{"id":43755,"date":"2024-06-02T01:18:51","date_gmt":"2024-06-01T17:18:51","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43755"},"modified":"2024-06-04T18:27:27","modified_gmt":"2024-06-04T10:27:27","slug":"fee7d205f5","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43755","title":{"rendered":"Cancer Research\u91cd\u78c5\u6765\u88ad\uff01\u5355\u7ec6\u80de\u6d4b\u5e8f+\u6210\u50cf\u8d28\u8c31\u6d4b\u5b9a\uff1a\u7ec6\u80de\u95f4\u7684\u9690\u79d8\u4e92\u52a8\u5927\u63ed\u79d8\uff01"},"content":{"rendered":"
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\u4eca\u5929\u7ed9\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u805a\u7126\u80bf\u7624\u5fae\u73af\u5883\u7684\u521b\u65b0\u529b\u6ee1\u6ee1\u7684\u6587\u7ae0\uff01\u6587\u7ae0\u8f6c\u8f7d\u81ea\u79d1\u7814\u72ee\u516c\u4f17\u53f7\uff0c\u70b9\u51fb\u4e0a\u65b9\u540d\u7247\u52a0\u5173\u6ce8~<\/p>\n<\/section>\n<\/blockquote>\n

\u8fd9\u7bc7\u7814\u7a76\u5c31\u50cf\u662f\u4f7f\u7528\u9ad8\u6e05\u5fae\u8ddd\u955c\u6df1\u5165\u80ba\u817a\u764c\u5fae\u4e16\u754c\u7684\u63a2\u9669\u3002\u4e0d\u4ec5\u53d1\u73b0\u4e86\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u7ec6\u80de\u7684\u4ea4\u6d41\u65b9\u5f0f\uff0c\u8fd8\u63ed\u793a\u4e86\u4e00\u4e2a\u5173\u952e\u7684\u89d2\u8272\uff1a<\/span>NOTCH3<\/span>\u3002NOTCH\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u80ba\u817a\u764c\u80bf\u7624\u76f8\u5173\u95f4\u5145\u8d28\u7ec6\u80de\uff0c\u589e\u52a0\u80f6\u539f\u751f\u6210\uff0c\u589e\u5f3a\u7ec6\u80de\u4fb5\u88ad\u80fd\u529b\uff0c\u5728\u80bf\u7624\u95f4\u8d28\u91cd\u5851\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u8fd9\u7bc7\u6587\u7ae0\u8fd8\u5e94\u7528\u4e86\u4e00\u4e2a\u6280\u672f\u201c<\/span>\u7ec4\u7ec7\u6210\u50cf\u8d28\u8c31\u6d41\u5f0f<\/span>\u201d\uff08Imaging Mass Cytometry\uff09\u6280\u672f\uff0c\u8fd9\u4e2a\u6280\u672f\u7a81\u7834\u4e86\u4f20\u7edf\u514d\u75ab\u8367\u5149\uff08IF\uff09\u4e32\u8272\u4ee5\u53ca\u7ec4\u7ec7\u81ea\u53d1\u8367\u5149\u7684\u4fe1\u53f7\u5e72\u6270\u7684\u95ee\u9898\uff0c\u5c06\u5355\u5f20\u7ec4\u7ec7\u5207\u7247\u53ef\u4ee5\u68c0\u6d4b\u7684\u53c2\u6570\u4e2a\u6570\u63d0\u5347\u81f3\u51e0\u5341\u4e2a\uff0c<\/span>\u5927\u5e45\u589e\u52a0\u4e86\u5355\u4e2a\u6837\u672c\u7684\u6570\u636e\u91cf<\/span>\uff0c\u6709\u52a9\u4e8e\u66f4\u52a0\u5168\u9762\u3001\u9ad8\u6548\u5730\u9274\u5b9a\u7ec4\u7ec7\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5feb\u6765\u8ddf\u5e08\u54e5\u4e00\u8d77\u770b\u770b\u5427\uff1a<\/span><\/p>\n

1\uff0c<\/span>\u5355\u7ec6\u80de\u5206\u6790\u63ed\u793a\u5fae\u73af\u5883\u91cd\u5851\u7684\u673a\u5236<\/span>\uff1a\u901a\u8fc7\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\u6df1\u5165\u63a2\u7d22\u80ba\u817a\u764c\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff1b<\/span><\/span><\/section>\n
2\uff0c<\/span>\u5bf9NOTCH3\u5728\u4e0d\u540c\u5fae\u73af\u5883\u4e0b\u7684\u5f71\u54cd\u8fdb\u884c\u6df1\u5165\u7814\u7a76<\/span>\uff1a\u6839\u636e\u80ba\u817a\u764c\u60a3\u8005\u7684\u57fa\u8d28\u6c34\u5e73\u5c06\u6837\u672c\u8fdb\u884c\u5206\u7ec4\uff0c\u8fdb\u4e00\u6b65\u5206\u6790\u4e86NOTCH3\u5728\u4e0d\u540c\u57fa\u8d28\u72b6\u6001\u4e0b\u7684\u8868\u8fbe\u4e0e\u60a3\u8005\u9884\u540e\u7684\u5173\u8054\u3002\u8fd9\u79cd<\/span>\u5206\u5c42\u5206\u6790<\/span>\u63d0\u4f9b\u4e86\u66f4\u7ec6\u81f4\u7684\u8ba4\u8bc6\uff0c\u53d1\u73b0\u9ad8NOTCH3\u8868\u8fbe\u53ef\u80fd\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u7279\u5b9a\u7c7b\u578b\u4ea7\u751f\u66f4\u4e3a\u663e\u8457\u7684\u5f71\u54cd\uff0c\u8fd9\u662f\u7814\u7a76\u65b9\u6cd5\u4e0a\u7684\u521b\u65b0\u4e4b\u5904\u3002<\/span><\/span><\/section>\n
\u7efc\u5408\u6765\u770b\uff0c\u8fd9\u9879\u7814\u7a76\u5728\u7406\u89e3\u80bf\u7624\u95f4\u8d28\u751f\u7269\u5b66\u3001NOTCH\u9a71\u52a8\u7684\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u4ee5\u53caNOTCH3\u4f5c\u4e3a\u6f5c\u5728\u95f4\u8d28\u9776\u70b9\u7684\u4e34\u5e8a\u76f8\u5173\u6027\u65b9\u9762\u63d0\u4f9b\u4e86<\/span>\u8d85\u8d8a\u5148\u524dscRNA-aeq\u7814\u7a76\u7684\u89c1\u89e3<\/span><\/span>~<\/span>(ps\uff1a\u7f3a\u4e4f\u65b0\u7684\u65b9\u6848\u601d\u8def\uff1f\u65b9\u6848\u8bbe\u8ba1\u6709\u56f0\u96be\uff1f\u6570\u636e\u751f\u4fe1\u5206\u6790\u6c34\u5e73\u51b3\u5b9a\u7740\u6d4b\u5e8f\u7ed3\u679c\u8d28\u91cf\uff0c\u5feb\u6765\u5e08\u54e5\u8fd9\u91cc\u591a\u5b66\u4e60\uff0c\u6211\u4eec\u8fd9\u91cc\u7684\u9ad8\u7ea7\u5206\u6790\uff0c\u53ef\u4ee5\u5e2e\u52a9\u60a8\u63d0\u9ad8\u5206\u6790\u5e7f\u5ea6\u548c\u6df1\u5ea6\uff01\u968f\u65f6\u8054\u7cfb\u5c0f\u4e91\uff0c\u4e3a\u60a8\u89e3\u51b3\u70e6\u607c\uff01)<\/span><\/o:page><\/section>\n
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\"Cancer<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n
\"Cancer<\/span><\/section>\n
\u9898\u76ee<\/span>\uff1a<\/span>\u5355\u7ec6\u80de\u5206\u6790\u786e\u5b9aNOTCH3\u4ecb\u5bfc\u7684\u4fc3\u8fdb\u80ba\u817a\u764c\u5fae\u73af\u5883\u91cd\u5851\u548c\u4fb5\u88ad\u7684\u57fa\u8d28\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/section>\n
\u6742\u5fd7<\/span>\uff1aCancer Research<\/span><\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50<\/span>\uff1aIF=11.2<\/span><\/span><\/section>\n
\u53d1\u8868\u65f6\u95f4<\/span>\uff1a2024\u5e745\u6708<\/span><\/span><\/section>\n
\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
\u80ba\u817a\u764c\uff08LUAD\uff09\u662f\u6700\u5e38\u89c1\u7684\u539f\u53d1\u6027\u80ba\u764c\u7c7b\u578b\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u6291\u5236PD-1\u7b49\u514d\u75ab\u6291\u5236\u4fe1\u53f7\u901a\u8def\u8fdb\u800c\u6cbb\u7597\u665a\u671fLUAD\uff0c\u7136\u800c\u5927\u591a\u6570\u60a3\u8005\u5bf9\u6b64\u6cbb\u7597\u4e0d\u54cd\u5e94\u6216\u4f1a\u51fa\u73b0\u590d\u53d1\u3002\u4f7f\u7528\u60a3\u8005\u6765\u6e90\u6837\u672c\u7684\u8f6c\u5f55\u7ec4\u5b66\u7814\u7a76\u8868\u660e\uff0c\u57fa\u8d28\u6216\u95f4\u8d28\u57fa\u56e0\u7279\u5f81\u7684\u5bcc\u96c6\u4e0e\u5bf9ICB\u62b5\u6297\u6027\u5bc6\u5207\u76f8\u5173\uff0c\u8fd9\u8868\u660e\u95f4\u8d28\u7ec6\u80de\uff0c\u5305\u62ec\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF\uff09\u5728\u4ecb\u5bfc\u80bf\u7624\u57fa\u8d28\u4e2d\u7684\u514d\u75ab\u6291\u5236\u548c\u6cbb\u7597\u62b5\u6297\u65b9\u9762\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5728LUAD\u4e2d\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\uff08scRNA-seq\uff09\u5df2\u88ab\u5229\u7528\u6765\u7814\u7a76\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u5f02\u8d28\u6027\uff0c\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u53ca\u80bf\u7624\u4fb5\u6da6\u514d\u75ab\u7ec6\u80de\u7684\u514d\u75ab\u8868\u578b\u3002<\/span><\/o:page><\/section>\n
\u7814\u7a76\u601d\u8def<\/span><\/section>\n
\u672c\u7814\u7a76\u4f7f\u7528scRNA-seq\u548c\u6210\u50cf\u8d28\u8c31\u7ec6\u80de\u6d4b\u5b9a\u6cd5\uff08IMC\uff09\u89e3\u8bfb\u95f4\u8d28\u5f02\u8d28\u6027\u548c\u7a7a\u95f4\u5b9a\u4f4d\u3002\u901a\u8fc7\u914d\u4f53-\u53d7\u4f53\u5206\u6790\u5bf9\u95f4\u8d28\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u6df1\u5165\u8c03\u67e5\uff0c\u63ed\u793a\u7531\u5185\u6e90\u6027NOTCH\u914d\u4f53\u9a71\u52a8\u7684\u80bf\u7624\u76f8\u5173\u8840\u7ba1\u5468\u7ec6\u80de\u548cCAF\u4e2dNOTCH\u901a\u8def\u7684\u6fc0\u6d3b\u3002\u5229\u7528<\/span>\u516c\u5f00\u53ef\u7528\u7684\u60a3\u8005\u6d4b\u5e8f\u6570\u636e<\/span>\uff0c\u4f5c\u8005\u9610\u660e\u4e86NOTCH3\u4e0e\u591a\u79cdICB\u54cd\u5e94\u751f\u7269\u6807\u5fd7\u7269\u7ed3\u5408\u7684\u80fd\u529b\uff0c\u4ee5\u9884\u6d4b\u751f\u5b58\u3002<\/span><\/section>\n
\"Cancer<\/span><\/section>\n
\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n
1.scRNA-seq\u6570\u636e\u5206\u6790\u786e\u5b9a\u4e86\u80ba\u817a\u764c\u4e2d\u95f4\u8d28\u7ec6\u80de\u548c\u5176\u4ed6\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b<\/span><\/section>\n
\u4f5c\u8005\u5bf99\u540d\u672a\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\uff08LUAD\uff09\u8fdb\u884cscRNA-seq\uff0c\u5176\u4e2d6\u540d\u60a3\u8005\u6709\u914d\u5bf9\u7684\u764c\u65c1\u7ec4\u7ec7\uff08ANT\uff09\uff0c\u65e8\u5728\u5206\u6790\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u975e\u514d\u75ab\u548c\u514d\u75ab\u7ec6\u80de\u7684\u6570\u91cf\u548c\u7c7b\u578b\uff08\u56fe1A\uff09\u3002\u7ecf\u8fc7\u8d28\u91cf\u63a7\u5236\u548c\u53bb\u9664\u540e\uff0c\u83b7\u5f97\u4e86256,379\u4e2a\u603b\u7ec6\u80de\u548c13,857\u4e2a<\/span>\u95f4\u8d28\u7ec6\u80de<\/span>\u3002\u901a\u8fc7UMAP\u964d\u7ef4\u53ef\u89c6\u5316\uff0c\u786e\u5b9a\u4e86<\/span>\u516b\u79cd<\/span>\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff08\u56fe1B-C\uff09\u3002<\/span><\/span><\/o:page><\/section>\n
\"Cancer <\/span><\/section>\n
\u56fe1 scRNA-seq\u6570\u636e\u5206\u6790\u786e\u5b9a\u4e86\u80ba\u817a\u764c\u4e2d\u95f4\u8d28\u7ec6\u80de\u548c\u5176\u4ed6\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b<\/span><\/section>\n
2. \u80ba\u80bf\u7624\u95f4\u8d28\u4e2d4\u4e2a\u4e0d\u540c\u7684\u95f4\u53f6\u7ec6\u80de\u4e9a\u7fa4<\/span><\/section>\n
\u4e3a\u4e86\u8868\u5f81LUAD\u4e2d\u95f4\u8d28\u7ec6\u80de\u7684\u5f02\u8d28\u6027\uff0c\u4f5c\u8005\u5bf9\u5176\u8fdb\u884c\u4e9a\u7fa4\u805a\u7c7b\uff0c\u89c2\u5bdf\u5230\u56db\u4e2a\u660e\u663e\u4e9a\u7fa4\uff1a<\/span>FAP+PDPN+ CAFs\u3001MCAM+ACTA2+\u5468\u7ec6\u80de\u3001ACTA2+\u5e73\u6ed1\u808c\u7ec6\u80de\uff08SMC\uff09\u548c\u80ba\u90e8\u9a7b\u7559\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08LRF\uff09<\/span>\uff08\u56fe2A-B\uff09\u3002LRF\u4e3b\u8981\u6765\u6e90\u4e8eANT\u7ec4\u7ec7\uff0c\u800cSMCs\u7531\u80bf\u7624\u548cANT\u7684\u7ec6\u80de\u7ec4\u6210\uff08\u56fe2C\uff09\u3002FAP+PDPN+ CAFs\u548cMCAM+\u5468\u7ec6\u80de\u51e0\u4e4e\u5b8c\u5168\u6e90\u81ea\u80bf\u7624\u3002\u4f5c\u8005\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u786e\u8ba4\u4e86\u8fd9\u4e24\u4e2a\u4e9a\u7fa4\u7684\u5b58\u5728\uff08\u56fe2D\uff09\u3002\u901a\u8fc7\u7814\u7a76\u5b83\u4eec\u8868\u8fbe\u7684\u5176\u4ed6\u6807\u8bb0\u57fa\u56e0\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u786e\u8ba4\u4e86\u8fd9\u56db\u4e2a\u4e9a\u7fa4\u7684\u6ce8\u91ca\uff08\u56fe2E\uff09\u3002<\/span><\/span><\/section>\n
\u5728\u80ba\u817a\u764c\u4e2d\uff0cCAFs\u548c\u5468\u7ec6\u80de\u4e0e\u95f4\u8d28\/EMT\/TGF\u03b2\u6807\u8bb0\u57fa\u56e0\u96c6\u9ad8\u5ea6\u76f8\u5173\uff0c\u800c\u5468\u7ec6\u80de\u4e0e\u8840\u7ba1\u751f\u6210\u6807\u8bb0\u57fa\u56e0\u76f8\u5173\u6027\u5bc6\u5207\uff08\u56fe2F\uff09\u3002\u6b64\u5916\uff0c<\/span>myCAF\u6807\u8bb0\u57fa\u56e0\u5728CAFs\u4e2d\u6700\u4e30\u5bcc\uff0ciCAF\u6807\u8bb0\u57fa\u56e0\u5219\u5728LRFs\u4e2d\u5bcc\u96c6<\/span>\uff08\u56fe2G\uff09\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"Cancer <\/span><\/section>\n
\u56fe2 \u80ba\u80bf\u7624\u95f4\u8d28\u4e2d4\u4e2a\u4e0d\u540c\u7684\u95f4\u53f6\u7ec6\u80de\u4e9a\u7fa4<\/span><\/section>\n
3. \u80bf\u7624\u76f8\u5173\u95f4\u53f6\u7ec6\u80de\u7fa4\u7684\u90bb\u57df\u5206\u6790<\/span><\/section>\n
\u4f5c\u8005\u4f7f\u7528<\/span>IMC\u6280\u672f<\/span>\uff08\u9ad8\u7ef4\u6210\u50cf\uff09\u57287\u4e2aLUAD\u6837\u672c\u4e2d\u6807\u8bb0\u4e8618\u79cd\u6807\u5fd7\u7269\uff0c\u4ee5\u7814\u7a76<\/span>\u7ec6\u80de\u7c7b\u578b\u7684\u7a7a\u95f4\u6392\u5217\u5bf9\u80bf\u7624\u57fa\u8d28\u7684\u5f62\u6210\u548c\u7ef4\u6301\u7684\u5f71\u54cd<\/span>\uff08\u56fe3A-B\uff09\u3002\u4f5c\u8005\u53d1\u73b0\uff0cMCAM+<\/sup>\u548cACTA2+<\/sup>\u7ec6\u80de\u73af\u7ed5CD31+<\/sup>\u8840\u7ba1\u7684\u8584\u5c42\uff0c\u4ee3\u8868\u7740\u8840\u7ba1\u5468\u7ec6\u80de\u6216\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u3002\u800cFAP+\u80f6\u539fI+<\/sup>CAFs\u5219\u4f4d\u4e8e\u8840\u7ba1\u533a\u548c\u80bf\u7624\u5b9e\u8d28\u4e4b\u95f4\u7684\u57fa\u8d28\u533a\u57df\u3002\u4e3a\u8fdb\u4e00\u6b65\u5206\u6790\u548c\u53ef\u89c6\u5316\uff0c\u4f5c\u8005\u4ece7\u4e2a\u6837\u672c\u79cd\u751f\u6210\u4e86\u7ec6\u80de\u5206\u5272\u63a9\u6a21\u548ct-SNE\u56fe\uff08\u56fe3C\uff09\u3002\u4e3a\u4e86\u5b9e\u73b0\u5bf9\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u5b9a\u91cf\u7a7a\u95f4\u7814\u7a76\uff0c\u4f5c\u8005\u4f7f\u7528\u4e86<\/span>PhenoGraph<\/span>\u6280\u672f\uff0c\u5e76\u57287\u4e2a\u4f9b\u4f53\u4e2d\u9274\u5b9a\u4e8625\u4e2a\u4ee5\u7279\u5b9a\u8868\u4f4d\u4e3a\u7279\u5f81\u7684\u805a\u7c7b\uff08\u56fe3D\uff09\u3002\u7136\u540e\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86<\/span>\u90bb\u57df\u5206\u6790<\/span>\uff0c\u4ee5\u7814\u7a76\u80bf\u7624\u4e2d\u7ec6\u80de\u95f4\u7684\u663e\u8457\u76f8\u4e92\u4f5c\u7528\u6216\u907f\u514d\uff08\u56fe3E\uff09\uff0c<\/span>\u90bb\u57df\u5206\u6790\u63ed\u793a\u4e86\u80bf\u7624\u76f8\u5173\u95f4\u5145\u8d28\u7ec6\u80de\u4e0e\u5185\u76ae\/T\u7ec6\u80de\u4e4b\u95f4\u7684\u5bc6\u5207\u5730\u5f62\u5173\u8054<\/span>\u3002<\/span><\/span><\/o:page><\/section>\n
\"Cancer <\/span><\/section>\n
\u56fe3 \u80bf\u7624\u76f8\u5173\u95f4\u53f6\u7ec6\u80de\u7fa4\u7684\u90bb\u57df\u5206\u6790<\/span><\/section>\n
4. \u914d\u4f53\u53d7\u4f53\u5206\u6790\u53d1\u73b0\u80bf\u7624\u95f4\u8d28\u4e2dNOTCH3\u4fe1\u53f7\u5931\u8c03    <\/span><\/o:page><\/section>\n
\u63a5\u4e0b\u6765\u4f5c\u8005\u9274\u5b9a\u8840\u7ba1\u548c\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\u5728UMAP\u4e2d\u5f62\u6210\u4e86\u4e00\u4e2a\u72ec\u7279\u7684\u805a\u7c7b\uff0c\u800c\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u5219\u88ab\u91cd\u65b0\u5206\u6210\u4e867\u4e2a\u4e9a\u805a\u7c7b\uff0c\u5176\u4e2d<\/span>\u4e9a\u805a\u7c7bN1\u3001N2\u548cN3\u5728ANT\u6837\u672c\u4e2d\u663e\u8457\u5bcc\u96c6\uff0c\u800c\u4e9a\u805a\u7c7bT1\u3001T2\u548cT3\u5728\u80bf\u7624\u4e2d\u5bcc\u96c6<\/span>\uff08\u56fe4A-C\uff09\u3002\u4f7f\u7528<\/span>CellChat<\/span>\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\uff0c\u4e0eANT\u76f8\u6bd4\uff0c\u4f5c\u8005\u5bf9\u80bf\u7624\u4e2d\u4fe1\u606f\u6d41\u7684\u7edf\u8ba1\u6d4b\u91cf\u503c\u6700\u9ad8\u768411\u4e2a\u4fe1\u53f7\u901a\u8def\u8fdb\u884c\u4f18\u5148\u6392\u5e8f\uff08\u56fe4D\uff09\uff0c11\u6761\u901a\u8def\u4e2d\u7684\u4e00\u4e9b\uff08\u5982ESAM\u548cSEMA6\uff09\u4e3b\u8981\u7531\u9884\u6d4b\u7684\u5185\u76ae\u7ec6\u80de\u6216\u95f4\u5145\u8d28\u7ec6\u80de\u5185\u7684\u76f8\u4e92\u4f5c\u7528\u9a71\u52a8\uff08\u56fe4E\uff09\uff0c<\/span>\u7b26\u5408\u8981\u6c42\u7684\u524d\u4e24\u6761\u901a\u8def\u662fMHC-II\u548cNOTCH<\/span>\u3002<\/span><\/span><\/section>\n
\u6b64\u5916\uff0c\u901a\u8fc7\u5bf9LUAD\u80bf\u7624\u95f4\u8d28\u4e2dNOTCH\u4fe1\u53f7\u901a\u8def\u7684\u8c03\u67e5\uff0c\u4f5c\u8005\u53d1\u73b0\u591a\u79cd\u5185\u76ae\u4e9a\u578b\u4fc3\u8fdb\u4e86\u914d\u4f53\u7684\u8868\u8fbe\uff0c\u800c<\/span>NOTCH3<\/span>\u662f\u4e3b\u8981\u7684\u53d7\u4f53\uff0c<\/span>\u4e3b\u8981\u7531\u5468\u7ec6\u80de\u548c\u8f83\u4f4e\u6c34\u5e73\u7684\u764c\u76f8\u5173\u7ea4\u7ef4\u5316\u7ec6\u80de\uff08CAFs\uff09\u8868\u8fbe\u3002<\/span>\u8fdb\u4e00\u6b65\u7684\u9a8c\u8bc1\u663e\u793a\uff0c<\/span>NOTCH3\u5728\u4f9b\u4f53\u4e2d\u663e\u8457\u5bcc\u96c6\uff0c\u4e14\u5728LUAD\u80bf\u7624\u6837\u672c\u4e2d\u663e\u8457\u4e0a\u8c03\uff08\u56fe4F-J\uff09\u3002<\/span><\/span><\/o:page><\/section>\n
\"Cancer <\/span><\/section>\n
\u56fe4 \u914d\u4f53\u53d7\u4f53\u5206\u6790\u53d1\u73b0\u80bf\u7624\u95f4\u8d28\u4e2dNOTCH3\u4fe1\u53f7\u5931\u8c03<\/span><\/section>\n
5. \u963b\u65adNOTCH\u4fe1\u53f7\u53ef\u51cf\u5c11\u80f6\u539f\u751f\u6210\u548c\u7ec6\u80de\u4fb5\u88ad<\/span><\/section>\n
\u901a\u8fc7\u5728\u80bf\u7624\u6837\u672c\u4e2d\u6269\u589eMCAM+<\/sup>NOTCH3+<\/sup>\u7ec6\u80de\u5e76\u4e0e\u539f\u4ee3\u4eba\u80ba\u52a8\u8109\u5185\u76ae\u7ec6\u80de\u5171\u57f9\u517b\uff0c\u5e76\u4f7f\u7528MRK003\u6291\u5236NOTCH\u901a\u8def\uff0c\u4f5c\u8005\u53d1\u73b0<\/span>MRK003\u5904\u7406\u663e\u8457\u964d\u4f4e\u4e86\u95f4\u5145\u8d28\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u5171\u57f9\u517b\u4e2d\u7684\u51e0\u4e2aNOTCH\u9776\u57fa\u56e0\u7684\u8868\u8fbe<\/span>\uff0c\u5305\u62ecCOL1A1\u548cCTGF\uff08\u56fe5A-C\uff09\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c<\/span>MRK003\u5904\u7406\u8fd8\u5bfc\u81f4\u4e86COL1A1\u86cb\u767d\u6c34\u5e73\u7684\u663e\u8457\u964d\u4f4e<\/span> (\u56fe5D)\u3002<\/span>    <\/span><\/o:page><\/section>\n
\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u53d1\u73b0\u901a\u8fc7<\/span>\u6291\u5236NOTCH\u901a\u8def<\/span>\uff0c\u7279\u522b\u662f\u4f7f\u7528MRK003\u7b49\u836f\u7269\uff0c<\/span>\u53ef\u4ee5\u6709\u6548\u51cf\u5c11\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u95f4\u5145\u8d28\u7ec6\u80de\u7684\u4fb5\u88ad\u6027\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u8f6c\u79fb\u548c\u4fb5\u88ad\u80fd\u529b<\/span>\uff08\u56fe5E-I\uff09\u3002<\/span><\/span><\/section>\n
\"Cancer<\/span> <\/span><\/o:page><\/section>\n
\u56fe5 \u963b\u65adNOTCH\u4fe1\u53f7\u53ef\u51cf\u5c11\u80f6\u539f\u751f\u6210\u548c\u7ec6\u80de\u4fb5\u88ad<\/span><\/section>\n
6. NOTCH3\u5728\u8c03\u8282\u80bf\u7624\u95f4\u8d28\u548c\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u4e2d\u7684\u4e34\u5e8a\u76f8\u5173\u6027<\/span><\/section>\n
\u63a5\u4e0b\u6765\u4f5c\u8005\u8bc4\u4f30\u4e86\u4e24\u4e2a\u72ec\u7acbLUAD\u60a3\u8005\u961f\u5217\u4e2dNOTCH3\u8868\u8fbe\u4e0e\u5168\u57fa\u56e0\u8868\u8fbe\u7684\u5173\u8054\uff08\u56fe6A\uff09\uff0c<\/span>COL1A1\u662f\u4e0eNOTCH3<\/span>\u76f8\u5173\u6027\u6700\u9ad8\u7684\u57fa\u56e0\u4e4b\u4e00\u3002\u4f5c\u8005\u8fdb\u884c<\/span>\u901a\u8def\u5bcc\u96c6\u5206\u6790<\/span>\uff08\u56fe6B\uff09\uff0c\u53d1\u73b0\u8fd9\u4e9b\u57fa\u56e0\u5728<\/span>\u7ec6\u80de\u7c98\u9644\u3001\u57fa\u8d28\u91cd\u5851\u3001TGF\u03b2\u8bf1\u5bfc\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u8fc1\u79fb\u548c\u57fa\u8d28\u4ea7\u751f\u7b49\u901a\u8def\u4e2d\u5bcc\u96c6<\/span>\u3002<\/span><\/span><\/section>\n
\u7814\u7a76\u53d1\u73b0\u5728LUAD\u60a3\u8005\u4e2d\uff0c\u5c3d\u7ba1NOTCH\u914d\u4f53JAG1\u3001JAG2\u548cDLL3\u4e0e\u8f83\u5dee\u751f\u5b58\u7ed3\u679c\u76f8\u5173\uff0c\u4f46NOTCH3\u8868\u8fbe\u4e0e\u4e4b\u65e0\u5173\uff08\u56fe6C\uff09\u3002\u7136\u800c\uff0c\u5728\u57fa\u8d28\u4e30\u5bcc\u7684\u60a3\u8005\u4e2d\uff0c\u9ad8NOTCH3\u8868\u8fbe\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u6807\u5fd7\u76f8\u5173\uff0c\u6697\u793a\u9ad8NOTCH3\u8868\u8fbe\u53ef\u80fd\u963b\u788dT\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u6548\u5e94\uff08\u56fe6D-G\uff09\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u8868\u660e\uff0c\u9ad8NOTCH3\u8868\u8fbe\u4e0ePD-1\u62ee\u6297\u5242\u6cbb\u7597\u8010\u836f\u76f8\u5173\u7684\u57fa\u56e0\u7b7e\u540d\u5b58\u5728\u663e\u8457\u6b63\u76f8\u5173\uff08\u56fe6H\uff09\u3002\u56fe6I\u8bf4\u660e<\/span>\u95f4\u5145\u8d28\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u901a\u8fc7NOTCH\u901a\u8def\u5728TME\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u6fc0\u6d3b\u95f4\u5145\u8d28\u7ec6\u80de\uff0c\u5bfc\u81f4\u80f6\u539f\u6c89\u79ef\u548c\u7ec6\u80de\u4fb5\u88ad\u3002<\/span><\/span><\/o:page><\/section>\n
\"Cancer <\/span><\/section>\n
\u56fe6 NOTCH3\u5728\u8c03\u8282\u80bf\u7624\u95f4\u8d28\u548c\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u4e2d\u7684\u4e34\u5e8a\u76f8\u5173\u6027<\/span><\/section>\n
\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n
\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86NOTCH3\u5728\u80ba\u817a\u764c\u5fae\u73af\u5883\u91cd\u5851\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u4e3a\u6211\u4eec\u6df1\u5165\u7406\u89e3\u80bf\u7624\u53d1\u5c55\u548c\u6cbb\u7597\u62b5\u6297\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u9ad8NOTCH3\u8868\u8fbe\u53ef\u80fd\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\uff0c\u8fd9\u4e3a\u672a\u6765\u4e2a\u6027\u5316\u6cbb\u7597\u7b56\u7565\u7684\u5236\u5b9a\u63d0\u4f9b\u4e86\u91cd\u8981\u7ebf\u7d22\u3002<\/span>\u5982\u679c\u4f60\u4e5f\u6709\u4e00\u4e9b\u60f3\u6cd5\u5374\u4e0d\u77e5\u9053\u5982\u4f55\u5f00\u5c55\u5b9e\u9a8c\uff0c\u6216\u8005\u662f\u60f3\u8981\u91cf\u8eab\u5b9a\u5236\u5b9e\u9a8c\u65b9\u6848\uff0c\u90fd\u53ef\u4ee5\u6765\u627e\u5c0f\u4e91\uff0c\u65e0\u8bba\u662f\u751f\u4fe1\u5206\u6790\u8fd8\u662f\u57fa\u7840\u5b9e\u9a8c\uff0c\u5404\u79cd\u521b\u65b0\u6027\u601d\u8def\u8bbe\u8ba1\uff0c\u5c0f\u4e91\u90fd\u53ef\u4ee5\u5e2e\u4f60\u89e3\u5fe7\u54e6<\/span>~<\/span><\/span><\/o:page><\/section>\n
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\"Cancer<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

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\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u70ed\u70b9\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u7ec6\u80de\u6d4b\u5e8f<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u4e0e\u5fae\u73af\u5883<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u673a\u5668\u5b66\u4e60<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u57fa\u56e0\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u751f\u4fe1\u4e91\u670d\u52a1\u5668<\/strong><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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