{"id":43769,"date":"2024-06-02T01:19:02","date_gmt":"2024-06-01T17:19:02","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43769"},"modified":"2024-06-04T18:26:00","modified_gmt":"2024-06-04T10:26:00","slug":"4c484feb24","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43769","title":{"rendered":"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d"},"content":{"rendered":"
\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/p>\n

\u66fe\u51e0\u4f55\u65f6\uff0c\u201clncRNA\u201d\u3001\u201ccircRNA\u201d\u662f\u57fa\u7840\u7814\u7a76\u7684\u6d41\u91cf\u660e\u661f\uff0c\u800c\u66fe\u7ecf\u7684\u201c\u5c0f\u751c\u751c\u201d\u5374\u597d\u4f3c\u53d8\u6210\u4e86\u201c\u725b\u592b\u4eba\u201d\uff0c\u8fd1\u51e0\u5e74\u7684\u6587\u7ae0\u53d1\u8868\u91cf\u5374\u51fa\u73b0\u4e0b\u964d\uff08\u89c1\u4e0b\u56fe\u4e2d\uff0cpubmed\u4e2d\u641c\u7d22\u201clncRNA\u201d\u7684\u53d1\u6587\u6570\u91cf\u793a\u4f8b\uff09<\/span><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u51fa\u73b0\u8fd9\u79cd\u73b0\u8c61\u4e5f\u662f\u5404\u65b9\u9762\u7efc\u5408\u539f\u56e0\uff0c\u6bd4\u5982\uff0clncRNA\u6d4b\u5e8f\u5bb9\u6613\uff0c\u5374\u673a\u5236\u96be\u505a\uff1bceRNA\u7814\u7a76\u4e5f\u663e\u8fc7\u65f6\u7b49\u3002\u90a3\u4e48\uff0c\u5f88\u591a\u5c0f\u4f19\u4f34\u4e4b\u524d\u7684lncRNA\u7814\u7a76\uff0c\u8fd8\u80fd\u518d\u6df1\u5165\u4e0b\u53bb\u5417\uff1f\u73b0\u5728\u8fd8\u6709\u4ec0\u4e48\u5207\u5165\u89d2\u5ea6\u4e86\uff1f\u4eca\u5929\u7ed9\u5927\u5bb6\u63a8\u8350\u8fd9\u7bc7\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u768412+\u6587\u7ae0\uff0c\u5c31\u53ef\u4ee5\u4f5c\u4e3alncRNA\uff08\u5305\u542bcircRNA\uff09\u7684\u7814\u7a76\u65b0\u89c6\u89d2\uff0c\u4f9b\u5927\u5bb6\u53c2\u8003\u3002<\/span><\/p>\n

\u672c\u6587\u6709\u5982\u4e0b\u51e0\u4e2a\u4eae\u70b9\uff1a<\/span><\/p>\n

1\uff0c<\/span>\u4ee5lncRNA\u7684\u8868\u89c2\u9057\u4f20\u4e0e\u514d\u75ab\u8c03\u63a7\u7684\u7ed3\u5408<\/span>\uff1a<\/span>\u6587\u7ae0\u521b\u65b0\u6027\u5730\u7ed3\u5408\u4e86\u8868\u89c2\u9057\u4f20\u5b66\uff08\u7279\u522b\u662fDNA\u7532\u57fa\u5316\uff09\u548c\u514d\u75ab\u8c03\u63a7\uff0c\u63a2\u7d22\u4e86lncRNA\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u4f5c\u7528\u548c\u514d\u75ab\u9003\u9038\u673a\u5236\uff1b<\/span><\/span><\/p>\n

2\uff0c<\/span>\u591a\u7ec4\u5b66\u6570\u636e\u7684\u7efc\u5408\u5229\u7528<\/span>\uff1a\u7814\u7a76\u4e0d\u4ec5\u5206\u6790\u4e86DNA\u7532\u57fa\u5316\u548c\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u8fd8\u8003\u8651\u4e86\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3001\u514d\u75ab\u9014\u5f84\u6d3b\u6027\u548c\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u7b49\u591a\u4e2a\u5c42\u9762\u7684\u4fe1\u606f\uff0c\u63d0\u4f9b\u4e86\u66f4\u5168\u9762\u7684\u751f\u7269\u5b66\u89c1\u89e3\u3002<\/span><\/p>\n

3\uff0c<\/span>\u7cfb\u7edf\u6027\u5206\u6790\u4ee5\u53ca\u5e72\u6e7f\u7ed3\u5408<\/span>\uff1a<\/span>\u6587\u7ae0\u5e94\u7528\u591a\u79cd\u5206\u6790\u65b9\u6cd5\uff0c\u5982TIDE\u7b97\u6cd5\u3001TIMER\u8d44\u6e90\u548cCpG\u4f4d\u70b9\u7684\u7532\u57fa\u5316\u5206\u6790\uff0c\u4ee5\u5168\u9762\u7406\u89e3\u80f6\u8d28\u7624\u7684\u514d\u75ab\u5fae\u73af\u5883\u3002\u540c\u65f6\u8fdb\u884c\u4e86\u4f53\u5916\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u7efc\u4e0a\uff0clncRNA\u76ee\u524d\u867d\u4e0d\u53caMR\u3001\u673a\u5668\u5b66\u4e60\u7b49\u70ed\u95e8\uff0c\u4f46\u662f\u798f\u516e\u7978\u6240\u4f9d\uff0c\u505a\u7684\u4eba\u5c11\u53cd\u800c\u7ade\u4e89\u5c0f\u4e86\u3002\u6240\u4ee5\u5982\u679c\u5c0f\u4f19\u4f34\u4e4b\u524d\u6709\u505a\u8fc7lncRNA\u6d4b\u5e8f\u7b49\uff0c\u90a3\u540e\u7eed\u53ef\u4ee5\u7ee7\u7eed\u8fdb\u884c\u6570\u636e\u6316\u6398\uff0c\u63d0\u9ad8\u7814\u7a76\u7684\u5ef6\u7eed\u6027\uff1b\u4e00\u4e9b\u76f8\u5bf9\u5c0f\u4f17\u7684\u75be\u75c5\uff0clncRNA\u6316\u6398\u4f9d\u7136\u521b\u65b0\u6027\u4e0d\u9519\uff0c\u7ed3\u5408\u8868\u89c2\u7b49\u89d2\u5ea6\uff0c\u8fd8\u975e\u5e38\u503c\u5f97\u4e00\u8bd5<\/span>\u3002\u5fc3\u52a8\u7684\u5c0f\u4f19\u4f34\u5c31\u5feb\u884c\u52a8\u5427\uff0c\u5982\u679c\u6280\u672f\u53d7\u9650\uff0c\u4e5f\u53ef\u4ee5\u627e\u5c0f\u4e91\u54e6\uff01<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n
\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/section>\n

\u9898\u76ee\uff1a\u8868\u89c2\u9057\u4f20\u8c03\u63a7lncRNA\u63a2\u7d22\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5f02\u8d28\u6027\u548c\u514d\u75ab\u9003\u9038<\/span><\/p>\n

\u6742\u5fd7\uff1aTheranostics<\/span><\/p>\n

IF= 12.4<\/span><\/p>\n

\u89c1\u520a\uff1a2023\u5e743\u6708<\/span><\/p>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u662f\u6700\u5177\u4fb5\u88ad\u6027\u548c\u5f02\u8d28\u6027\u7684CNS\u80bf\u7624\uff0c\u514d\u75ab\u6cbb\u7597\u662f\u4e00\u4e2a\u6709\u524d\u666f\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4f46\u8840\u8111\u5c4f\u969c\u5e26\u6765\u7684\u7279\u6b8aTIME\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7528\u6784\u6210\u6311\u6218\u3002\u5173\u4e8elncRNA\u7684\u8868\u89c2\u9057\u4f20\u53d8\u5316\u53ca\u5176\u5bf9\u80f6\u8d28\u7624\u514d\u75ab\u5f02\u8d28\u6027\u7684\u8d21\u732e\u7684\u77e5\u8bc6\u4ecd\u7136\u7f3a\u4e4f\u3002<\/span><\/p>\n

\u6570\u636e\u6765\u6e90<\/span><\/p>\n\n\n\n\n\n
\n

\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u7c7b\u578b<\/span><\/p>\n<\/td>\n

\n

\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

PANCAN<\/span><\/p>\n<\/td>\n

\n

UCSC Xena<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

551\u540d\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u57fa\u56e0\u8868\u8fbe\u8c31<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GSE121723<\/span><\/p>\n<\/td>\n

\n

GEO<\/span><\/p>\n<\/td>\n

\n

RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

59\u540d\u80f6\u8d28\u7624\u60a3\u8005\u57fa\u56e0\u8868\u8fbe\u8c31<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7814\u7a76\u601d\u8def<\/span><\/p>\n

\u4f5c\u8005\u6574\u5408\u4e86\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u914d\u5bf9\u7532\u57fa\u5316\u7ec4\u548c\u8f6c\u5f55\u7ec4\u6570\u636e\u96c6\uff0c\u5e76\u6839\u636elncRNA\u7532\u57fa\u5316\u7279\u5f81\u8bc6\u522b\u4e862\u79cd\u514d\u75ab\u4e9a\u578b\uff0c\u5e76\u6bd4\u8f83\u4e86\u4ee5\u4e0a\u4e9a\u578b\u7684\u514d\u75ab\u7279\u6027\u3002\u6b64\u5916\uff0c\u8fd8\u8bc6\u522b\u4e86\u514d\u75ab\u76f8\u5173\u7684lncRNA\uff0c\u5e76\u8bc4\u4f30\u4e86\u5b83\u4eec\u4e0e\u514d\u75ab\u9003\u9038\u7684\u5173\u7cfb\u3002<\/span><\/o:page><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n

1.LncRNA\u7532\u57fa\u5316\u5f02\u8d28\u6027\u63ed\u793a\u80f6\u8d28\u7624\u514d\u75ab\u8868\u578b<\/span><\/p>\n

\u4f5c\u8005\u901a\u8fc7lncRNA\u7532\u57fa\u5316\u6570\u636e\u7684\u805a\u7c7b\u5206\u6790\uff0c\u533a\u5206\u51faC1\u548cC2\u4e24\u4e2a\u80bf\u7624\u4e9a\u578b\uff0c\u5b83\u4eec\u5728\u514d\u75ab\u76f8\u5173\u901a\u8def\u7684\u57fa\u56e0\u8868\u8fbe\u548c\u514d\u75ab\u6d3b\u6027\u8bc4\u5206\u4e0a\u6709\u663e\u8457\u5dee\u5f02\u3002C1\u4e9a\u578b\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u548c\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u66f4\u9ad8\uff0c\u8868\u73b0\u4e3a\u201c\u70ed\u201d\u514d\u75ab\u8868\u578b\uff0c\u800cC2\u4e9a\u578b\u5219\u76f8\u53cd\uff0c\u5448\u73b0\u201c\u51b7\u201d\u514d\u75ab\u8868\u578b\u3002\u6b64\u5916\uff0c\u514d\u75ab\u7ec6\u80de\u6807\u8bb0\u57fa\u56e0\u7684\u7532\u57fa\u5316\u6a21\u5f0f\u5728\u4e24\u79cd\u4e9a\u578b\u4e2d\u4e5f\u5b58\u5728\u5dee\u5f02\uff0c\u4e3a\u80f6\u8d28\u7624\u7684\u514d\u75ab\u5f02\u8d28\u6027\u63d0\u4f9b\u4e86\u8868\u89c2\u9057\u4f20\u5b66\u8bc1\u636e\u3002<\/span><\/o:page><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u56fe1.\u795e\u7ecf\u80f6\u8d28\u7624\u4e2dlncRNA\u7532\u57fa\u5316\u7684\u80bf\u7624\u514d\u75ab\u8868\u578b\u7279\u5f81<\/span><\/p>\n

2.\u80f6\u8d28\u7624\u514d\u75ab\u8868\u578b\u5177\u6709\u660e\u663e\u7684\u4e34\u5e8a\u548c\u8868\u89c2\u9057\u4f20\u5b66\u7279\u5f81<\/span><\/p>\n

\u4f5c\u8005\u901a\u8fc7\u6bd4\u8f83\u5173\u952e\u5206\u5b50\u548c\u4e34\u5e8a\u7279\u5f81\uff0c\u53d1\u73b0C1\u4e9a\u578b\u60a3\u8005\u7684\u9884\u540e\u4e0d\u4f73\uff0c\u4e14\u5728\u7f16\u7801\u533a\u5177\u6709\u66f4\u9ad8\u7684\u80bf\u7624\u7a81\u53d8\u8d1f\u62c5\uff08TMB\uff09\u548c\u67d3\u8272\u4f53\u975e\u6574\u500d\u4f53\u6c34\u5e73\u3002\u5229\u7528TCGA\u6570\u636e\uff0c\u5c06\u5f25\u6f2b\u6027\u80f6\u8d28\u7624\u5206\u4e3a\u516d\u4e2a\u4e9a\u578b\uff0cC1\u4e9a\u578b\u4e0e\u5168\u57fa\u56e0\u7ec4\u4f4e\u7532\u57fa\u5316\u7684LGm4-6\u76f8\u5173\uff0c\u800cC2\u4e9a\u578b\u4e0eLGm1-3\u76f8\u5173\u3002\u901a\u8fc7ChromHMM\u6a21\u578b\u7684\u5206\u6790\uff0cC1\u4e9a\u578b\u5728\u591a\u79cd\u67d3\u8272\u8d28\u72b6\u6001\u4e0b\u663e\u793a\u51fa\u8f83\u4f4e\u7684\u7532\u57fa\u5316\u6c34\u5e73\uff0c\u4e14\u5728C1\u4e9a\u578b\u4e2d\u9274\u5b9a\u51fa119\u4e2a\u5dee\u5f02\u8868\u8fbe\u7684\u67d3\u8272\u8d28\u8c03\u8282\u56e0\u5b50\u3002<\/span> <\/span><\/o:page><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u56fe2. \u80f6\u8d28\u7624\u4e9a\u578b\u7684\u4e34\u5e8a\u75c5\u7406\u548c\u8868\u89c2\u9057\u4f20\u5b66\u7279\u5f81<\/span><\/p>\n

3.\u8868\u89c2\u57fa\u56e0\u8c03\u63a7\u7684lncRNA\u4e0e\u764c\u75c7\u8fc7\u7a0b\u6709\u5173<\/span><\/p>\n

\u7814\u7a76\u8005\u901a\u8fc7\u5206\u6790lncRNA\u7684\u8868\u8fbe\u4e0e\u7532\u57fa\u5316\u6570\u636e\uff0c\u8bc6\u522b\u51fa149\u4e2a\u4e0e\u795e\u7ecf\u80f6\u8d28\u7624\u60a3\u8005\u9884\u540e\u76f8\u5173\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7lncRNA\u3002\u8fd9\u4e9blncRNA\u5728C1\u60a3\u8005\u4e2d\u8868\u8fbe\u4e0a\u8c03\uff0c\u4e0e\u5176\u542f\u52a8\u5b50\u533a\u4f4e\u7532\u57fa\u5316\u6709\u5173\u3002eForge\u5206\u6790\u663e\u793a\uff0c\u8fd9\u4e9blncRNA\u7684CpG\u4f4d\u70b9\u4e0e\u6d3b\u6027\u67d3\u8272\u8d28\u72b6\u6001\u76f8\u5173\uff0c\u8868\u660eDNA\u7532\u57fa\u5316\u901a\u8fc7\u6fc0\u6d3blncRNA\u8868\u8fbe\u6765\u8c03\u63a7\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u514d\u75ab\u8c03\u8282\u548c\u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2\u3002<\/span><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/p>\n

\u56fe3 \u8868\u89c2\u9057\u4f20\u5b66\u8c03\u63a7\u7684lncRNA\u4e0e\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u53d1\u5c55\u76f8\u5173<\/span><\/p>\n

4.\u4e0e\u514d\u75ab\u8c03\u63a7\u76f8\u5173\u7684\u8868\u89c2\u8c03\u63a7lncRNA<\/span><\/span><\/p>\n

\u4f5c\u8005\u53d1\u73b0130\u4e2alncRNA\u5728\u7532\u57fa\u5316\u548c\u8f6c\u5f55\u7ec4\u6c34\u5e73\u4e0a\u4e0e\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u663e\u8457\u76f8\u5173\uff0c\u4e14\u5927\u591a\u6570 lncRNA\u6b63\u5411\u8c03\u63a7\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3002\u4ee5PVT1\u4e3a\u4f8b\uff0c\u5176\u4f4e\u7532\u57fa\u5316\u72b6\u6001\u4e0eC1\u60a3\u8005\u7684\u9ad8\u8868\u8fbe\u76f8\u5173\uff0c\u4e14PD-L1\u7684\u8868\u8fbe\u4e0ePVT1\u6b63\u76f8\u5173\uff0c\u8868\u660elncRNA\u901a\u8fc7\u5f71\u54cd\u4e0b\u6e38\u57fa\u56e0\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u3002\u6b64\u5916\uff0cER lncRNA\u4e0e\u591a\u79cd\u514d\u75ab\u901a\u8def\u76f8\u5173\uff0c\u5176\u4e2d29\u4e2alncRNA\u53c2\u4e0e\u514d\u75ab\u901a\u8def\u8c03\u8282\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u5b83\u4eec\u5728\u80f6\u8d28\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u56fe4 \u8868\u89c2\u9057\u4f20\u5b66\u8c03\u63a7\u7684lncRNA\u53c2\u4e0e\u514d\u75ab\u8c03\u63a7<\/span><\/p>\n

5.\u4f53\u5916\u5b9e\u9a8c\u4e2dER lncRNA\u4e0e\u514d\u75ab\u9003\u9038\u76f8\u5173\u6027\u7684\u9a8c\u8bc1<\/span><\/span><\/p>\n

\u4f5c\u8005\u901a\u8fc7qRT-PCR\u68c0\u6d4b\u56db\u79cdlncRNA\u5728\u4e24\u79cdGBM\u7ec6\u80de\u7cfb\u4e2d\u7684\u8868\u8fbe\uff0c\u53d1\u73b0CD109-AS1\u548cLINC02447\u9ad8\u8868\u8fbe\u3002\u5229\u7528siRNA\u6280\u672f\u6572\u4f4e\u8fd9\u4e9blncRNA\u540e\uff0c\u89c2\u5bdf\u5230U251\u7ec6\u80de\u589e\u6b96\u51cf\u7f13\uff0c\u514d\u75ab\u9003\u9038\u6807\u8bb0\u7269PD-L1\u3001CTLA4\u548cFOXP3\u7684\u86cb\u767d\u8868\u8fbe\u4e0b\u964d\uff0c\u7ec6\u80de\u8fc1\u79fb\u548c\u4fb5\u88ad\u80fd\u529b\u964d\u4f4e\uff0c\u8bc1\u5b9e\u4e86\u8fd9\u4e9blncRNA\u5728GBM\u7ec6\u80de\u751f\u7269\u5b66\u884c\u4e3a\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n

\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/span><\/p>\n

\u56fe5 CD109-AS1\u5728GBM\u7ec6\u80de\u7cfb\u589e\u6b96\u3001\u8fc1\u79fb\u3001\u4fb5\u88ad\u548c\u514d\u75ab\u9003\u9038\u4e2d\u7684\u4f5c\u7528<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n

\u603b\u4e4b\uff0c\u8be5\u7814\u7a76\u57fa\u4e8elncRNA\u7532\u57fa\u5316\u7cfb\u7edf\u5730\u8868\u5f81\u4e86\u80f6\u8d28\u7624\u60a3\u8005\u7684\u514d\u75ab\u4e9a\u578b\uff0c\u5e76\u63cf\u8ff0\u4e86DNA\u7532\u57fa\u5316\u3001lncRNA\u548c\u514d\u75ab\u8c03\u63a7\u4e4b\u95f4\u7684\u4e32\u6270\u3002\u901a\u8fc7\u591a\u79cd\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u548c\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u53d1\u73b0\u5e76\u9a8c\u8bc1\u4e86\u4e24\u4e2a\u53c2\u4e0e\u514d\u75ab\u9003\u9038\u7684lncRNA\u751f\u7269\u6807\u5fd7\u7269\u3002\u6240\u4ee5\uff0c<\/span>lncRNA\u53ea\u8981\u9009\u597d\u89d2\u5ea6\uff0c\u53d1paper\u4f9d\u7136\u6ca1\u95ee\u9898\uff0c\u5404\u4f4d\u5c0f\u4f19\u4f34\u5feb\u884c\u52a8\u5427\uff01\u5982\u9700\u6280\u672f\u534f\u52a9\uff0c\u8bb0\u5f97call\u5c0f\u4e91\u54e6\uff01<\/span><\/p>\n

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\"lncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

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\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70ed\u70b9\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u7ec6\u80de\u6d4b\u5e8f<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u4e0e\u5fae\u73af\u5883<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u673a\u5668\u5b66\u4e60<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u57fa\u56e0\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u751f\u4fe1\u4e91\u670d\u52a1\u5668<\/strong><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u4e91\u751f\u4fe1\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff09\uff1alncRNA\u6210\u201c\u70eb\u624b\u5c71\u828b\u201d\uff1f\u6551\u661f\u5728\u8fd9\u91cc\uff01\u6d77\u5357\u533b\u5b66\u9662\u674e\u5b54\u5b81\u6559\u6388\u56e2\u961f1\u533a12+\uff0c\u591a\u7ec4\u5b66+\u8868\u89c2\u9057\u4f20\u6210\u9999\u998d\u998d<\/a><\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u66fe\u51e0\u4f55\u65f6\uff0c\u201clncRNA\u201d\u3001\u201ccircRNA\u201d\u662f\u57fa\u7840\u7814\u7a76\u7684\u6d41\u91cf\u660e\u661f\uff0c\u800c\u66fe\u7ecf\u7684\u201c\u5c0f\u751c\u751c\u201d\u5374\u597d\u4f3c\u53d8\u6210\u4e86\u201c\u725b\u592b\u4eba\u201d\uff0c […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43769"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43769"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43769\/revisions"}],"predecessor-version":[{"id":46194,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43769\/revisions\/46194"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43769"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}