{"id":43784,"date":"2024-06-02T01:19:11","date_gmt":"2024-06-01T17:19:11","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43784"},"modified":"2024-06-04T14:43:34","modified_gmt":"2024-06-04T06:43:34","slug":"f776aa1883","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43784","title":{"rendered":"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01"},"content":{"rendered":"
\n

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\u671f\u520a\u5b98\u7f51\uff1a<\/span><\/section>\n
https:\/\/www.ebiomedicine.com\/<\/span><\/section>\n
\u6295\u7a3f\u7f51\u7ad9\uff1a<\/span><\/section>\n

https:\/\/www.editorialmanager.com\/EBIOM<\/span><\/p>\n

\u7814\u7a76\u9886\u57df<\/span>\uff1a\u57fa\u7840\u7814\u7a76\u3001\u8f6c\u5316\u7814\u7a76\u3001\u4e34\u5e8a\u7814\u7a76\u548c\u536b\u751f\u7cfb\u7edf\u7814\u7a76<\/span>    <\/span><\/o:page><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1a<\/span>11.1<\/span><\/span><\/p>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u5e74\u6587\u7ae0\u91cf<\/span>\uff1a518<\/span><\/span><\/p>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u81ea\u5f15\u7387\uff1a<\/span>0.9%<\/span><\/span><\/p>\n

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\u5ba1\u7a3f\u5468\u671f\uff1a<\/span>\u7ea62\u4e2a\u6708\u5de6\u53f3\uff0c\u63a5\u6536\u5230\u5728\u7ebf\u53d1\u8868\u4e3a2-3\u5468\uff0c\u901f\u5ea6\u8fd8\u662f\u6bd4\u8f83\u5feb\u7684\u3002<\/span><\/span><\/p>\n

\u63a5\u6536\u7387\uff1a<\/span>\u901a\u8fc7\u5b98\u7f51\u67e5\u8be2\uff0c\u53bb\u5e74\u53d1\u8868\u7684\u6587\u7ae0\u4e2d\u56fd\u4eba\u6587\u7ae0\u5360\u6bd435%\uff0c\u8bf4\u660e\u8be5\u6742\u5fd7\u5bf9\u56fd\u4eba\u6587\u7ae0\u8fd8\u662f\u5f88\u53cb\u597d\u7684\uff01<\/span>    <\/span><\/o:page><\/p>\n

\u7248\u9762\u8d39\uff1a<\/span>\u5f00\u653e\u83b7\u53d6\uff08OA\uff09\u51fa\u7248\u65b9\u5f0f\uff0c\u7248\u9762\u8d395000\u7f8e\u5143\u3002<\/span><\/span><\/p>\n

\u8fd9\u79cd\u96c6\u9ad8IF\uff0c\u81ea\u5f15\u7387\u4f4e\uff0c\u89c1\u520a\u5feb\uff0c\u7eaf\u751f\u4fe1\u53cb\u597d\uff0c\u56fd\u4eba\u53cb\u597d\u7b49\u4f18\u70b9\u4e8e\u4e00\u8eab\u671f\u520a\u600e\u80fd\u4e0d\u8ba9\u4eba\u9752\u7750\uff01<\/span>\u4e0b\u9762\u5c0f\u4e91\u4ee5\u4e00\u7bc7\u6d59\u5927\u56e2\u961f\u8fd1\u671f\u53d1\u8868\u7684\u6587\u7ae0\u5e26\u5927\u5bb6\u4f53\u9a8c\u4e00\u4e0b\u8fd9\u672c\u671f\u520a\u7684\u9b45\u529b\u5427~<\/span><\/span><\/p>\n

\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/p>\n

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\u6742\u5fd7\uff1aEBioMedicine<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=11.1<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e741\u6708<\/span><\/p>\n

\u5173\u6ce8\u516c\u4f17\u53f7\uff0c\u540e\u53f0\u53d1\u9001<\/span>\u201c123\u201d<\/span>\u53ef\u4ee5\u76f4\u63a5\u83b7\u53d6\u539f\u6587PDF\uff0c\u6587\u732e\u7f16\u53f7\uff1a240525<\/span><\/section>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

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\u7814\u7a76\u601d\u8def<\/span><\/p>\n

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<\/o:p><\/span><\/p>\n

\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n

1.\u7ebf\u7c92\u4f53\u57fa\u56e0\u7532\u57fa\u5316\u4e0eIBD<\/span><\/p>\n

\u7ebf\u7c92\u4f53\u57fa\u56e0\u7532\u57fa\u5316\u5bf9IBD\u53ca\u5176\u4e9a\u578b\u7684\u56e0\u679c\u5f71\u54cd\u7ed3\u679c\u5982\u56fe1\u548c\u56fe2\u6240\u793a\u3002\u7ecf\u8fc7\u591a\u6b21\u6d4b\u8bd5\u6821\u6b63\uff0c\u572816\u4e2a\u72ec\u7279\u57fa\u56e0\u9644\u8fd1\u9274\u5b9a\u4e8629\u4e2aCpG\u4f4d\u70b9(\u56fe1)\u3002\u572837\u4e2a\u5df2\u9274\u5b9a\u7684\u4fe1\u53f7\u4e2d\uff0c\u53d1\u73b0\u4e8619\u4e2a\u72ec\u7279\u7684\u57fa\u56e0(PPH4>0.70)\u3002\u5bf9\u4e8e\u540c\u4e00\u57fa\u56e0\u7684\u4e0d\u540cCpG\u4f4d\u70b9\u7684\u6548\u5e94\u65b9\u5411\u5e76\u4e0d\u603b\u662f\u4e00\u81f4\u7684\u3002\u57fa\u56e0\u9884\u6d4b\u7684cg21249771\u4f4d\u7684BOK\u7532\u57fa\u5316\u589e\u52a0\u4e00\u4e2aSD\u4e0eIBD\u7684\u98ce\u9669\u964d\u4f4e\u76f8\u5173(OR 0.86\uff0c95% CI 0.81-0.92)\uff0c\u800c\u57fa\u56e0\u9884\u6d4b\u7684cg27088072\u4f4d\u7684BOK\u7532\u57fa\u5316\u589e\u52a0\u4e00\u4e2aSD\u4e0eIBD\u7684\u9ad8\u98ce\u9669\u76f8\u5173(OR 1.23\uff0c95%CI 1.12-1.34)\u3002\u6709218\u4e2aCpG\u4f4d\u70b9\u6ca1\u6709\u68c0\u6d4b\u5230\u4e0eUC\u98ce\u9669\u76f8\u5173\u7684\u591a\u6548\u6027\uff0c7\u4e2aCpG\u4f4d\u70b9\u67094\u4e2a\u72ec\u7279\u57fa\u56e0\u5728FDR\u6821\u6b63\u540e\u5b58\u6d3b\uff1aACADM\u3001DNLZ\u3001GPX1\u548cPMPCA\u3002Cg05467918(\u4f4d\u4e8eACADM)\u3001cg12603531(\u4f4d\u4e8eDNLZ)\u548ccg14316865(\u4f4d\u4e8ePMPCA)\u5177\u6709\u9ad8\u5ea6\u652f\u6301\u5171\u5b9a\u4f4d\u7684\u8bc1\u636e\u3002Cg12603531\u548ccg14316865\u7684\u5173\u8054\u5728UK Biobank\u4e2d\u590d\u5236\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728CD\u548cUC\u4e2d\u90fd\u89c2\u5bdf\u5230\u4e86cg12603531\u548ccg14316865\u7684\u5173\u8054\u3002<\/span><\/span><\/section>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u56fe1\u5b5f\u5fb7\u5c14\u968f\u673a\u5206\u6790\u4e2d\u9057\u4f20\u9884\u6d4b\u7684\u7ebf\u7c92\u4f53\u57fa\u56e0\u7532\u57fa\u5316\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u7684\u5173\u8054\u3002OR\uff0c\u4f18\u52bf\u6bd4\uff1bCI\uff0c\u7f6e\u4fe1\u533a\u95f4\uff1bPPH4\uff0cH4 \u7684\u540e\u9a8c\u6982\u7387<\/span><\/p>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u56fe2 \u5b5f\u5fb7\u5c14\u968f\u673a\u5206\u6790\u4e2d\u9057\u4f20\u9884\u6d4b\u7684\u7ebf\u7c92\u4f53\u57fa\u56e0\u7532\u57fa\u5316\u4e0e\u514b\u7f57\u6069\u75c5\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u5173\u8054\u3002OR\uff0c\u4f18\u52bf\u6bd4\uff1bCI\uff0c\u7f6e\u4fe1\u533a\u95f4\uff1bPPH4\uff0cH4 \u7684\u540e\u9a8c\u6982\u7387<\/span><\/p>\n

2.\u7ebf\u7c92\u4f53\u57fa\u56e0\u8868\u8fbe\u548c IBD<\/span><\/p>\n

\u8868 1 \u5217\u51fa\u4e86\u7ebf\u7c92\u4f53\u57fa\u56e0\u8868\u8fbe\u5bf9 IBD \u53ca\u5176\u4e9a\u578b\u7684\u56e0\u679c\u5f71\u54cd\u7684\u7ed3\u679c\u3002\u603b\u5171\u786e\u5b9a\u4e86 67 \u4e2a\u4e0e IBD \u76f8\u5173\u7684\u540d\u4e49\u663e\u7740\u6c34\u5e73 (P < 0.05)\u3002\u7ecf\u8fc7\u591a\u91cd\u6d4b\u8bd5\u6821\u6b63\u548c\u5171\u5b9a\u4f4d\u5206\u6790\u540e\uff0c\u57fa\u56e0\u9884\u6d4bTUFM\u3001MTX1\u3001MRPL20\u3001CISD1\uff1b\u3001BCL2L11\u548c PMPCA\u4e0e IBD \u98ce\u9669\u5448\u6b63\u76f8\u5173\u3002\u76f8\u53cd\uff0c\u57fa\u56e0\u9884\u6d4b\u7684 PARK7 \u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\u4e0e IBD \u98ce\u9669\u5448\u8d1f\u76f8\u5173\uff08\u8868 1\uff09\u3002\u7ecf\u8fc7 FDR \u6821\u6b63\u548c\u5171\u5b9a\u4f4d\u8bc1\u636e\u8fc7\u6ee4\u540e\uff0c\u4ece\u57fa\u56e0\u89d2\u5ea6\u9884\u6d4b MRPL20\u3001BCL2L11\u548c PMPCA\u7684 SD \u589e\u52a0 1 \u4e2a\u8868\u8fbe\u4e0e UC \u98ce\u9669\u589e\u52a0\u76f8\u5173\uff0c\u800c\u57fa\u56e0\u9884\u6d4b MRPL23\u3001NDUFAF7\u3001NDUFAF7\u3001GLDC\u3001ABHD11\u4e0e UC \u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff08\u8868 1 \uff09\u3002MRPL23\u548cABHD11\u5728\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93(UK Biobank)\u7814\u7a76\u548cFinnGen\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u5728FinnGen\u7814\u7a76\u4e2d\u9a8c\u8bc1\u4e86MRPL20\u3001MRPL23\u3001BCL2L11\u548cPMPCA\u3002<\/span><\/span><\/section>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u88681 \u5b5f\u5fb7\u5c14\u968f\u673a\u5206\u6790\u4e2d\u9057\u4f20\u9884\u6d4b\u7684\u7ebf\u7c92\u4f53\u57fa\u56e0\u8868\u8fbe\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u53ca\u5176\u4e9a\u578b\u7684\u5173\u8054\u3002<\/span><\/p>\n

3.\u7ebf\u7c92\u4f53\u86cb\u767d\u548c IBD<\/span><\/p>\n

\u6709 11\u30019 \u548c 12 \u4e2a\u7ebf\u7c92\u4f53\u86cb\u767d\u5206\u522b\u4e0e IBD\u3001CD \u548c UC \u98ce\u9669\u76f8\u5173\u3002\u7ecf\u8fc7\u591a\u6b21\u6d4b\u8bd5\u8c03\u6574\u540e\uff0c\u57fa\u56e0\u9884\u6d4b\u8f83\u9ad8\u6c34\u5e73\u7684 PARK7\u548c HINT1\u4e0e IBD \u98ce\u9669\u5448\u8d1f\u76f8\u5173\uff08\u56fe 3\uff09\u3002\u57fa\u56e0\u9884\u6d4b\u8f83\u9ad8\u6c34\u5e73\u7684 HINT1 \u4e0e CD \u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff0c\u8f83\u9ad8\u6c34\u5e73\u7684 ACADM\u3001PDK1\uff0cFIS1\u4e0e UC \u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff08\u56fe 3\uff09\u3002\u5728 PARK7 \u548c IBD \u4e4b\u95f4\u89c2\u5bdf\u5230\u5171\u5b9a\u4f4d\u8bc1\u636e (PPH4 = 0.70)\u3002ACADM (PPH4 = 0.86) \u548c PDK1 (PPH4 = 0.83) \u5728 UC \u4e2d\u5177\u6709\u9ad8\u5ea6\u652f\u6301\u5171\u5b9a\u4f4d\u7684\u8bc1\u636e\u3002<\/span><\/span><\/section>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u56fe3 \u5b5f\u5fb7\u5c14\u968f\u673a\u5206\u6790\u4e2d\u9057\u4f20\u9884\u6d4b\u7684\u7ebf\u7c92\u4f53\u57fa\u56e0\u7f16\u7801\u86cb\u767d\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u53ca\u5176\u4e9a\u578b\u7684\u5173\u8054\u3002OR\uff0c\u4f18\u52bf\u6bd4\uff1bCI\uff0c\u7f6e\u4fe1\u533a\u95f4\uff1bPPH4\uff0cH4 \u7684\u540e\u9a8c\u6982\u7387\u3002<\/span><\/p>\n

4.\u6574\u5408\u591a\u7ec4\u5b66\u6c34\u5e73\u7684\u8bc1\u636e<\/span><\/p>\n

\u6574\u5408\u591a\u7ec4\u5b66\u8bc1\u636e\u540e\uff0c\u9274\u5b9a\u4e86\u4e24\u4e2a\u5177\u6709\u4e00\u7ea7\u591a\u7ec4\u5b66\u8bc1\u636e\u7684\u57fa\u56e0 IBD \u548c UC\u75be\u75c5\u76f8\u5173\uff0c\u5305\u62ec PARK7 \u548c ACADM\u3002MR \u5206\u6790\u4e2d 4 \u4e2a\u5df2\u8bc6\u522b\u57fa\u56e0\u7684\u8868\u8fbe\u4e0e\u76f8\u5e94\u7684\u86cb\u767d\u8d28\u6c34\u5e73\u5448\u6b63\u76f8\u5173\uff08\u8868 2\uff09\u3002ACADM\u4e2dcg05467918\u7684\u7532\u57fa\u5316\u4e0eACADM\u7684\u8f83\u4f4e\u8868\u8fbe\u76f8\u5173\uff0c\u8fd9\u4e0ecg05467918\u7532\u57fa\u5316\u5bf9UC\u7684\u79ef\u6781\u4f5c\u7528\u76f8\u7b26\uff08\u56fe1\uff09\u3002\u540c\u6837\uff0c\u5728 PARK7 (cg10385390) \u548c PDK1 (cg17679246) \u4e2d\u4e5f\u89c2\u5bdf\u5230\u57fa\u56e0\u7532\u57fa\u5316\u4e0e\u57fa\u56e0\u8868\u8fbe\u4e4b\u95f4\u7684\u8d1f\u76f8\u5173\uff0c\u8bc1\u5b9e\u4e86\u5176\u5728 IBD \u548c UC \u4e2d\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<\/span><\/section>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u88682\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u7684\u7532\u57fa\u5316\u4e0e\u8868\u8fbe\u3001\u8868\u8fbe\u548c\u86cb\u767d\u4e30\u5ea6\u7684\u5173\u7cfb<\/span><\/p>\n

5.\u7ec4\u7ec7\u7279\u5f02\u6027\u9a8c\u8bc1<\/span><\/p>\n

\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4e86\u80a0\u7ec4\u7ec7\u4e2d\u5df2\u8bc6\u522b\u57fa\u56e0\u7684\u8868\u8fbe\u4e0e IBD \u6216 UC \u7684\u56e0\u679c\u5173\u7cfb\u3002\u7531\u4e8e\u7ed3\u679c\u6570\u636e\u4e2d\u6ca1\u6709\u9488\u5bf9 PDK1 \u548c FIS1 \u7684\u5de5\u5177\u53d8\u91cf\uff0c\u56e0\u6b64\u5206\u6790\u4e0d\u5305\u62ec\u8fd9\u4e24\u4e2a\u57fa\u56e0\u3002\u57fa\u56e0\u9884\u6d4b\u7684 PARK7 \u8868\u8fbe\u6c34\u5e73\u4e0e\u4e59\u72b6\u7ed3\u80a0\u548c\u6a2a\u7ed3\u80a0\u7ec4\u7ec7\u4e2d\u7684 IBD \u98ce\u9669\u5448\u8d1f\u76f8\u5173\uff08\u88683\uff09\u3002IBD \u6570\u636e\u96c6\u4e2d\u7f3a\u5c11\u5c0f\u80a0\u4e2d PARK7 \u8868\u8fbe\u7684\u5de5\u5177\u3002\u57fa\u56e0\u9884\u6d4b\u7684 ACADM \u8868\u8fbe\u6c34\u5e73\u4e0e\u4e59\u72b6\u7ed3\u80a0\u548c\u6a2a\u7ed3\u80a0\u7ec4\u7ec7\u4e2d IBD \u98ce\u9669\u964d\u4f4e\u76f8\u5173\u3002<\/span><\/span><\/section>\n

\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/span><\/p>\n

\u88683\u7ec4\u7ec7\u7279\u5f02\u6027\u57fa\u56e0\u8868\u8fbe\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u5173\u7cfb<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n

\u672c\u7814\u7a76\u63a2\u7d22\u4e86\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u7532\u57fa\u5316\u3001\u8868\u8fbe\u548c\u86cb\u767d\u4e30\u5ea6\u4e0eIBD\u7684\u6f5c\u5728\u56e0\u679c\u5173\u7cfb\uff0c\u8bc1\u660e\u4e86\u51e0\u79cd\u7ebf\u7c92\u4f53\u76f8\u5173\u57fa\u56e0\u53ca\u5176\u8c03\u63a7\u5728IBD\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u91cd\u8981\u6027\u3002\u5bf9\u4e8e\u60f3\u5728\u708e\u75c7\u6027\u80a0\u75c5\u836f\u7406\u5b66\u7814\u7a76\u4e2d\u9776\u70b9\u7684\u5bfb\u627e\u548c\u786e\u5b9a\u7684\u7814\u7a76\u8005\u4e5f\u4f1a\u63d0\u4f9b\u65b0\u7684\u7814\u7a76\u601d\u8def\u3002\u7279\u522b\u662f\u7ed3\u5408\u4e86\u76ee\u524d\u56fd\u81ea\u7136\u7814\u7a76\u7684\u70ed\u70b9\u201c\u7ebf\u7c92\u4f53\u201d\uff0c\u53d6\u5f97\u4e8611+\u5206\u7684\u597d\u6210\u7ee9\u3002<\/span>\u5927\u6570\u636e\u65f6\u4ee3\uff0c\u79d1\u7814\u4eba\u62ff\u516c\u5f00\u6570\u636e\uff0c\u53d1\u81ea\u5df1\u7684\u6587\u7ae0\uff01\u60f3\u590d\u73b0\u7684\u5c0f\u4f19\u4f34\u6293\u7d27\u626b\u7801\u8054\u7cfb\u5c0f\u4e91\u5427\uff01<\/span><\/section>\n
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\"\u63a5\u6536\u7eaf\u751f\u4fe1\u7684\u67f3\u53f6\u5200\u5b50\u520a\u89c1\u8fc7\u5417\uff1f\u89c1\u520a\u5feb\uff0c\u56fd\u4eba\u53d1\u6587\u5360\u6bd4\u8d853\u6210\uff01\u4e0d\u4fe1\u770b\u8fd9\u7bc7\u6d59\u5927\u674e\u96ea\u56e2\u961f\u65b0\u4f5c\uff0cMR\u8054\u5408\u7ebf\u7c92\u4f530\u5b9e\u9a8c\u62ff\u4e0b11+\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

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