279\u5f81<\/span><\/span><\/section>\n
\u9996\u5148\uff0c\u4ece\u516c\u5f00\u7f51\u7ad9<\/span>(<\/span><\/span>http:\/\/www.cdc.gov\/nchs\/nhanes.htm<\/span>)<\/span>\u4e0a\u83b7\u5f97CDC 2003~2018\u5e74NHANES\u7684\u6570\u636e\uff0c\u8be5\u6570\u636e\u6bcf\u4e24\u5e74\u4e00\u66f4\u65b0\u3002\u6700\u521d\u5171\u670980312\u4eba(\u8868S2)\u3002\u9009\u62e9\u540c\u65f6\u6d4b\u91cf\u8840\u6e05\/\u5c3f\u6db2\u4e2d\u91d1\u5c5e\u3001\u9ad8\u6c2f\u9178\u76d0\u3001\u90bb\u82ef\u4e8c\u7532\u9178\u76d0\u3001\u915a\u7c7b\u3001\u519c\u836f\u3001\u591a\u6c1f\u70f7\u57fa\u5316\u5b66\u54c1(pfc)\u3001\u591a\u82b3\u70c3(PAHs)\u548c\u6325\u53d1\u6027\u6709\u673a\u5316\u5408\u7269(VOCs)\u7684\u4e2a\u4f53(\u6392\u9664\u6837\u672c:N = 78447)\u3002\u8fdb\u4e00\u6b65\u6392\u9664\u5e74\u9f84\u5c0f\u4e8e18\u5c81(N = 254)\u3001\u56e0\u4f24\u6b7b\u4ea1(N = 9)\u7684\u60a3\u8005\u3002\u6700\u7ec8\u5171\u7eb3\u51651602\u540d\u53c2\u4e0e\u8005\uff0c\u5e73\u5747\u5e74\u9f84\u4e3a46.33\u5c81\u00b118.39\u5c81\uff0c\u5176\u4e2d51.06%\u4e3a\u7537\u6027\u3002\u5728154,646\u4eba\u6708\u7684\u968f\u8bbf\u4e2d(\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a96.53\u4e2a\u6708)\uff0c\u53d1\u751f\u4e86127\u4f8b\u5168\u56e0\u6b7b\u4ea1\uff0c\u5305\u62ec34\u4f8b\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\uff0c35\u4f8b\u764c\u75c7\u6b7b\u4ea1(\u8868S3)\u30021602\u540d\u53d7\u8bd5\u8005\u73af\u5883\u5316\u5b66\u54c1\u6d53\u5ea6\u7684\u5206\u5e03\u89c1\u8868S4\u3002\u6837\u672c\u9009\u62e9\u6d41\u7a0b\u56fe\u5982\u56fe2\u6240\u793a\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
\u56fe2 \u6837\u672c\u9009\u62e9\u6d41\u7a0b\u56fe<\/span><\/section>\n
2.\u73af\u5883\u5316\u5b66\u54c1\u4e0e\u6b7b\u4ea1\u7387\u4e4b\u95f4\u7684\u5173\u8054<\/span><\/section>\n
\u901a\u8fc7\u4f7f\u7528Cox\u56de\u5f52\u6a21\u578b\u5206\u522b\u5206\u6790\u4e86\u4e0e\u4e09\u4e2a\u6b7b\u4ea1\u7387\u76f8\u5173\u7684\u73af\u5883\u5316\u5b66\u7269\u8d28\u6d53\u5ea6\u3002\u7ed3\u679c\u8868\u660e\uff0c\u5728\u8c03\u6574\u4e86\u6f5c\u5728\u7684\u6df7\u6742\u56e0\u7d20\u540e\uff0c\u8840\u6e05\u4e2dCd\u6d53\u5ea6\u4e0e\u8f83\u9ad8\u7684\u5168\u56e0\u6b7b\u4ea1\u98ce\u9669\u76f8\u5173\u3002\u5c3f\u6db2\u4e2dMP\u548c2-NAP\u7684\u6d53\u5ea6\u4e0e\u8f83\u4f4e\u7684\u5168\u56e0\u6b7b\u4ea1\u98ce\u9669\u76f8\u5173(\u88681)\u3002\u5c3f\u6db2\u4e2dBPA\u7684\u6d53\u5ea6\u4e0eCVD\u6b7b\u4ea1\u98ce\u9669\u8f83\u9ad8\u6709\u5173\u3002HMB\u7684\u5c3f\u6d53\u5ea6\u4e0eCVD\u6b7b\u4ea1\u7387\u5448\u8d1f\u76f8\u5173(\u88682)\u3002\u5c3fMNBP\u4e0e\u764c\u75c7\u6b7b\u4ea1\u98ce\u9669\u589e\u52a0\u6709\u5173(\u88683)\u3002\u5176\u4ed6\u73af\u5883\u5316\u5b66\u54c1\u7684\u7ed3\u679c\u89c1\u8868S5\u3001\u8868S6\u548c\u8868S7\u3002\u5728\u654f\u611f\u6027\u5206\u6790\u4e2d\uff0c\u663e\u793a\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c(\u8868S8\u3001\u8868S9\u548c\u8868S10)\u3002<\/span><\/section>\n
\u88681 \u73af\u5883\u5316\u5b66\u7269\u8d28\u4e0e\u5168\u56e0\u6b7b\u4ea1\u7387\u7684\u5173\u7cfb<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
Modela <\/sup>\u6ca1\u6709\u9488\u5bf9\u4efb\u4f55\u53d8\u91cf\u8fdb\u884c\u8c03\u6574\u3002Modelb <\/sup>\u6839\u636e\u5e74\u9f84\uff0c\u6027\u522b\uff0c\u79cd\u65cf\uff0c\u6559\u80b2\u7a0b\u5ea6\uff0c\u5a5a\u59fb\u72b6\u51b5\uff0c\u5438\u70df\uff0c\u996e\u9152\uff0c\u81ea\u6211\u62a5\u544a\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u7cd6\u5c3f\u75c5\uff0c\u9ad8\u8840\u538b\uff0c\u8170\u56f4(cm) \uff0c\u7cd6\u8840\u7ea2\u86cb\u767d(%)\u548c\u5e73\u5747\u8840\u5c0f\u677f\u4f53\u79ef(fL)\u8fdb\u884c\u8c03\u6574\u3002<\/span><\/section>\n
\u88682\u73af\u5883\u5316\u5b66\u7269\u8d28\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u7684\u5173\u7cfb<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
Modela <\/sup>\u6ca1\u6709\u9488\u5bf9\u4efb\u4f55\u53d8\u91cf\u8fdb\u884c\u8c03\u6574\u3002Modelb<\/sup> \u6839\u636e\u5e74\u9f84\uff0c\u6559\u80b2\u7a0b\u5ea6\uff0c\u5a5a\u59fb\u72b6\u51b5\uff0c\u996e\u9152\uff0c\u81ea\u6211\u62a5\u544a\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u7cd6\u5c3f\u75c5\uff0c\u8170\u56f4(cm) \uff0c\u7cd6\u8840\u7ea2\u86cb\u767d(%) \uff0cHDL- \u80c6\u56fa\u9187(mg\/dL)\u548c\u603b\u80c6\u56fa\u9187(mg\/dL)\u8fdb\u884c\u8c03\u6574\u3002<\/span><\/section>\n
\u88683 \u73af\u5883\u5316\u5b66\u7269\u8d28\u4e0e\u764c\u75c7\u6b7b\u4ea1\u7387\u7684\u5173\u7cfb<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
Modela<\/sup> \u6ca1\u6709\u9488\u5bf9\u4efb\u4f55\u53d8\u91cf\u8fdb\u884c\u8c03\u6574\u3002Modelb <\/sup>\u6839\u636e\u5e74\u9f84\uff0c\u79cd\u65cf\uff0c\u6559\u80b2\u7a0b\u5ea6\uff0c\u5a5a\u59fb\u72b6\u51b5\uff0c\u5438\u70df\uff0c\u996e\u9152\uff0c\u9ad8\u8840\u538b\uff0c\u7cd6\u8840\u7ea2\u86cb\u767d(%)\u548c\u5e73\u5747\u8840\u5c0f\u677f\u4f53\u79ef(fL)\u8fdb\u884c\u8c03\u6574\u3002<\/span>P\u2009<\/span><\u20090.05*\u3002<\/span><\/span><\/section>\n
3. \u7279\u5f81\u9009\u62e9\u548c\u6a21\u578b\u6784\u5efa<\/span><\/section>\n
\u5206\u522b\u6839\u636e\u5168\u56e0\u6b7b\u4ea1\u7387\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u548c\u764c\u75c7\u6b7b\u4ea1\u7387\u8bb0\u5f55\u8bad\u7ec3\u96c6\u4e0a\u7684c\u6307\u6570\uff0c\u9009\u62e9\u4e86\u524d20\u79cd\u73af\u5883\u5316\u5b66\u7269\u8d28\u7528\u4e8e\u6a21\u578b\u7684\u6784\u5efa(<\/span>\u8868S11\u3001\u8868S12\u548c\u8868S13)\u3002\u5728\u6d4b\u8bd5\u96c6\u4e2d\uff0c\u5bf9\u4e8e\u5168\u56e0\u6b7b\u4ea1\u7387\uff0c\u4e0e Coxnet\u3001RSF\u3001GBS \u548c EST \u6a21\u578b\u76f8\u6bd4\uff0cCoxPH \u5177\u6709\u6700\u4f73\u7684\u533a\u5206\u5ea6\uff0c\u5177\u6709\u6700\u9ad8\u7684\u65f6\u95f4\u4f9d\u8d56\u6027 AUROC \u548c C \u6307\u6570\u3002\u540c\u65f6\uff0cCoxPH\u7684\u65f6\u53d8\u6027Brier\u8bc4\u5206\u4e5f\u5f88\u4f4e\uff0c\u662f\u5168\u56e0\u6b7b\u4ea1\u7387\u7684\u6700\u4f73\u6a21\u578b(\u88684)\u3002\u800cCoxnet\u88ab\u9009\u4e3a\u5177\u6709\u65f6\u95f4\u4f9d\u8d56\u6027AUROC\u7684CVD\u6b7b\u4ea1\u7387\u7684\u6700\u4f73\u6a21\u578b(\u88685)\u3002\u540c\u6837\uff0cCoxnet\u88ab\u9009\u4e3a\u5177\u6709\u65f6\u95f4\u4f9d\u8d56\u6027AUROC\u7684\u764c\u75c7\u6b7b\u4ea1\u7387\u7684\u6700\u4f73\u6a21\u578b(\u88686)\u3002\u9884\u6d4b\u4e09\u79cd\u6b7b\u4ea1\u7387\u7684\u6700\u4f18\u6a21\u578b\u7684\u968f\u65f6\u95f4\u53d8\u5316\u7684ROC\u66f2\u7ebf\u5982\u56fe3\u6240\u793a\u3002\u9884\u6d4b\u6b7b\u4ea1\u7387\u7684\u4e0d\u540c\u6a21\u578b\u7684\u65f6\u95f4\u4f9d\u8d56\u6027 AUROC(\u56fe4)\uff0c\u73af\u5883\u5316\u5b66\u7269\u8d28\u7565\u5fae\u63d0\u9ad8\u4e86\u764c\u75c7\u6b7b\u4ea1\u7387\u7684\u9884\u6d4b\u51c6\u786e\u6027(<\/span>P<\/span> < 0.05)\uff0c\u4f46\u5bf9\u5168\u56e0\u6b7b\u4ea1\u7387\u548cCVD\u6b7b\u4ea1\u7387\u7684\u9884\u6d4b\u6ca1\u6709(\u8868S14)\u3002<\/span>    <\/span><\/span><\/o:page><\/section>\n
\u88684\u9884\u6d4b\u5168\u56e0\u6b7b\u4ea1\u7387\u6a21\u578b\u7684\u6027\u80fd<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
\u88685\u9884\u6d4b\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u6a21\u578b\u7684\u6027\u80fd<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span><\/section>\n
\u88686\u9884\u6d4b\u764c\u75c7\u6b7b\u4ea1\u7387\u6a21\u578b\u7684\u6027\u80fd<\/span><\/section>\n
\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/span>    <\/span><\/o:page><\/section>\n

\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/p>\n

\u56fe3\u9884\u6d4b\u4e09\u79cd\u6b7b\u4ea1\u7387\u7684\u6700\u4f73\u6a21\u578b\u7684 ROC \u66f2\u7ebf\uff0c(a)\u5177\u6709\u5168\u56e0\u6b7b\u4ea1\u7387\u7684\u6a21\u578b\uff0c(b)\u5177\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u7684\u6a21\u578b\uff0c(c)\u5177\u6709\u764c\u75c7\u6b7b\u4ea1\u7387\u7684\u6a21\u578b\u3002<\/span><\/section>\n

\"2024\u73af\u5883\u65b9\u5411\u4ecd\u7136\u5927\u6709\u53ef\u4e3a\uff01\u53a6\u95e8\u5927\u5b66\u65b9\u4e9a\u56e2\u961f\uff0cNHANES\uff0b\u673a\u5668\u5b66\u4e60+\u73af\u5883\u6c61\u67d3\u7269\u5173\u8054\u5206\u6790\uff0c\u8fd9\u9009\u9898\u7b80\u76f4\u7edd\u7edd\u5b50\uff01\"<\/p>\n

\u56fe4\u7528\u4e8e\u9884\u6d4b\u6b7b\u4ea1\u7387\u7684\u4e0d\u540c\u6a21\u578b\u7684\u65f6\u95f4\u4f9d\u8d56\u6027 AUROC\uff0c(a) \u5168\u56e0\u6b7b\u4ea1\u7387\u6a21\u578b\uff0c(b) CVD \u6b7b\u4ea1\u7387\u6a21\u578b\uff0c(c) \u764c\u75c7\u6b7b\u4ea1\u7387\u6a21\u578b\u3002\u5e73\u5747\u968f\u65f6\u95f4\u53d8\u5316\u7684 AUROC \u4ee5\u865a\u7ebf\u8868\u793a\u3002<\/span><\/section>\n
4. \u6a21\u578b\u89e3\u91ca<\/span><\/section>\n
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\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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